close ABB brings fuel cell technology a step closer to powering large ships By www.abb.com Published On :: Wed, 8 Apr 2020 12:00:00 GMT 2020-04-08 - Full Article
close Taking a closer look at where Notre Dame football players may land in 2021 NFL draft By rssfeeds.indystar.com Published On :: Sun, 03 May 2020 14:35:10 +0000 NFL draft analyst Scott Wright takes a closer look at the Fighting Irish roster and 2021 draft hopefuls. Full Article
close Masks, hand sanitizer and closed stores: What malls looked like as Indiana began to reopen By rssfeeds.indystar.com Published On :: Tue, 05 May 2020 10:00:34 +0000 Customers ranged from enthusiastic to wary on first day they were able to shop again at suburban Indianapolis malls during the coronavirus pandemic. Full Article
close Zest! and Twist in SoBro close By rssfeeds.indystar.com Published On :: Fri, 12 Oct 2018 22:01:53 +0000 Busy weekend traffic couldn't sustain the restaurant, co-owner says Full Article
close The Vanguard restaurant closes in Broad Ripple after chef, bar manager quit By rssfeeds.indystar.com Published On :: Wed, 27 Jun 2018 14:12:23 +0000 The owner claims he was left no choice after sudden departure of the chef and bar manager. Full Article
close South of Chicago pizzeria closes at Fletcher Place By rssfeeds.indystar.com Published On :: Fri, 06 Jul 2018 22:04:17 +0000 Greenwood South of Chicago 'remains open and is doing quite well.' Full Article
close Many suburban places of worship will remain closed despite lifting of crowd limits By rssfeeds.indystar.com Published On :: Fri, 08 May 2020 20:25:52 +0000 Many suburban churches plan to keep their doors shut this weekend despite an easing of restrictions on public gatherings by Gov. Eric Holcomb. Full Article
close Victims of Visalia triple homicide identified; no suspect or motive disclosed By www.latimes.com Published On :: Wed, 6 May 2020 20:47:56 -0400 Late Tuesday night, police officers in Visalia, a San Joaquin Valley city about 40 miles southeast of Fresno, responded to a report of shots fired at a high school. Full Article
close Coronavirus: Germany's Bundesliga to resume behind closed doors on 16 May By www.bbc.co.uk Published On :: Thu, 07 May 2020 16:37:00 GMT The Bundesliga will resume behind closed doors on Saturday 16 May - becoming the first European league to restart following the coronavirus shutdown. Full Article
close Salman Khan: From closet to classroom By news.bbc.co.uk Published On :: Tue, 26 Jun 2012 07:45:05 GMT Founder of the Khan Academy, Salman Khan, wants to make a world class education available to everyone. Full Article Click
close Elon Musk says Tesla will 'immediately' leave California after coronavirus shutdowns forced the company to close its main car factory (TSLA) By feedproxy.google.com Published On :: Sat, 09 May 2020 13:34:00 -0400 Elon Musk says Tesla may leave its Palo Alto headquarters and Fremont, California factory. In a tweet Saturday morning, the chief executive continued his outrage against shelter-in-place orders that have forced most non-essential businesses to close. Last week, Musk likened the rules to fascism, and urged leaders to "give people their goddamn freedom back." Visit Business Insider's homepage for more stories. After a week of decrying coronavirus shelter-in-place orders that have left Tesla's main factory shuttered and unable to produce vehicles, Elon Musk says the company may move its factory out of the state. "Tesla is filing a lawsuit against Alameda County immediately," the chief executive said on Twitter Saturday morning. "The unelected & ignorant 'Interim Health Officer' of Alameda is acting contrary to the Governor, the President, our Constitutional freedoms & just plain common sense!" That was followed up with a threat to move Tesla's headquarters outside the state. "Frankly, this is the final straw," he replied. "Tesla will now move its HQ and future programs to Texas/Nevada immediately. If we even retain Fremont manufacturing activity at all, it will be dependent on how Tesla is treated in the future. Tesla is the last carmaker left in CA." Frankly, this is the final straw. Tesla will now move its HQ and future programs to Texas/Nevada immediately. If we even retain Fremont manufacturing activity at all, it will be dependen on how Tesla is treated in the future. Tesla is the last carmaker left in CA. — Elon Musk (@elonmusk) May 9, 2020 It wasn't