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Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis




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Blockade of High-Fat Diet Proteomic Phenotypes using Exercise as Prevention or Treatment [Technological Innovation and Resources]

The increasing consumption of high-fat foods combined with a lack of exercise is a major contributor to the burden of obesity in humans. Aerobic exercise such as running is known to provide metabolic benefits, but how the over-consumption of a high fat diet (HFD) and exercise interact is not well characterized at the molecular level. Here, we examined the plasma proteome in mice for the effects of aerobic exercise as both a treatment and as a preventative regime for animals on either HFD or a healthy control diet. This analysis detected large changes in the plasma proteome induced by the HFD, such as increased abundance of SERPINA7, ALDOB, and down-regulation of SERPINA1E, CFD (adipsin). Some of these changes were significantly reverted using exercise as a preventative measure, but not as a treatment regime. To determine if either the intensity, or duration, of exercise influenced the outcome, we compared high-intensity interval training (HIIT) and endurance running. Endurance running slightly out-performed HIIT exercise, but overall, both provided similar reversion in abundance of plasma proteins modulated by the high-fat diet including SERPINA7, APOE, SERPINA1E, and CFD. Finally, we compared the changes induced by over-consumption of HFD to previous data from mice fed an isocaloric high saturated fat (SFA) or polyunsaturated fat (PUFA) diet. This identified several common changes including increased APOC2 and APOE, but also highlighted changes specific for either over-consumption of HFD (ALDOB, SERPINA7, CFD), SFA-based diets (SERPINA1E), or PUFA-based diets (Haptoglobin - Hp). Together, these data highlight the importance of early intervention with exercise to revert HFD-induced phenotypes and suggest some of the molecular mechanisms leading to the changes in the plasma proteome generated by high fat diet consumption. Web-based interactive visualizations are provided for this dataset (larancelab.com/hfd-exercise), which give insight into diet and exercise phenotypic interactions on the plasma proteome.




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HIV: Breakthrough study raises hopes of effective prevention if drug’s cost can be lowered




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Low molecular weight heparin does not prevent VTE after knee arthroscopy, studies show




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Patients taking dabigatran to prevent stroke should avoid simvastatin and lovastatin, study suggests




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Stroke: Take test for genetic variant to ensure clopidogrel works for prevention, says NICE




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Scarlett McNally: Preventing obesity is different from curing it—and even more urgent




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SGLT-2 inhibitors for diabetes may help prevent dementia, study finds




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Members event

Members event 1 February 2023 — 7:00PM TO 7:30PM Anonymous (not verified) 1 February 2023 Chatham House




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Members event (open ticket)

Members event (open ticket) 1 February 2023 — 9:00PM TO 10:00PM Anonymous (not verified) 1 February 2023 Chatham House and Online




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Blugolds men’s and women’s basketball have home opener, first games in the new Sonnentag Event Center

EAU CLAIRE— This weekend saw the first basketball games for Blugold men’s and women’s basketball during the Market & Johnson Blugold Tip-Off Tournament. The games were the first to be played at the Sonnentag Event Center, a part of the new $122 million multi-purpose facility which opened earlier this year. The event center has a capacity of 3,500 people for sporting events as compared to the ...




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Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota–gut–brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.




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BRCA1 Promotes Repair of DNA Damage in Cochlear Hair Cells and Prevents Hearing Loss

Cochlear hair cells (HCs) sense sound waves and allow us to hear. Loss of HCs will cause irreversible sensorineural hearing loss. It is well known that DNA damage repair plays a critical role in protecting cells in many organs. However, how HCs respond to DNA damage and how defective DNA damage repair contributes to hearing loss remain elusive. In this study, we showed that cisplatin induced DNA damage in outer hair cells (OHCs) and promoted OHC loss, leading to hearing loss in mice of either sex. Cisplatin induced the expression of Brca1, a DNA damage repair factor, in OHCs. Deficiency of Brca1 induced OHC and hearing loss, and further promoted cisplatin-induced DNA damage in OHCs, accelerating OHC loss. This study provides the first in vivo evidence demonstrating that cisplatin mainly induces DNA damage in OHCs and that BRCA1 promotes repair of DNA damage in OHCs and prevents hearing loss. Our findings not only demonstrate that DNA damage–inducing agent generates DNA damage in postmitotic HCs but also suggest that DNA repair factors, like BRCA1, protect postmitotic HCs from DNA damage–induced cell death and hearing loss.




