A novel sample cell with control of temperature and relative humidity permitted collection of data of excellent quality, enabling unrestrained refinement of all atomic parameters. One of the K atoms in the structure is disordered; very strong anisotropy in three of the four water O atoms indicates partial static disorder, which does not involve the bonded H atoms.

Decision day looms over Ellesmere Port shale gas plan  Cheshire Live

From the perspective of a young(ish) structural biologist who currently specialises in macromolecular X-ray crystallography, are the best years of crystallography over? Some evidence and hopefully thought-provoking analysis is presented here on the subject.

Olfactomedins are a family of modular proteins found in multicellular organisms that all contain five-bladed β-propeller olfactomedin (OLF) domains. In support of differential functions for the OLF propeller, the available crystal structures reveal that only some OLF domains harbor an internal calcium-binding site with ligands derived from a triad of residues. For the myocilin OLF domain (myoc-OLF), ablation of the ion-binding site (triad Asp, Asn, Asp) by altering the coordinating residues affects the stability and overall structure, in one case leading to misfolding and glaucoma. Bioinformatics analysis reveals a variety of triads with possible ion-binding characteristics lurking in OLF domains in invertebrate chordates such as Arthropoda (Asp–Glu–Ser), Nematoda (Asp–Asp–His) and Echinodermata (Asp–Glu–Lys). To test ion binding and to extend the observed connection between ion binding and distal structural rearrangements, consensus triads from these phyla were installed in the myoc-OLF. All three protein variants exhibit wild-type-like or better stability, but their calcium-binding properties differ, concomitant with new structural deviations from wild-type myoc-OLF. Taken together, the results indicate that calcium binding is not intrinsically destabilizing to myoc-OLF or required to observe a well ordered side helix, and that ion binding is a differential feature that may underlie the largely elusive biological function of OLF propellers.

A remarkable 5,000-year-old deposit of bones representing an entire herd of Persian gazelles recently discovered in northeastern Syria is firm evidence, scientists say, of an ancient hunting practice largely responsible for the near extinction of gazelles in this region today.

The post Archaeological evidence confirms mass hunting of gazelles 5,000 years ago appeared first on Smithsonian Insider.

Covered in venomous spines the exotic and strikingly banded Indo-Pacific lionfish would be a painful mouthful to any creature that may try to catch and […]

The post Biologist Andrew Sellers turns lionfish invasion into research opportunity appeared first on Smithsonian Insider.

It is related to one of the world’s most destructive invasive species, and possibly the slimiest. Thirty-five pounds of live giant West African snails (Archachatina […]

The post Slimy invaders, giant snails: Q&A with mollusk expert Ellen Strong appeared first on Smithsonian Insider.

The number of new X-ray crystallography-based submissions to the Protein Data Bank appears to be at the beginning of a decline, perhaps signalling an end to the era of the dominance of X-ray crystallography within structural biology. This letter, from the viewpoint of a young structural biologist, applies the Copernican method to the life expectancy of crystallography and asks whether the technique is still the mainstay of structural biology. A study of the rate of Protein Data Bank depositions allows a more nuanced analysis of the fortunes of macromolecular X-ray crystallography and shows that cryo-electron microscopy might now be outcompeting crystallography for new labour and talent, perhaps heralding a change in the landscape of the field.

Monday, April 30 marks planetary geologist Dr. Ellen Stofan’s first day as the new John and Adrienne Mars Director of the National Air and Space […]

The post Ellen Stofan leads Air and Space Museum appeared first on Smithsonian Insider.

Follow botanist Candy Feller of the Smithsonian Environmental Research Center as she conducts field work on mangrove ecosystems at Carrie Bow Cay, a Smithsonian field research station in the Caribbean.

The post Mangroves research by Candy Feller, Smithsonian Environmental Research Center botanist appeared first on Smithsonian Insider.

The Trump administration asked the Supreme Court to block Congress from seeking the materials, saying, "The government will suffer irreparable harm absent a stay."; Credit: Andrew Harnik/AP

The Supreme Court has temporarily put on hold the release of redacted grand jury material from the Russia investigation to a House panel.

The Trump administration is trying to block the release.

Last October, a district court judge ruled the Justice Department had to turn over the materials, which were blacked out, from former special counsel Robert Mueller's report into Russian interference in the 2016 election.

An appeals court upheld the decision, but the Trump administration, hoping to keep the evidence secret, appealed to the Supreme Court.

Chief Justice John Roberts' order temporarily stops the process. Lawyers for the House Judiciary Committee have until May 18 to file their response to the Justice Department's attempts to keep the materials from the House panel.

The Justice Department had until Monday to turn over the material following the appeals court order. But on Thursday, the Trump administration asked the Supreme Court to block Congress from seeking it, saying, "The government will suffer irreparable harm absent a stay."

This content is from Southern California Public Radio. View the original story at SCPR.org.

The Trump administration asked the Supreme Court to block Congress from seeking the materials, saying, "The government will suffer irreparable harm absent a stay."; Credit: Andrew Harnik/AP

The Supreme Court has temporarily put on hold the release of redacted grand jury material from the Russia investigation to a House panel.

