db JBL® Introduces Its First Soundbar with Dolby Atmos, the JBL Bar 9.1 True Wireless Surround Sound By news.harman.com Published On :: Mon, 06 Jan 2020 13:00:00 GMT CES 2020, LAS VEGAS – JANUARY 6, 2020 – Movie lovers, listen up. The latest addition to JBL’s popular Bar Series brings the audio experience of a movie theater to your living room. The JBL Bar 9.1 creates true wireless surround sound with crowd-pleasing... Full Article
db JBL verlegt de lat met een nieuwe Soundbar serie By news.harman.com Published On :: Thu, 05 Sep 2019 13:00:00 GMT Een gestroomlijnd model, krachtige bas en nog intenser geluid: JBL tilt home entertainment naar een hoger plan. Op IFA worden vandaag drie splinternieuwe producten gelanceerd: een compacte alles-in-één oplossing, een kamervullende surround-sound en een diepe bas Bar. Voor ieder wat wils in de nieuwe Soundbar serie. Full Article
db JBL raises the bar with new Soundbar series By news.harman.com Published On :: Thu, 05 Sep 2019 13:00:00 GMT Slimmer, punchier bass and more immersive sound; JBL has taken home entertainment to the next level. With three brand new products launching today at IFA including a compact, all-in-one solution, a deep bass beauty and a surround-sound room-filler, there is something for everyone in JBL’s new soundbar range. Full Article
db JBL raises the bar with new Soundbar series By news.harman.com Published On :: Thu, 05 Sep 2019 13:00:00 GMT Slimmer, punchier bass and more immersive sound; JBL has taken home entertainment to the next level. With three brand new products launching today at IFA including a compact, all-in-one solution, a deep bass beauty and a surround-sound room-filler, there is something for everyone in JBL’s new soundbar range. Full Article
db Pi Day: How to calculate pi using a cardboard tube and a load of balls By www.newscientist.com Published On :: Fri, 13 Mar 2020 14:46:49 +0000 This Pi Day, try calculating everyone’s favourite mathematical constant using balls and a cardboard tube, thanks to a mathematical trick involving the balls’ masses Full Article
db The Good Place review: It is over, but I’m never going to say goodbye By www.newscientist.com Published On :: Mon, 24 Feb 2020 16:00:18 +0000 The Good Place, a sitcom on Netflix about an afterlife with characters who represent me at my worst – and best – is over, but I can’t stop rewatching the show, says Chelsea Whyte Full Article
db Returning to Intimacy After Childbirth By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Returning to Intimacy After ChildbirthCategory: Health NewsCreated: 5/1/2019 12:00:00 AMLast Editorial Review: 5/1/2019 12:00:00 AM Full Article
db I Want to Retire, But Just Can't Say Goodbye By www.webmd.com Published On :: Wed, 06 May 2020 12:44:11 EST Many doctors are considering retiring, but fear they'll miss the patient interaction, mental stimulation, and income. There are ways to have it all. Full Article
db Thanks for Your Feedback on the New PubMed By www.nlm.nih.gov Published On :: Thu, 27 Feb 2020 16:00:00 EST Since the launch of the new PubMed on November 18, 2019, we have been delighted to see many users trying the new site and sharing feedback on their experience. Full Article
db Bedbugs (Bed Bugs) vs. Lice By www.medicinenet.com Published On :: Tue, 18 Feb 2020 00:00:00 PDT Title: Bedbugs (Bed Bugs) vs. LiceCategory: Diseases and ConditionsCreated: 2/18/2020 12:00:00 AMLast Editorial Review: 2/18/2020 12:00:00 AM Full Article
db Feedback Control of a Two-Component Signaling System by an Fe-S-Binding Receiver Domain By mbio.asm.org Published On :: 2020-03-17T01:30:15-07:00 ABSTRACT Two-component signaling systems (TCSs) function to detect environmental cues and transduce this information into a change in transcription. In its simplest form, TCS-dependent regulation of transcription entails phosphoryl-transfer from a sensory histidine kinase to its cognate DNA-binding receiver protein. However, in certain cases, auxiliary proteins may modulate TCSs in response to secondary environmental cues. Caulobacter crescentus FixT is one such auxiliary regulator. FixT is composed of a single receiver domain