The notorious North East prison has been dubbed 'Monster Mansion' due to list of violent killers and rapists it houses

Singer-songwriter JP SAXE and GRAMMY Award-nominated artist JULIA MICHAELS today released a new video of their duet "If The World Was Ending" to help support the international … more

Research Highlights: Hypertensive pregnancy disorders, especially preeclampsia – may increase the risk of psychological development disorders and behavioral and emotional disorders in children. This is the first study to show that preeclampsia...

The City of Cedar Rapids Thursday morning issued a drinking water boil order for portions of southwest Cedar Rapids. A rupture in a water main feeding the Bowling Street Booster Station and C Street...

The City of Cedar Rapids Thursday morning issued a drinking water boil order for portions of southwest Cedar Rapids.

A rupture in a water main feeding the Bowling Street Booster Station and C Street Water Tower caused a loss of pressure, which created the potential for bacteria contamination to occur, according to a news release.

The two affected areas are bounded by these streets:

• For the first area, Schaeffer Drive SW east to C Street SW and 19th Avenue SW south to Highway 30.

• For the second area, Sixth Street SW east to J Street SW and 29th Avenue south to 36th Avenue SW.

The city is advising affected residents to:

1) Bring water to a boil

2) Let it rapidly boil for at least 1 minute

3) Allow to cool completely before consuming

The boil order should be lifted or extended by 1 p.m. Sunday, after repairs are complete, pressure is restored, flushing has occurred, chlorine levels have been monitored and two consecutive sets of bacteria samples have been collected for analysis, the city stated.

Water is safe to consume in all other areas of Cedar Rapids.

Imperfect Foods, an online surplus-stock grocery delivery company aimed at eliminating food waste, has begun is offering JetBlue Airline cheese and snack trays — $2.99 for three ounces of mixed cheeses, dried cherries and crackers.

Imperfect Foods CEO Philip Behn says the cheese and snack trays were an early casualty of the coronavirus pandemic.

“Almost two months ago, before it became a nationwide pandemic, this catering and airplane meal supplier said they saw a decline in economy and business-class seats,” he said. “This was one of our first COVID-19 food waste recovery opportunities. We could only take a fraction of what they had.”

Behn said his company has sold 40,000 cheese and snack trays.

“We call that ‘breaking bulk,’” Behn said. “We have stepped up with co-packers to try to repackage some of those products — it’s hard work and it’s slow, given the importance of food safety.”

Yet there are bright spots. Imperfect Foods is a budget-conscious company, so high-end products such as pineapples are usually too expensive to offer their customers.

Where do people eat pineapples? Hotels. And with hotels stalled, Imperfect Foods has been able to buy and offer them for a fair price.

It has redistributed popcorn kernels previously destined for movie theaters and broccoli florets usually reserved for restaurants. Since the beginning of March, Imperfect Foods has doubled the volume of food it was previously buying, the JetBlue snacks among many.

Julianna Bryan, communications specialist for JetBlue, said the airline has had to dramatically reduce its in-flight food and beverage service to minimize contact between customers and crew members.

“We have temporarily suspended the sales of buy-onboard products including our EatUp Snack Boxes, EatUp Café fresh food items, beer, wine and liquor,” she said.

JetBlue has donated leftover inventory of snacks to Feeding America and other food banks, as well as hospitals.

JetBlue has worked with its business partners to sell unused inventory, such as the cheese trays, at a heavily discounted price with the goal of moving it quickly and minimizing waste, Bryan said.

JetBlue is not the only airline to have to find new outlets for its in-flight overflow.

Delta has had to unload its Biscoff cookies — and it serves 80 million to 85 million of these spiced shortbread favorites each year.

At United, the Dutch stroopwafels have been piling up.

In addition to selling some of their excess, airlines have put donation programs in place. Southwest has donated more than $400,000 in snacks and other in-flight items to not-for-profit organizations and nearly 13 tractor-trailers full of groceries to 15 food banks that are a part of the Feeding America network.

Delta has donated 500,000 pounds of food around the world in the past six weeks. Front-line workers and hospitals get the Biscoff cookies along with coffee and other in-flight beverages, while other perishable food has gone to Feeding America’s partner agencies like Georgia Food & Resource Center and Missouri’s Carthage Crisis Center.

