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Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived PGE2




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PSMA PET–CT outperforms conventional imaging in high-risk prostate cancer




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Brightfield multiplex immunohistochemistry with multispectral imaging




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Molecular signatures of tumor progression in myxoid liposarcoma identified by <i>N</i>-glycan mass spectrometry imaging




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Phase imaging with an untrained neural network




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Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo




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Mapping the twist-angle disorder and Landau levels in magic-angle graphene




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Does multiparametric imaging with <sup>18</sup>F-FDG-PET/MRI capture spatial variation in immunohistochemical cancer biomarkers in head and neck squamous cell carcinoma?




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Resurrecting a magic bullet

Heidelberg Pharma has resuscitated a long-dead ADC toxin with updated conjugation techniques, and its partner Roche has thrown the company a lifeline that could help validate the platform.




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Machine intelligence lights up imaging




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The reimagination of downtown Los Angeles


Los Angeles has long been a city associated with the common ills of urban excess: sprawl, homelessness, and congestion. More charitable descriptions paint it as West Coast paradise, boasting sunshine and celebrities in equal measure.

A three-day visit to downtown Los Angeles exposed the nuances behind these stereotypes. Hosted by the Los Angeles Downtown Center Business Improvement District, which is focused on strengthening downtown as an innovation district, our visit began as a real estate tour but quickly revealed regeneration and innovation activity that confounded our expectations. 

Downtown LA (DTLA)’s innovation district focuses not just on tech firms but also on historic LA industry strengths like fashion, design, and real estate. LA may have sat in the shadow of the Silicon Valley tech boom, but it appears to be revitalizing in time for the convergence economy, in which tech is no longer a separate sector but ingrained in all forms of economic and creative activity.

And at a time where firms are revaluing proximity, vibrancy, and authenticity, DTLA could not be in a better place. While a number of U.S. cities subjected their downtowns to a range of urban renewal initiatives, the urban fabric of DTLA is largely intact. Vibrant areas like South Broadway feature boutique hotels, a dozen theatres, and clothing stores and bars that exist in historic infrastructure like reclaimed theatres. There is an urban feel that is authentically LA.

The initial renaissance of DTLA began in the late 1990s, after the residential units within its 65 blocks had dwindled to just 10,000.

Along with transportation improvements, permissive planning policies such as adaptive reuse—which allowed commercial buildings to be converted into residential use—were instrumental in increasing DTLA’s residential population. Since 1999, the residential population and housing units have tripled. With new bars and restaurants springing up on every corner, it is no surprise that three-quarters of DTLA’s current residents are aged between 23 and 44.

Building on this residential surge, an increasing number of businesses are now setting up or relocating downtown.

DTLA office space has not always been an easy sell. Employers balk at the prospect of subjecting their workforce to the punishing commute. And Bunker Hill and the adjacent Financial District, the epicenter of the central business district, offers little more than unpopulated plazas and cubicled office space.

DTLA has worked to serve its newfound residential population and attract more workers and companies by retrofitting buildings to modern aesthetic standards. The exposed brickwork and ceiling equipment of many DTLA offices like those of Nationbuilder, an online platform used for political and civic campaigns, is not just a statement of style but a conscious decision to make downtown office buildings feel hospitable to creative firms. The BLOC, a 1.9 million square foot retail development, is essentially a mall that has been turned inside out, with the roof removed to reveal an open air plaza, unrecognizable from the fortress-style building that once sat in the same spot.

While downtown’s office blocks are a fantastic asset in attracting innovation activity, the area also boasts a vast amount of warehouse space. These larger footprints, most often used for textile or food production, are attracting a range of activities that require space or, in the case of Tesla’s Hyperloop, secrecy. Such industrial firms are interspersed with new art galleries and a historic knitting mill, proof of the area’s artistic heritage.

The individuals leading the drive for a DTLA innovation district, such as Nick Griffin, director of Economic Development for the Downtown Center Business Improvement District, are realistic about challenges, such as the lack of quality public space, and proactive in leveraging existing assets, such as the large supply of creative office space.

These efforts and LA’s distinctive industry strengths are combatting one of the biggest challenges to attracting businesses downtown: the strength of competing areas like Silicon Beach, which includes Santa Monica and Playa del Rey and offers an established tech ecosystem alongside an attractive location.

Another challenge? Like many U.S. cities, LA bears the scars of suburban sprawl and a legacy of under investment in public transportation. Congestion is a constant complaint.

But here too LA is making progress.

In November, Angelinos will vote on an extension of Measure R—a 2008 ballot initiative raising the sales tax to fund core transportation projects—to provide sustainable funding for transportation infrastructure and improve access to the city center through the metro system.

