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Trump To Biden: ‘There’s Nothing Smart About You, Joe’

President Trump fired back at Democratic presidential nominee Joe Biden intelligence after the former Vice President took a jab at his rival response to the coronavirus pandemic, stating the president needs “to get a lot smarter” or more people are going to die. The first of many sparring moments between the two candidates during the […]

The post Trump To Biden: ‘There’s Nothing Smart About You, Joe’ appeared first on Hispolitica.




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There was always a pathway - Harwood-Bellis on first England call-up

Southampton defender Taylor Harwood-Bellis says "there was always a pathway" after being handed his first England senior call-up by interim manager Lee Carsley - the pair worked together with England Under-21s.






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velocityconf: @tsantero @garethr No, there's just a lot that goes into producing #velocityconf. Plus the chairs are getting ready for Santa Clara + NY! :)

velocityconf: @tsantero @garethr No, there's just a lot that goes into producing #velocityconf. Plus the chairs are getting ready for Santa Clara + NY! :)




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Is AI Photography Here to Stay? Ethics, Goals, and Questions.

I’ve been toying at the idea of recording a podcast about my thoughts on AI photography for a while now. For a while, I’ve put it off because I really don’t know if I want to add any more volume to a subject that’s already been talked about and debated for a while. But, it seems like AI photography, or even just AI photography tools aren’t going anywhere. So, here are my thoughts, questions, and my own personal ethics when […]

The post Is AI Photography Here to Stay? Ethics, Goals, and Questions. appeared first on Brendan van Son Photography.



  • Travel Photography Blog
  • AI generated photography

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Taylor Swift is in her WAG era — here's every time she's cheered on Travis Kelce and the Chiefs

Taylor Swift has made a habit of cheering for the Kansas City Chiefs since she began dating NFL star Travis Kelce.







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Here's how much more laptops, TVs, and smartphones could cost under Trump's proposed tariffs, consumer group says

Donald Trump's proposed tariffs would hit the consumer tech sector, raising prices on US consumers' favorite gadgets, an October report found.




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We got married at a luxury resort in Thailand. If I could go back, there are 5 things I'd do differently.

Looking back, Ellie Furuya says her wedding reception in Thailand was too adult-centric. If she could go back, she'd make it more kid-friendly.




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SoftBank is Nvidia's first Blackwell chips customer. Here's what they're going to be used for.

The collaboration comes amid skyrocketing demand for Nvidia chips, as companies scramble to secure supplies.




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Where Is the Music in Your Life?

Earlier this year, Barakah Beats by Maleeha Siddiqui made it to the top of my “to be read” stack. The cover had caught my eye and I’d heard good things about it from friend and author Madelyn Rosenberg, who has excellent taste in books. 




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Traveling to Asia? Here’s Why You Should Try Dragon Tiger

Key Takeaways Description Dragon Tiger’s Popularity Dragon Tiger is a popular game in Asian casinos due to its simplicity and speed. Cultural Experience Playing Dragon Tiger offers travelers a unique cultural experience and a chance to engage with locals. Online Play Dragon Tiger can be played online, allowing travelers to enjoy the game regardless of […]

The post Traveling to Asia? Here’s Why You Should Try Dragon Tiger first appeared on UPGRADE: TRAVEL BETTER.




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News24 Business | Work has begun on Google's cable linking SA to Aus. - here's why it's such good news

Construction has started on the undersea component of Google's Umoja fibre-optic cable.




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News24 | Do you have any complaints or feedback about News24's content? Here's how to get in touch

Any complaints, queries or suggestions about content on News24 may be sent to our public editor George Claassen.




