MLflow — an open source platform to manage the ML lifecycle, including experimentation, reproducibility, and deployment. It currently offers three components: tracking, projects, and models. Eventing Facets (Tim Bray) — the word “eventing” makes my skin crawl, but this series of posts has A+ info in it. Workbox — JavaScript Libraries for adding offline support […]

Pluralistic — Cory Doctorow’s news site and newsletter, where you can learn about African WhatsApp modders among other things. Mapnik — LGPLed software that combines pixel-perfect image output with lightning-fast cartographic algorithms, and exposes interfaces in C++, Python, and Node. pi node — A π-box is a modular system of radio/streaming broadcast, composed of multiples […]

AWS Bill Analysis — always interesting to see how to approach lowering your costs. In this case, the project owner works for Amazon on AWS, but still there were savings to be had. A Design Guide to Writing Offline-first Apps — In this article, we will be diving into some of the engineering challenges that […]

OpenAM — an open-access management solution that includes authentication, SSO, authorization, federation, entitlements and web services security. Building Relationships as a Remote Engineering Manager — And if you haven’t realized it yet, get used to this—you’re going to spend a lot of time writing. API Security Maturity Model — I’m not sure if I agree […]

The Uncensored Library — Reporters Without Borders built a library in Minecraft, in which you can read banned books. (via Gizmodo) Shmoocon 2020 Talk Recordings — everything from email addresses to Verilog by way of Zero Trust, social media, and choose-your-own-adventure ransomware. Differential Privacy: A Comparison of Libraries — We will have a look at […]

How the Great Firewall Discovers Hidden Circumvention Servers — really interesting CCC talk from a few years ago. The Challenge of Software Liability — Liability for insecure software is already a reality. The question is whether Congress will step in to give it shape and a coherent legal structure. XOXO Talks — video archive of […]

Inklewriter — open source interactive text adventure game creator. (Fun for adults, but also great to give to kids who love to read) (via Andy Baio) The Virus Survival Strategy Guide for Your Startup (Steve Blank) — Unfortunately, it’s no longer a normal market. All your assumptions about customers; sales cycle; and, most importantly, revenue, […]

Dos and Don’ts in Open Source (Olaf Geirsson) — really useful advice to would-be contributors and project owners. It’s tempting to respond to a welcome contribution with a quick, “This looks amazing, I will review tomorrow!” Consider giving a thumbs-up reaction instead and wait with commenting until you complete the review. Promises are estimates and […]

NASCAR Replaces Canceled Races with Esports Featuring Pro Drivers (Engadget) — the world is getting weirder. Firebase Scrutinized By Antitrust Regulators — Firebase tools give Google, the internet’s top ad seller, information on what consumers are doing inside apps that it can exploit to target ads to users, according to makers of Firebase alternatives. Journey […]

Stanza: A Python Natural Language Processing Toolkit for Many Human Languages — Stanza features a language-agnostic fully neural pipeline for text analysis, including tokenization, multi-word token expansion, lemmatization, part-of-speech and morphological feature tagging, dependency parsing, and named entity recognition. Code and models available for 66 languages. Dropbear SSH — Dropbear is a relatively small SSH […]

Potential Distributed Reading Group on Distributed Systems — for some folks, this will be a great time to start reading groups to work through papers. You’ll never get a time with less physical distraction. (Just remember to ration your socials time or you and your time will vanish into the maelstrom.) Jitsi Meet — open […]

Medtronic Releases Ventilator Designs — not open source, as the license is a limited-time limited-purpose license that retains rights. I imagine some corporate lawyers have done some frantic Googling for open meditech licensing clauses. dolt — version history for tabular data. Compare to sno, which is version control for geospatial and tabular data. Toast UI […]

Replaying Traffic to Test Proprietary Systems — using Wiresham to replay traffic to test blackbox proprietary systems. Outlaw Innovations — This paper will explore how the often illegal activities of hackers (in the original usage of the term to refer to individuals who modify computer hardware and software) may produce valuable innovations. It will explore […]

Imperial College’s COVID19 Model — in github, in R, MIT-licensed. This repository has code for replication purposes. The bleeding edge code and advancements are done in a private repository. Readings on Time — I bumped on this idea while reading Alan Kay’s writing about making the difference between mutable and immutable data “moot” in the […]

The Zero Trust Learning Curve (Palo Alto Networks) — don’t learn with the Crown Jewels. The trouble with starting with the most sensitive protect surfaces is that they’re often too fragile and many people don’t know how they work. Starting there with Zero Trust frequently results in failures. Too often, when this happens, organizations blame […]

Rufus — Create bootable USB drives the easy way. Improving Audio Quality in Duo with WaveNetEQ — Google filling in missing packets in voice calls using deep learning. CRN++ — language for programming deterministic (mass-action) chemical kinetics to perform computation. Crafting Crafting Interpreters — story behind the writing of the Crafting Interpreters book.

locust — open source load testing tool: define user behaviour with Python code, and swarm your system with millions of simultaneous users. (via @nzigel) Background Matting — a method for creating a matte – the per-pixel foreground color and alpha – of a person by taking photos or videos in an everyday setting with a […]