and functions as a feedback inhibitor of the FixL-FixJ (FixLJ) TCS, which regulates the transcription of genes involved in adaptation to microaerobiosis. We sought to define the impact of fixT on Caulobacter cell physiology and to understand the molecular mechanism by which FixT represses FixLJ signaling. fixT deletion results in excess production of porphyrins and premature entry into stationary phase, demonstrating the importance of feedback inhibition of the FixLJ signaling system. Although FixT is a receiver domain, it does not affect dephosphorylation of the oxygen sensor kinase FixL or phosphoryl-transfer from FixL to its cognate receiver FixJ. Rather, FixT represses FixLJ signaling by inhibiting the FixL autophosphorylation reaction. We have further identified a 4-cysteine motif in Caulobacter FixT that binds an Fe-S cluster and protects the protein from degradation by the Lon protease. Our data support a model in which the oxidation of this Fe-S cluster promotes the degradation of FixT in vivo. This proteolytic mechanism facilitates clearance of the FixT feedback inhibitor from the cell under normoxia and resets the FixLJ system for a future microaerobic signaling event. IMPORTANCE Two-component signal transduction systems (TCSs) are broadly conserved in the bacterial kingdom and generally contain two molecular components, a sensor histidine kinase and a receiver protein. Sensor histidine kinases alter their phosphorylation state in direct response to a physical or chemical cue, whereas receiver proteins "receive" the phosphoryl group from the kinase to regulate a change in cell physiology. We have discovered that a single-domain receiver protein, FixT, binds an Fe-S cluster and controls Caulobacter heme homeostasis though its function as a negative-feedback regulator of the oxygen sensor kinase FixL. We provide evidence that the Fe-S cluster protects FixT from Lon-dependent proteolysis in the cell and endows FixT with the ability to function as a second, autonomous oxygen/redox sensor in the FixL-FixJ signaling pathway. This study introduces a novel mechanism of regulated TCS feedback control by an Fe-S-binding receiver domain. Full Article
db MtSSPdb: The Medicago truncatula Small Secreted Peptide Database By www.plantphysiol.org Published On :: 2020-05-08T08:30:48-07:00 A growing number of small secreted peptides (SSPs) in plants are recognized as important regulatory molecules with roles in processes such as growth, development, reproduction, stress tolerance, and pathogen defense. Recent discoveries further implicate SSPs in regulating root nodule development, which is of particular significance for legumes. SSP-coding genes are frequently overlooked, because genome annotation pipelines generally ignore small open reading frames, which are those most likely to encode SSPs. Also, SSP-coding small open reading frames are often expressed at low levels or only under specific conditions, and thus are underrepresented in non-tissue-targeted or non-condition-optimized RNA-sequencing projects. We previously identified 4,439 SSP-encoding genes in the model legume Medicago truncatula. To support systematic characterization and annotation of these putative SSP-encoding genes, we developed the M. truncatula Small Secreted Peptide Database (MtSSPdb; https://mtsspdb.noble.org/). MtSSPdb currently hosts (1) a compendium of M. truncatula SSP candidates with putative function and family annotations; (2) a large-scale M. truncatula RNA-sequencing-based gene expression atlas integrated with various analytical tools, including differential expression, coexpression, and pathway enrichment analyses; (3) an online plant SSP prediction tool capable of analyzing protein sequences at the genome scale using the same protocol as for the identification of SSP genes; and (4) information about a library of synthetic peptides and root and nodule phenotyping data from synthetic peptide screens in planta. These datasets and analytical tools make MtSSPdb a unique and valuable resource for the plant research community. MtSSPdb also has the potential to become the most complete database of SSPs in plants. Full Article
