Studies on the consequences of abnormal prenatal hemoglobin (Hb) concentration have focused on maternal morbidities and adverse birth outcomes. To date, very little is known about the association between prenatal Hb concentration and infant cognitive and motor functions.

There is an inverted U-shaped relationship between maternal Hb concentration and infant gross motor function. Hb concentration between 90 and 110 g/L appears to be optimal for early gross motor function of children. (Read the full article)

Permanent neuronal deletion and neurocognitive impairment after anesthetic exposure in animals raised substantial concern that similar effects occur in children. Human studies were equivocal but have not combined structural and intelligence tests in otherwise healthy children after childhood anesthesia.

Anesthetic exposure for surgery did not lead to measurable neuronal elimination in brain regions previously identified in animals. However, language comprehension and performance IQ were decreased in exposed children and associated with decreased gray matter, primarily in posterior brain regions. (Read the full article)

Associations have been reported between celiac disease (CD) and numerous autoimmune conditions in adults and children. However, current screening guidelines do not consider patients with rheumatic diseases to be at high risk for CD.

The prevalence of CD in children presenting for rheumatology evaluation was found to be 2% by routine serologic screening. The majority of screening-detected CD cases had no CD-associated symptoms. Gluten restriction was found to relieve some musculoskeletal complaints. (Read the full article)

Hospital quality-of-care measures are publicly reported to inform consumer choice and stimulate quality improvement. The number of hospitals and states with a sufficient number of pediatric hospital discharges to detect worse-than-average pediatric inpatient care quality remains unknown.

Most children are admitted to hospitals in which all-condition measures of inpatient quality are powered to show differences in performance from average, but most condition-specific measures are not. Policy on incentives for pediatric inpatient quality should take these findings into account. (Read the full article)

Children born very preterm (VP) or with very low birth weight (VLBW) are at risk for cognitive deficits and low IQ in childhood. Recent evidence indicates that IQ discrepancies between VP/VLBW and term-born individuals are still found in adulthood.

Development of cognitive function is more stable for VP/VLBW than term-born individuals from infancy into adulthood and can be predicted fairly well from age 20 months onward. However, when adults with cognitive impairment are excluded, group differences in stability disappear. (Read the full article)

A student-centered approach to teaching mathematics enables students to develop conceptual understanding and to grow as confident mathematicians.

The Penn State Department of Mechanical Engineering is honoring several outstanding undergraduate students through its annual awards.

Multi-drug resistance among Gram-negative bacteria is a major global public health threat. Metallo-β-lactamases (MBLs) target the most widely-used antibiotic class, the β-lactams, including the most recent-generation carbapenems. Interspecies spread renders these enzymes a serious clinical threat and there are no clinically-available inhibitors. We present crystal structures of IMP-13, a structurally-uncharacterized MBL from Gram-negative Pseudomonas aerugionasa found in clinical outbreaks globally, and characterize the binding using solution NMR-spectroscopy and molecular-dynamics simulations. Crystal structures of apo IMP-13 and bound to four clinically-relevant carbapenem antibiotics (doripenem, ertapenem, imipenem and meropenem) are presented. Active site plasticity and the active-site loop, where a tryptophan residue stabilizes the antibiotic core scaffold, are essential to the substrate-binding mechanism. The conserved carbapenem scaffold plays the most significant role in IMP-13 binding, explaining the broad substrate specificity. The observed plasticity and substrate-locking mechanism provide opportunities for rational drug design of novel metallo-β-lactamase inhibitors, essential in the fight against antibiotic resistance.

