Brian Neelon.

Source: Bayesian Analysis, Volume 14, Number 3, 849--875.

Abstract:
Motivated by a study examining spatiotemporal patterns in inpatient hospitalizations, we propose an efficient Bayesian approach for fitting zero-inflated negative binomial models. To facilitate posterior sampling, we introduce a set of latent variables that are represented as scale mixtures of normals, where the precision terms follow independent Pólya-Gamma distributions. Conditional on the latent variables, inference proceeds via straightforward Gibbs sampling. For fixed-effects models, our approach is comparable to existing methods. However, our model can accommodate more complex data structures, including multivariate and spatiotemporal data, settings in which current approaches often fail due to computational challenges. Using simulation studies, we highlight key features of the method and compare its performance to other estimation procedures. We apply the approach to a spatiotemporal analysis examining the number of annual inpatient admissions among United States veterans with type 2 diabetes.

Xiao-Jing Wang
Oct 15, 1996; 16:6402-6413
Articles

Fiona Doetsch
Jul 1, 1997; 17:5046-5061
Articles

A Bragin
Jan 1, 1995; 15:47-60
Articles

Gamma-band oscillations (GBOs) elicited by transient nociceptive stimuli are one of the most promising biomarkers of pain across species. Still, whether these GBOs reflect stimulus encoding in the primary somatosensory cortex (S1) or nocifensive behavior in the primary motor cortex (M1) is debated. Here we recorded neural activity simultaneously from the brain surface as well as at different depths of the bilateral S1/M1 in freely-moving male rats receiving nociceptive stimulation. GBOs measured from superficial layers of S1 contralateral to the stimulated paw not only had the largest magnitude, but also showed the strongest temporal and phase coupling with epidural GBOs. Also, spiking of superficial S1 interneurons had the strongest phase coherence with epidural GBOs. These results provide the first direct demonstration that scalp GBOs, one of the most promising pain biomarkers, reflect neural activity strongly coupled with the fast spiking of interneurons in the superficial layers of the S1 contralateral to the stimulated side.

SIGNIFICANCE STATEMENT Nociceptive-induced gamma-band oscillations (GBOs) measured at population level are one of the most promising biomarkers of pain perception. Our results provide the direct demonstration that these GBOs reflect neural activity coupled with the spike firing of interneurons in the superficial layers of the primary somatosensory cortex (S1) contralateral to the side of nociceptive stimulation. These results address the ongoing debate about whether nociceptive-induced GBOs recorded with scalp EEG or epidurally reflect stimulus encoding in the S1 or nocifensive behavior in the primary motor cortex (M1), and will therefore influence how experiments in pain neuroscience will be designed and interpreted.

To determine whether Cav1.2 voltage-gated Ca²⁺ channels contribute to astrocyte activation, we generated an inducible conditional knock-out mouse in which the Cav1.2 α subunit was deleted in GFAP-positive astrocytes. This astrocytic Cav1.2 knock-out mouse was tested in the cuprizone model of myelin injury and repair which causes astrocyte and microglia activation in the absence of a lymphocytic response. Deletion of Cav1.2 channels in GFAP-positive astrocytes during cuprizone-induced demyelination leads to a significant reduction in the degree of astrocyte and microglia activation and proliferation in mice of either sex. Concomitantly, the production of proinflammatory factors such as TNFα, IL1β and TGFβ1 was significantly decreased in the corpus callosum and cortex of Cav1.2 knock-out mice through demyelination. Furthermore, this mild inflammatory environment promotes oligodendrocyte progenitor cells maturation and myelin regeneration across the remyelination phase of the cuprizone model. Similar results were found in animals treated with nimodipine, a Cav1.2 Ca²⁺ channel inhibitor with high affinity to the CNS. Mice of either sex injected with nimodipine during the demyelination stage of the cuprizone treatment displayed a reduced number of reactive astrocytes and showed a faster and more efficient brain remyelination. Together, these results indicate that Cav1.2 Ca²⁺ channels play a crucial role in the induction and proliferation of reactive astrocytes during demyelination; and that attenuation of astrocytic voltage-gated Ca²⁺ influx may be an effective therapy to reduce brain inflammation and promote myelin recovery in demyelinating diseases.

SIGNIFICANCE STATEMENT Reducing voltage-gated Ca²⁺ influx in astrocytes during brain demyelination significantly attenuates brain inflammation and astrocyte reactivity. Furthermore, these changes promote myelin restoration and oligodendrocyte maturation throughout remyelination.

A sweeping new study of 101 mammal species found that females live, on average, 18.6 percent longer than their male counterparts

How do you encapsulate everything that goes into a full week of teaching, worship music, workshops, meals and so much more? Enjoy a brief overview of TeenStreet 2019.

In a new twist on oral history, University of Alberta paleontologists have discovered that an Argentinian reptile from 95 million years ago developed a type of tooth enamel that is common in humans and other mammals but rare among reptiles.