db MtSSPdb: A New Database for the Small Secreted Peptide Research Community By www.plantphysiol.org Published On :: 2020-05-08T08:30:48-07:00 Full Article
db Chemical roadblocking of DNA transcription for nascent RNA display [RNA] By www.jbc.org Published On :: 2020-05-08T03:41:14-07:00 Site-specific arrest of RNA polymerases (RNAPs) is fundamental to several technologies that assess RNA structure and function. Current in vitro transcription “roadblocking” approaches inhibit transcription elongation by blocking RNAP with a protein bound to the DNA template. One limitation of protein-mediated transcription roadblocking is that it requires inclusion of a protein factor extrinsic to the minimal in vitro transcription reaction. In this work, we developed a chemical approach for halting transcription by Escherichia coli RNAP. We first established a sequence-independent method for site-specific incorporation of chemical lesions into dsDNA templates by sequential PCR and translesion synthesis. We then show that interrupting the transcribed DNA strand with an internal desthiobiotin-triethylene glycol modification or 1,N6-etheno-2'-deoxyadenosine base efficiently and stably halts Escherichia coli RNAP transcription. By encoding an intrinsic stall site within the template DNA, our chemical transcription roadblocking approach enables display of nascent RNA molecules from RNAP in a minimal in vitro transcription reaction. Full Article
db Paleomagnetic and magnetic fabric data from Lower Triassic redbeds of the Central Western Carpathians: new constraints on the paleogeographic and tectonic evolution of the Carpathian region By jgs.lyellcollection.org Published On :: 2020-05-04T02:10:48-07:00 In the Central Western Carpathians (CWC), most published paleomagnetic results from Permo-Mesozoic rocks document extensive remagnetizations and come from thin-skinned thrust units that have undergone multistage deformation. We present results from lower Triassic redbeds from the autochthonous cover overlying the basement that carry a primary magnetization. Petromagnetic results indicate that the dominant ferromagnetic carrier is hematite, while magnetic susceptibility and its anisotropy are controlled by both ferromagnetic and paramagnetic minerals. Magnetic fabrics document weak deformation related to Late Cretaceous shortening. The directions of the high unblocking temperature remanence components pass both reversal and fold tests, attesting to their primary nature. Paleomagnetic inclinations are flatter than expected from reference datasets, suggesting small latitudinal separation between the CWC and stable Europe. Paleomagnetic declinations are mostly clustered within individual mountain massifs, implying their tectonic coherence. They show only minor differences between the massifs, indicating a lack of significant vertical-axis tectonic rotations within the studied central parts of the CWC. The paleomagnetic declinations are therefore representative of the whole of the CWC in terms of regional paleogeographic interpretations, and imply moderate counterclockwise rotations (c. 26°) of the region with respect to stable Europe since the Early Triassic. Full Article
db Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons [Research Papers] By genesdev.cshlp.org Published On :: 2020-05-01T06:30:22-07:00 Peripheral somatosensory input is modulated in the dorsal spinal cord by a network of excitatory and inhibitory interneurons. PTF1A is a transcription factor essential in dorsal neural tube progenitors for specification of these inhibitory neurons. Thus, mechanisms regulating Ptf1a expression are key for generating neuronal circuits underlying somatosensory behaviors. Mutations targeted to distinct cis-regulatory elements for Ptf1a in mice, tested the in vivo contribution of each element individually and in combination. Mutations in an autoregulatory enhancer resulted in reduced levels of PTF1A, and reduced numbers of specific dorsal spinal cord inhibitory neurons, particularly those expressing Pdyn and Gal. Although these mutants survive postnatally, at ~3–5 wk they elicit a severe scratching phenotype. Behaviorally, the mutants have increased sensitivity to itch, but acute sensitivity to other sensory stimuli such as mechanical or thermal pain is unaffected. We demonstrate a requirement for positive transcriptional autoregulatory feedback to attain the level of the neuronal specification factor PTF1A necessary for generating correctly balanced neuronal circuits. Full Article