immediately clear if a suit had yet been filed, or in which court Tesla will file the lawsuit. Most state and federal courts are closed on weekends and do not allow filing. In a subsequent Tweet, Musk alsourged shareholders to file a class action suit for damages caused by shutdown. Tesla's press relations department did not immediately respond to a request for comment. Alameda County did not immediately respond to a request for comment. Alameda County — the East Bay locale which includes Fremont, California, and Tesla's gigafactory about 30 miles southeast of San Francisco — extended its shelter-in-place order on April 29 "until further notice." Local authorities have not allowed Tesla to reopen the factory, and all manufacturing remains prohibited under the order. The San Francisco Chronicle reported that Tesla was planning to resume some manufacturing operations at the factory as soon as last Wednesday, May 6. Local officials said it did not have permission to do so. "Right now, the same health order is in place so nothing has changed," Fremont Police Department spokeswoman Geneva Bosques told Business Insider at the time. "Operating the assembly line was determined early on to be a violation." Last week, following Tesla's first-quarter earnings announcement, Musk decried the shutdowns as a substantial risk to the company's financials. "Frankly, I would call it forcible imprisoning of people in their homes against all of, their constitutional rights, in my opinion," he said on a conference call. "It's breaking people's freedoms in ways that are horrible and wrong and not why they came to America or built this country. What the f---. Excuse me. Outrage. Outrage." "If somebody wants to stay in their house, that's great and they should be able to," he continued. "But to say they cannot leave their house and that they will be arrested if they do, that's fascist. That is not democratic — this is not freedom. Give people back their goddamn freedom." Some states, including Texas, Georgia, and others, have begun to slowly allow certain businesses to re-open in recent weeks. Musk praised counties neighboring Alameda, like San Joaquin for what he said were more "reasonable" responses. In a podcast released May 7, he told Joe Rogan that the company had learned from the coronavirus in China, where it briefly forced Tesla to close its Shanghai factory — a claim he repeated on Twitter Saturday. "Our castings foundry and other faculties in San Joaquin have been working 24/7 this entire time with no ill effects. Same with Giga Nevada," Musk said. "Tesla knows far more about what needs to be done to be safe through our Tesla China factory experience than an (unelected) interim junior official in Alameda County." As Musk began to complain about factory shutdowns in April, workers at Tesla's Fremont factory told Business Insider that the comments made them anxious. "I'm for going back to work, but only if it is safe for me, my family, coworkers," said one production employee. "I don't feel like I'm being forced to stay home or that my freedom has been taken away. It's for the good of California."Join the conversation about this story » NOW WATCH: A cleaning expert reveals her 3-step method for cleaning your entire home quickly Full Article
close Fin24.com | Apple closes all stores outside greater China for 2 weeks By www.fin24.com Published On :: Sat, 14 Mar 2020 09:44:03 +0200 The technology giant says it is moving to remote work in order to help reduce the spread of coronavirus. Full Article
close Boston Dynamics' robot dog warns Singapore parkgoers not to get too close By feedproxy.google.com Published On :: Sat, 09 May 2020 16:45:05 +0000 In a startling turn for a robot that has long haunted your dreams, Boston Dynamics' Spot has been tasked to encourage healthy behavior. According to the Straits Times, the robot "dog" has been assigned to patrol the Bishan-Ang Mo Kio park in Singapore with the express purpose of encouraging social distancing. "Let's keep Singapore healthy," sounds a recording from the robot as it trots by two terrified people relaxing on a park bench in the above video. "For your own safety, and those around you, please stand at least one meter apart. Thank you." Notably, Spot's jaunt is part of a two-week trial that began Friday. The robot will supposedly not collect any personal information on the people it admonishes. Read more...More about Boston Dynamics, Coronavirus, Tech, and Other Full Article Boston Dynamics Coronavirus Tech Other
