Qwen2.5-Coder-32B is an LLM that can code well that runs on my Mac 12th November 2024 There’s a whole lot of buzz around the new Qwen2.5-Coder Series of open source (Apache 2.0 licensed) LLM releases from Alibaba’s Qwen research team. On first impression it looks like the buzz is well…

Kaiserstraße is a new residential building currently under construction in Blumenau, Brazil. The project is designed by Alencar Arquitetura and aims to harness connections between residents and the natural world.[...]

Within the vast musical landscape, songs dedicated to flowers have blossomed as lyrical tributes to the natural wonders that captivate and inspire. The countless compositions celebrating the beauty and symbolism of flowers highlight their enduring allure and universal appeal. In this article, we embark on a detailed exploration of the world of songs about flowers, ... Read more

The post Songs About Flowers: Exploring The Vast Melodic Garden appeared first on Star Two.

In this tutorial, I'll show you how to install the ALIUNDE Kodi Addon on your Android TV box or Amazon Firestick, plus, unique features in ALIUNDE.

In this tutorial guide, I'll show you exactly how to install the M-E-T-V Kodi Addon on your Android TV box or Amazon Firestick, and unique features.

In this tutorial, I'll show you exactly how to install the SEALTEAM 6 Kodi Addon on your Android TV box or Amazon Firestick, plus unique features.

Pakistan crush world champions Australia by nine wickets in Adelaide to set up a one-day international series decider.

Video shows a flooded terminal inside El Prat airport and partially submerged cars on a highway.

1. Manipur on boil: 2 more bodies found, 6 missing  The Times of India
2. Additional paramilitary forces rushed to Manipur amid spike in ethnic violence  Hindustan Times
3. Three women, three children missing after Jiribam gunfight; Meiteis and Kukis hold bandhs in Manipur  The New Indian Express
4. Letters to The Editor — November 13, 2024  The Hindu
5. Centre rushes 20 more CAPF companies to Manipur after fresh violence  Deccan Herald

1. PM Modi’s Rs 12,100 crore infrastructure push to transform Bihar’s railways and roadways – Here’s all you need to know  The Financial Express
2. PM Modi to visit Bihar on Wednesday, inaugurate projects worth Rs 12,100 Cr  Deccan Herald
3. PM Modi lays foundation stone for AIIMS Darbhanga, says NDA Govt committed to welfare of people  The Hindu
4. PM Modi Bihar Visit Live: Nitish Kumar removed 'jungle raj' in Bihar, says PM Modi in Darbhanga  Moneycontrol
5. Politics News Today Live Updates on November 13, 2024: ‘BJP trying to create controversy’: Karnataka Deputy CM Shivakumar on ‘Kaalia’ remark against Kumaraswamy  Mint

Illustrator, writer, and filmmaker Mordicai Gerstein died earlier this month. He leaves behind an amazing body of work which is sure to be read and appreciated; several have already been anointed as modern classics.

The Houthis launched a complex attack consisting of anti-ship missiles and drones, a Pentagon spokesperson said Tuesday.

Coding for #AI and #machinelearning – online course/workshop We are exploring a new way to learning how to code for AI and Machine Learning by applying ideas of  deliberate practise Starting Oct 2018 – the workshop has limited places Please contact info@futuretext.com if you want to sign up for our online workshop (300 USD)   [...]

Canan Moodie used his start against Scotland to show that he is about far more than just pace out wide and aerial ability.

Yue Chen
May 1, 2007; 6:812-819
Research

Ivan Matic
Jan 1, 2008; 7:132-144
Research

Yasushi Ishihama
Sep 1, 2005; 4:1265-1272
Research

This article is by Emma Lammers.

Author’s note: neurodivergent is term used to refer to people whose neurological functions differ from the norm because of an innate or acquired condition. Examples of these conditions include autism, learning disabilities, mood disorders, traumatic brain injuries, and more. People who do not have any neurodivergent conditions are considered neurotypical.

To the delight of many readers, more characters in fantasy literature reflect aspects of real-world people than ever before. Today’s heroes can be people of colour, people of any gender or sexual identity, people of nearly any age. Writers are answering the call for more diversity in their work, and oftentimes they do it well, portraying realistic, nuanced characters from marginalized communities.

Some people, however, aren’t as likely to see themselves accurately reflected in the pages of a fantasy story. I’ve searched long and hard to find literary characters who experience autism, anxiety, and sensory processing disorder as I do, and very few of these characters show up in fantasy – a detriment to my favourite genre. Villainous characters are often portrayed as neurodivergent because writers think that this will make them scarier, and you will encounter the occasional hero with post-traumatic stress disorder, but  these depictions tend to lack accuracy, diversity, and consideration for the people who actually have the conditions used in the story.

Continue reading Writing Neurodivergent Characters in Fantasy at Mythic Scribes.