db MG53 Does Not Manifest the Development of Diabetes in db/db Mice By diabetes.diabetesjournals.org Published On :: 2020-04-20T12:00:34-07:00 MG53 is a member of the TRIM protein family that is predominantly expressed in striated muscles and participates in cell membrane repair. Controversy exists regarding MG53’s role in insulin signaling and manifestation of diabetes. We generated db/db mice with either whole-body ablation or sustained elevation of MG53 in the bloodstream in order to evaluate the physiological function of MG53 in diabetes. To quantify the amount of MG53 protein in circulation, we developed a monoclonal antibody against MG53 with high specificity. Western blot using this antibody revealed lower or no change of serum MG53 levels in db/db mice or patients with diabetes compared with control subjects. Neither whole-body ablation of MG53 nor sustained elevation of MG53 in circulation altered insulin signaling and glucose handling in db/db mice. Instead, mice with ablation of MG53 were more susceptible to streptozotocin-induced dysfunctional handling of glucose compared with the wild-type littermates. Alkaline-induced corneal injury demonstrated delayed healing in db/db mice, which was restored by topical administration of recombinant human (rh)MG53. Daily intravenous administration of rhMG53 in rats at concentrations up to 10 mg/kg did not produce adverse effects on glucose handling. These findings challenge the hypothetical function of MG53 as a causative factor for the development of diabetes. Our data suggest that rhMG53 is a potentially safe and effective biologic to treat diabetic oculopathy in rodents. Full Article
db Insecticidal Activity of Doxycycline against the Common Bedbug [Experimental Therapeutics] By aac.asm.org Published On :: 2020-04-21T08:01:09-07:00 There is an ongoing need for safe and effective anti-bedbug compounds. Here, we tested the toxicity of three antimicrobial agents against bedbugs when administered orally. We reveal that doxycycline has direct insecticidal activity at 250 μg/ml (0.025%) that is particularly strong against immature bedbugs and appears to be independent of antimicrobial activity. Future studies to determine the mechanisms behind this property could be useful for the development of orally active insecticides or anti-bedbug therapeutics. Full Article
db Correction: Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1 [Correction] By cancerdiscovery.aacrjournals.org Published On :: 2020-05-01T00:05:26-07:00 Full Article
db HDB Plaza By batdongsan.com.vn Published On :: Fri, 20 Jul 2018 09:32:23 GMT HDB Plaza nằm trên tuyến đường được xem là trung tâm thương mại và dịch vụ của huyện Thanh Trì, là cầu nối giao thông giữa thành phố Hà Đông với tuyến đường thuộc Quốc lộ 1A cũ, HDB Plaza có vị trí vô cùng thuận lợi, dễ dàng kết nối với các vùng lân cận thông qua nhiều tuyến đường được quy hoạch mở rộng. Full Article
db Sonos Finally Supports Dolby Atmos With New Arc Soundbar By feedproxy.google.com Published On :: Thu, 07 May 2020 16:00:23 +0000 Sonos has been busy these past few months. Full Article
db RPGCast – Episode 250: “Feedback Festivus” By feedproxy.google.com Published On :: Sat, 22 Dec 2012 19:47:40 +0000 In this very special episode of the RPGCast, there’s a Christmas miracle! That’s right, we come up with a useful idea for the Wii U... Full Article News Podcasts RPG Cast
db RPGCast – Episode 284: “Feedback Frenzy” By feedproxy.google.com Published On :: Sat, 26 Oct 2013 20:58:34 +0000 From realism in Final Fantasy games to the sordid history of Pokémon patches, we get all sorts of feedback this week. And then we play... Full Article News Podcasts RPG Cast