Other ambitious projects, such as the Regional Connector, a light rail subway through the middle of downtown, will have a profound effect on the area's connectivity. This project is not just about getting people to and from downtown—it will also have a transformative effect on public space. The city is working with Project for Public Spaces to redesign one of the Connector’s hubs, Pershing Square, with the aim of providing a public space where employees and residents can convene and collaborate.

Connectivity will play a vital role in the continuing success of DTLA’s resurgence. But the DTLA innovation district’s main opportunity lies in better serving and connecting the people who make it work. With hometown authenticity and civic commitment, DTLA is on its way to creating a city center that is greater than the sum of its parts.

DOWNTOWN LA IN NUMBERS

Size: Approx 8.6 sq. miles

Major districts: Civic Center, Bunker Hill, Financial District, South Park, Fashion District, Jewelry District, Historic Core, Little Tokyo, Exposition Park, Toy District, Central City East, Arts District, City West, Chinatown, and Central Industrial District

Residential population: 60,600
66% of residents are between the ages of 23 and 44

Average median household income: $98,000

Education status: 79% of residents hold a college degree

Average workday population: 500,000


Photo Credit: Hunter Kerhart

Authors

  • Kat Hanna
  • Andrew Altman
Image Source: Hunter
      
 
 




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Imagining assistance: Tales from the American aid experience in Iraq in 2006 and Pakistan in 2011


For more than a decade, government assistance to Afghanistan, Iraq, and Pakistan (the so-called AIP countries) has dominated United States aid efforts. And as the examples below illustrate, American institutions and mindsets found it extraordinarily difficult to adjust to aid in unsafe places. Cameron Munter draws on his experience as the head of the Provincial Reconstruction Team (PRT) in Mosul, Iraq in 2006 and as ambassador of the United States to Pakistan in Islamabad in 2011, with a description of U.S. reconstruction and state-building from which we may find lessons to consider in the future.

In 2006, when he went to Mosul as the first leader of the first PRT, the American civilian and military authorities in Baghdad painfully learned that the post-conflict situation would not correct itself. The undergrowth of our own bureaucratic structure prevented us from gaining a sophisticated understanding of our surroundings. Members of the PRT came and left after a few months, without passing on their hard-obtained knowledge. Local authorities quickly realized that the PRT had neither the money nor the firepower of the brigade commanders. And most of all, the guiding principles in place were still the creation of a kind of constitutional framework where political leaders, police, courts, businesspeople, and citizens would have institutions familiar to Americans, institutions that would work as we knew how to make them work.

Munter arrived in Pakistan at a time of great hope for U.S.-Pakistani relations. In 2011, in a series of meetings with the U.S. deputy secretary of state for resources and the head of USAID, Kerry-Lugar-Berman priorities took center stage: education, energy efficiency, job creation, special projects in the tribal areas, and public health. It is one thing to define a task and quite another to apply it to the specific context of a country in which security considerations prevent most USAID workers from even laying eyes on their projects. Overall, it seems the United States was much better at measuring its commitment to a prosperous, democratic Pakistan at peace with its neighbors by counting how much it spent and how fast rather than creating the proper relationship with those on the ground with whom it might have partnered.

Under these circumstances, what are lessons learned? When security is shaky, assistance is difficult. It may be that in situations like the AIP countries, we only have the capacity to engage in humanitarian aid and immediate reconstruction. If that is so, then the whole question of engagement in dangerous places is reopened: In a military setting, with military tasks, and thus a military system of organization, can civilian assistance succeed? Money spent is the way we measure commitment in such a setting, and that doesn’t bring the results we need.

Downloads

Authors

  • Cameron Munter
Image Source: © STRINGER Iraq / Reuters
     
 
 




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Redesign required: Principles for reimagining federal rural policy in the COVID-19 era

The COVID-19 crisis is testing America’s resilience. The rapidly accelerating economic fallout makes concrete the risks for a national economy built on the success of just a few key economic centers. When the nation turns to the work of recovery, our goal must be to expand the number and breadth of healthy communities, jump-starting a…

       




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Concept for smarter wave power device a winner in GE's Ecomagination Challenge

The company says this system is simpler than other wave devices that need to be finely tuned to the waves to pick up their energy.




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Ollies Blocks encourage kids' imagination & creativity (Review)

Building with blocks and construction toys is a great unstructured activity for kids, and Ollies Wooden Blocks are a superb new addition to the category.




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Paper engineer's 3D pop-up art leaps off the page magically (Video)

The versatile, two-dimensional medium of paper is reconstructed into art that pops off the page.




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Steven M. Johnson imagined the shower of the future 25 years ago

Once again our favorite visionary was ahead of his time.




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Tea is actually magical creativity juice

More than just a comfortable habit, science has shown that sipping tea throughout the day improves and prolongs creative performance.




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Magical thatched wooden pavilion contains "portals to the universes" (Video)

Built using traditional and local techniques of construction, this distinctive structure sits on the edge of a national forest and a long-vanished lake.