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EIT Elsewhere | How to Experience Japan in San Francisco

Get a taste of Japan — without leaving San Francisco! I’m excited to see my latest post is up on Thrillist. Some of my favorite Japan-inspired things to do and ways to experience Japanese history, art, and culture here in the Bay Area. Check it out: How to Experience Japan in San Francisco

The article EIT Elsewhere | How to Experience Japan in San Francisco originated at EverInTransit.com




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EIT Elsewhere | “Time Out: San José” in Delta Sky Magazine

I was excited to finally get the word that an article I wrote sharing my love for my hometown – San Jose, California – is out in Delta Sky Magazine this month! Time Out: San José – (Image / PDF) (Thanks to Deb L. and Ginni R. for sending copies for me!)    

The article EIT Elsewhere | “Time Out: San José” in Delta Sky Magazine originated at EverInTransit.com




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EIT Elsewhere | Sharing the World’s Weirdest Plants on Fodor’s Travel

The quirky folks at Fodor’s let me share some of the world’s weirdest plants, fungi, and microorganisms to inspire your #plantnerd bucket list (I’ve seen 5 out of 10 of these weirdos out in the wild!) 10 Plants From Around the World That Will Upset and Delight | Fodor’s Travel

The article EIT Elsewhere | Sharing the World’s Weirdest Plants on Fodor’s Travel originated at EverInTransit.com




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Ads, Ads Everywhere

The advertising world is uncomplicated at its core, and utterly bewildering when seen from the outside. The easy bit stems from a simple axiom: Wherever you can find the attention of potential customers, you pay to get your message in front of them. That’s the essence of advertising: paying for attention. It gets complicated by … Continue reading "Ads, Ads Everywhere"






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Sport | Here are the 3 candidates in line to replace Bill Beaumont as World Rugby chairman

The race to succeed Bill Beaumont as chairman of World Rugby comes to a conclusion in a vote in Dublin at the governing body's headquarters on Thursday.




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Beijing briefing: is the Belt and Road going nowhere?

Beijing briefing: is the Belt and Road going nowhere? The World Today mhiggins.drupal 29 July 2022

Scaling back infrastructure plans and investment in the Global South could cause China problems, says Yu Jie.

Over the past two decades, China specialists around the world have tried to analyze Beijing’s approach to developing countries in the Global South, including Africa, Latin America, parts of Asia and the Pacific islands.
 
China’s relationships with nations in these regions vary considerably. In some, ideology or geography are the biggest influencing factors; for others, economic and commercial gains matter most. However, many of Beijing’s recent engagements have attracted more criticism than praise. A domestic economic downturn means that Beijing has tightened its belt, spending less on overseas development.

When President Xi Jinping came to power, he was keen to highlight how China’s power could shape and dictate the global agenda across multilateral platforms. His vision was for China to project discursive power and become an agenda-setter rather than a rule-follower. The Global South is the route to fulfilling his proposal.

To this end, China’s Belt and Road Initiative (BRI) and the latest Global Development Initiative are the means to Beijing’s ends. The former, launched in 2013, focuses on building physical infrastructure linking Global South countries; the latter aims to allow development through grants and capacity-building in line with the UN’s Sustainable Development Goals.

China’s engagements with Africa and Latin America seem characterized by the rapid extension of Chinese finance to resource-rich African states, particularly oil producers, since the early 2000s. From 2003, for example, oil-backed infrastructure loans were made to the Angolan government for reconstruction after decades of civil conflict. By 2016, they totalled some $15 billion. 

However, Beijing’s appetite for offering cheap loans in exchange for natural resources has shrunk. It faces a dilemma between protecting the value of its investments while also defending its strategic interests and maintaining its self-image as a partner, not a predator, of Africa.

Some of China’s Global South investments include serious climate and financial risks


Beijing has historically preferred bilateral relationships for its development finance and investments over multilateral ones. This allows China control over the terms and conditions, while demonstrating its unwillingness to accept without question rules and frameworks devised years ago by western countries.

China has already realized that some elements of its engagements with the Global South are no longer the flavour of the day, partly because some of its programmes include serious climate and financial risks without proper third-party due diligence in place. 

Growth through gigantic infrastructure investments of the sort that drove China’s own economic miracle is not a panacea applicable everywhere. Nor is relentlessly seeking endorsements from its neighbours and other countries from afar.