Spectinomycin is a ribosome-binding antibiotic that blocks the translocation step of translation. A prevalent resistance mechanism is the modification of the drug by aminoglycoside nucleotidyl transferase (ANT) enzymes of the spectinomycin-specific ANT (9) family or by the dual-specificity ANT(3") (9) family that also acts on streptomycin. We previously reported the structural mechanism of streptomycin modification by the ANT(3") (9) AadA from Salmonella enterica. ANT (9) from Enterococcus faecalis adenylates the 9-hydroxyl of spectinomycin. We here present the first structures of spectinomycin bound to an ANT enzyme. Structures were solved for ANT (9) in apo form, in complex with ATP, spectinomycin and magnesium or in complex with only spectinomycin. ANT (9) shows similar overall structure as AadA with an N-terminal nucleotidyltransferase domain and a C-terminal α-helical domain. Spectinomycin binds close to the entrance of the interdomain cleft, while ATP is buried at the bottom. Upon drug binding, the C-terminal domain rotates by 14 degrees to close the cleft, allowing contacts of both domains with the drug. Comparison with AadA shows that spectinomycin specificity is explained by a straight α₅ helix and a shorter α_5-α₆ loop that would clash with the larger streptomycin substrate. In the active site, we observe two magnesium ions, one of them in a previously un-observed position that may activate the 9-hydroxyl for deprotonation by the catalytic base Glu-86. The observed binding mode for spectinomycin suggests that also spectinamides and aminomethyl spectinomycins, recent spectinomycin analogues with expansions in position 4 of the C ring, will be subjected to modification by ANT (9) and ANT(3") (9) enzymes.

BACKGROUND AND OBJECTIVES:

Children born very preterm (VPT) are at high risk of cognitive impairment that impacts their educational and social opportunities. This study examined the predictive accuracy of assessments at 2, 4, 6, and 9 years in identifying preterm children with cognitive impairment by 12 years.

Ebonie Slade, a senior majoring in biobehavioral health at Penn State Greater Allegheny, is the recipient of the 2020 Jackson Lethbridge Tolerance Award.

Forty-nine Penn State Berks students received recognition for the University Scholastic awards on April 2, through personalized emails. The awards presented included the Evan Pugh Scholars Award,

The Multicultural Resource Center at Penn State has announced this year’s Senior and Faculty/Staff Diversity Recognition Awards recipients. The 2020 awards honor multicultural University Park graduating seniors who excel in academics, leadership, and service, as well as faculty and staff throughout Penn State who demonstrate a commitment to diversity, equity and inclusion efforts beyond the responsibilities of their position.

Maureen Hack
Aug 1, 2005; 116:333-341
ARTICLES

Penn State Harrisburg this spring recognized staff members who have served the college for 25 years.

Penn State Harrisburg has selected six graduates to represent each academic school and graduate studies as student marshals for spring 2020.

Penn State Harrisburg recently honored students for accomplishments in academics, service, and leadership.

Bridget O’Donnell, assistant director of student engagement at Penn State Brandywine, has been recognized as Advisor of the Year by the Association for the Promotion of Campus Activities.

Penn State Brandywine has recognized students who have earned academic honors. Their accomplishments were celebrated through a virtual academic recognition website, which included a video message of congratulations from Chancellor Marilyn J. Wells. Due to the coronavirus pandemic, the annual ceremony that is usually held on campus was held in a virtual format.

Penn State Brandywine students who have impacted the campus through their leadership and service have been honored with student leadership awards. The annual awards program highlights the achievements of students involved with clubs, student government and campus programs

Six accomplished seniors will celebrate the culmination of their collegiate involvement and success by representing the Donald P. Bellisario College of Communications as student marshals for the Class of 2020.

Penn State New Kensington student-athletes from seven varsity sports teams were recognized virtually for academic and athletic performance during the 2019-20 academic year.

Penn State New Kensington announced its academic, teaching and extracurricular award winners on May 1, and shared a dedicated, virtual recognition web page, including video messages, photos and award winners.

Penn State Beaver has announced the Academic Award winners for the 2019-20 academic year, including the recipient of the Walker Award.

Biometrics are generally a good alternative to passwords, but authentication via face-scanning is a terrible idea, according to security expert Max Eddy.

Regulation moves at a snail's pace, so it's up to CEOs, executives, and employees to reject projects that put profit over privacy. Clearview AI facial-recognition tech is just the latest example of 'innovation' that could quickly get out of hand.

Delaware’s State Rental Assistance Program (SRAP) received national attention last week when it was honored with an Award for Program Excellence during the National Council of State Housing Agencies (NCSHA) 2013 Annual Conference & Showplace in New Orleans, LA. This year’s conference was attended by more than 900 affordable housing industry professionals.