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Magical eco-resin jewelry encapsulates Ireland's wildflowers & fungi

These delightful mementos of the Irish countryside remind us of nature's beauty, but are also responsibly sourced and packaged.




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Retractible stairs make buildings accessible just like magic

This is a big problem in old buildings: providing universal access without ruining the look of the building.




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Finnish concept of 'sisu' is all about our magical hidden strength

The cultural construct describes the enigmatic inner power that pushes people to get through hardships.




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De-Dimension furniture magically folds flat to hang on the wall like art (Video)

These pre-assembled pieces of furniture can fold completely flat, and when needed, are opened up into three-dimensional functionality.




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Ecovative's magical mushroom insulation wins 2013 Buckminster Fuller Challenge

The styrofoam substitute that they grow into packaging and insulation is the next big thing in building.




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Food pharmacies are the closest thing to a magical cure-all

When doctors team up with food banks, it improves health and staves off chronic hunger.




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The future of food: Imaginary brands cooked up in ghost kitchens

We will all be poor, fat, and buried in plastic.




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The 2018 Evolo Competition entries are wonders of drawing talent and imagination

It always amazes, how much work people do for this.




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Imaginative kids' bedroom features space-saving, cave-like bunk bed

Reminiscent of a bear's cozy cave, this bedroom for children maximizes the small space in a playful way.




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Congestion Charge Is Traffic-Cutting Magic in Milan

Stockholm and London are famous for congestion charging to keep cars out of central districts. Now Milan's heading that direction, with impressive results




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How to make air travel (a bit) less damaging

We know it's bad, but people still do it, which is why we still need to talk about it.




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How hard is it to walk in American suburbs? Worse than I imagined

On the Mouzon scale of 1 to 10 for walkability, this intersection gets -10.




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Artist's repurposed vintage pocket watches reveal magical miniature worlds

These intricately redone antique pocket watches and other timepieces feature scenes inspired by fairytales and steampunk.




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Imagine a world reliant on robot bees to roam the fields and meadows

Welcome to your dystopian nightmare installment #4692.




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Imagine meatless Monday at the school cafeteria

Is the dream of sustainable agriculture a nightmare for the beef industry?




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Danish Council on Ethics releases its report on beef as a 'climate damaging food'

The report argues why a beef tax would be an effective step toward curbing greenhouse gas emissions and why we should all be paying more for climate-damaging foods.




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The most magical salt water swimming hole is in Samoa

Samoa's To Sua Ocean Trench is a natural salt water swimming hole that looks too beautiful to be real.




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New imaging technique sees inside lithium batteries

A new way to see inside batteries in real time as they go through charging cycles could help prevent battery fires and increase battery lifespans




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Let's take an imaginary trip to these gorgeous glamping destinations

Who says you have to rough it in the bush? These gorgeous spots prove otherwise.




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This modern-meets-rustic tiny home opens up like a magic trick

The Joshua Tree is a 231-SF timber-framed tiny house on wheels – and has the cutest interior.




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The life-changing magic of the short-stack coffee mug

This could be the key to getting people to carry reusable mugs each day.




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What if a chef with a logistics degree imagines a no waste restaurant?

Can the hospitality industry learn something when a French chef with a degree in logistics opens a no waste restaurant in London?




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Minotair "Magic Box" heats, cools, ventilates and dehumidifies

Can one device to it all? Should it? Has its time finally come?




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Compost poetry and the 'magic at work in the rotten stench'

Another great example of compost poetry that celebrates the magic in our muck.




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The hottest thing at CES is the FLIR thermal imaging iPhone case

Everyone in the green home improvement biz needs one of these, and they can make great cat videos on the side.





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Prismick Denim: Camille Seydoux para Roger Vivier - Magic Denim - Camille Seydoux for Roger Vivier

Magic Denim - Camille Seydoux for Roger Vivier




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Prismick Denim: Camille Seydoux para Roger Vivier - Magic Denim - Camille Seydoux for Roger Vivier

Magic Denim - Camille Seydoux for Roger Vivier




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Prismick Denim: Camille Seydoux para Roger Vivier - Magic Denim - Camille Seydoux for Roger Vivier

Magic Denim - Camille Seydoux for Roger Vivier




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Invest in a Child's Future: St. Baldrick's Foundation Calls for Increased Focus on Funding Pediatric Cancers - Just Imagine

St. Baldrick’s Foundation grants reach the best research far and wide, funding both individual doctors and groups of institutions focused on childhood cancers and their cures. Every cent benefits children everywhere.




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Op-ed: How the US can use the Covid-19 crisis to reimagine the energy world, save jobs and stabilize markets

The U.S. role as the world's leading oil and gas producer doesn't feel as empowering as it recently did, with oil prices heading into negative territory for the first time ever this week.