China wants to be a ‘brother’ to the Global South

Ideologically, China wants to be seen and respected as a leader of the Global South. Since its founding in 1949, the People’s Republic has maintained a ‘brotherly’ relationship with developing countries, notably in the UN context, where it remains a member of the G77 group of developing nations. 

The West has responded to China’s development agenda with its own infrastructure programmes, such as Washington’s Build Back Better World and the European Union’s Global Gateway. 

Great power rivalry should not be ignored, but it shouldn’t blind world powers to the need for collaboration in tackling global poverty and sustainable development. Nor should Beijing’s efforts to adjust its diplomatic and aid programmes to become a likeable partner of choice in search of a better economic future, be disregarded.

Developing countries recovering from the pandemic crave meaningful assistance rather than diplomatic rhetoric


Since launching BRI, China has poured hundreds of billions of dollars into building infrastructure in the Global South. And many developing countries hope that advanced economies and China can continue to act to alleviate poverty. But the brakes have been applied to Beijing’s spree as a result of China’s domestic economic slowdown. It has no wish to continue spending its foreign reserves.

To go forward, China must remain open to what others want – or fear – from Beijing’s development initiatives and infrastructure investments. Many developing countries, facing insurmountable costs and damage exacerbated by the Covid pandemic, crave meaningful assistance rather than diplomatic rhetoric. 

The ultimate test of Beijing’s economic statecraft is whether it can engage with the Global South beyond relationships built on financial resources and political capital. It must also become more self-aware of how its words and deeds are received – and then act accordingly. Showering dollars and renminbi is not always guaranteed to win hearts and minds. In this respect, Beijing has more bridges to build.




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Where is Georgia now heading?

Where is Georgia now heading? 28 October 2024 — 2:30PM TO 3:30PM Anonymous (not verified) Online

After pivotal elections, experts discuss what the declared results and reactions mean for Georgia.

Following a year marked by protests over the controversial ‘Foreign Agents’ bill and broader concerns over democratic backsliding, Georgia faces pivotal parliamentary elections on 26 October. Regardless of the outcome, the results are expected to be contested as well as consequential.

In the wake of the election, experts will discuss the immediate and longer-term consequences.

Key questions:

  • These were the first fully-proportional elections in Georgia. How much difference did it make
  • What will the election results, as we currently understand them, mean for Georgia’s path to European integration? How will they affect Georgia’s foreign policy priorities?
  • What role should the EU play? Is Georgia a test case for the EU as an aspiring geopolitical power?
  • Is the oligarchic grip likely to be tightened or loosened? What role for undue influence now?
  • Has Russia done all it can for now in Georgia? Or is there more it can do?




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Is there an end to the Central Bank of Libya crisis?

Is there an end to the Central Bank of Libya crisis? 14 November 2024 — 3:00PM TO 4:00PM Anonymous (not verified) Online

Experts discuss implications for Libya’s economic governance.

In August this year, the Libyan Presidency Council moved to replace Libya’s longtime central bank governor, Sadiq al-Kabir. Kabir had been in position since September 2011, and in the period following the administrative division of Libya, he rose to prominence as one of the most influential figures on the Libyan political scene.

In the absence of a functioning relationship between executive and legislature, the Central Bank of Libya (CBL) took on many of the competencies of the ministry of finance and became an arbiter of which payments were made and when. In October, following UN-led and parallel back-channel negotiations, a new governor was selected and the CBL board of directors reconstituted.

In this webinar, experts will examine:

  • What challenges will the new CBL leadership face?
  • Can we expect significant changes for Libya’s economic governance?
  • What are the implications for the balance of power between Libya’s rival power centres?

This webinar is organized in partnership with the North Africa Initiative (NAI) at the Foreign Policy Institute (FPI) of the Johns Hopkins Paul H. Nitze School of Advanced International Studies.




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The election shows that Trumpism is here to stay

The election shows that Trumpism is here to stay Expert comment rgold.drupal

World leaders must engage with the new president’s view of America’s priorities and accept that the US has changed.