System Design for Advanced Beginners — a friendly explanation of the what and why of systems, with acknowledgement of the real world like There are many tools out there, each with different strengths and weaknesses, and many ways to build a technology company. The real, honest reasons that we will make many of our technological […]

The Fuzzy Edges of Character Encoding — the history, politics, and computational basics of text-based character encoding and digital representations of text, from Morse Code to ASCII to Unicode (and emoji), as well as alternative text encoding schemes. (via Everest Pipkin) AutoHotkey — an automation scripting language for Windows. The Electronic Nose and its Applications: […]

FairMOT — one-shot multi-object tracking that remarkably outperforms the state-of-the-arts on the MOT challenge datasets at 30 FPS. pipedream — IFTTT for coders. Compiler Explorer — an interactive tool that lets you type code in one window and see the results of its compilation in another window. Using the site should be pretty self-explanatory: by […]

Introduction to COBOL — a 1999 web site (!) with slides from a University of Limerick course. IBM will offer free (presumably more modern) training. zoombot — a highly advanced AI to handle Zoom calls. storybook.js — open source toolkit and sandbox to build UI components in isolation so you can develop hard-to-reach states and […]

The Science of Happiness — free enrolment in Berkeley’s MOOC to teach positive psychology. Learn science-based principles and practices for a happy, meaningful life. The New Business of AI (A16Z) — many AI companies have: Lower gross margins due to heavy cloud infrastructure usage and ongoing human support; Scaling challenges due to the thorny problem […]

Coding vs Programming (John Gruber) — I’d noticed this linguistic change too. See also Engineering vs Programming vs Computer Science. Coding is shorter so it’s probably gaining in popularity because shorter is easier to say and thus more convenient. micrograd (Andre Karpathy) — A tiny Autograd engine (with a bite! :D). Implements backpropagation (reverse-mode autodiff) […]

Kanboard — free and open source Trello-like Kanban boards. Remote Work Playbook — really useful advice on the actual mechanics of working remotely, not just which tools to use but how to use them. E.g., As an individual contributor, is there something you just did that you think a colleague would have to do at […]

Nebula —open source distributed, scalable, lightning-fast graph database. COBOL Programming Course — from the Open Mainframe Project. Serverless Handbook — a resource teaching frontend engineers everything they need to know to dive into backend. Novel Annealing Processor Is the Best Ever at Solving Combinatorial Optimization Problems (IEEE Spectrum) — Dubbed STATICA (Stochastic Cellular Automata Annealer […]

CastleDB — a structured static database […]. CastleDB looks like any spreadsheet editor, except that each sheet has a data model. […] stores both its data model and the data contained in the rows into an easily readable JSON file. […] allows efficient collaboration on data editing. Mainframes Are Having a Moment (IEEE Spectrum) — […]

It’s Time to Learn (Scott Berkun) — a strong response to Marc Andreessen’s It’s Time to Build. It feels like we are in a disrupted time when anything is possible, and folks are wondering where the levers are to pull. pygraphistry — a library to extract, transform, and visually explore big graphs. Desert Island Devops […]

Posthog — open source product analytics. Into the Mainframe (Recurse) — the interviews with two mainframe programmers are a great reminder of how much things have changed. And how they haven’t. For instance, later in my career I kept a weighted punching clown in my office. As programmers, we liked our users, but we also […]

Moloch — Large scale, open source, indexed packet capture and search. 3Dify Instagram Photos — open source toolset for adding a 3d effect to photos on Instagram’s web site. It uses 3d-photo-inpainting running in Colab (free GPU) and Cloud pubsub/storage for communication. A glimpse of the future: we could augment all our apps with deep […]

The Suddenly Remote Playbook — I just want to note that if you have to look after kids when you’re supposed to be working, you’re not working from home. Not everyone’s getting a glorious introduction to the delights of working from home. taichi — a programming language designed for high-performance computer graphics. It is deeply […]

Teleforking a Process onto a Different Computer — a working proof of concept (I just don’t replicate tricky things so that I could keep it simple, meaning it’s just a fun tech demo you probably shouldn’t use for anything real) of a telefork() function call that spawns a process on another machine and returns the […]

Learning a Language — this list of questions facing anyone taking a new language for a test run just burns with truth. (Also: encouraging to see how many of these questions are answered by the Cookbook format) OpenVAS — Open Vulnerability Assessment Scanner, aka “what a cheap external security assessment vendor will run and then […]

podpaperscissors — From the classic “prisoner’s dilemma” to more obscure coördination games, Pod Paper Scissors takes game theory out of the dry textbook and into the real world. … Each episode will feature different kinds of games and situations. Experts in a variety of fields will casually converse with the hosts about how the particular […]

To Microservices and Back Again: Why Segment Went Back to a Monolith — microservices came with increased operational overhead and problems around code reuse. … If microservices are implemented incorrectly or used as a band-aid without addressing some of the root flaws in your system, you’ll be unable to do new product development because you’re […]