A randomized, controlled clinical trial evaluating the safety and efficacy of a treatment regimen of the investigational antiviral remdesivir plus the anti-inflammatory drug baricitinib for coronavirus disease 2019 (COVID-19) has begun.

Cleveland Indians reliever Emmanuel Clase was suspended 80 games by Major League Baseball on Friday for testing positive for a banned performance-enhancing drug.

Hanna Jovin and Adrian Morphy say many, including themselves, have been experiencing strange and vivid dreams since the pandemic began and the pair decided to illustrate and share them on social media.

Making a film when you can't leave home means being creative — with everything from the scenery to your cast. C.J. Bernauer talked to Windsor Morning host Tony Doucette about his new short horror film, called 'You're It.'

To me, one of the handiest SOLIDWORKS ease-of-use functions hides in plain view: The Command Search. Found at the top of the application, the SOLIDWORKS Search box can be set to several different types of search, but the one I

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The post Finding New Commands in SOLIDWORKS Command Search appeared first on SOLIDWORKS Tech Blog.

Learn how to easily delete a face from a solid or surface body when modeling in SOLIDWORKS. Our #TechTip this week is by Training Manager John Setzer. Video Transcript Hi and welcome to another GSC tech tip. Today we’re going

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The post SOLIDWORKS Command, Delete Face: Easily Remove Faces From a Solid or Surface Body appeared first on SOLIDWORKS Tech Blog.

Amendments to the Price Increments of the 3-Year U.S. Treasury Note Futures Contract

Click here for the full text of the advisory

20-188

A new missions experience in Namibia is not as much a programme as it is a journey.

A Thousand Moons

OM Costa Rica team members celebrated Emmanuel with their friends in a home for patients suffering from HIV and AIDS.

K-12 teachers are faced with a question many likely thought they'd never have to ask: How often during the school day do my students need to see me and when?

With the first charter school strike in the books—and teachers coming out victorious—experts say both unions and charter schools may need to rethink how they’ve long operated.

With the first charter school strike in the books—and teachers coming out victorious—experts say both unions and charter schools may need to rethink how they’ve long operated.

Three high school basketball players in Tennessee were charged with aggravated rape and aggravated assault in late December after allegedly sending one of their 15-year-old teammates to the hospital.

We need a way to radically reimagine the mindset and the methodology of working toward equity. The concept of "street data," which allows for real-time feedback loops rooted in the voices and experiences of students, staff, and families, is key to this transformation.

Although China has the largest birth population in the world and a number of multicenter studies of neonatal respiratory failure are reported, there is a paucity of data regarding outcome measurement of very premature neonates requiring respiratory care and surfactant therapy.

This study is the largest survey, to date, in a Chinese network of 55 NICUs that presents the incidence, morbidity, and mortality rates, with risk factors of neonatal respiratory failure, with special emphasis on surfactant-treated very immature infants. (Read the full article)

Knowledge is limited regarding the epidemiology of persistent pulmonary hypertension of the newborn (PPHN). Previous work has implicated a host of perinatal risk factors and a few antenatal antecedents of PPHN, including maternal consumption during pregnancy of nonsteroidal antiinflammatory medications.

In contrast to results of previous studies, we found no association between PPHN and maternal consumption during late pregnancy of nonsteroidal antiinflammatory drugs in general or ibuprofen in particular. (Read the full article)

Yearly influenza immunization is recommended in patients with inflammatory bowel disease (IBD). However, concern regarding vaccine-related adverse events may limit uptake, and case reports in the literature detail disease flares after immunization.

Influenza immunization rates in children with IBD are low but immunization did not result in increased outpatient visits, hospitalizations or emergency visits. Immunization was associated with fewer IBD-related visits in the post-vaccine period, which may indicate protection against IBD symptoms. (Read the full article)

High sodium intake is considered an indirect cause of obesity because it is often accompanied by higher energy intake and sugar-sweetened soft drink consumption. High sodium intake is associated with increased inflammatory response in adult patients.

This study shows that high sodium intake is positively associated with adiposity, leptin, and tumor necrosis factor-α independent of total energy intake and sugar-sweetened soft drink consumption in healthy white and African American adolescents. (Read the full article)

IP-10 is a novel immunologic marker for tuberculosis (TB) infection. It has been suggested that IP-10 may perform better in children compared with the QuantiFERON test, but only a few studies have investigated IP-10 for diagnosing active TB in children.

This study is the first to investigate IP-10 and QuantiFERON for diagnosing TB in children by using consensus classifications. Both IP-10 and QuantiFERON exhibited poor performance in children from a high-burden setting, and performance was especially compromised in young children. (Read the full article)

Election fever has spread across Central Africa. For the second time since the end of the disastrous civil wars in the region, electoral processes have been launched in Burundi, Rwanda, Central African Republic and the Congo.