In a landslide victory, former President Donald Trump has been elected to be the 47th president of the United States. This election was laden with the expectation that a dead heat would lead to delay, legal challenge, extremism, and possible violence. It has instead passed quickly, decisively, and peacefully.  More than 67 million Americans who voted for Kamala Harris have demonstrated restraint and accepted the result. By this measure, democracy in the United States has prevailed. 

Across Asia and Latin America, leaders have been preparing for a second Trump term. They are pragmatic and resolute in their belief that they can work with the once and 

also future US president. In Europe, leaders have been less certain. They have oscillated between two approaches. The first, of ‘Trump-proofing’ – an instinct if not a strategy  that builds on the quest for strategic autonomy, championed by the President of France, Emmanuel Macron. The second, a calculation by some, not least the Prime Minister of Hungary, Viktor Orbán, that they can present themselves as top-tier partners to the US in a new approach to transatlantic security. 

Trumpism is not an aberration

For eight years, world leaders and foreign policy experts have been debating whether President Trump was the cause of a radical change in the US, or merely a symptom of powerful trends in the American body politic: rising inequality, a loss of manufacturing jobs –a demographic defined by white male non-college-educated voters who feel left behind a deeply engrained anti-elitism, and a society in desperate need of a new kind of political leadership. 

In Trump’s first term, many leaders acted on the basis that he was an aberration, not a symptom. That meant that foreign leaders assumed his policies might disappear with his future electoral defeat, and short-term strategies designed to ‘work around’ Trump were a good bet. 

In Trump’s first term… foreign leaders assumed his policies might disappear with his future electoral defeat and short-term strategies designed to ‘work around’ Trump were a good bet. 

The next US president would return to a familiar agenda (free trade, market access, strong alliances, a commitment to climate action, extended nuclear deterrence and deepening transatlantic ties) and so America’s friends could wait this out. Indeed, civil servants frequently pointed to the strength of bilateral working relations, despite an often disruptive high-level political style. 

President Joe Biden’s commitment to multilateralism, the transatlantic partnership and Ukraine seemed to confirm the view that Trump’s policies were an anomaly and that America had reverted to normal. Gradually, though, Biden’s policies began to chip away at this assumption. He continued Trump’s tariffs, executed a reckless and unilateral exit from Afghanistan with little consultation, and pushed through a transformative but also protectionist climate investment bill in the Inflation Reduction Act. 

Fast forward to this election result. A stunning – many would say shocking – victory must put to rest any assumption that Trump is an aberration. It may have started that way, but today it appears there is no going back. The world is now confronted with a president that has had time to sharpen and hone his instincts, to prioritise loyalty in appointing a close circle of advisers, and to lay the foundation for his Vice President JD Vance to carry forward his vision once his second term ends. 

First moves

What will Trump do first? Several things are in store: A sharp immigration policy including deportations is likely to be top of Team Trump’s agenda in its first 100 days. This may prove to be inflationary – deporting millions of undocumented migrants would shrink the labour supply – but that is unlikely to restrain Trump in the short-term. A 2.0 version of his so-calledMuslim ban could also feature. And immigrants will continue to take a hit rhetorically, labelled as outsiders and as criminals. 

The punishment for noncompliance could also be harsh. If Mexico does not demonstrate its willingness to cooperate, retaliation might take the form of tariffs, or a tough review or even renegotiation of the United States-Mexico-Canada Agreement (USMCA) in 2026. 

The return to tariffs as the front line of trade policy  is virtually certain. Trump has telegraphed this for months. China can expect far harsher tariffs. What is more difficult to discern is whether these will be a bargaining tool with conditions attached, or a ratcheting up towards a new level of protectionism. 

For Asia, there is grave uncertainty. No one can be sure what Trump’s strategy will be towards Taiwan. Investment in the latticework of mutually-reinforcing partnerships across the region may take a back seat. But how Trump will manage North Korea’s nuclear threat is unclear. So too is the question of whether under his watch, US nuclear deterrence will continue to provide enough assurance to prevent South Korea and Japan from developing their own nuclear weapons. 

