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Jess Ennis-Hill wins silver medal in heptathlon as Belgian Nafissatou Thiam takes gold

Andy Hill, who married the athlete in 2013, shared a photograph of the '#supermum' moments after she crossed the finish line in the 800m, the final round of the event.




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Fashionable W Residences holiday homes for sale on the Algarve

There may not be a better way to enjoy benefits of hotel living than with a luxury W residency, with the first being built in Portugal, on the Algarve.




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Will Young thanks Prince William for his LGBT speech

'I want to let him know what a wonderful thing he did,' Young says. 'Him standing up and saying, "I wouldn't mind if my child was gay" is just incredible,' the 40-year-old singer enthuses.




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Banned Akmal refuses to divulge details of two meetings with suspected bookies: PCB sources

Pakistan batsman Umar Akmal has refused to divulge details of his two meetings with suspected bookies before the Disciplinary Panel which handed him a three-year ban after a hearing, according to Board sources. According to the source, Akmal had a meeting with two unidentified men in Defence Housing Society in Lahore. "Umar claims both these gentlemen met him at parties thrown by friends in DHA. But he has refused to even tell the Anti-Corruption officials what was discussed at these meetings," a reliable source in the Pakistan Cricket Board told PTI. "Even when the Anti-Corruption officials first presented their report to him on the night between 19th and 20th February in Karachi, Akmal admitted he committed a mistake by not reporting the meetings to them but refrained from giving any details, the source said. Akmal was found guilty of two charges under the PCB Anti-Corruption Code and on April 27, he was banned from cricket activities till February 19, 2023. The 29-year-old has 14 ..




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Lalgarh: Deprived of a peace of life


Not many trace their way back to the human tragedy that has given rise to the culture of violence that marks Lalgarh today. The women do not appear scared of any police reaction in response to their protests. Soma Mitra has more.




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Akmal refuses to divulge details of two meetings with suspected bookies

Umar Akmal, who was found guilty of two charges under the PCB Anti-Corruption Code has refused to divulge details of his two meetings with suspected bookies. According to the source, Akmal had a meeting with two unidentified men in Defence Housing Society in Lahore. The PCB source said Akmal also gave conflicting statements before the Disciplinary Panel hearing on April 27.




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New Covid-19 case reported in Nilgiris




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Migrant Workers, Pilgrims, Tourists, Students Can Hire Buses for Travel amid Lockdown, Says K'taka Govt

Inter-State travel of migrant workers, pilgrims, tourist, students and other persons stranded in different states due to lockdown were recently permitted to travel through notified entry and exit points of Karnataka by the government.




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ವಿಶಾಖಪಟ್ಟಣದ LG Polymers ಕಂಪೆನಿ ಬಗ್ಗೆ ನಿಮಗೆಷ್ಟು ಗೊತ್ತು?

ವಿಶಾಖಪಟ್ಟಣದಲ್ಲಿ ಗುರುವಾರದ ಅನಿಲ ಸೋರಿಕೆ ಘಟನೆಯು ಕನಿಷ್ಠ ಎಂಟು ಮಂದಿಯ ಪ್ರಾಣ ತೆಗೆದಿದೆ. ನೂರಾರು ಮಂದಿ ಅಸ್ವಸ್ಥರಾಗಿದ್ದಾರೆ. ಈ ಘಟನೆಯ ಮೂಲ ಇರುವುದು ಎಲ್.ಜಿ. ಪಾಲಿಮರ್ಸ್ ಒಡೆತನದ ಕಾರ್ಖಾನೆಯಲ್ಲಿ. ಪ್ಲಾಸ್ಟಿಕ್ ರಿಸಿನ್ ಮತ್ತು ಸಿಂಥೆಟಿಕ್ ಫೈಬರ್ ಉತ್ಪಾದನೆ ಮಾಡುವ ಕೈಗಾರಿಕೆಯ ಒಂದು ಭಾಗವಷ್ಟೇ ಈ ಘಟಕ. ಇನ್ನು ಇದರ ಮಾಲೀಕತ್ವ ಯಾರದು ಅಂತ ನೋಡಿದರೆ, ದಕ್ಷಿಣ ಕೊರಿಯಾದ




