In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

I was wondering why the iconic Civic Centre clock in Southampton is not lit up blue on Thursday at 8pm to clap for the NHS.

Bandcamp is waiving their fees, so we're going to spotlight and promote you, our community members.

The post Operation: Help DJTT Artists – submit your Bandcamp project and we’ll promote you. appeared first on DJ TechTools.

The new AMC series Dispatches From Elsewhere was inspired by a massive art project created by the Oaklandish founder. Before it premiered last Sunday, months of promotional teasers for the AMC series Dispatches From Elsewhere intrigued viewers with scintillating visuals emerging from mundane settings, while only hinting at the show's quixotic premise. AMC describes its 10-hour series as the story of four people "brought together by chance — or perhaps it's by design — when they stumble onto a puzzle hiding just behind the veil of everyday life."…

A gas separation process for treating exhaust gases from combustion processes. The invention involves routing a first portion of the exhaust stream to a carbon dioxide capture step, while simultaneously flowing a second portion of the exhaust gas stream across the feed side of a membrane, flowing a sweep gas stream, usually air, across the permeate side, then passing the permeate/sweep gas back to the combustor.

The present invention relates to an optical clear resin and a method for producing a liquid optical clear photo-curable adhesive.

A method of verifying removal of peel ply material from a composite structure is provided. The method includes doping a layer of peel ply fabric with an identifier. The method also includes curing the composite structure with the layer of peel ply fabric disposed on a surface of the composite structure. The method further includes removing the layer of peel ply fabric from the surface. The method yet further includes scanning the surface of the composite structure for the identifier.

A machine (1) and a method for thermobonding using an emission of electromagnetic waves (13), for example microwaves, to activate one or a plurality of adhesive layers located between a support and one or a plurality of layers of flexible covering, through a bed of particles (4) fluidized by a humidified gas. A multi-layer upholstery item including at least one non-permeable layer and produced in a single operation is also described.

Systems and methods for recovering light hydrocarbons from refinery waste gas using a back-end turboexpander to generate a higher recovery of the light hydrocarbons for use as petrochemical feedstock and to remove the liquid light hydrocarbons before entering the turboexpander.

A process is described herein for removing high freeze point hydrocarbons, including benzene compounds, from a mixed feed gas stream. The process involves cooling process streams in one or more heat exchangers and separating condensed compounds in multiple separators to form a methane-rich product gas stream. Select solvent streams from a fractionation train and/or separate solvent streams are employed to lower the freeze point of one or more streams that contain high freeze point hydrocarbons. A corresponding system also is disclosed.

The old saying; ‘You might get run over by a bus tomorrow’ took on a sinister edge recently...

News you don't want to miss for April 9:

1. Six residents at a nursing home in Hayward have died from covid-19, the East Bay Times reports.…

News you don't want to miss for April 14:

1. Six of the 15 confirmed covid-19 cases at Santa Rita Jail have recovered, the East Bay Times reports.…

News you don't want to miss for April 15:

1. The number of covid-19 deaths in Alameda County increased from 23 to 36 over a two-day period, SFGate reports.…

News you don't want to miss for May 5:

1. "UC Berkeley is in negotiations to purchase — and then potentially tear down — a 111-year-old rent-controlled apartment building on Walnut Street where some residents have lived for more than 25 years," Berkeleyside reports.…

Former Australia captain Steve Waugh has urged England to move on from Kevin Pietersen, believing the controversial batsman no longer merits a place in the side and brings too much baggage as well.

Eastleigh came from behind to defeat struggling Chesterfield and move themselves safely into midtable in the National League.

A third clean-sheet in a row for Saints must be a positive to cling onto - view pictures here.

West Brom have sacked Tony Pulis, the club has announced.

A HAMPSHRIE 12-year-old with cerebral palsy spent time with the captain of Southampton Football Club, Pierre-Emile Hojbjerg.

MOST of us will be watching the game from the comfort of our settees – but one young Hampshire boy will lead the Three Lions out in Brazil.

POLICE are appealing for witnesses following a serious incident.

THOUSANDS of children in Hampshire are at risk of contracting life-threatening illnesses from breathing in second-hand smoke, health chiefs have warned.

AN UNDER-FIRE health trust has admitted it missed chances to intervene when a mentally ill Southampton man was in “crisis”.

A MAN who fell from a cruise ship and gouged his leg open on a propeller has been airlifted to hospital.

If your idea of a beauty regime is normally just a splash of water combined with a bit of soap when you're really making an effort, read on.

THE future of a much-loved Southampton band considered one of the rising stars of British indie pop is in doubt after music equipment worth thousands was stolen.

A SOUTHAMPTON orchestra is going virtual - and global.

A CYCLIST in his 80s has been found collapsed in a Hampshire road.

ANDY Samuels is standing down as manager of Sydenhams Wessex One side Romsey Town at the end of the season.

POLICE are appealing for witnesses following a serious incident.

A CYCLIST has completed an epic journey of more than 11,000 miles from Hampshire to Hong Kong.

IT’S been three months since we were treated to the rip-roaring hilarity-fest which was the opening episode of Tales from the Borderlands. It’s been a long wait.

A second win in three matches has given Romsey hope of avoiding the drop into the Hampshire League.

by Mike Vimpany

WICKHAM Festival chiefs have promised to top their best ever event next year.

A ROYAL is saddling up for the unveiling a hampshrie 's tribute to horses that died on the battlefield in the Great War.

ROMSEY’S £86,000 tribute to horses that died in the Great War has been give royal approval.

Our friends at The Pro Audio Files have compiled a big list of the best audio articles, videos and podcast from 2014. I’ve been seriously…

Matthew Weiss just launched a new training series of videos on mixing EDM. It’s actually called Mixing EDM and it’s on sale for 30% off…

I spent a lot of time watching myself mix while editing my Mixing in REAPER Vol 1 video series. I’ve learned quite a bit from…

Sound Design tutorials from Krotos

In this podcast, Scott Davert shows us the features available with MFi supported hearing aids or Cochlear Implant processors from the perspective of a VoiceOver user. MFi compatible hearing aids come from many manufacturers and there are numerous models supported. You can see Apple's official support page which gives a fairly accurate account of which hearing aids have MFi support. However, this article has not been updated since October 2018, so anything newer than that will not be listed on this page.

For more general information about hearing aids from a blindness perspective, you can listen to this Accessibility Moving Forward podcast featuring some familiar voices to AppleVis.

Finally, there is a mailing list for blind hearing aid users that you can join by sending a blank email to blindhearingaidusers+subscribe@groups.io.

If you receive or initiate a phone call or text message, from a number that isn't in your iPhone Contacts, you may want to add that information to an existing contact or create a new contact.

Columbus-based Nationwide Insurance plans to require coporate office employees in Columbus, Des Moines, Scottsdale and San Antonio to work from home permanently.

Following a nearly billion dollar drop in the state's economic picture, Ohio Governor Mike DeWine plans to cut $775 in state spending over the next two months.

We've got a special "Ten O'Clock Doc" set for you this time, with two of Doc's visits to WNCW back in the 1990's: Doc with Wayne Henderson and Charles Welch from March of 1996, and with Jack Lawrence from March of 1997.

We go back in time to two years ago to the day -- May 11th, 2018 -- for this smokin' hot session from Samantha Fish and her band, not long after we'd discovered her music.

It's quite possibly the most adventurous ukulele player ever, in this encore session from Jake Shimabukuro. Join us as we revisit this interview/performance with WNCW morning host Martin Anderson. Mahalo, Jake!