And United has donated 173,000 pounds of food to food banks and charities, pulling from airport lounges and catering kitchens. United volunteers have also processed more than 428,000 pounds of food and household goods for the Houston Food Bank.

Until recently it was something normal for any restaurant to have a well-maintained website. Even so, it seems that for many restaurants this was something difficult to achieve. In these difficult times, for many restaurant owners and other businesses in this field, owning just a simple website is no longer enough. If you still want to remain in business you […]

Listening without judgement is one of the best things you can do for someone with PTSD.

Listening without judgement is one of the best things you can do for someone with PTSD.

Want to create a wholesale order form in WordPress? If you’re a wholesaler looking to get online, but don’t want to manage a full-fledged eCommerce store, then you might want to consider adding a simple wholesale order form to your WordPress site. In this article, we’ll show you how to properly create a simple wholesale […]

The post How to Properly Create a Wholesale Order Form in WordPress appeared first on IsItWP - Free WordPress Theme Detector.

Listening without judgement is one of the best things you can do for someone with PTSD.

This paper considers the distributed nonconvex optimization problem of minimizing a global cost function formed by a sum of local cost functions by using local information exchange. We first propose a distributed first-order primal-dual algorithm. We show that it converges sublinearly to the stationary point if each local cost function is smooth and linearly to the global optimum under an additional condition that the global cost function satisfies the Polyak-{L}ojasiewicz condition. This condition is weaker than strong convexity, which is a standard condition for proving the linear convergence of distributed optimization algorithms, and the global minimizer is not necessarily unique or finite. Motivated by the situations where the gradients are unavailable, we then propose a distributed zeroth-order algorithm, derived from the proposed distributed first-order algorithm by using a deterministic gradient estimator, and show that it has the same convergence properties as the proposed first-order algorithm under the same conditions. The theoretical results are illustrated by numerical simulations.

We study a class of fourth order nonlinear parabolic equations which include the thin-film equation and the quantum drift-diffusion model as special cases. We investigate these equations by first developing functional inequalities of the type $ int_Omega u^{2gamma-alpha-eta}Delta u^alphaDelta u^eta dx geq cint_Omega|Delta u^gamma |^2dx $, which seem to be of interest on their own right.

In 1978, Dwight Duffus---editor-in-chief of the journal "Order" from 2010 to 2018 and chair of the Mathematics Department at Emory University from 1991 to 2005---wrote that "it is not obvious that $P$ is connected and $P^P$ isomorphic to $Q^Q$ implies that $Q$ is connected," where $P$ and $Q$ are finite non-empty posets. We show that, indeed, under these hypotheses $Q$ is connected and $Pcong Q$.

We establish the functional convex order results for two scaled McKean-Vlasov processes $X=(X_{t})_{tin[0, T]}$ and $Y=(Y_{t})_{tin[0, T]}$ defined by

[egin{cases} dX_{t}=(alpha X_{t}+eta)dt+sigma(t, X_{t}, mu_{t})dB_{t}, quad X_{0}in L^{p}(mathbb{P}),\ dY_{t}=(alpha Y_{t},+eta)dt+ heta(t, Y_{t}, u_{t})dB_{t}, quad Y_{0}in L^{p}(mathbb{P}). end{cases}] If we make the convexity and monotony assumption (only) on $sigma$ and if $sigmaleq heta$ with respect to the partial matrix order, the convex order for the initial random variable $X_0 leq Y_0$ can be propagated to the whole path of process $X$ and $Y$. That is, if we consider a convex functional $F$ with polynomial growth defined on the path space, we have $mathbb{E}F(X)leqmathbb{E}F(Y)$; for a convex functional $G$ defined on the product space involving the path space and its marginal distribution space, we have $mathbb{E},Gig(X, (mu_t)_{tin[0, T]}ig)leq mathbb{E},Gig(Y, ( u_t)_{tin[0, T]}ig)$ under appropriate conditions. The symmetric setting is also valid, that is, if $ heta leq sigma$ and $Y_0 leq X_0$ with respect to the convex order, then $mathbb{E},F(Y) leq mathbb{E},F(X)$ and $mathbb{E},Gig(Y, ( u_t)_{tin[0, T]}ig)leq mathbb{E},G(X, (mu_t)_{tin[0, T]})$. The proof is based on several forward and backward dynamic programming and the convergence of the Euler scheme of the McKean-Vlasov equation.