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Major outcomes and follow-ups of the Seventh Session of the Governing Body of the ITPGRFA

The Governing Body took a number of decisions that require action by Contracting Parties. This communication draws the attention of Contracting Parties to those decisions that are addressed to [...]




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A new phase for the Africa Solidarity Trust Fund, a Council Side Event

On Friday, 7 December during the 160th session of the Council, a side event on the Africa Solidarity Trust [...]




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Join the Food Coalition virtual launch event

On 5 November 2020, from 12.30 to 14.30hrs, FAO Director-General, Dr QU Dongyu, will host a virtual High-Level event launching the Food Coalition. This dialogue will call for international cooperation [...]




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High-level event commemorating the Fifth Anniversary of the Paris Agreement

On the occasion of the fifth anniversary of the Paris Agreement, the event will highlight the key role of the agricultural sectors in supporting the Paris Agreement. The Paris Agreement, [...]




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Invitation for the launch event: The impact of disasters and crises on agriculture and food security, 2021

Understanding and managing disaster risks in global agriculture: Better data for ambitious action



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ROME WATER DIALOGUE, a Special Event on the road to the UN 2023 Water Conference 29 November 2022, 09.00-16.15 (CET)

Water is one of the world´s most important resources. It is central to agriculture that accounts for 72 percent of global freshwater withdrawals, to other economic sectors and is essential [...]




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Earth Is on the Brink of Breaching a Seventh of Nine 'Planetary Boundaries' That Support Life

A new “health check” for our planet sounds an alarm bell on rising ocean acidification, which is driven by carbon dioxide levels in the atmosphere




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The 'World's Most Famous Grizzly' Was Killed by a Car. Was Her Death Preventable?

Grizzly 399 became a celebrity of Grand Teton National Park in her lifetime. Now, her death has drawn attention to wildlife-vehicle collisions and how they might be reduced




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This veteran decolonized Remembrance Day events to honour Indigenous military service

Jeff Monague has worked to incorporate Indigenous elements into Base Borden's Remembrance Day ceremonies — an acknowledgement he never had as a soldier.




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Montreal's Fournier Beaudry, Sorensen earn ice dance bronze for 4th medal in 4 events

Montreal's Laurence Fournier Beaudry and Nikolaj Sorensen finished the Rostelecom Cup in bronze position Saturday for their fourth medal in as many figure skating competitions this season.



  • Sports/Olympics/Winter Sports/Figure Skating

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2-time Olympian Gabrielle Daleman wins women's event at Skate Canada Challenge

Two-time Olympian Gabrielle Daleman was victorious in Sunday's free skate to win the women's event at the 2022 Skate Canada Challenge in Regina.



  • Sports/Olympics/Winter Sports/Figure Skating

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Keegan Messing holds on for win at ISU Challenger Series event in Croatia

A clean, fifth-place performance in Saturday's free skate was enough for Canada's Keegan Messing to hold off Russia's Andrei Mozalev for the win at figure skating's Golden Spin of Zagreb in Croatia.



  • Sports/Olympics/Winter Sports/Figure Skating

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Pandemic continues to impact curling events across northern Ontario

As some qualifying events in curling get cancelled, organizers in this region and across the country are starting to have to choose teams based on a ranking system to determine who gets to compete.



  • News/Canada/Sudbury

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SolidWorks Scores Seventh Consecutive Appearance In Boston Business Journal ‘Best Places to Work’ Ranking

One Of Only Four Companies To Place Among Top Employers In Each Year Of The Publication’s Survey




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Mont Alto announces spring talk series, planetarium events

Penn State Mont Alto has announced a lineup of events for the spring semester, including the Evening Talks lecture series and planetarium programming. Events are open to the public and cover a broad range of topics, from forestry during the Civil War to the nighttime sky.