close Legendary East Village corner store, Gem Spa, closes its doors By feedproxy.google.com Published On :: Fri, 08 May 2020 10:14:17 PDT The Gothamist is reporting the sad news that Gem Spa, the iconic NY corner store that has been a fixture at St. Marks Place and Second Avenue for around 100 years is being forced to shutter its doors and windows for the last time. The Spa has been struggling to keep up with increasing rent prices and COVID-19 has apparently proven to be the final nail in its coffin. "It’s where Robert Mapplethorpe bought Patti Smith an egg cream on the day they met. It’s on the back cover of the New York Dolls’ 1973 debut (and where, according to lore, Johnny Thunders and others went for post-heroin sugar fixes between sets at CBGB). Before that, it was where Abbie Hoffman gathered Yippies to rain money on the New York Stock Exchange. It’s where Allen Ginsberg, Ted Berrigan, and other neighborhood poets went to pick up the Sunday New York Times on Saturday nights (and which was inevitably commemorated in their poems)." Read the rest. Image: Alex Lozupone, CC BY-SA 4.0 Read the rest Full Article Post loss new york city sad endings
close Narcisse Snake Dens closed to the public By winnipeg.ctvnews.ca Published On :: Fri, 8 May 2020 19:43:38 -0600 Any plans to visit the Narcisse Snake Dens this Mother's Day weekend will have to be put on hold, after the province announced they are closed until further notice. Full Article
close Close but Distracted: The Future of the UK-US Partnership By feedproxy.google.com Published On :: Thu, 16 Oct 2014 14:00:01 +0000 Invitation Only Research Event 16 October 2014 - 9:00am to 10:30am Chatham House, London Meeting Summarypdf | 145.17 KB Transcriptpdf | 45.62 KB In an open podcast recorded following the event, Robin Niblett discussed the state of the transatlantic relationship with International New York Times London Bureau Chief Steven Erlanger, former UK defence secretary Liam Fox and former Foreign Affairs Committee chair Mike Gapes.The roundtable was held under the Chatham House Rule. While revelations about the activities of the NSA and GCHQ confirmed the depth of cooperation between the US and the UK over intelligence, the debate over the UK’s membership of the EU and difficulties in coordinating a response to the Syria crisis have raised tensions between policy-makers in Washington and London. With the two countries now facing an array of shared international challenges – not least in Ukraine, Afghanistan and Iraq – this roundtable will examine the current state of the transatlantic relationship. Event attributes Chatham House Rule Full Article
close The UK-Saudi Arabia Relationship: A Closer Look By feedproxy.google.com Published On :: Tue, 04 Sep 2018 00:00:00 +0100 Full Article
close International Security Institutions: A Closer Look By feedproxy.google.com Published On :: Tue, 13 Nov 2018 00:00:00 +0000 Full Article
close Screening Room: Brexit - Behind Closed Doors By feedproxy.google.com Published On :: Thu, 27 Jun 2019 00:00:00 +0100 Full Article
close Ever Closer Alliance? New Developments in Russia-China Relations By feedproxy.google.com Published On :: Wed, 20 Nov 2019 13:45:01 +0000 Invitation Only Research Event 11 December 2019 - 9:00am to 1:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Agendapdf | 125.8 KB Event participants Yang Cheng, Professor of International Relations, Assistant Dean, School of International Relations and Public Affairs, Shanghai International Studies UniversityYu Jie, Senior Research Fellow, Asia-Pacific Programme, Chatham HouseMarcin Kaczmarski, Lecturer in Security Studies, University of GlasgowNatasha Kuhrt, Lecturer, Department of War Studies, King’s College LondonBobo Lo, Non-Resident Fellow, Lowy InstituteAlexey Maslov, Professor, School of Asian Studies, National Research University, Higher School of Economics, Moscow At face value, recent years have seen a deepening in Sino-Russian cooperation, from energy agreements, to the recent Huawei-MTS deal developing a 5G network in Russia. Ever larger-in-scale joint military exercises add to fears by some that the 'axis of convenience' is now a more genuine – and threatening – partnership.This workshop will offer a sober assessment of the latest developments in