Faced with the dilemma of respecting the constitutional deadline and organising botched elections, or ignoring that deadline and sliding into a situation of unconstitutional power, the Congolese authorities have chosen the first option.

Mar 1, 1992; 89:525-527
ARTICLES

Most Pi projects run on Linux, so having some command-line chops makes the Pi much easier to work with. These commands can teach you a lot as you tinker.

University Police and Public Safety Deputy Chief Stephanie Delaney has been appointed as the district commander at the University Park campus, according to UPPS Assistant Vice President Charlie Noffsinger.

Screenwriters Anjum Rajabali and Sudip Sharma and cinematographer Siddharth Diwan have also joined the initiative

Russian MMA fighter Dmitry 'Anubis' Kuznetsov has revealed scorned fans threatened he would receive "a bullet in the head" in response to releasing a diss track titled 'Hypocrisy King,' aimed at UFC champ Khabib Nurmagomedov.
Read Full Article at RT.com

Ambassador of France to India Emmanuel Lenain says CAA is a domestic issue, assures Paris is firm over FATF action against Pak, insists Rafale row was linked to Indian politics and that planes are on schedule, and hopes for ‘good news’ on the Jaitapur n-units

Pakistan on Monday conferred its highest civilian award Nishan-e-Pakistan on Saudi Crown Prince Mohammad bin Salman for his “outstanding support” in reinvigorating the ties between the two countries.

Director and producer Timur Bekmambetov, who is regarded as one of the inventors of the 'Screenlife' format, in which movies take place entirely on computer screens, wants to produce a film about the lockdown in the new genre

Michael Gewitz, Physician-in-Chief of Maria Fareri Children's Hospital, where the boy passed away, said the child suffered "serious neurological complications" from the pediatric multi-symptom inflammatory syndrome.

Riyaz Naikoo was member of region’s largest indigenous militant group, Hizbul Mujahideen

Indian government forces have killed a top rebel commander and his aide in disputed Kashmir, and shut down mobile phone and mobile internet services during subsequent anti-India protests.

Riyaz Naikoo, 35, was the chief of operations of the region’s largest indigenous rebel group, Hizbul Mujahideen, which has spearheaded an armed rebellion against Indian rule.

(August 1, 1947) 

HI, I have been using the Innovus GUI commands for several things and wonder if those command can be written to a log or cmd file so I can use it in my flow script? Is there such options that we can set?

Thanks

Hi Folks, Check out this great new video on YouTube: CDNLive SV 2014: PMC Improves Visibility and Performance with Spectre APS In this video from CDNLive Silicon Valley 2014, Jurgen Hissen, principal engineer, MSCAD, at PMC, discusses an aggressive...(read more)

Hi,

I am trying to use "sed -e 's " from SKILL code to edit unix file "FileA", to replace 3 words in the 2nd line.

How to run below multiple commands using  ipcBeginProcess, Should I use ipcWait or ipcCloseProcess ?

Using && to combine , will that work as I have to work serially on each command. ?

With below code only the first command gets executed. Please advise.

FileA="/user/tmp/text1.txt"

sprintf(Command1 "sed -e '2s/%s/%s/g' %s > %s" comment1 get(form concat("dComment" RDWn))->value FileA FileA)
cid = ipcBeginProcess(Command1)


sprintf(Command2 "sed -e '2s/%s/%s/g' %s > %s"  Time getCurrentTime() FileA FileA)
cid1 = ipcBeginProcess(Command2)


sprintf(Command3 "sed -e '2s/%s/%s/g' %s > %s"  comment2 get(form concat("Duser" RDWn))->value FileA FileA)
cid2 = ipcBeginProcess(Command3)

Thanks,

Ajay

hello there, i'm a student studying allegro PCB designer.

There are some commands that i can do with GUI, but i want to know what kind of commands i used so that i can route with commands only(ex) skill).

Is there any file that i can see what kind of commands i used something like log files or command history?

thank you for reading this long boring question.

Hi,

I found a basic Specman E/Verilog program at http://www.asic-world.com/examples/specman/memory.html and I would like to run it through a vsif file, with vManager.

I'm able to run it, without problems, with this command : xrun -Q -unbuffered '-timescale' '1ns/1ns' '-access' '+rw' memory_tb.v mem_tb_top.e test_write_read_all.e.

I wrote a first vsif which look like this:

---- vm_basic.vsif -----

session vm_basic {
        top_dir : /home/cadence/xrunTest/;
        output_mode: terminal;
};

group basic {
        test test {
                run_script: xrun -Q -unbuffered '-timescale' '1ns/1ns' '-access' '+rw' memory_tb.v mem_tb_top.e test_write_read_all.e
        };
};

----------------------------

This solution didn't work due to the prompt change with xrun, and I have no clue how to manage this issue.

Have you any idea?

Best regards,

Yohan