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LG ಪಾಲಿಮರ್ಸ್ ಕಂಪೆನಿಗೆ 50 ಕೋಟಿ ಠೇವಣಿ ಇಡುವಂತೆ NGT ಸೂಚನೆ

ವಿಶಾಖಪಟ್ಟಣದಲ್ಲಿ ನಡೆದ ವಿಷಾನಿಲ ಸೋರಿಕೆ ದುರಂತದಲ್ಲಿ ಹನ್ನೊಂದು ಮಂದಿ ಸಾವನ್ನಪ್ಪಿದ್ದು, ಎಲ್.ಜಿ. ಪಾಲಿಮರ್ಸ್ ಪ್ರೈವೇಟ್ ಲಿಮಿಟೆಡ್ ಗೆ ಆರಂಭಿಕ ಮೊತ್ತವಾಗಿ 50 ಕೋಟಿ ರುಪಾಯಿ ಠೇವಣಿ ಮೊತ್ತವನ್ನು ಕಟ್ಟುವಂತೆ ರಾಷ್ಟ್ರೀಯ ಹಸಿರು ನ್ಯಾಯಮಂಡಳಿಯು (ಎನ್ ಜಿಟಿ) ಆದೇಶ ನೀಡಿದೆ. ಈ ಘಟನೆಯು ಗುರುವಾರ ಬೆಳಗಿನ ಜಾವ 3.30ರ ಹೊತ್ತಿಗೆ ಸಂಭವಿಸಿದೆ. ಆ ವೇಳೆ ನೂರಾರು ಮಂದಿ ಹತ್ತಿರದ




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Vizag gas leak: LG Polymers issues official statement, says doing our best to help victims

On May 7, 11 persons were killed while over 1,000 were hospitalised due to gas leakage from LG Polymers chemical plant at RR Venkatapuram in Andhra Pradesh's Visakhapatnam.




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The new general and mining telegraph code / by C. Algernon Moreing and Thomas Neal

Archives, Room Use Only - HE7677.M6 M67 1903




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The new general and mining telegraph code ...: alphabetically arranged for the use of mining companies, mining engineers, stockbrokers, financial agents, and trust and finance companies / by C. Algernon Moreing and Thomas Neal

Archives, Room Use Only - HE7677.M6 M67 1907




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Telephone service / by A.C. Belgrave

Archives, Room Use Only - TK6169.B45 1937




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Dhoni resurfaces with grey beard, sparks memes and nostalgia




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Vizag gas leak: NGT notice to LG Polymers, others; directs company to deposit Rs 50 cr




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Gas leak at LG Polymers plugged: Andhra Police Chief




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Situation at Vizag plant under control: LG Polymers




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LG Baijal visits riot-hit areas, interacts with locals

Interacting with locals, he observed that the situation is gradually improving day by day, and urged them not to pay attention to rumours and avoid circulating unconfirmed messages.




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Vizag gas leak: LG Polymers issues official statement, says doing our...

Vizag gas leak: LG Polymers issues official statement, says doing our...




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Locals demand relocation of LG Polymers after gas leak




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Visakhapatnam gas leak: LG Polymers apologises, offers ‘every support’ to affected

Visakhapatnam gas leak: LG Polymers apologises, offers ‘every support’ to affected




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Hindu pilgrims leaves for Pakistan to visit Katas Raj temple




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SGPC flags off free bus service from Golden Temple, Amritsar to Dera Baba Nanak for Kartarpur pilgrims




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COVID-19: SGPC hopes situation improves before Baisakhi pilgrimage to Nankana Sahib




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Punjab CM seeks evacuation of 2,000 pilgrims from Nanded