Sino-Russian relations, shedding light on the underpinnings and practical realities of the relationship as well as on the long-term challenges of upholding cooperation.The panel will discuss the different and potentially diverging interpretations of contemporary Sino-Russian relations as well as the implications for the rules-based international order.This event is co-organized by the Chatham House Russia and Eurasia Programme and the University of Exeter and is supported by the British International Studies Association.Attendance at this event is by invitation only. Department/project Asia-Pacific Programme, Russia and Eurasia Programme Anna Morgan Administrator, Ukraine Forum +44 (0)20 7389 3274 Email Full Article
close Stop Video on Modal Close By forums.digitalpoint.com Published On :: Sat, 09 May 2020 17:02:45 +0000 Full Article
close CBD Joint Press Release: Mobilizing society to support biodiversity: As Countdown 2010 initiative closes, local coordinated actions show way to solving the global biodiversity crisis. By www.cbd.int Published On :: Wed, 20 Oct 2010 00:00:00 GMT Full Article
close CBD News: The Nagoya-Kuala Lumpur Supplementary Protocol on Liability and Redress to the Cartagena Protocol on Biosafety closed for signature yesterday with a total of 51 signatories. By www.cbd.int Published On :: Thu, 08 Mar 2012 00:00:00 GMT Full Article
close CBD News: The Convention on Biological Diversity closed the 12th meeting of the Conference of the Parties today with Governments committing to step up actions to achieve, by the end of the decade, the Aichi Biodiversity Targets agreed four years ago, and By www.cbd.int Published On :: Fri, 17 Oct 2014 00:00:00 GMT Full Article
close CBD News: On 10 June, HSH Prince Albert II of Monaco closed a historic meeting of biodiversity and Antarctic experts. The purpose of the meeting was to examine the extent to which conservation of the biodiversity of Antarctica and the Southern Ocean is re By www.cbd.int Published On :: Tue, 23 Jun 2015 00:00:00 GMT Full Article
close CBD News: With continued growth and deepening diversification, tourism has become one of the fastest growing economic sectors in the world. And because tourism is closely linked to development, it has become a key driver for socio-economic progress. By www.cbd.int Published On :: Thu, 24 Sep 2015 00:00:00 GMT Full Article
close CBD News: The twentieth meeting of the Subsidiary Body on Scientific, Technical and Technological Advice (SBSTTA-20) of the Convention on Biological Diversity (CBD) came to a close on 30 April 2016 with the adoption of a number of key recommendations that By www.cbd.int Published On :: Wed, 04 May 2016 00:00:00 GMT Full Article
close CBD News: The first meeting of the Subsidiary Body on Implementation (SBI 1) of the Convention on Biological Diversity (CBD) came to a close on 6 May 2016 in Montreal, Canada. Delegates from around the world advanced attention on national action by recom By www.cbd.int Published On :: Sun, 08 May 2016 00:00:00 GMT Full Article
close CBD News: As we all know, the business and environment communities were historically not close allies. It was long believed that economic growth could not be compatible with a healthy environment. Thankfully, that has changed. We now know that the conserv By www.cbd.int Published On :: Wed, 29 Nov 2017 00:00:00 GMT Full Article
close CBD News: Delegates to the science body of the Convention on Biological Diversity (CBD) closed their meeting this week, sending a number of recommendations to the next UN Biodiversity Conference that set the stage for achievement of the Aichi Biodiversity By www.cbd.int Published On :: Sat, 16 Dec 2017 00:00:00 GMT Full Article
close CBD News: The 2018 UN Biodiversity Conference of the Parties (COP14) closed tonight with broad international agreement on reversing the global destruction of nature and biodiversity loss threatening all forms of life on Earth. By www.cbd.int Published On :: Thu, 29 Nov 2018 00:00:00 GMT Full Article
close CBD News: The inaugural Nature Champions Summit closed Thursday with a call to put nature at the centre of the global discourse together with climate action and sustainable development. By www.cbd.int Published On :: Mon, 29 Apr 2019 00:00:00 GMT Full Article
