The following article, 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO], was first published on 100PercentFedUp.com.

Emergency orders that “non-essential businesses” remain closed during the Covid-19 crisis have devastated small business owners across America. A wave of business owners across the nation are defying executive orders by their governors and opening their businesses anyhow. Yesterday, we reported about a small business owner in the state of Michigan, where Governor Gretchen Whitmer […]

Continue reading: 77-Yr-Old MI Barber Defies Gov Whitmer’s Shutdown Order: ”I don’t need another mother” Shop Will Stay Open Until “Jesus walks in or until they arrest me” [VIDEO] ...

The following article, Mother of the Year, Michelle Obama Explains How Having Kids Was A “Concession”… Had To Give Up Her “Aspirations and Dreams” [VIDEO], was first published on 100PercentFedUp.com.

While campaigning for her community organizer turned presidential candidate husband, Barack, Michelle Obama told a crowd of his supporters in Milwaukee, Wisconsin that for the first time in her life, she was proud to be an American. Four years later, Michelle Obama was a keynote speaker at the DNC convention, where she told Democrats how […]

Continue reading: Mother of the Year, Michelle Obama Explains How Having Kids Was A “Concession”… Had To Give Up Her “Aspirations and Dreams” [VIDEO] ...

Mother's Day is Sunday, but with COVID-19, it's forcing many to change their plans.

A beverage company in the U.S. is inviting moms to let out a ‘quaranscream’ this Mother’s Day on a designated ‘zero-judgement venting hotline’ for a chance to win its wine spritzers.

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

(University of Adelaide) An international team of scientists led by the University of Adelaide's Davies Research Centre has shown that it is possible to disentangle the DNA sequences of the chromosomes inherited from the mother and the father, to create true diploid genomes from a single individual.

A Manchester mother is pleading with the authorities to provide her with the results of COVID-19 tests done on her and her week-old baby. The woman claims that she has been in isolation in hospital since April 27, a day after she gave birth to...

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

Join Henry Burrell as he asks Davids Price why Snopes, the fact checking website, has run into trouble and how crowdfunding could save the day. Is it still important in this age of fake news? Then Scott Carey commentates on the bout between Mark Zuckerberg and Elon Musk. Who knows the most about AI? When will the killer robots descend upon us? Does Mark do all his online Q & A’s in front of a cooking brisket? All this answered and more.  

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Just last year, one could find a variety of deals and promotions for Mother’s Day with ease, but for 2020, the opposite is true. This change could be connected with the coronavirus pandemic and a number of businesses having to close their doors for...

You have to wake up Democratic or not Atheist or deciding Male or female You have to wake up. You must. By force. No, this is not a question of belief No, not one of freedom You are free. You have to wake up until You die. -evocative short poetry- Picture: Mondolithic Studios

It’s not news that the current fight against COVID-19 has overshadowed plans of artistes worldwide, having impacted some of their biggest stages and platforms with the cancellation of not only large-scale events but private ones as well. Birthday...

Despite its best efforts, COVID-19 will not be allowed to steal the joy of Mother’s Day this year. An array of the island’s top singers and musicians have pledged to infuse the accustomed specialness into the day dedicated to mothers with a concert...

Lily was diagnosed at 14 years old with stage four Hodgkin's lymphoma and received six rounds of chemotherapy and two weeks of radiotherapy. She survived but now lives with the long term effects of that therapy - and joins us to discuss how it has impacted her quality of life. We're also joined by Saif Ahmad and Thankamma Ajithkumar, oncologists...

Latoya Rose used the last $3,000 she had to invest in 26 baby chicks and feed with the hope of turning a profit after they matured. Last Friday, as the Spaldings resident went to her coop to feed the chickens, they were all gone. “When I don’t see...

Vendors and store operators who would normally score big on Mother’s Day baskets are lamenting that the novel coronavirus has put a dent in their sales. Kaydyonne Thomas, owner of a gift store in the Pavilion Mall, located in Half Way Tree, said...

No pets no electronics so maybe something that is nice and simple but homemade

Lorraine Elliott is the author of Not Quite Nigella. You can find her blog at www.notquitenigella.com This recipe was featured on Foodie Tuesday, every 3:30 PM Tuesday, 774 ABC Melbourne Drive show.

There's a simple and powerful way to confront the world's most pressing crises, says women's rights activist Yifat Susskind: think like a mother. As she puts it: "When you think like a mother, you prioritize the needs of the many, not the whims of the few." Follow along as she shares moving stories of people around the world who embody this mindset -- and shows how it can also help you see beyond suffering and act to build a better world.

A young artist inherits her Grammy's home in The Vales and begins to remember the stories her Grammy once shared with her. Where they real or has Grammy already lost her marbles a wee bit? When some friends come to visit she regales them with the stories and gives them a tub of her Grammy's favourite chees - the Bless Family Vegan Parmesan Cheese that she had procured from the famous Blessed Cheese cafe run by the Bless family.