The Trump administration is trying to block the release.

Last October, a district court judge ruled the Justice Department had to turn over the materials, which were blacked out, from former special counsel Robert Mueller's report into Russian interference in the 2016 election.

An appeals court upheld the decision, but the Trump administration, hoping to keep the evidence secret, appealed to the Supreme Court.

Chief Justice John Roberts' order temporarily stops the process. Lawyers for the House Judiciary Committee have until May 18 to file their response to the Justice Department's attempts to keep the materials from the House panel.

The Justice Department had until Monday to turn over the material following the appeals court order. But on Thursday, the Trump administration asked the Supreme Court to block Congress from seeking it, saying, "The government will suffer irreparable harm absent a stay."

This content is from Southern California Public Radio. View the original story at SCPR.org.

A new study of attitudes towards transport and mobility has identified five groups of travellers. The groups differ significantly in their choice of transport, distance travelled and the impact their transport choices have on the environment in terms of greenhouse gas (GHG) emissions.

In this brave new world, an IP that can help a business quickly adapt to remote working conditions, provide reliable and safe supply chain, and safeguard security, will become the game-changer for businesses to survive and even thrive.

A new study of attitudes towards transport and mobility has identified five groups of travellers. The groups differ significantly in their choice of transport, distance travelled and the impact their transport choices have on the environment in terms of greenhouse gas (GHG) emissions.

Increased insulation in homes could reduce ventilation and lead to greater exposure to indoor air pollution, a new study suggests. This, in turn, could affect health. The researchers modelled exposure to fine particles, which indicated that insulating half the homes in Greece by 2020 could lead to a 6% increase in adverse health effects. Sources of indoor air pollution should be reduced as far as possible and, failing that, sufficient airing is key, they recommend.

Zillow is the first company to help Cincinnati sellers avoid common hassles of selling traditionally; With this launch, Zillow is expanding its local presence, in addition to the existing Zillow Group office

Because yes, you should still get them a present.

Danone general secretary Michelle Weese joins The PR Week to discuss her role working for the world's largest B corp and the latest industry news.

Defecating sea lions and marine birds wreak economic havoc on the affluent oceanside San Diego community of La Jolla.

In a recently released video, the first lady talks up the healthy new choices that kids will see in their school lunches this year

Kelley Blue Book releases its list of top 10 green cars for 2011, and the all-electric Nissan Leaf ousts the 2010 winner, the Toyota Prius.

Annual award, given by PETA, presented in recognition of both actors' commitment to animal-free diets.

Shoppers went gaga for 'Leisurama' vacation homes showcased on the department store's ninth floor in the early 1960s.

Danielle Fong was only 19 years old when she founded a technology company with the goal of perfecting green energy storage and utilization.

'Inception' star chats with Bill Maher about colony collapse disorder and how industrialized farming is harming bee populations.

NASA will send off the "Sunjammer," a 128-ft solar sail, to record space weather and study the Sun.

U.S. first lady Michelle Obama and Dr. Jill Biden, wife of U.S. Vice President Joe Biden, host a party at the White House on May 10 for mothers, grandmothers an

Actress, currently starring in the eco-thriller 'The East,' describes freeganism and her experiences on an eco-village studying permaculture.

Social entrepreneur harnesses the power of stories to help illiterate communities leverage their ingenuity to find solutions to local problems.

Jay Harman developed technologies from the Lily Impeller that he says may fundamentally change how humans do almost everything.

Video: Catch up with the Begleys at The Environmental Media Awards.

Danielle Brigida is one of the most respected people in the world of nonprofit social media. Read more about this 1-woman army who convinced the National Wildli

The FDA is opening up public comments for reaction to two possible nutrition labels. One will replace the label we’ve been looking at for 20 years.

Actor and comedian co-host massive fundraiser to benefit the green rebuilding of New Orleans Lower 9th Ward.

These cubicle-dwellers aren't afraid to show how much they like the season.

Vacuum manufacturer Dyson drops a patent for headphones that filter air to an integrated mouthpiece.

The editors of Architectural Record have compiled a list of the 'most significant works that defined architecture in our era.'

Like any business, reseller web hosting has its pros and cons.

State-of-the-Art SEO Reseller Programs Twitter Good refereneces. Learn more about this topic here. Keywords: Reselling seo, Search marketing, Resell web design, Web design, Seo reseller plan, Web design reseller.

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The post What are the Benefits of SEO Reseller Programs? appeared first on RSS News Feed.

The Underground Secrets behind a successful eBay PowerSeller finally revealed! If you want to know how they make it, see the complete, simple and step by step guide over here.

Travelers and Staycationers planning to relax in warm destinations now have a natural, eco-friendly and effective solution to help protect them from mosquito bites following the launch of a natural indoor mosquito repellent plugin collection.

Using probably the World's Smallest Heart Rate Sensing Technology (ActivHearts)

Monica Deller, an Amazon Bestselling author, hopes to bring more awareness to the issue of human trafficking and is compiling stories for a new book series on human trafficking and related subjects.

Astronaut, leader & role model to keynote nation's largest multicultural & multidisciplinary STEM diversity conference