close CBD News: Following a summer of dramatic heat waves and forest fires, and close on the heels of a landmark scientific report charting an unprecedented decline in nature, the global community came together from 27-30 August in Nairobi to deliberate over an By www.cbd.int Published On :: Mon, 02 Sep 2019 00:00:00 GMT Full Article
close A closer look at a Poisson-like condition on the Drury-Arveson space By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Quanlei Fang and Jingbo Xia Proc. Amer. Math. Soc. 148 (2020), 2497-2507. Abstract, references and article information Full Article
close Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope [Protein Structure and Folding] By www.jbc.org Published On :: 2020-04-17T00:06:05-07:00 Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes recognized by cytotoxic T lymphocytes (CTLs) has hindered the utilization of CD8+ T-cell–mediated immunity and has precluded the development of effectively diversified epitope-based vaccination approaches. In particular, an HPAIV H5N1 CTL-recognized epitope based on the peptide MHC-I–β2m (pMHC-I) complex has not yet been designed. Here, screening a collection of selected peptides of several HPAIV strains against a specific pathogen-free pMHC-I (pBF2*1501), we identified a highly-conserved HPAIV H5N1 CTL epitope, named HPAIV–PA123–130. We determined the structure of the BF2*1501–PA123–130 complex at 2.1 Å resolution to elucidate the molecular mechanisms of a preferential presentation of the highly-conserved PA123–130 epitope in the chicken B15 lineage. Conformational characteristics of the PA123–130 epitope with a protruding Tyr-7 residue indicated that this epitope has great potential to be recognized by specific TCRs. Moreover, significantly increased numbers of CD8+ T cells specific for the HPAIV–PA123–130 epitope in peptide-immunized chickens indicated that a repertoire of CD8+ T cells can specifically respond to this epitope. We anticipate that the identification and structural characterization of the PA123–130 epitope reported here could enable further studies of CTL immunity against HPAIV H5N1. Such studies may aid in the development of vaccine development strategies using well-conserved internal viral antigens in chickens. Full Article
close Application for Exemption from the Language Proficiency Requirement is to close on 29 May 2020 By www.edb.gov.hk Published On :: Thu, 30 Apr 2020 00:00:02 Full Article
close AFCD, LCSD facilities to close By www.news.gov.hk Published On :: Fri, 27 Mar 2020 00:00:00 +0800 The Agriculture, Fisheries & Conservation Department (AFCD) and the Leisure & Cultural Services Department (LCSD) announced today that some of their facilities will be closed in light of the latest developments of COVID-19. Country park barbecue sites and campsites of the AFCD will be closed from 6pm on March 28 for 14 days. There are 163 barbecue sites and 41 campsites under the management of the AFCD. During the closure of these facilities, barbecue or camping activities in country parks will not be allowed and AFCD staff will step up patrols of the sites concerned and take appropriate action against any violation of relevant regulations. Call 1823 for enquiries and visit the Enjoy Hiking website for updates on country park facilities. As for LCSD facilities, its free outdoor leisure facilities will be closed from 6pm on March 28. Other venues and facilities with services already suspended will continue to be closed until further notice. All booking applications for the department's recreation and sports facilities, wedding venues, amphitheatres and non-fee charging leisure venues for non-designated use are also suspended. Meanwhile, the Housing Authority will close its outdoor sports and recreational facilities from 6pm tomorrow until further notice. Full Article
close AFCD facilities remain closed By www.news.gov.hk Published On :: Wed, 08 Apr 2020 00:00:00 +0800 The Agriculture, Fisheries & Conservation Department (AFCD) announced today that country park barbecue sites and campsites will remain closed until April 23. The 163 barbecue sites and 41 campsites managed by AFCD have been closed since March 28. Given the latest development of COVID-19, the department has decided to extend the closure. During the closure of these facilities, no barbecuing or camping activities are allowed in country parks. AFCD staff will step up patrols of these sites and violation of relevant regulations will be subject to prosecution. Call 1823 for enquiries or visit the Enjoy Hiking website for updates. The department also reminded people visiting country parks to maintain personal and environmental hygiene and maintain social distancing. Full Article