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Penn State Mont Alto to host 'Spend a Summer' event for highschoolers

Spend a Summer Evening is Tuesday, July 16, and Spend a Summer Day will be Tuesday, Aug. 13. Advance registration is recommended.




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News24 Business | MONEY CLINIC | How can I financially prepare for life's unpredictable events?

George Kolbe, Head of Life Insurance Marketing at Momentum discusses the recommended ways to prepare for unexpected occurrences.








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Penn State to celebrate 2024 Indigenous Peoples Day with October events

Indigenous Peoples Day will be celebrated at Penn State with events on Monday, Oct. 14. The Indigenous Peoples' Student Association and the Indigenous Faculty and Staff Alliance, in partnership with the Office of Educational Equity, Student Affairs, and the Office of the Provost, have coordinated events in recognition and celebration.




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Preventing Dropouts

Some 58 dropout prevention programs in nine school districts in Delaware, Maryland, New Jersey, Pennsylvania, and the District of Columbia were reviewed by researchers at New Jersey's Rutgers University.




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Preventing Dropouts

School districts' efforts to prevent students from dropping out are profiled in a new survey from the National Center for Education Statistics.




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Maintaining Ties When School Closes Is Critical to Preventing Dropouts

Students who were chronically absent or at risk of dropping out before the coronavirus outbreak are even more at risk now that schools are closed, experts say.




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Upcoming events supporting graduate student success, Sept. 18-25

This coming week, graduate students can learn new teaching strategies, find tips for setting healthy academic boundaries, build research communication skills and learn about library resources. 




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Penn State Great Valley to host 'Bollywood Bonanza' community event on Oct. 24

Join Penn State Great Valley at the campus' Conference Center in Malvern on Oct. 24 for an electrifying evening in the vibrant world of Bollywood, where the magic of Indian cinema will be celebrated.




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News24 Business | Zimbabwe central bank chief says ZiG 43% devaluation is 'once-off' event

Zimbabwe sought to assure citizens that its gold-backed currency would not suffer another steep devaluation and steps were being taken to assure its defence.




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Panelists at PSU-LV event discuss importance, challenges facing reading literacy

Shifts in how reading is taught have led to declining reading literacy scores on standardized tests across U.S.




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Community members ‘shake it off’ during Penn State Berks Eras Tour event

How do you translate what you learned in a semester-long course to a community celebration for an audience ranging in age from kindergarteners to senior citizens? That was the challenge to Penn State Berks students in the “Taylor Swift, Gender and Communication” course, and they rose to the occasion.




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Penn State Altoona hosts fall 2024 Hard Freight Café open mic event

Attendees were invited to read or perform their own work or music or share a favorite piece of poetry or prose. The event began with a reading by English professors Todd Davis and Erin Murphy.




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Eco-friendly 'LionGlass' developed at Penn State to be showcased at Nov. 8 event

A new type of eco-friendly glass developed by researchers at Penn State offers higher crack resistance, potentially allowing for thinner, lighter and more sustainable products. “LionGlass” will be the subject of PSAA Presents: EMS Showcase, an event on Nov. 8 hosted by the College of Earth and Mineral Sciences in partnership with the Penn State Alumni Association.




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Penn State Fayette to host suicide prevention and awareness events in September

Penn State Fayette, The Eberly Campus is dedicating September to raising awareness about suicide prevention through a series of events and activities. This initiative follows the official proclamation by the Fayette County Commissioners, recognizing September as Suicide Prevention and Awareness Month.




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LinkUp: Relevent topics for youth

During OM France’s last LinkUp, an interdenominational event for all teens and young adults in the Nantes region, OMers focused on the theme of sexuality.




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Veterans Day message, events for the Penn State community

On Veterans Day, President Bendapudi shares a message with the University community. Today's events include Penn State's annual Military Appreciation Breakfast and Veterans Day Ceremony. 




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Upcoming events supporting graduate student success, Nov. 13-19

Whether you are interested in a STEM workshop on finding or requesting standards or you’d like to learn about how to assess company culture during the job hunt, graduate students can find events for those topics and more between Nov. 13-19 designed to support their success at Penn State.