It's been two years since Kuzy sent the Caps to the Eastern Conference Final with a legendary goal in overtime.

Rockville, Maryland : National Institute on Drug Abuse, 1986.

Durham, N.C. : [publisher not identified], [1946-1965]

[New York, N.Y.] : [The Foundation] [195-?]-1970.

Durham, North Carolina : [Duke Station, 1957-[197-?]

In a public-private partnership to develop housing, resident services and hope for 102 working families in Haster Orangewood community, Jamboree Housing Corporation and the City of Anaheim announce...

(PRWeb April 27, 2020)

Read the full story at https://www.prweb.com/releases/jamboree_begins_construction_on_capstone_development_to_change_trajectory_of_neighborhood_in_anaheim_ca/prweb17073166.htm

Andrés F. Barrientos, Víctor Peña.

Source: Bayesian Analysis, Volume 15, Number 2, 363--388.

Abstract:
In this article, we present data-subsetting algorithms that allow for the approximate and scalable implementation of the Bayesian bootstrap. They are analogous to two existing algorithms in the frequentist literature: the bag of little bootstraps (Kleiner et al., 2014) and the subsampled double bootstrap (Sengupta et al., 2016). Our algorithms have appealing theoretical and computational properties that are comparable to those of their frequentist counterparts. Additionally, we provide a strategy for performing lossless inference for a class of functionals of the Bayesian bootstrap and briefly introduce extensions to the Dirichlet Process.

Peter M. Zygmunt
Jun 1, 2002; 22:4720-4727
Behavioral

KM Harris
Jul 1, 1992; 12:2685-2705
Articles

Thomas Schikorski
Aug 1, 1997; 17:5858-5867
Articles

Exiting low inflation traps by "consensus": nominal wages and price stability - Speech by Luiz A Pereira da Silva and Benoît Mojon, based on the keynote speech at the Eighth High-level Policy Dialogue between the Eurosystem and Latin American Central Banks, Cartagena de Indias, Colombia, 28-29 November 2019.

Synaptic dysfunction provoking dysregulated cortical neural circuits is currently hypothesized as a key pathophysiological process underlying clinical manifestations in Alzheimer's disease and related neurodegenerative tauopathies. Here, we conducted PET along with postmortem assays to investigate time course changes of excitatory and inhibitory synaptic constituents in an rTg4510 mouse model of tauopathy, which develops tau pathologies leading to noticeable brain atrophy at 5-6 months of age. Both male and female mice were analyzed in this study. We observed that radiosignals derived from [¹¹C]flumazenil, a tracer for benzodiazepine receptor, in rTg4510 mice were significantly lower than the levels in nontransgenic littermates at 2-3 months of age. In contrast, retentions of (E)-[¹¹C]ABP688, a tracer for mGluR5, were unaltered relative to controls at 2 months of age but then gradually declined with aging in parallel with progressive brain atrophy. Biochemical and immunohistochemical assessment of postmortem brain tissues demonstrated that inhibitory, but not excitatory, synaptic constituents selectively diminished without overt loss of somas of GABAergic interneurons in the neocortex and hippocampus of rTg4510 mice at 2 months of age, which was concurrent with enhanced immunoreactivity of cFos, a well-characterized immediate early gene, suggesting that impaired inhibitory neurotransmission may cause hyperexcitability of cortical circuits. Our findings indicate that tau-induced disruption of the inhibitory synapse may be a critical trigger of progressive neurodegeneration, resulting in massive neuronal loss, and PET assessments of inhibitory versus excitatory synapses potentially offer in vivo indices for hyperexcitability and excitotoxicity early in the etiologic pathway of neurodegenerative tauopathies.

SIGNIFICANCE STATEMENT In this study, we examined the in vivo status of excitatory and inhibitory synapses in the brain of the rTg4510 tauopathy mouse model by PET imaging with (E)-[¹¹C]ABP688 and [¹¹C]flumazenil, respectively. We identified inhibitory synapse as being significantly dysregulated before brain atrophy at 2 months of age, while excitatory synapse stayed relatively intact at this stage. In line with this observation, postmortem assessment of brain tissues demonstrated selective attenuation of inhibitory synaptic constituents accompanied by the upregulation of cFos before the formation of tau pathology in the forebrain at young ages. Our findings indicate that selective degeneration of inhibitory synapse with hyperexcitability in the cortical circuit constitutes the critical early pathophysiology of tauopathy.