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Facilitate evacuation of pilgrims stranded at Nanded Sahib Gurudwara: Punjab CM urges Shah, Thackeray




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Punjab CM thanks Amit Shah, Uddhav Thackeray for allowing Sikh pilgrims stuck in Nanded to travel to Punjab




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Punjab Govt requests Maha to allow safe passage to 3,000 pilgrims stranded in Nanded




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After 1,750-km odyssey, Sikh pilgrims reach Punjab




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Sikh pilgrims 'Jatha' returns to Punjab from Nanded




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Punjab seeks return of pilgrims stranded in Delhi




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Five returnees from Shri Hazur Sahib test positive for COVID-19, all pilgrims to be quarantined: Punjab govt




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Apologise for mismanaging pilgrims' return: Sukhbir to Amarinder




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137 Hazur Sahib pilgrims returned to Amritsar test COVID-19 positive: Minister




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63 Hazur Sahib pilgrims test positive for COVID-19 in Punjab's Nawanshahr




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Family members of stranded pilgrims seek govt. help

With 22 senior citizens from Madurai, who were on a pilgrimage to north India, stranded in Gaya in Bihar for over 40 days following the lockdown, fami




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AP villagers protest with dead bodies against LG plant

Emotions ran high as the villagers demanded that the plant be shut down immediately as it completely ruined their lives.




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On Mother’s Day, relive nostalgia with these 3 recipes for dips




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Banned Umar Akmal refuses to divulge details of two meetings with suspected bookies: PCB sources




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The indexing ambiguity in serial femtosecond crystallography (SFX) resolved using an expectation maximization algorithm

An expectation maximization algorithm is implemented to resolve the indexing ambiguity which arises when merging data from many crystals in protein crystallography, especially in cases where partial reflections are recorded in serial femtosecond crystallography (SFX) at XFELs.




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Crystal structure of gluconate 5-dehydrogenase from Lentibacter algarum

Gluconate 5-dehydrogenase (Ga5DH; EC 1.1.1.69) from Lentibacter algarum (LaGa5DH) was recombinantly expressed in Escherichia coli and purified to homogeneity. The protein was crystallized and the crystal structure was solved at 2.1 Å resolution. The crystal belonged to the monoclinic system, with space group P1 and unit-cell parameters a = 55.42, b = 55.48, c = 79.16 Å, α = 100.51, β = 105.66, γ = 97.99°. The structure revealed LaGaDH to be a tetramer, with each subunit consisting of six α-helices and three antiparallel β-hairpins. LaGa5DH has high structural similarity to other Ga5DH proteins, demonstrating that this enzyme is highly conserved.




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Scaling diffraction data in the DIALS software package: algorithms and new approaches for multi-crystal scaling

A new scaling program is presented with new features to support multi-sweep workflows and analysis within the DIALS software package.




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Isomorphism: `molecular similarity to crystal structure similarity' in multicomponent forms of analgesic drugs tolfenamic and mefenamic acid

The non-steroidal anti-inflammatory drugs mefenamic acid (MFA) and tolfenamic acid (TFA) have a close resemblance in their molecular scaffold, whereby a methyl group in MFA is substituted by a chloro group in TFA. The present study demonstrates the isomorphous nature of these compounds in a series of their multicomponent solids. Furthermore, the unique nature of MFA and TFA has been demonstrated while excavating their alternate solid forms in that, by varying the drug (MFA or TFA) to coformer [4-di­methyl­amino­pyridine (DMAP)] stoichiometric ratio, both drugs have produced three different types of multicomponent crystals, viz. salt (1:1; API to coformer ratio), salt hydrate (1:1:1) and cocrystal salt (2:1). Interestingly, as anticipated from the close similarity of TFA and MFA structures, these multicomponent solids have shown an isomorphous relation. A thorough characterization and structural investigation of the new multicomponent forms of MFA and TFA revealed their similarity in terms of space group and structural packing with isomorphic nature among the pairs. Herein, the experimental results are generalized in a broader perspective for predictably identifying any possible new forms of comparable compounds by mapping their crystal structure landscapes. The utility of such an approach is evident from the identification of polymorph VI of TFA from hetero-seeding with isomorphous MFA form I from acetone–methanol (1:1) solution. That aside, a pseudopolymorph of TFA with di­methyl­formamide (DMF) was obtained, which also has some structural similarity to that of the solvate MFA:DMF. These new isostructural pairs are discussed in the context of solid form screening using structural landscape similarity.