David A. Mitchell
Jun 1, 2006; 47:1118-1127
Thematic Reviews

Food system transformation: A blind spot for climate and biodiversity action? 20 October 2022 — 12:00PM TO 1:00PM Anonymous (not verified) 5 October 2022 Chatham House and Online

How can COP27 and COP15 accelerate the agenda for sustainable food systems and land use?

Tackling the dual crises of climate change and biodiversity loss requires extraordinary levels of action at an unprecedented speed. Agriculture is the biggest user of land, the biggest source of methane emissions, a major contributor to total greenhouse gas emissions and the leading driver of biodiversity loss.

Anything short of a food system transformation puts climate and biodiversity objectives in peril. However, governments have not yet produced credible pathways and strong policies for tackling our growing ‘foodprint’ – the negative impacts of what we grow and eat.

In advance of COP27 in Sharm El-Sheikh for climate and COP15 in Montreal for biodiversity, Chatham House has published a new briefing paper which examines aligning food systems with climate and biodiversity targets.

The paper reviews the climate and biodiversity policy landscape to 2030, with a focus on land-based aspects and the inclusion of food and agriculture. The paper highlights serious conflicts between the impacts of the food system and goals to protect and restore biodiversity and mitigate climate change.

In light of this, opportunities for joined-up action on food, climate and biodiversity are identified, including three key steps for countries to take this decade to produce suitably ambitious and effective policies across the climate–biodiversity–food nexus.

This event brings together leading voices from the international policy arenas for climate and biodiversity to react to the briefing paper and discuss how COP27 and COP15 can accelerate the agenda for sustainable food systems and land use.

Zhaonan Wang and Yingpu Deng
Math. Comp. 93 (), 2921-2942.
Abstract, references and article information

Reliable, specific polyclonal and monoclonal antibodies are important tools in research and medicine. However, the discovery of antibodies against their targets in their native forms is difficult. Here, we present a novel method for discovery of antibodies against membrane proteins in their native configuration in mammalian cells. The method involves the co-expression of an antibody library in a population of mammalian cells that express the target polypeptide within a natural membrane environment on the cell surface. Cells that secrete a single-chain fragment variable (scFv) that binds to the target membrane protein thereby become self-labeled, enabling enrichment and isolation by magnetic sorting and FRET-based flow sorting. Library sizes of up to 109 variants can be screened, thus allowing campaigns of naïve scFv libraries to be selected against membrane protein antigens in a Chinese hamster ovary cell system. We validate this method by screening a synthetic naïve human scFv library against Chinese hamster ovary cells expressing the oncogenic target epithelial cell adhesion molecule and identify a panel of three novel binders to this membrane protein, one with a dissociation constant (KD) as low as 0.8 nm. We further demonstrate that the identified antibodies have utility for killing epithelial cell adhesion molecule–positive cells when used as a targeting domain on chimeric antigen receptor T cells. Thus, we provide a new tool for identifying novel antibodies that act against membrane proteins, which could catalyze the discovery of new candidates for antibody-based therapies.

Abnormal changes of neuronal Tau protein, such as phosphorylation and aggregation, are considered hallmarks of cognitive deficits in Alzheimer's disease. Abnormal phosphorylation is thought to precede aggregation and therefore to promote aggregation, but the nature and extent of phosphorylation remain ill-defined. Tau contains ∼85 potential phosphorylation sites, which can be phosphorylated by various kinases because the unfolded structure of Tau makes them accessible. However, methodological limitations (e.g. in MS of phosphopeptides, or antibodies against phosphoepitopes) led to conflicting results regarding the extent of Tau phosphorylation in cells. Here we present results from a new approach based on native MS of intact Tau expressed in eukaryotic cells (Sf9). The extent of phosphorylation is heterogeneous, up to ∼20 phosphates per molecule distributed over 51 sites. The medium phosphorylated fraction Pm showed overall occupancies of ∼8 Pi (± 5) with a bell-shaped distribution; the highly phosphorylated fraction Ph had 14 Pi (± 6). The distribution of sites was highly asymmetric (with 71% of all P-sites in the C-terminal half of Tau). All sites were on Ser or Thr residues, but none were on Tyr. Other known posttranslational modifications were near or below our detection limit (e.g. acetylation, ubiquitination). These findings suggest that normal cellular Tau shows a remarkably high extent of phosphorylation, whereas other modifications are nearly absent. This implies that abnormal phosphorylations at certain sites may not affect the extent of phosphorylation significantly and do not represent hyperphosphorylation. By implication, the pathological aggregation of Tau is not likely a consequence of high phosphorylation.

Felicia Grasso
Dec 1, 2020; 19:1986-1996
Research

Xiao-Ting Wen
Dec 17, 2020; 0:RA120.002119v1-mcp.RA120.002119
Research

Weixian Deng
Dec 22, 2020; 0:RA120.002411v1-mcp.RA120.002411
Research

Congcong Lu
Nov 17, 2020; 0:R120.002257v1-mcp.R120.002257
Review

Daniel J. Geiszler
Dec 1, 2020; 0:TIR120.002216v1-mcp.TIR120.002216
Technological Innovation and Resources