Monadic second order logic can be used to express many classical notions of sets of vertices of a graph as for instance: dominating sets, induced matchings, perfect codes, independent sets or irredundant sets. Bounds on the number of sets of any such family of sets are interesting from a combinatorial point of view and have algorithmic applications. Many such bounds on different families of sets over different classes of graphs are already provided in the literature. In particular, Rote recently showed that the number of minimal dominating sets in trees of order $n$ is at most $95^{frac{n}{13}}$ and that this bound is asymptotically sharp up to a multiplicative constant. We build on his work to show that what he did for minimal dominating sets can be done for any family of sets definable by a monadic second order formula.

We first show that, for any monadic second order formula over graphs that characterizes a given kind of subset of its vertices, the maximal number of such sets in a tree can be expressed as the extit{growth rate of a bilinear system}. This mostly relies on well known links between monadic second order logic over trees and tree automata and basic tree automata manipulations. Then we show that this "growth rate" of a bilinear system can be approximated from above.We then use our implementation of this result to provide bounds on the number of independent dominating sets, total perfect dominating sets, induced matchings, maximal induced matchings, minimal perfect dominating sets, perfect codes and maximal irredundant sets on trees. We also solve a question from D. Y. Kang et al. regarding $r$-matchings and improve a bound from G'orska and Skupie'n on the number of maximal matchings on trees. Remark that this approach is easily generalizable to graphs of bounded tree width or clique width (or any similar class of graphs where tree automata are meaningful).

We live and cooperate in networks. However, links in networks only allow for pairwise interactions, thus making the framework suitable for dyadic games, but not for games that are played in groups of more than two players. To remedy this, we introduce higher-order interactions, where a link can connect more than two individuals, and study their evolutionary dynamics. We first consider a public goods game on a uniform hypergraph, showing that it corresponds to the replicator dynamics in the well-mixed limit, and providing an exact theoretical foundation to study cooperation in networked groups. We also extend the analysis to heterogeneous hypergraphs that describe interactions of groups of different sizes and characterize the evolution of cooperation in such cases. Finally, we apply our new formulation to study the nature of group dynamics in real systems, showing how to extract the actual dependence of the synergy factor on the size of a group from real-world collaboration data in science and technology. Our work is a first step towards the implementation of new actions to boost cooperation in social groups.

Recent beyond worst-case optimal join algorithms Minesweeper and its generalization Tetris have brought the theory of indexing and join processing together by developing a geometric framework for joins. These algorithms take as input an index $mathcal{B}$, referred to as a box cover, that stores output gaps that can be inferred from traditional indexes, such as B+ trees or tries, on the input relations. The performances of these algorithms highly depend on the certificate of $mathcal{B}$, which is the smallest subset of gaps in $mathcal{B}$ whose union covers all of the gaps in the output space of a query $Q$. We study how to generate box covers that contain small size certificates to guarantee efficient runtimes for these algorithms. First, given a query $Q$ over a set of relations of size $N$ and a fixed set of domain orderings for the attributes, we give a $ ilde{O}(N)$-time algorithm called GAMB which generates a box cover for $Q$ that is guaranteed to contain the smallest size certificate across any box cover for $Q$. Second, we show that finding a domain ordering to minimize the box cover size and certificate is NP-hard through a reduction from the 2 consecutive block minimization problem on boolean matrices. Our third contribution is a $ ilde{O}(N)$-time approximation algorithm called ADORA to compute domain orderings, under which one can compute a box cover of size $ ilde{O}(K^r)$, where $K$ is the minimum box cover for $Q$ under any domain ordering and $r$ is the maximum arity of any relation. This guarantees certificates of size $ ilde{O}(K^r)$. We combine ADORA and GAMB with Tetris to form a new algorithm we call TetrisReordered, which provides several new beyond worst-case bounds. On infinite families of queries, TetrisReordered's runtimes are unboundedly better than the bounds stated in prior work.