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Scaling diffraction data in the DIALS software package: algorithms and new approaches for multi-crystal scaling

In processing X-ray diffraction data, the intensities obtained from integration of the diffraction images must be corrected for experimental effects in order to place all intensities on a common scale both within and between data collections. Scaling corrects for effects such as changes in sample illumination, absorption and, to some extent, global radiation damage that cause the measured intensities of symmetry-equivalent observations to differ throughout a data set. This necessarily requires a prior evaluation of the point-group symmetry of the crystal. This paper describes and evaluates the scaling algorithms implemented within the DIALS data-processing package and demonstrates the effectiveness and key features of the implementation on example macromolecular crystallographic rotation data. In particular, the scaling algorithms enable new workflows for the scaling of multi-crystal or multi-sweep data sets, providing the analysis required to support current trends towards collecting data from ever-smaller samples. In addition, the implementation of a free-set validation method is discussed, which allows the quantification of the suitability of scaling-model and algorithm choices.




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Crystal structure of gluconate 5-dehydrogenase from Lentibacter algarum

The crystal structure of gluconate 5-dehydrogenase from Lentibacter algarum is reported. It has high structural similarity to other gluconate 5-dehydrogenase proteins, demonstrating that this enzyme is highly conserved.




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Structure of the Mycobacterium smegmatis α-maltose-1-phosphate synthase GlgM

Mycobacterium tuberculosis produces glycogen (also known as α-glucan) to help evade human immunity. This pathogen uses the GlgE pathway to generate glycogen rather than the more well known glycogen synthase GlgA pathway, which is absent in this bacterium. Thus, the building block for this glucose polymer is α-maltose-1-phosphate rather than an NDP-glucose donor. One of the routes to α-maltose-1-phosphate is now known to involve the GlgA homologue GlgM, which uses ADP-glucose as a donor and α-glucose-1-phosphate as an acceptor. To help compare GlgA (a GT5 family member) with GlgM enzymes (GT4 family members), the X-ray crystal structure of GlgM from Mycobacterium smegmatis was solved to 1.9 Å resolution. While the enzymes shared a GT-B fold and several residues responsible for binding the donor substrate, they differed in some secondary-structural details, particularly in the N-terminal domain, which would be expected to be largely responsible for their different acceptor-substrate specificities.




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Smithsonian bat expert Kristofer Helgen answers common questions about bats

To celebrate a cool Halloween creature--bats--we teamed up with the Smithsonian’s Kristofer Helgen, curator of mammals at the National Museum of Natural History. Here, he answers three commonly asked questions about these winged mammals.

The post Smithsonian bat expert Kristofer Helgen answers common questions about bats appeared first on Smithsonian Insider.




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Algae bloom toxins may make Florida’s manatees and sea turtles susceptible to deadly accidents

Fond of a range of marine and freshwater vegetation such as turtle grass and eelgrass, the Florida manatee spends most of its waking hours grazing […]

The post Algae bloom toxins may make Florida’s manatees and sea turtles susceptible to deadly accidents appeared first on Smithsonian Insider.




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Algae assassin found responsible for whale mass grave in Chile

It has all the hallmarks of a paleontological crime scene: a massive graveyard along a remote desert highway containing the fossil bones of at least […]

The post Algae assassin found responsible for whale mass grave in Chile appeared first on Smithsonian Insider.