"24 1⁄2 Almond Tree Grove is the second story in the series In the Vales. A fun, light fantasy story about a young girl who inherits her Grammy's Cottage in the Vales, then starts to remember some of Grammy's favourite stories of her wee friends. The Almond Tree fairies are so helpful to us all, just read my wee story and see. "These stories allow you to enter into a parallel world set within our local community. They will take you on a journey to allow your imagination to tell the tales of the adventurous characters in a variety of unique situ's. The dialogue twists between now and then to provide a rich connection to the character's shenanigans, which motivates the reader to visualise beyond the text to create deeper meaning and connection to self, family and the community we live in."

Secret wee Caves the third story in the series "In the Vales" A fun, light fantasy story about a young girl who inherits her Grammy's Cottage in the Vales, then starts to remember some of Grammy's favourite stories of her wee friends. I hear Max the Purple Dragon is such a gentleman, find out more by reading my wee story. "These stories allow you to enter into a parallel world set within our local community. They will take you on a journey to allow your imagination to tell the tales of the adventurous characters in a variety of unique situ's. The dialogue twists between now and then to provide a rich connection to the character's shenanigans, which motivates the reader to visualise beyond the text to create deeper meaning and connection to self, family and the community we live in."

With two quick bursts of the Ghost train's whistle it indicates that the time is 12 midnight, but as quick as we rush out of the front door we have never been able to catch a glimpse of that train, till now! Grammy's tales are being shared through her granddaughter, but are they tales or real events and people, hmm? Read on to find out for yourself. He He. A fictional story set In the Vales as a Children's Bedtime Story. History and characters of this rolling countryside between sea and hills has been packaged up to be fun, informative and thought provoking.

A fun light story by Grammy of camping in the Vales with nighttime noises and shadows scaring all. She knew who was scurrying around the campsite. Would you like to know too? -- Publisher.

Heredity -- Genetics.

[Spain?], An. 1817.

London : James Nisbet & Co., MDCCCLXXX [1880]

(Edin.r [Edinburgh] : Printed by A. Mc.Glashon), [1842]

London (No. 29 Newman Street, Oxford Street) : Published ... by V. & R. Green, January 18th 1788

Rockville, Maryland : National Institute on Drug Abuse, 1979.

Pac-12 student-athletes give shout-outs to their moms ahead of Mother's Day on May 10th, 2020 including UCLA's Michaela Onyenwere, Oregon's Sabrina Ionescu and Satou Sabally, Arizona's Aari McDonald, Cate Reese, and Lacie Hull, Stanford's Kiana Williams, USC's Endyia Rogers, and Aliyah Jeune, and Utah's Brynna Maxwell.

In the past 20 years, malnutrition in mothers and children has decreased by almost half. But despite this progress, child undernutrition is still the greatest nutrition-related health burden in the world. One of the biggest problems with child undernutrition is that it continues the cycle of stunting: stunted girls grow up to be stunted mothers, and stunted mothers are much [...]

From pregnancy to birth and beyond, mothers, both animal and human, show off some amazing skills

This Sunday, celebrate the moms of the animal kingdom with kittens, polar bear cubs, eaglets and more

These paintings, sculptures and illustrations honor the bonds of motherhood

Browse the collections for artworks with a CC0 license as part of the Smithsonian's Open Access Initiative,

It was a quiet morning at Nagarahole Tiger Reserve, Sun was opening up and the mist from the night was clearing. As we made a drive through the wood we saw this beautiful leopardess perching on her favourite tree. This leopardess was marking her presence by rubbing her scent glands to the tree trunk by hugging it. This behaviour was very interesting to witness as it was marking her scent on the top branches of the tree. This is one of the favourite pictures that I took recently because of the whole setup. Artistically one can visualize the tree branch as an "Arm of the Mother Nature" and leopard is holding on to it. It shows the unmitigated bonding shared between the tree and the Leopard.

In the early 20th century, Native people responded to the proclamation of Mother’s Day with powwows, ceremonies, rodeos, feasts, and songs

If New Brunswickers were planning on doing any yard work this weekend they will likely be using their snow shovels instead of their lawn rakes. 

Long-term care homes in Eastern Health's jurisdiction are allowing for people to again visit their relatives by windows, just in time for Mother's Day. 

We're answering your questions about the pandemic. Send yours to COVID@cbc.ca and we’ll answer as many as we can. We’ll publish a selection of answers every weekday online, and also put some questions to the experts during The National and on CBC News Network.

Manitoba health officials says visits can be done via the internet, through window panes, or outside at a distance if everyone is healthy. People whose moms are in a hospital or a care home can still drop off gifts of food or clothing.