When time-dependent partial differential equations (PDEs) are solved numerically in a domain with curved boundary or on a curved surface, mesh error and geometric approximation error caused by the inaccurate location of vertices and other interior grid points, respectively, could be the main source of the inaccuracy and instability of the numerical solutions of PDEs. The role of these geometric errors in deteriorating the stability and particularly the conservation properties are largely unknown, which seems to necessitate very fine meshes especially to remove geometric approximation error. This paper aims to investigate the effect of geometric approximation error by using a high-order mesh with negligible geometric approximation error, even for high order polynomial of order p. To achieve this goal, the high-order mesh generator from CAD geometry called NekMesh is adapted for surface mesh generation in comparison to traditional meshes with non-negligible geometric approximation error. Two types of numerical tests are considered. Firstly, the accuracy of differential operators is compared for various p on a curved element of the sphere. Secondly, by applying the method of moving frames, four different time-dependent PDEs on the sphere are numerically solved to investigate the impact of geometric approximation error on the accuracy and conservation properties of high-order numerical schemes for PDEs on the sphere.

Within the field of multilinear algebra, inverses and generalized inverses of tensors based on the Einstein product have been investigated over the past few years. In this paper, we explore the singular value decomposition and full-rank decomposition of arbitrary-order tensors using {it reshape} operation. Applying range and null space of tensors along with the reshape operation; we further study the Moore-Penrose inverse of tensors and their cancellation properties via the Einstein product. Then we discuss weighted Moore-Penrose inverses of arbitrary-order tensors using such product. Following a specific algebraic approach, a few characterizations and representations of these inverses are explored. In addition to this, we obtain a few necessary and sufficient conditions for the reverse-order law to hold for weighted Moore-Penrose inverses of arbitrary-order tensors.

The present invention relates to a process for preparing a compound of formula wherein: R2 is cycloalkyl or alkyl, each of which may be optionally substituted; Y is —CONR3R4, —CN or CO2R5; R3, R4 and R5 are each independently H or alkyl; n is 1 to 6; wherein said process comprising the steps of: (i) treating a compound of formula (IV), where R1 is alkyl, with a compound of formula (V) and forming a compound of formula (IIIb); (ii) treating said compound of formula (IIIb) with a compound of formula (I1) to form a compound of formula (I).

The present invention provides a use of a lipid composition for the preparation of a nutritional, pharmaceutical or nutraceutical composition or a functional food, for the prevention and treatment of gastrointestinal diseases and disorders, and for promoting intestinal development, maturation, adaptation and differentiation.

A system and method for reordering storage levels in a virtualized environment includes identifying a virtual machine (VM) to be transitioned and determining a new storage level order for the VM. The new storage level order reduces a VM live state during a transition, and accounts for hierarchical shared storage memory and criteria imposed by an application to reduce recovery operations after dynamic resource allocation actions. The new storage level order recommendation is propagated to VMs. The new storage level order applied in the VMs. A different storage-level order is recommended after the transition.

According to an embodiment, based on task border information, and first-type dependency relationship information containing N number of nodes corresponding to data accesses to one set of data, containing edges representing dependency relationship between the nodes, and having at least one node with an access reliability flag indicating reliability/unreliability of corresponding data access; task border edges, of edges extending over task borders, are identified that have an unreliable access node linked to at least one end, and presentation information containing unreliable access nodes is generated. According to dependency existence information input corresponding to the set of data, conversion information indicating absence of data access to the unreliable access nodes is output. According to the conversion information, the first-type dependency relationship information is converted into second-type dependency relationship information containing M number of nodes (0≦M≦N) corresponding to data accesses to the set of data and containing edges representing inter-node dependency relationship.

A processor for processing loop instructions can include an instruction reorder structure and a loop processing controller. The instruction reorder structure is configured to store decoded instructions according to program order and issue the decoded instructions for execution out of program order. The loop processing controller is configured to detect a loop in the decoded instructions stored in the instruction reorder structure and cause the instruction reorder structure to reissue the decoded instructions that form the loop for re-execution.

