In a case from Montana, conservative justices suggested they were inclined to rule for parents who seek to reinstate a state tax credit funding scholarships for use at religious schools.

In a case from Montana, conservative justices suggested they were inclined to rule for parents who seek to reinstate a state tax credit funding scholarships for use at religious schools.

The university’s Center for Vaccine Research is working to create a coronavirus vaccine.

"The purpose of this paper is to provide an introductory overview about the making of family provision claims in South Australia under the Inheritance (Family Provision) Act 1972".

This paper assesses whether the Newstart Allowance for unemployed people should be increased. It investigates the relationship of the Newstart Allowance to Average Weekly Earnings, the Federal Minimum Wage, and Australian poverty lines, and considers the typical the duration of unemployment and long term unemployment, duration of time on income support, overseas allowances, cost of living, and a comparison with policy makers' remuneration. It finds that the value of the allowance has eroded since it was first set and that unemployment for many is not a transitional situation, and concludes that an increase is warranted to bridge the gap to the poverty line.

Death -- Philosophy.

Fox, Peter.

Caterpillars -- Australia, Southern -- Identification -- Pictorial works.

Mayor, Thomas -- Travel -- Australia.

A new generation of Iowans are preparing to caucus for the first time. Here's how their teachers are preparing them, and what it says about civics education in 2020.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

With their state’s caucuses the first official marker in the 2020 presidential contest, Iowa teenagers are in a unique position to observe and participate.

Primary season is now upon us. Here are three ideas for teaching in the wake of the Iowa caucus fallout.

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

That brings the number of states with approved plans to 44, plus the District of Columbia and Puerto Rico. Still awaiting the OK: California, Florida, Nebraska, North Carolina, Oklahoma, and Utah

[London] (17, Church Street, Soho) : Published ... by M.A. Bourlier, August, 1813.

Current explanation techniques towards a transparent Convolutional Neural Network (CNN) mainly focuses on building connections between the human-understandable input features with models' prediction, overlooking an alternative representation of the input, the frequency components decomposition. In this work, we present an analysis of the connection between the distribution of frequency components in the input dataset and the reasoning process the model learns from the data. We further provide quantification analysis about the contribution of different frequency components toward the model's prediction. We show that the vulnerability of the model against tiny distortions is a result of the model is relying on the high-frequency features, the target features of the adversarial (black and white-box) attackers, to make the prediction. We further show that if the model develops stronger association between the low-frequency component with true labels, the model is more robust, which is the explanation of why adversarially trained models are more robust against tiny distortions.

Vice President Pence’s trip to Iowa shows how the Trump administration’s aims to move past coronavirus are sometimes complicated by the virus itself.

Thomas Staudt, Timo Aspelmeier, Oskar Laitenberger, Claudia Geisler, Alexander Egner, Axel Munk.

Source: Statistical Science, Volume 35, Number 1, 92--111.

Abstract:
Super-resolution microscopy is rapidly gaining importance as an analytical tool in the life sciences. A compelling feature is the ability to label biological units of interest with fluorescent markers in (living) cells and to observe them with considerably higher resolution than conventional microscopy permits. The images obtained this way, however, lack an absolute intensity scale in terms of numbers of fluorophores observed. In this article, we discuss state of the art methods to count such fluorophores and statistical challenges that come along with it. In particular, we suggest a modeling scheme for time series generated by single-marker-switching (SMS) microscopy that makes it possible to quantify the number of markers in a statistically meaningful manner from the raw data. To this end, we model the entire process of photon generation in the fluorophore, their passage through the microscope, detection and photoelectron amplification in the camera, and extraction of time series from the microscopic images. At the heart of these modeling steps is a careful description of the fluorophore dynamics by a novel hidden Markov model that operates on two timescales (HTMM). Besides the fluorophore number, information about the kinetic transition rates of the fluorophore’s internal states is also inferred during estimation. We comment on computational issues that arise when applying our model to simulated or measured fluorescence traces and illustrate our methodology on simulated data.

CPMI Press release "Jurisdictions move towards full implementation of standards for financial market infrastructures", 8 April 2020.

Within just a few weeks, the corona crisis has led to a collapse of over 90 percent of flight operations in the capital region. In light of this dramatic situation, the Flughafen Berlin Brandenburg GmbH (FBB) Executive Board concluded a works agreement ...

Philadelphia-based recording artiste M-Gee is enjoying much success from his latest release, Then A So, which is a collaboration among him, Noah Powa and ZiZi6ixx.The track comes as a collaborative project between GS Entertainment Music and Sky Height.Then A So is available on all major digital distributing platforms through Johnny Wonder.After promoting the single, the song copped a number of features on several mixtapes.

Police have charged a man after a spate of poisonings killed birds of prey over a two-year period.

AN item for the “there’s always one” file. Only days into the great lockdown and some people are just not coping. Take the holidaymaker – British, of course – who decided she would flout the rules and have a dip at Paradise Park in Tenerife.

ONE of the few benefits of living in the Unprecedented Era is having the chance to experience life at another time and in a different place.