It will be the existential and enduring shift in America’s commitment to Europe and its security that will hit hardest.

Still, it is Europe that is likely to face the sharpest edge of Trump’s second term. Tariffs in search of reciprocal market access and reducing America’s trade deficit with Europe are more likely than not. But it will be the existential and enduring shift in America’s commitment to Europe and its security that will hit hardest. 






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Loss and damage: Where are we now and what happens next?

Loss and damage: Where are we now and what happens next? 25 January 2022 — 1:00PM TO 2:00PM Anonymous (not verified) 17 January 2022 Online

This event discusses the progress of the loss and damage agenda within climate negotiations. 

Loss and damage refers to harms and destruction caused by climate change impacts that cannot be avoided through mitigation or adaptation.

While it has gained increasing recognition in international climate change negotiations, turning the concept of loss and damage into tangible action for climate-vulnerable countries has been contentious.

Loss and damage is interwoven with issues of fairness and equity. The issue is highly disputed due to its connection with the historical responsibility of developed countries in causing climate change, as well as associated calls for compensation from developing countries.

At COP26, Scotland became the first government to pledge funds for loss and damage for countries in the Global South. However, most climate-vulnerable countries left disappointed by the failure of the Glasgow Climate Pact to secure the establishment of a dedicated loss and damage financing facility.

Developing countries have made it clear that they will continue to push for a new financing facility in the Glasgow Dialogue, a set of international discussions on loss and damage kicking off in June.

The Environment and Society Discussion Series is hosting two events on loss and damage ahead of that date. This first event outlines the key debates and discuss what progress has been made on advancing the loss and damage agenda within climate negotiations to date.

The second event focuses on solutions and possible ways forward, looking ahead to the COP27 negotiations in Egypt later in 2022, where loss and damage is expected to be a high-profile agenda item.




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Reply to Introduce Yourself: Click Here!

outrageous toes posted a reply:

Hi everyone I am Emily Naomi wanna give a big thanks to this wonderful psychic for bringing my husband back to me.. I never really believed in magic spells or anything spiritual but a trusted friend opened my eyes to the truth about life. My marriage was heading to divorce a few months ago. I was so confused and devastated with no clue or help on how to prevent it, till I was introduced to this psychic Priest Ray that did a love spell and broke every spiritual distraction from my marriage. A day later my husband started showing me love and care even better than it used to be, he’s ready to talk things through and find ways for us to stay happy. It’s such a miracle that my marriage can be saved so quickly without stress. You can also contact him for help by email psychicspellshrine@gmail.com or you can also visit his website: psychicspellshrine.wixsite.com/my-site




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Reply to Introduce Yourself: Click Here!

Drummerdelight posted a reply:

emilynaomi126:

Does your husband have a camera?




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Reply to Introduce Yourself: Click Here!

Ian Razey. posted a reply:

Drummerdelight:
emilynaomi126 is a SPAM account.




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Reply to Introduce Yourself: Click Here!

rageforst posted a reply:

Hi I'm Rage and I'm a Designer from Mexico, I love colors and I hope all of you doing well




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Reply to Introduce Yourself: Click Here!

rslbturner posted a reply:

Hello, I have very recently joined Flickr, as everybody else looking to share my photographs. I live in the UK and consider myself mostly a pleasure photographer, I do love it! I hope you like my pictures.
Thank you




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Reply to Introduce Yourself: Click Here!

Maskimov1935 posted a reply:

Hello everyone. I'm Igor. I've joined Flickr today. I live in Russia and taking pictures mostly in "dark fantasy" style, as one of my friend calls it. Hope you'll check my photos. Have a good day!