A multi-threaded in-order superscalar processor 2 includes an issue stage 12 including issue circuitry 22, 24 for selecting instructions to be issued to execution units 14, 16 in dependence upon a currently selected issue policy. A plurality of different issue policies are provided by associated different policy circuitry 28, 30, 32 and a selection between which of these instances of the policy circuitry 28, 30, 32 is active is made by policy selecting circuitry 34 in dependence upon detected dynamic behavior of the processor 2.

In accordance with embodiments, there are provided mechanisms and methods for controlling a process using a process map. These mechanisms and methods for controlling a process using a process map can enable process operations to execute in order without necessarily having knowledge of one another. The ability to provide the process map can avoid a requirement that the operations themselves be programmed to follow a particular sequence, as can further improve the ease by which the sequence of operations may be changed.

Vehicle event recorder systems are arranged to be in constant communication with remote servers and administrators via mobile wireless cellular networks. Vehicle event recorders equipped with video cameras capture video and other data records of important events relating to vehicle use. These data are then transmitted over special communications networks having very high coverage space but limited bandwidth. A vehicle may be operated over very large region while maintaining continuous communications connections with a remote fixed server. As such, systems of these inventions may be characterized as including a mobile unit having: a video camera; a microprocessor; memory; an event trigger; and mobile wireless transceivers, and a fixed network portion including: mobile wireless cellular network, a protocol translation gateway, the Internet and an application-specific server.

The disclosed device enables the recording of television broadcasts which are preprogrammed in a memory. The presence of data lines of the television signal in combination with the presence of a color television signal is checked. When the data lines stop, the video recorder is switched on in real time by a clock time signal.

A method and system for treating brain disorders comprises detecting activity of a first target area of the brain via a first implanted sensor and determining the presence of target brain activity by analyzing the detected brain activity in combination with treating the user based upon the determined presence of target brain activity by supplying a first therapeutic agent to the first target area via a first implanted fluid delivery member including at least one distal opening adjacent to the first target area. In addition, the system may be used as well for testing the effectiveness of drugs.

An apparatus for the carrying of a woodwind musical instrument, known as a recorder, consisting of a ring with sufficient inside diameter to fit around the shaft of the recorder and a strap attached to the ring and of sufficient length so as to fit around the neck of the person playing the recorder and allowing the recorder to hang in a position of easy access to the user.

Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof.

This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, and more particularly, for inhibiting Th1 cell-mediated immune responses. This invention relates to soluble forms of the lymphotoxin-β receptor extracellular domain that act as lymphotoxin-β receptor blocking agents. This invention also relates to the use of antibodies directed against either the lymphotoxin-β receptor or its ligand, surface lymphotoxin, that act as lymphotoxin-β receptor blocking agents. A novel screening method for selecting soluble receptors, antibodies and other agents that block LT-β receptor signalling is provided.

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.

Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.

The invention relates to compositions comprising vasoactive intestinal peptide (VIP) or fragments thereof, and the use of such compositions in the treatment of kidney disease, in particular kidney fibrosis, and other associated conditions.

Methods and systems for detecting azetidine-2-carboxylic acid (Aze) in food consumable by humans and animals are provided. Also provided are methods and systems for inactivating Aze in food and byproducts, as well as other methods for the diagnosis, prevention, and treatment of disorders associated with Aze.

A method and apparatus for treating ocular disorders such as blepharitis, meibomitis, and dry eye syndrome. The method includes using an electromechanical device to move a swab relative to the eye to create cyclical movement that impacts debris present at the eyelid margin and effectively removes the debris from the eye to encourage healing and prevent further digression of the health of the eye. The apparatus is an electromechanical device that includes a mechanical drive unit operatively connected to a swab to create a precise relative movement of the swab to the eye to remove debris present therein.

A third-order distributed feedback laser has an active medium disposed on a substrate as a linear array of segments having a series of periodically spaced interstices therebetween and a first conductive layer disposed on a surface of the active medium on each of the segments and along a strip from each of the segments to a conductive electrical contact pad for application of current along a path including the active medium. Upon application of a current through the active medium, the active medium functions as an optical waveguide, and there is established an alternating electric field, at a THz frequency, both in the active medium and emerging from the interstices. Spacing of adjacent segments is approximately half of a wavelength of the THz frequency in free space or an odd integral multiple thereof, so that the linear array has a coherence length greater than the length of the linear array.