db RPGCast – Episode 369: “Feedback Fills Us With Determination” By feedproxy.google.com Published On :: Sat, 12 Dec 2015 21:13:51 +0000 Some people answer some questions. Chris tries to give us a Just Cause for why he attached that cow to that helicopter. Alice gets Fruity... Full Article News Podcasts RPG Cast
db RPGCast – Episode 453: “Say Goodbye To Big Hole” By feedproxy.google.com Published On :: Sat, 27 Jan 2018 23:28:10 +0000 Lots of mechs today. Watch out that they don’t break you. Were you a supporter of Obsidian’s last kickstarter? See when you get your reward... Full Article News Podcasts RPG Cast
db Study reveals foodborne illness burden in Taiwan By feedproxy.google.com Published On :: Fri, 08 May 2020 04:01:21 +0000 One in six Taiwanese people suffered from foodborne illness annually during a four year period studied by researchers. From 2012 to 2015, almost 3.9 million foodborne illnesses and 50 deaths occurred annually in the country. Scientists said the study, published in the Journal of the Formosan Medical Association, provided the first national estimates on the... Continue Reading Full Article Foodborne Illness Investigations World beef imports E coli O157 FERG foodborne disease microorganisms norovirus Salmonella Taiwan Vibrio parahaemolyticus
db 'The privilege to say goodbye': Hospitals move to allow family visits for people dying of coronavirus By www.nbcnews.com Published On :: Sat, 09 May 2020 08:56:00 GMT After stories of people not being allowed to say goodbye to loved ones dying of coronavirus, hospitals around the world are moving to change the rules. Full Article
db In Groundbreaking Find, Three Kinds of Early Humans Unearthed Living Together in South Africa By www.smithsonianmag.com Published On :: Thu, 02 Apr 2020 18:00:00 +0000 The different hominid species, possibly including the oldest-known Homo erectus, existed in the region's hills and caves Full Article
db With new 13-inch MacBook Pro, Apple waves goodbye to the butterfly keyboard By arstechnica.com Published On :: Mon, 04 May 2020 14:25:30 +0000 Keyboard aside, cheaper storage and 10th-generation Intel CPUs headline this refresh. Full Article Tech 13-inch MacBook Pro apple butterfly keyboard Mac MacBook Pro
db Shocking moment man snatches handbag off woman in her 80s and knocks her to ground By www.standard.co.uk Published On :: 2020-04-14T18:23:21Z Full Article
db Matt Hancock announces 'right to say goodbye' to loved ones dying from Covid-19 By www.standard.co.uk Published On :: 2020-04-15T15:35:00Z Follow our live coronavirus updates HERE Coronavirus: the symptoms Full Article
db Family of boy, 13, who died alone after contracting Covid-19 'comforted' that others will get chance to say goodbye By www.standard.co.uk Published On :: 2020-04-16T12:00:03Z Follow our live coronavirus updates HERE Coronavirus: The symptoms Full Article
db Virgin Media down: Customers across the UK complain about broadband outage despite issue being 'fixed' By www.standard.co.uk Published On :: 2020-04-28T07:21:00Z Virgin Media customers are still complaining about issues with their broadband despite the provider saying the issue has been fixed. Full Article
db Moment carer reads heartbreaking goodbye letter to grandma hours before she died with coronavirus By www.standard.co.uk Published On :: 2020-04-29T14:33:13Z This is the heartbreaking moment a carer read a granddaughter's final goodbye to her grandmother, just two days before she died while suffering coronavirus symptoms. Full Article
db London's Nightingale hospital to be put on standby as coronavirus cases pass peak in capital By www.standard.co.uk Published On :: 2020-05-04T09:40:00Z London's Nightingale hospital will be put "on standby" within days as a result of the capital passing the peak of coronavirus cases. Full Article
db Ajit Pai uses bad data to claim ISPs are deploying broadband to everyone By arstechnica.com Published On :: Mon, 27 Apr 2020 19:48:28 +0000 Pai’s “baffling” report ignores broadband gaps and high prices, Democrats say. Full Article Biz & IT Policy ajit pai broadband FCC