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Reply to Introduce Yourself: Click Here!

clarasouzin posted a reply:

En besoin d'aide financière veuillez nous contacter par E-mail: clarasouzin@gmail.com

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Reply to Introduce Yourself: Click Here!

clarasouzin posted a reply:

En besoin d'aide financière veuillez nous contacter par E-mail: clarasouzin@gmail.com

E-mail: clarasouzin@gmail.com

E-mail: clarasouzin@gmail.com.




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Reply to Introduce Yourself: Click Here!

clarasouzin posted a reply:

In need of financial assistance please contact us by E-mail: clarasouzin@gmail.com

E-mail: clarasouzin@gmail.com

E-mail: clarasouzin@gmail.com...




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Look Up! The Northern Lights May Be Visible in the U.S. Tonight—Here's Where to See Them




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Here are 5 signs you’re financially healthy in America even if you don't feel like it — how many do you show?




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I’m Retired and Regret Claiming Social Security at 70 — Here’s Why




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Emerging Economies: Where is the Debt Problem?

16 July 2020

David Lubin

Associate Fellow, Global Economy and Finance Programme
Just two months ago it appeared self-evident that emerging economies faced a devastating inability to service their foreign debt, mostly denominated in dollars. That has turned out to be wrong, for now at least.

2020-07-16-India-Banking

Yes Bank branch of Malcha Marg, in New Delhi, India. Photo by Vipin Kumar/Hindustan Times via Getty Images.

Back in April, nervousness about external debts reached its peak when highly-respected economists Carmen Reinhart and Kenneth Rogoff suggested emerging economies with less than a AAA credit rating be offered a moratorium on all their external debt service payments.

Although such a proposal might make sense if emerging economies were actually facing any serious shortage of access to foreign exchange, it is a difficult case to make. What we should worry about is not the external debt of emerging economies, but rather the large increases in government debts denominated in their own currencies.

In the first six months of 2020, borrowers from emerging economies issued more than $400 billion of Eurobonds to international investors, up by one-fifth over the same period in 2019. Most of these bonds were sold by borrowers with relatively high credit ratings, but many of the poorest countries do not fear for their access to international capital markets - largely because the US Federal Reserve increased global supply of dollars to a point where their availability is beyond question.

Much of the panic about emerging economies’ external debt comes from ‘sticker shock’ - the bald fact that developing countries’ external debt rose by $4.1 trillion in the decade to 2018 generates much hand-wringing.

But the increase in gross external debt of developing countries looks a lot scarier than the net increase in debt, which sets off a country’s foreign assets - mostly foreign exchange reserves - against its liabilities. And it is net that counts.

At the end of 2018, foreign exchange reserves covered 70% of the external debt of low and middle income developing countries - much lower than a decade ago, when that coverage was above 100%. But in the 1980s and 1990s – two decades of financial instability largely because of excessive foreign debt – the coverage was 15%. By that measure, we are far from crisis territory.

Complacency about the external debt burden of developing countries is quite wrong. But, if complacency is misplaced, so is panic.

The debt growing most worryingly is the domestic debt of governments. There are large, systemically important emerging economies who will suffer eye-watering increases in public debt this year thanks to a combination of collapsing GDP and the fiscal effort needed to save lives.

In Brazil, public debt is rising from 75% GDP last year to a level that could top 100% in 2020. South African public debt is rising from just over 60% last year to something close to 80% GDP. These are truly unprecedented levels of debt.

So why worry about a government’s domestic debt? These are debts which are denominated in these countries’ own currency. So surely the central bank can just print the currency needed to repay their obligations if more conventional solutions – such as tax increases – will not work.

But it is one thing for the US Federal Reserve to increase supply of dollars on a massive scale, since the world is hungry for them - it is quite another thing if emerging economies do the same with their currencies which almost entirely lack the many attractions of the dollar. That remains the currency of the pre-eminent global superpower whose capital markets offer legal certainty and depth of liquidity. And other highly developed economies have a similar privilege.

And yet printing money – in effect, asking the central bank to finance budget deficits – does seem as though it could become a more attractive option for many emerging countries. Importantly, international fund managers have lost interest in buying bonds issued by emerging economy governments in their local currencies. Just a few years ago, foreign investors owned more than 40% of South Africa’s public debt. That has fallen sharply to 30% and is unlikely to rise.