In response to the growing coronavirus pandemic, orders from the state government and recommendations from global public health organizations, Penn State will hold its spring 2020 commencement ceremony via livestream on May 9. The virtual ceremony will recognize all Penn State undergraduate students and all graduate students in the Penn State Graduate School.

In keeping with Penn State Scranton's current continuing adjustment to an all-virtual environment, the annual Student Recognition Dinner will be held virtually at 6 p.m. on Wednesday, April 22.

In an inspiring show of support, a large contingent of Penn State Scranton’s campus community logged onto their computers the evening of April 22 to celebrate the accomplishments of the student body.

Wilmington, Del. (November 20, 2017) – People You Won’t Recognize will be on view in the Mezzanine Gallery from December 1-29, 2017. An opening reception to meet the artist will be held on Friday, December 1 from 5-7 p.m. The opening will include live music performed by Karen Mercer, the artist’s cousin. Trepper received a […]

Governor signs proclamation marking March as Social Work Month WILMINGTON, Del. – Governor John Carney on Thursday recognized the role of Delaware’s social workers as he signed a proclamation marking Social Work Month. The Governor signed the proclamation during an event at the Wilmington Public Library, one of seven libraries statewide where since January social […]

Accreditation is the highest recognition afforded to museums in the United States.

The State of Delaware was one of just five states recognized by the U.S. Department of Energy for its leadership in the first year of the Better Buildings Challenge.

Twenty-seven state employees were recognized for their acts of bravery.

American and Delaware flags at state buildings and facilities are to remain lowered to half-staff until Monday, December 8, to recognize Pearl Harbor Remembrance Day.

Dover – Today, the State of Delaware announced that it appears as No. 56 on the U.S. Environmental Protection Agency’s (EPA’s) National Top 100 list of the largest green power users from the Green Power Partnership. Delaware is using nearly 122 million kilowatt-hours (kWh) of green power annually, which represents 40 percent of its total […]

Delaware’s farming future and long agricultural heritage were both recognized today in a ceremony honoring the newest participants in the state’s Young Farmers Program and the latest inductees into the Century Farm Program, with the announcement that 10 young farmers would be receiving no-interest loans from the First State’s new innovative assistance program, now in its second year.

Gov. Jack Markell has presented the Order of the First State to two noted Delaware agricultural leaders and public servants, Bob Garey of Felton and Bill Vanderwende of Bridgeville.

Six Delaware families which have owned their farms for at least 100 years were honored as 2017 Century Farms. “Today we are recognizing farm families that have made a commitment for 100 years or more to keep their land in agriculture for future generations,” said Delaware Secretary of Agriculture Michael T. Scuse. “It’s in the true spirit of farm families who weather the ups and downs of farming that Delaware agriculture is able to remain strong.”

Delaware Secretary of Agriculture Michael T. Scuse recognized long-time Delaware State University Department Chair Dr. Richard Barczewski with the Secretary’s Award for Distinguished Service to Delaware Agriculture. With thirty-five years of dedicated service, Barczewski was recognized for developing Delaware’s agricultural industry though educating generations of agriculturalists, promoting animal agriculture, and service to agricultural organizations, including 4-H and FFA.

NEW CASTLE (May 15, 2019) – During Supervised Visitation Awareness Month, the Department of Health and Social Services’ Office of Community Services is conducting a toy drive to provide new toys, books and games for use at Delaware’s six Family Visitation Centers (FVCs). Through June 10, drop-off bins will be located at all State Service […]

Cognizant follows January-December as financial year. Its net profit was at USD 441 million in the March 2019 quarter.

Jaiprakash Dandegaonkar, ex-minister of state for co-operation, Maharashtra has been elected as the vice president of the association.

Cognizant has reported a decline of 16.78% in net income at $367 million for the quarter ended March 31, 2020, as compared to $441 million in the same period a year ago.

This Metasploit module exploits an injection vulnerability in Cogent DataHub prior to 7.3.5. The vulnerability exists in the GetPermissions.asp page, which makes insecure use of the datahub_command function with user controlled data, allowing execution of arbitrary datahub commands and scripts. This Metasploit module has been tested successfully with Cogent DataHub 7.3.4 on Windows 7 SP1.