Nitric oxide (NO) is an important signaling molecule that fulfills diverse functional roles as a neurotransmitter or diffusible second messenger in the developing and adult CNS. Although the impact of NO on different behaviors such as movement, sleep, learning, and memory has been well documented, the identity of its molecular and cellular targets is still an area of ongoing investigation. Here, we identify a novel role for NO in strengthening inhibitory GABA_A receptor-mediated transmission in molecular layer interneurons of the mouse cerebellum. NO levels are elevated by the activity of neuronal NO synthase (nNOS) following Ca²⁺ entry through extrasynaptic NMDA-type ionotropic glutamate receptors (NMDARs). NO activates protein kinase G with the subsequent production of cGMP, which prompts the stimulation of NADPH oxidase and protein kinase C (PKC). The activation of PKC promotes the selective strengthening of α3-containing GABA_ARs synapses through a GABA receptor-associated protein-dependent mechanism. Given the widespread but cell type-specific expression of the NMDAR/nNOS complex in the mammalian brain, our data suggest that NMDARs may uniquely strengthen inhibitory GABAergic transmission in these cells through a novel NO-mediated pathway.

SIGNIFICANCE STATEMENT Long-term changes in the efficacy of GABAergic transmission is mediated by multiple presynaptic and postsynaptic mechanisms. A prominent pathway involves crosstalk between excitatory and inhibitory synapses whereby Ca²⁺-entering through postsynaptic NMDARs promotes the recruitment and strengthening of GABA_A receptor synapses via Ca²⁺/calmodulin-dependent protein kinase II. Although Ca²⁺ transport by NMDARs is also tightly coupled to nNOS activity and NO production, it has yet to be determined whether this pathway affects inhibitory synapses. Here, we show that activation of NMDARs trigger a NO-dependent pathway that strengthens inhibitory GABAergic synapses of cerebellar molecular layer interneurons. Given the widespread expression of NMDARs and nNOS in the mammalian brain, we speculate that NO control of GABAergic synapse efficacy may be more widespread than has been appreciated.

A new book explores the evolution of cartography throughout more than a century of commercial air travel

As a result of the pandemic, USPS, which has run at a loss for years, is even more cash-strapped. It expects to lose $2 billion each month during the pandemic. That prompted Postmaster General Megan Brennan to ask Congress for $50 billion in funds -- $25 billion to offset lost revenue from declining mail volume due to the pandemic, and another $25 billion for modernization.

The Vancouver Whitecaps said it has ordered two player to self-quarantine for 14 days after they violated club and league orders to abide by physical distancing guidelines in B.C.

Since early 2019, the Russell 2000, the primary index for small cap stocks, has lagged mid and large cap benchmarks....

The post Why Small Caps Lag In This Economic Downturn appeared first on OpenMarkets.

The number of cases of COVID-19 in First Nations reserves continues to rise this week, with 161 confirmed positive cases reported as of May 5.

Advanced preliminary release for Q4 2019 quarterly data on credit-to-GDP gaps covering 44 economies have been updated. These time-series data show the difference between the credit-to-GDP ratio and its long-run trend, which can serve as an early warning indicator of financial crises. As input, the data used are the credit-to-GDP ratio as published in the BIS database of total credit to the private non-financial sector. The credit series capture total borrowing by the private non-financial sector (ie households and non-financial corporations) from all sources.

Schools need help from the federal government to prepare millions of U.S. students for remote learning this fall and beyond.

Schools and tech companies in the U.S. and abroad have experience deploying virtual learning should a coronavirus emergency arise.

To celebrate 15 years of Google Maps, the popular mapping program gets a redesign, a host of new features, and an installation in New York's Madison Square Park.

As black-white achievement gaps widen in schools, so, too, do disparities in discipline rates between black and white students, according to a study published Wednesday of 2,000 schools.