Monetising budget deficits was once anathema, since it was routinely associated with uncontrolled rates of inflation - bad news not only for firms trying to decide whether to invest but also for the poor, who suffer disproportionately when inflation accelerates.

Right now there are emerging economies – such as Indonesia – whose central banks lend directly to the government, and the sky has not fallen in. The rupiah has been remarkably stable this year. However, there are other examples – Argentina, Turkey – where central bank financing of government deficits has been associated with uncomfortably high inflation rates.

This needs careful watching. The biggest risk is the accumulation of public debt threatening longer-term growth. If firms stop investing because they worry about the risks to the value of their currency as domestic public debt explodes, emerging economies will have a tough time growing their way out of these debts.

It could be this, rather than the external debt of emerging economies, that is the biggest risk to the post-coronavirus economic environment in the developing world.




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LDL apheresis as an alternate method for plasma LPS purification in healthy volunteers and dyslipidemic and septic patients

Auguste Dargent
Dec 1, 2020; 61:1776-1783
Research Articles




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LDL apheresis as an alternate method for plasma LPS purification in healthy volunteers and dyslipidemic and septic patients [Research Articles]

Lipopolysaccharide (LPS) is a key player for innate immunity activation. It is therefore a prime target for sepsis treatment, as antibiotics are not sufficient to improve outcome during septic shock. An extracorporeal removal method by polymyxin (PMX) B direct hemoperfusion (PMX-DHP) is used in Japan, but recent trials failed to show a significant lowering of circulating LPS levels after PMX-DHP therapy. PMX-DHP has a direct effect on LPS molecules. However, LPS is not present in a free form in the circulation, as it is mainly carried by lipoproteins, including LDLs. Lipoproteins are critical for physiological LPS clearance, as LPSs are carried by LDLs to the liver for elimination. We hypothesized that LDL apheresis could be an alternate method for LPS removal. First, we demonstrated in vitro that LDL apheresis microbeads are almost as efficient as PMX beads to reduce LPS concentration in LPS-spiked human plasma, whereas it is not active in PBS. We found that PMX was also adsorbing lipoproteins, although less specifically. Then, we found that endogenous LPS of patients treated by LDL apheresis for familial hypercholesterolemia is also removed during their LDL apheresis sessions, with both electrostatic-based devices and filtration devices. Finally, LPS circulating in the plasma of septic shock and severe sepsis patients with gram-negative bacteremia was also removed in vitro by LDL adsorption. Overall, these results underline the importance of lipoproteins for LPS clearance, making them a prime target to study and treat endotoxemia-related conditions.




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To be there when the picture is being painted [Protein Structure and Folding]

There is nothing quite like the excitement of discovery in science—of finding something no one else knew and seeing a story unfold. One has to be part of an emerging picture to feel the elation. These moments in a lifetime are few and far between, but they fuel enthusiasm and keep one going. They are embedded in struggles and joys of everyday life, years of establishing what Louis Pasteur called “the prepared mind,” working with mentors, trainees, and colleagues, failures and successes. This article recalls 1) how I got to be a biochemist; 2) my contributions as an educator and researcher, especially regarding meprin metalloproteases; and 3) my participation in communities of science. Perhaps my reflections will help an aspiring scientist see how fulfilling a career in science can be.




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Here are the Phillies' Top 30 Prospects

The Phillies list isn't quite as strong as it once was because of the Realmuto deal, but there's still some very good talent at the top and some exciting players on the rise.




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Here's your guide to Angels Spring Training

It's almost time for Spring Training yet again, as Angels pitchers and catchers report to their Spring Training complex in Tempe, Ariz. on Feb. 12.




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Where are Trout, Ohtani on Top 100 Right Now?

The 2019 MLB season feels so close now. Spring Training has begun. Players are taking the field. So it's time to rank the best of the best.