close AFCD facilities remain closed By www.news.gov.hk Published On :: Tue, 21 Apr 2020 00:00:00 +0800 The Agriculture, Fisheries & Conservation Department (AFCD) today announced that its barbecue sites and campsites in country parks will be closed until May 7. It made the decision in light of the latest development of the COVID-19 epidemic and to reduce social contact. All of these sites have been closed since 6pm on March 28. During the closure of these facilities, no one should carry out barbecuing or camping activities in country parks. AFCD staff will step up patrols of the sites and violation of relevant regulations may be subject to prosecution. In the past two weeks, AFCD took enforcement action against 34 people who carried out barbecuing or camping activities in country parks. The department will continue to closely monitor the situation and review the arrangement as appropriate. For the latest updates on facilities in country parks, visit the Enjoy Hiking website. Full Article
close ESO instrument finds closest black hole to Earth By www.eurekalert.org Published On :: Wed, 06 May 2020 00:00:00 EDT (ESO) Astronomers have discovered a black hole lying just 1,000 light-years from Earth. The black hole is closer to our solar system than any other found to date and forms part of a triple system that can be seen with the naked eye. The astronomers found evidence for the invisible object by tracking its two companion stars using the MPG/ESO 2.2-meter telescope at ESO's La Silla Observatory in Chile. They say this system could just be the tip of the iceberg. Full Article
close Ever Closer Alliance? New Developments in Russia-China Relations By feedproxy.google.com Published On :: Wed, 20 Nov 2019 13:45:01 +0000 Invitation Only Research Event 11 December 2019 - 9:00am to 1:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Agendapdf | 125.8 KB Event participants Yang Cheng, Professor of International Relations, Assistant Dean, School of International Relations and Public Affairs, Shanghai International Studies UniversityYu Jie, Senior Research Fellow, Asia-Pacific Programme, Chatham HouseMarcin Kaczmarski, Lecturer in Security Studies, University of GlasgowNatasha Kuhrt, Lecturer, Department of War Studies, King’s College LondonBobo Lo, Non-Resident Fellow, Lowy InstituteAlexey Maslov, Professor, School of Asian Studies, National Research University, Higher School of Economics, Moscow At face value, recent years have seen a deepening in Sino-Russian cooperation, from energy agreements, to the recent Huawei-MTS deal developing a 5G network in Russia. Ever larger-in-scale joint military exercises add to fears by some that the 'axis of convenience' is now a more genuine – and threatening – partnership.This workshop will offer a sober assessment of the latest developments in Sino-Russian relations, shedding light on the underpinnings and practical realities of the relationship as well as on the long-term challenges of upholding cooperation.The panel will discuss the different and potentially diverging interpretations of contemporary Sino-Russian relations as well as the implications for the rules-based international order.This event is co-organized by the Chatham House Russia and Eurasia Programme and the University of Exeter and is supported by the British International Studies Association.Attendance at this event is by invitation only. Department/project Asia-Pacific Programme, Russia and Eurasia Programme Anna Morgan Administrator, Ukraine Forum +44 (0)20 7389 3274 Email Full Article
close Elevated First-Trimester Neutrophil Count Is Closely Associated with the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes By diabetes.diabetesjournals.org Published On :: 2020-04-24T14:58:49-07:00 Chronic low-grade inflammation plays a central role in the pathophysiology of gestational diabetes mellitus (GDM). In order to investigate the ability of different inflammatory blood cell parameters in predicting the development of GDM and pregnancy outcomes, 258 women with GDM and 1154 women without were included in this retrospective study. First-trimester neutrophil count outperformed white blood cell (WBC) count, and neutrophil-to-lymphocyte ratio (NLR) in the