Academic gender gaps in reading and math follow different paths as American students move from their school years into adulthood, according to new federal data.

In spite of stereotypes, gender gaps in math and reading aren't universal. The most comprehensive study to date on gender gaps suggests the size and even the direction of the gaps vary from one school district to another.

How the UEFA HatTrick scheme has helped build new stadia and training facilities in Sweden.

Objectives: Antibiotic combination therapy is used for severe infections caused by multidrug-resistant (MDR) Gram-negative bacteria. Yet, data of which combinations are most effective is lacking. This study aimed to evaluate the in vitro efficacy of polymyxin B in combination with 13 other antibiotics against four clinical strains of MDR Pseudomonas aeruginosa.

Methods: We evaluated the interactions of polymyxin B in combination with amikacin, aztreonam, cefepime, chloramphenicol, ciprofloxacin, fosfomycin, meropenem, minocycline, rifampicin, temocillin, thiamphenicol or trimethoprim by automated time-lapse microscopy using predefined cut-off values indicating inhibition of growth (≤10⁶ CFU/mL) at 24 h. Promising combinations were subsequently evaluated in static time-kill experiments.

Results: All strains were intermediate or resistant to polymyxin B, anti-pseudomonal β-lactams, ciprofloxacin and amikacin. Genes encoding β-lactamases (e.g., bla_PAO and bla_OXA-50) and mutations associated with permeability and efflux were detected in all strains. In the time-lapse microscopy experiments, positive interactions were found with 39 of 52 antibiotic combination/bacterial strain setups. Enhanced activity was found against all four strains with polymyxin B used in combination with aztreonam, cefepime, fosfomycin, minocycline, thiamphenicol and trimethoprim. Time kill experiments showed additive or synergistic activity with 27 of the 39 tested polymyxin B combinations, most frequently with aztreonam, cefepime, and meropenem.

Conclusion: Positive interactions were frequently found with the tested combinations, also against strains that harboured several resistance mechanisms to the single drugs and with antibiotics that are normally not active against P. aeruginosa. Further study is needed to explore the clinical utility of these combinations.

After months of hard work and preparation, nearly a dozen Penn State Hazleton seniors are now one step closer to graduating after presenting their Capstone Research and Design Thesis projects.

A new study finds that extracurricular activities have differing positive effects for rural boys compared to girls.

By Bishop Arthur Serratelli

Beneath the soil of every continent lie buried the ruins of fallen civilizations. The Sumerians, Akkadians, Mayans, Assyrians, Babylonians, Minoans, Romans: all of them, faded memories of past grandeur and glory. History records the collapse of at least thirty-two major civilizations that once thrived and prospered before our time. 

No great civilization is built in a day. No great civilization disappears in a single instant. Historians try to explain how these civilizations once so great have slowly vanished into the dustbin of history. Weather, economics, population decline, wars, politics are some of the reasons that they offer. But, ultimately, a civilization disappears when it loses its identity, forfeits its unity and jettisons its commitment to the common good.

Today’s relentless front-page news reports of scandal and sin (many times, stale news served up as current), the incessant discord of our politicians, the unending string of acrimonious tweets, and the rage of angry voices make one wonder whether or not we are facing the decline of our own civilization. Has our unity as a nation become so fragmented that it cannot be repaired?

The TV sitcoms, the talk shows, the din of warring cable news channels do little to promote serious discourse. Rather, they seem at times to make us despair of receiving unbiased reporting. They hardly inspire us to respond to the gospel’s clarion call for truth, justice, compassion and charity. Have we lost our commitment to the common good? Are we in the midst of an unstoppable decline of our nation? 

Some say this is the age of tolerance. As a result, good and evil, right and wrong, vice and virtue, truth and error are accepted as equally valid. But, this is not the age of tolerance. Those who are pro-life are marginalized. Those who cherish and protect the life of the child waiting-to-be-born, the elderly and the terminally ill are branded as bigots, unwilling to show compassion to those suffering. Those who accept the sanctity of marriage and human sexuality as designed by the Creator are vilified. We live at a time when some are not only intolerant to our basic Christian values, but are actively engaged to silence Christians, target the Church and reduce her to ruins. 