OKAY, the tale that follows is not exactly up there with the yarns spun by those Florentines fleeing the plague in The Decameron, but bear with me. It is hard to be a Ustinov-standard raconteur when that big wide world you took for granted has shrunk to the size of an egg.

WHILE watching the daily Downing Street press conferences it is possible to feel a range of emotions. Frustration, for instance, as one inquiry after another goes unanswered, or disappointment at the quality of the questioning.

STRANGE things you never thought would come to pass. Queueing to enter a supermarket. Being thrilled by the sight of the bin lorry arriving. Making your own surgical mask. These days. But the oddest thing of all? Being glad to see politicians.

ONE trusts the stork’s passage across London was peaceful, its job of delivering Baby Johnson to his delighted parents made easier by the emptiness of the skies. Congratulations and welcome, young man.

HELLO and welcome to Step on a Rake, the game show where clever people do dumb things. Previous winners of the show have included Catherine “Second Home” Calderwood, Scotland’s former chief medical officer, and Robert Jenrick, England’s well-travelled Communities Minister.

Detained youth represent a vulnerable pediatric population with worse health outcomes than their nondetained peers. To date, little work has been done to determine whether health information technologies may be effectively used to improve the health of this underserved population.

The Internet is accessible to youth involved in the juvenile justice system. A securely accessible online system to store detained youth’s health information may be both feasible and acceptable for engaging these adolescents more actively in their health care. (Read the full article)

Pediatric specialists are increasingly involved in prenatal care, particularly for congenital fetal conditions. Questions remain about pediatricians’ role in the management of maternal conditions that may affect postnatal health, and the attitudes of obstetric and pediatric specialists around such care.

Obstetric and pediatric specialists’ attitudes differ substantially regarding pediatricians’ role in providing consultation for maternal conditions that may affect a child’s health postnatally, and regarding whether court authorization may be appropriate when a woman refuses certain treatment recommendations. (Read the full article)

Juice consumption among 2- to 5-year-old children exceeds dietary recommendations. In 2007, the US Department of Agriculture revised the composition and quantities of prescribed foods in WIC food packages to align them with dietary guidelines. Juice allowances were reduced by approximately half.

WIC participants purchased about a quarter less juice volume after implementation of the revised WIC packages. Large reductions in WIC-provided juice were only partly compensated for by extra juice purchases with non-WIC funds. Little compensation occurred for other beverages. (Read the full article)

Federal law requires states to report student test scores in achievement levels, but leaders in the Golden State want to take a different approach.

Background. CLSI and EUCAST susceptibility breakpoints for voriconazole and C. albicans differ by one dilution (≤0.125 and ≤0.06 mg/l, respectively) whereas the epidemiological cutoff values (ECOFF/ECV) with both methodologies are the same (0.03 mg/L). We therefore determined the pharmacokinetic-pharmacodynamic (PK/PD) breakpoints of voriconazole against C. albicans for both methodologies with an in vitro PK/PD model, which was validated using existing animal PK/PD data.

Methods. Four clinical wild-type and non-wild-type C. albicans isolates (voriconazole MICs 0.008-0.125 mg/l) were tested in an in vitro PK/PD model. For validation purposes, mouse PK were simulated and in vitro PD were compared with in vivo outcome. Human PK were simulated and the exposure-effect relationship fAUC_0-24/MIC was described for EUCAST and CLSI24/48h methods. PK/PD breakpoints were determined using the fAUC_0-24/MIC associated with half-maximal activity (EI₅₀) and Monte Carlo simulation analysis.

Results. The in vitro 24h-PD EI₅₀ of voriconazole against C. albicans were 2.5-5 (1.5-17) fAUC/MIC. However, the 72h-PD were higher, 133 (51-347) fAUC/MIC for EUCAST and 94 (35-252) fAUC/MIC for CLSI. The mean (95% confidence interval) probability of target attainment (PTA) was 100(95-100)%, 97(72-100)%, 83(35-99)%, and 49(8-91)% and 100(97-100)%, 99(85-100)%, 91(52-100)% and 68(17-96)% for EUCAST and CLSI MICs 0.03, 0.06, 0.125, and 0.25 mg/L, respectively. Significantly, >95% PTAs were found for EUCAST/CLSI MICs ≤0.03 mg/ll. For MICs 0.06-0.125 mg/l trough levels 1-4 mg/ll would be required.

Conclusion. A PK/PD breakpoint of C. albicans voriconazole at the ECOFF/ECV of 0.03 mg/L was determined for both EUCAST/CLSI methods, indicating the need for breakpoint harmonization for the reference methodologies.

Iowa appears to be poised to consider a pay-for-performance compensation plan for teachers, following the lead of a handful of districts and schools that have embraced the controversial policy.

A multi-disciplinary collaborative relationship, developed between Penn State EMS Energy Institute researchers and a Pittsburgh-based start-up company, may hold the answer to reducing global greenhouse gas (GHG) emissions while also paving the way to disrupt the chemical and material industries.

The app failed for the same reason that every tech rollout struggles: bugs, user training, and the known unknowns.

An OM France couple works among trafficked women and fights for justice before government officials.

In a case from Montana, conservative justices suggested they were inclined to rule for parents who seek to reinstate a state tax credit funding scholarships for use at religious schools.