The invention concerns an oscillator generating a wave composed of a frequency of on the order of terahertz from a beat of two optical waves generated by a dual-frequency optical source. The oscillator includes a modulator the transfer function of which is non-linear for generating harmonics with a frequency of less than one terahertz for each of the optical waves generated by the dual-frequency optical source, an optical detector able to detect at least one harmonic for each of the optical waves generated by the dual-frequency optical source and transforming the harmonics detected into an electrical signal, a phase comparator for comparing the electrical signal with a reference electrical signal, and a module for controlling at least one element of the dual-frequency optical source with a signal obtained from the signal resulting from the comparison.

A computerized chart recorder is revealed, comprises a signal conversion unit, an operation control unit, a printing control unit, and a database. A signal conversion unit receives measurement signals of a measurement instrument, and converts the measurement signals to signal conversion data. A operation control unit receives the signal conversion data required for printing, produces corresponding chart data, and prints the curve of signal variations, which can be also displayed on a human-machine interface unit. Whether to store the data or to print can be determined. Besides, the data can be also transmitted to a printing control unit. When the printing control unit is activated, it can receive the chart data and the quality assurance data, and control a printing unit to emulate the chart recorder for executing chart recording. In addition, the quality assurance data can be printed as well for complying with the requirements of the quality-assurance operations.

A time recorder includes a first sensor that detects the side edge of a time card having a cut-out formed at at least one corner of the bottom, a second sensor that detects the bottom of the time card, and a card feeding unit that feeds the time card. When the time card is fed by this card feeding unit, a pulse counter of the card feeding unit counts the number of pulses of predetermined pulse signals after the first sensor detects the time card and until the second sensor detects the time card. Next, the front and back faces of the time card are determined based on the number of pulses that is a counting result. Hence, the front and back faces can be determined by the first sensor and the second sensor only.

An apparatus includes a biquad filter having first and second lossy integrators and multiple input networks. Each lossy integrator includes an amplifier, and each input network is coupled to an input of the amplifier in one of the lossy integrators. Each input network includes multiple resistors and a capacitor arranged in a T-structure. In a single-ended configuration, each input network includes a grounded capacitor. In a fully-differential configuration, each input network includes one of: a grounded capacitor and a floating capacitor coupled to another input network. The amplifiers and resistors could form a portion of an integrated circuit chip, which also includes multiple input/output pins. A single grounded capacitor could be coupled to a single input/output pin of the integrated circuit chip for an input network. A single floating capacitor could be coupled to two input/output pins of the integrated circuit chip for a pair of input networks.

Touch screens with more compact border regions can include an active area that includes touch sensing circuitry including drive lines, and a border region around the active area. The border region can include an area of sealant deposited on conductive lines, and transistor circuitry, such as gate drivers, between the active area and the sealant. The conductive lines can extend from the sealant to the active area without electrically connecting to the transistor circuitry. The conductive lines can have equal impedances and can connect the drive lines to a touch controller off of the touch screen. A set of drive signal characteristics for the drive lines can be obtained by determining a transfer function associated with each drive line, obtaining an inverse of each transfer function, and applying a set of individual sense signal characteristics to the inverse transfer functions to obtain the corresponding set of drive signal characteristics.

Various embodiments associated with an at least fourth-order cumulant of a signal are described. The at least fourth-order noise-insensitive cumulant of the signal can be taken and compared against an at least fourth-order noise-insensitive cumulant of known signals. A match can be found between the signal and a known signal and from this match, a demodulation scheme of the signal can be determined. The demodulation scheme can be used to demodulate the signal.

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.

The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Described herein are methods and compositions for treatment of immune-related diseases or disorders by modulating DD1α activity, alone or in combination with modulation of PD-1 activity. In some embodiments, the methods and compositions described herein are directed to treatment of cancer and/or infections (e.g., bacterial infection, and/or fungal infection). In some embodiments, the methods and compositions described herein are directed to treatment of autoimmune diseases and/or inflammation. In some embodiments, the methods and compositions described herein are directed to treatment of asthma, and allergy. Methods for identifying patients who are more likely to be responsive to and benefit from an immunotherapy that targets DD1α and/or PD-1 activity or expression are also described herein.

The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.