In an age of relativism, has it become almost impossible to dialogue rationally on the major issues that face us, such as poverty, migration, and the sanctity of life itself ? “Relativism is the order of the day. Good and evil, right and wrong, innocence and guilt – all these binaries are deliberately confused as antipodal extremes are brought into artificial congruence. Moral clarity is muddled and logical cogency diluted. All inherent preference is suspended out of a misguided attempt to achieve balance where there is none” (Brandon Marlon, “The Decline and Fall of Modern Civilization: 8 Simple Steps to Squandering It All,” The Algemeiner, January 22, 2015).

From the Church, we receive a rich heritage of truth, morality and charity. We have solid and clear moral principles given to us by Jesus. These are the solid building blocks with which to construct a just and peaceful society. Could it be that we ourselves are slowly abandoning these principles? How is it possible that those trained in the Catholic faith assume leadership roles in government and then jettison their Catholic morals? How is it that any one of us can remain complacent to the slow moral deterioration of our country? 

Our country will not collapse if we refuse to hand over our future to those who deny the existence of God and live as if this world is all that there is. Our society will not collapse if we are courageous enough to draw on our moral and spiritual heritage to solve the issues that divide us. Our nation will not collapse if we remain true to our identity given to us by our Founding Fathers as a nation founded on Judeo-Christian principles. Our courage as moral individuals to stand for justice, truth and compassion is the antidote to the collapse of our country.
 

There are many ways to add more "visual impact" to your maps. Some techniques grab the users' attention, but often don't add anything useful to the message the map is trying to convey (such as 3D tricks, or flashy/gratuitous images and infographics). I encourage you to design maps that have [...]

The post Giving your maps more visual impact! appeared first on Graphically Speaking.

Gianluigi Buffon won his 175th and final Italy cap on Monday, a record for a European. Could that soon be under threat, though? We check out the top ten.

The United States has gained ground against other countries in a global assessment of teenagers' reading, math, and science skills. That's ironic, though, considering this country has been running in place for years in all three subjects.

The Nebula Capsule II by Anker is an unusual entertainment projector: It runs the Android TV operating system, and can double as a Bluetooth speaker.

White teachers are generally less optimistic about their black students' chances of obtaining a four-year degree than black teachers—and those lowered expectations could become "self-fulfilling prophecies" when students internalize them or when teachers change their approach to students as a result,

Flipped classrooms have been getting attention as a way for teachers to find more time for activities and individual support during the regular school day, but a new study cautions that the model could trade short-term gains for wider achievement gaps.

In 50 years, the achievement gap has been unchanged, with the poorest 10 percent of students performing three to four years behind the wealthiest 10 percent of peers, finds a new study in the journal Education Next.

As black-white achievement gaps widen in schools, so, too, do disparities in discipline rates between black and white students, according to a study published Wednesday of 2,000 schools.

Auto production in Mexico and Brazil, Latin America's top producers, plunged by an unprecedented 99% in April as a result of the coronavirus crisis, with the two countries building a total of just...

Billionaire Mukesh Ambani just sealed three deals in as many weeks to raise a combined $8 billion, including from Facebook Inc.

Delaware's wildfire crew returns to the First State this week after wrapping up a successful two-week assignment fighting blazes in northern Idaho's Panhandle National Forests.  The crew is scheduled to be back at Blackbird State Forest on Thursday, August 23, at approximately 6:15 p.m. The Delaware Forest Service dispatched the team of 20 wildland firefighters to Montana on August 4 and the crew was immediately sent to northern Idaho to fight the Copper Mountain Fire, situated on the Canadian border. This past week, the crew battled the Cougar Fire, a 5,880-acre blaze burning in steep rugged terrain located approximately 5 miles east of Hope, Idaho.

The minister also noted that the pendency of dues owed to MSME units by the central government, state governments, public sector undertakings and major industries was "very high".

Ranked as Counterpoint’s top location and mapping platform in the world

  Google recently unveiled a huge makeover to its Google Maps. Currently available in beta mode, it lets you discover changes in its interface and improved accessibilities. However, the search results i...