predictability for GDM. Subjects were grouped based on tertiles of neutrophil count during their first-trimester pregnancy. The results showed that as the neutrophil count increased, there was a step-wise increase in GDM incidence, as well as glucose and glycosylated hemoglobin (HbA1c) level, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), macrosomia incidence and newborn weight. Neutrophil count was positively associated with pre-pregnancy Body Mass Index (BMI), HOMA-IR and newborn weight. Additionally, neutrophil count was an independent risk factor for the development of GDM, regardless of the history of GDM. Spline regression showed that there was a significant linear association between GDM incidence and continuous neutrophil count when it exceeded 5.0 x 109/L. This work suggested that first-trimester neutrophil count is closely associated with the development of GDM and adverse pregnancy outcomes. Full Article
close Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope [Protein Structure and Folding] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes recognized by cytotoxic T lymphocytes (CTLs) has hindered the utilization of CD8+ T-cell–mediated immunity and has precluded the development of effectively diversified epitope-based vaccination approaches. In particular, an HPAIV H5N1 CTL-recognized epitope based on the peptide MHC-I–β2m (pMHC-I) complex has not yet been designed. Here, screening a collection of selected peptides of several HPAIV strains against a specific pathogen-free pMHC-I (pBF2*1501), we identified a highly-conserved HPAIV H5N1 CTL epitope, named HPAIV–PA123–130. We determined the structure of the BF2*1501–PA123–130 complex at 2.1 Å resolution to elucidate the molecular mechanisms of a preferential presentation of the highly-conserved PA123–130 epitope in the chicken B15 lineage. Conformational characteristics of the PA123–130 epitope with a protruding Tyr-7 residue indicated that this epitope has great potential to be recognized by specific TCRs. Moreover, significantly increased numbers of CD8+ T cells specific for the HPAIV–PA123–130 epitope in peptide-immunized chickens indicated that a repertoire of CD8+ T cells can specifically respond to this epitope. We anticipate that the identification and structural characterization of the PA123–130 epitope reported here could enable further studies of CTL immunity against HPAIV H5N1. Such studies may aid in the development of vaccine development strategies using well-conserved internal viral antigens in chickens. Full Article
close Close cousins in protection: the evolution of two norms By feedproxy.google.com Published On :: Thu, 02 May 2019 09:37:09 +0000 2 May 2019 , Volume 95, Number 3 Read online Emily Paddon Rhoads and Jennifer Welsh The Protection of Civilians (PoC) in peacekeeping and the Responsibility to Protect (R2P) populations from atrocity crimes are two norms that emerged at the turn of the new millennium with the aim of protecting vulnerable peoples from mass violence and/or systematic and widespread violations of human rights. To date, most scholars have analysed the discourses over the status, strength and robustness of both norms separately. And yet, the distinction between the two has at times been exceptionally fine. In this article, we analyse the constitutive relationship between PoC and R2P, and the impact of discursive and behavioural contestation on their joint evolution within the UN system and state practice over three phases (1999–2005; 2006–10; 2011–18). In so doing, we contribute to the International Relations literature on norms by illuminating ideational interplay in the dynamics of norm evolution and contestation. More specifically, we illustrate how actors may seek to strengthen support for one norm, or dimension of a norm, by contrasting it or linking it with another. Our analysis also reveals that while the two norms of R2P and PoC were initially debated and implemented through different institutional paths and policy frameworks, discursive and behavioural contestation has in more recent years brought them closer together in one important respect. The meaning ascribed to both norms—by representatives of states and institutions such as the United Nations—has become more state-centric, with an emphasis on building and strengthening the capacity of national authorities to protect populations. This meaning contrasts with the more cosmopolitan origins of R2P and PoC, and arguably limits possibilities for the external enforcement of both norms through any form of international authority that stands above or outside sovereign states. This article forms part of the special section of the May 2019 issue of International Affairs on ‘The dynamics of dissent’, guest-edited by Anette Stimmer and Lea Wisken. Full Article