db Frontier, amid bankruptcy, is suspected of lying about broadband expansion By arstechnica.com Published On :: Fri, 01 May 2020 18:00:36 +0000 Small ISPs want investigation as Frontier tries to block FCC funding for rivals. Full Article Biz & IT Policy FCC frontier
db CenturyLink still hasn’t met 2019 FCC deadline, now faces pandemic roadblocks By arstechnica.com Published On :: Tue, 05 May 2020 18:15:03 +0000 Pandemic disrupts broadband progress as cities halt construction. Full Article Biz & IT Policy centurylink FCC
db DB Realty, Unitech stocks rose By economictimes.indiatimes.com Published On :: 2011-11-30T03:55:23+05:30 The stocks of DB Realty and Unitech rose after top executives of these companies were granted bail in the 2G scam case. Full Article
db TV Throws Its Biggest Ad Pitch at a Madison Avenue Filled With Roadblocks By variety.com Published On :: Sat, 09 May 2020 15:39:20 +0000 Linda Yaccarino, the hard-charging ad-sales chief of NBCUniversal. will soon be running into uncharted territory. In recent years, Yaccarino has railed against Nielsen and taken a public swipe at Facebook. She has urged advertisers to consider running fewer commercials on NBC and to work to make the ones that remain more ambitious and interesting. On […] Full Article Linda Yaccarino NBCUniversal Rita Ferro Tv Advertising Upfront 2020 ViacomCBS
db RuPaul's Drag Race: Jeff Goldblum receives backlash for Islam comments to Jackie Cox By www.independent.co.uk Published On :: 2020-04-25T07:05:00Z 'As if America hasn't been anti-gay and anti-woman from the outset, or killed and displaced millions of Muslims, including women and queers,' one critic retorted Full Article
db Big Bang Theory: Jim Parsons had 'no idea' where career would go after saying goodbye to Sheldon Cooper By www.independent.co.uk Published On :: 2020-04-29T13:26:43Z Parsons stars in Ryan Murphy's new Netflix series, Hollywood Full Article
db Amanda Holden praises NHS for saving her life after she nearly died in childbirth By www.standard.co.uk Published On :: 2020-05-01T09:31:41Z Holden is raising money for the NHS through the release of her first single Full Article
db Can 5G become your new broadband connection? By rssfeeds.usatoday.com Published On :: Sun, 03 May 2020 15:19:51 +0000 Most of us get high-speed internet via a wired connection. But not everyone has access, like in rural areas. 5G could broaden those broadband options. Full Article
db Rachel Weisz found physical Black Widow role ‘daunting’ after childbirth By www.film-news.co.uk Published On :: Wed, 06 May 2020 12:00:00 +0100 The 50-year-old stars alongside Scarlett Johansson in the upcoming Marvel spin-off movie. Full Article
db Raheem Sterling knows David Silva will be 'sorely missed' as Manchester City goodbye draws closer By www.standard.co.uk Published On :: 2020-04-25T12:49:17Z Raheem Sterling believes team-mate David Silva's will be "sorely missed" as Manchester City prepare for life without their Spanish superstar. Full Article
db Premier League clubs place overseas players on 48-hour standby ahead of training return By www.standard.co.uk Published On :: 2020-04-27T12:59:00Z Premier League clubs have put all players based abroad on standby as a return to training draws near. Full Article
db Free clothes at Keith's Closet allow psychiatric ward patients to say goodbye to hospital gowns By www.abc.net.au Published On :: Wed, 23 Oct 2019 08:59:00 +1100 As vulnerable patients arrive at one hospital's psychiatric ward with just the clothes on their back, a support service is ensuring access to free, clean garments of their choice. Full Article ABC Radio Sydney sydney Arts and Entertainment:Design:Fashion Community and Society:Charities:All Community and Society:Charities and Community Organisations:All Health:Healthcare Facilities:All Health:Mental Health:All Human Interest:People:All Australia:NSW:Randwick 2031
db Chinese authorities' latest wildlife trade outrage is mindbogglingly reckless By www.brisbanetimes.com.au Published On :: Tue, 14 Apr 2020 00:32:03 GMT China's government is putting on a show of sending aid to countries suffering from COVID-19, but undermining efforts to control the source of further pandemics. Full Article