Tasmota — Alternative firmware for ESP8266 with easy configuration using webUI, OTA updates, automation using timers or rules, expandability and entirely local control over MQTT, HTTP, Serial or KNX. Selfie 2 Waifu — deep learning constructs an anime character from your photo. Paper for the underlying technique. (via @tkasasagi) The Handbook of Cyber Wargames: Wargaming […]

Popcorn Linux — exploring how to improve the programmability of emerging heterogeneous hardware, in particular, those with Instruction Set Architecture (ISA)-diverse cores, from node-scale (e.g., Xeon/Xeon-Phi, ARM/x86, CPU/GPU/FPGAs) to rack-scale (e.g., Scale-out processors, Firebox, The Machine), in both native and virtualized settings. Additionally, the project is exploring how to automatically compile/synthesize/execute code on ISA-heterogeneous hardware. […]

Leaving Amazon (Tim Bray) — May 1st was my last day as a VP and Distinguished Engineer at Amazon Web Services, after five years and five months of rewarding fun. I quit in dismay at Amazon firing whistleblowers who were making noise about warehouse employees frightened of Covid-19. Observability is a Many-Splendoured Thing (Charity Majors) […]

Raman Spectroscopy — Low Cost, High Performances, 100% Open Source Raman Spectrometer. […] We currently offer the spectrometer in a Starter Edition version designed for teaching Raman spectroscopy and we will soon release a Performance Edition version which achieves a tested 12 cm-1 resolution at low costs. Great to see this getting into the hands […]

Super Bootable 64 — Super Mario 64 shipped before the SDK was finalised, and it had to be compiled with optimisations turned off. This meant the binary was easily reversed to source code, and now the unportable has been ported. This site probably won’t last long, because DMCA, but it’s technically a sweet feat. (via […]

Mathematics for Machine Learning — We wrote a book on Mathematics for Machine Learning that motivates people to learn mathematical concepts. The book is not intended to cover advanced machine learning techniques because there are already plenty of books doing this. Instead, we aim to provide the necessary mathematical skills to read those other books. […]

Who is Patrick Mason? I just ran across a few short horror films he wrote and directed, and they're truly scary. Like edge-of-your-seat gasp-out-loud scary. Not only that, but they're beautifully made with good actors, especially Ayuda (see below). The three videos posted here are the ones I've seen so far, but there are more on his site, which I plan to watch tonight. Can't wait to see where this director takes us next.

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In Lakeshore, it may be a little while longer before a retail cannabis store opens.

You’ve got a short story that goes on too long? A chapter that reads at a dying snail’s pace? A challenge entry that trails beyond the maximum word count? You’re also relatively new to writing and haven’t yet dragged your way through all the millions of writing articles? If yes to the last and anything else to the rest, here’s your article.

1. Remove all redundancies. I repeat: Remove all redundancies. I repeat: ….

“Unknown strangers” or “asked a question” can be removed right away. While it may sound silly, there’s a good chance you have a few of those rummaging around in your work for you to weed out.

More significantly you will want to root out the various strings of wordy words writers conjure up. “At that point in time,” can be replaced with “back then,” or even “then,” if the placement in the sentence allows it. “Despite the fact” can be “although.” “Less than great,” is just a polite man’s “mediocre.”

As a lone appreciator of purple prose I won’t tell you to always cull all of these combos, for there’s a time and place for everything and it’s called colle… a long-form story, but if you’re trying to shorten things up these are the first words to go.

Continue reading Keeping It Short at Mythic Scribes.

Gijs den Besten
Sep 1, 2013; 54:2325-2340
Reviews

Optic atrophy 1 (OPA1) is a dynamin protein that mediates mitochondrial fusion at the inner membrane. OPA1 is also necessary for maintaining the cristae and thus essential for supporting cellular energetics. OPA1 exists as membrane-anchored long form (L-OPA1) and short form (S-OPA1) that lacks the transmembrane region and is generated by cleavage of L-OPA1. Mitochondrial dysfunction and cellular stresses activate the inner membrane–associated zinc metallopeptidase OMA1 that cleaves L-OPA1, causing S-OPA1 accumulation. The prevailing notion has been that L-OPA1 is the functional form, whereas S-OPA1 is an inactive cleavage product in mammals, and that stress-induced OPA1 cleavage causes mitochondrial fragmentation and sensitizes cells to death. However, S-OPA1 contains all functional domains of dynamin proteins, suggesting that it has a physiological role. Indeed, we recently demonstrated that S-OPA1 can maintain cristae and energetics through its GTPase activity, despite lacking fusion activity. Here, applying oxidant insult that induces OPA1 cleavage, we show that cells unable to generate S-OPA1 are more sensitive to this stress under obligatory respiratory conditions, leading to necrotic death. These findings indicate that L-OPA1 and S-OPA1 differ in maintaining mitochondrial function. Mechanistically, we found that cells that exclusively express L-OPA1 generate more superoxide and are more sensitive to Ca2+-induced mitochondrial permeability transition, suggesting that S-OPA1, and not L-OPA1, protects against cellular stress. Importantly, silencing of OMA1 expression increased oxidant-induced cell death, indicating that stress-induced OPA1 cleavage supports cell survival. Our findings suggest that S-OPA1 generation by OPA1 cleavage is a survival mechanism in stressed cells.