close Ever Closer Alliance? New Developments in Russia-China Relations By feedproxy.google.com Published On :: Wed, 20 Nov 2019 13:45:01 +0000 Invitation Only Research Event 11 December 2019 - 9:00am to 1:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Agendapdf | 125.8 KB Event participants Yang Cheng, Professor of International Relations, Assistant Dean, School of International Relations and Public Affairs, Shanghai International Studies UniversityYu Jie, Senior Research Fellow, Asia-Pacific Programme, Chatham HouseMarcin Kaczmarski, Lecturer in Security Studies, University of GlasgowNatasha Kuhrt, Lecturer, Department of War Studies, King’s College LondonBobo Lo, Non-Resident Fellow, Lowy InstituteAlexey Maslov, Professor, School of Asian Studies, National Research University, Higher School of Economics, Moscow At face value, recent years have seen a deepening in Sino-Russian cooperation, from energy agreements, to the recent Huawei-MTS deal developing a 5G network in Russia. Ever larger-in-scale joint military exercises add to fears by some that the 'axis of convenience' is now a more genuine – and threatening – partnership.This workshop will offer a sober assessment of the latest developments in Sino-Russian relations, shedding light on the underpinnings and practical realities of the relationship as well as on the long-term challenges of upholding cooperation.The panel will discuss the different and potentially diverging interpretations of contemporary Sino-Russian relations as well as the implications for the rules-based international order.This event is co-organized by the Chatham House Russia and Eurasia Programme and the University of Exeter and is supported by the British International Studies Association.Attendance at this event is by invitation only. Department/project Asia-Pacific Programme, Russia and Eurasia Programme Anna Morgan Administrator, Ukraine Forum +44 (0)20 7389 3274 Email Full Article
close Closet By kolembo.wordpress.com Published On :: Tue, 25 Aug 2015 19:41:31 +0000 Quantum physics dictates that Looked at directly matter will disappear. Big physics says that electrons can be bound, Entangled, still Unified theory does not allow multiple existences. These are matters of the heart; Sometimes looking at love directly can destroy it, And we don’t want lovers disappearing, To burnt, brawny, Ulaanbaatar without us, we Want […] Full Article Poetry gay identity Ozan Kosec Photography poetry politics Relationships ulaanbaatar
close Inner Circle to create song from winning poem - Close to 100 entries for Circle of Light contest By jamaica-gleaner.com Published On :: Tue, 05 May 2020 00:07:04 -0500 IT IS said that every cloud has a silver lining, and that could still hold true, even in the midst of a terrifying global pandemic. Despite COVID-19, the cycle of life continues, and out of it has sprung forth an inspiring poetry competition,... Full Article
close Too close for comfort - St Mary families in cramped homes have eyes on virus By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:26:06 -0500 Sandra Ferguson resides with her children and grandchildren in a concrete dwelling that is sectioned into four living quarters in the Fort George Road area of Annotto Bay. With 10 of them sharing kitchen and bathroom facilities, Ferguson said... Full Article
close Inbox: Is D-backs' closer Holland or Bradley? By mlb.mlb.com Published On :: Fri, 8 Feb 2019 17:55:36 EDT With Greg Holland now signed, will he be the closer or is that still going to be Archie Bradley? Beat reporter Steve Gilbert answers this question and more from fans as Spring Training approaches. Full Article
close D-backs to sort out closer role in spring By mlb.mlb.com Published On :: Wed, 13 Feb 2019 19:59:44 EDT After watching his pitchers and catchers go through their first workout Wednesday, D-backs manager Torey Lovullo said it was too early to say whether Archie Bradley, Greg Holland or Yoshihisa Hirano would be his closer come Opening Day. Full Article