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India-European Free Trade Association deal | $100-billion investment target was breakthrough moment: Swiss official

EFTA negotiator cautions that actual investment can only come from European private sector, not guaranteed by governments, and hopes FTA will be ratified by 2024-end




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‘There’s no pure European culture,’ says Josephine Quinn, author of How the World Made the West

In an ambitious narrative on history, Josephine Quinn argues that the West is a product of links with a much larger network of societies




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Characterisation and quantification of phenolic, anthocyanidin and terpene species in plant foods and plant food-based complementary products with antioxidant and neuroprotective properties

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02942A, Paper
Naomi May, Jiahua Shi, Helen Clunas, Julianna Lys de Sousa Alves Neri, Celine Kelso, Jody Morgan, Yinghua Yu, Karen Charlton, Katrina Weston-Green
Phytochemicals, including phenolic compounds and terpenes, are of interest for the treatment and prevention of conditions with oxidative stress, inflammatory and neurodegenerative pathologies.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The co-fermentation of whole-grain black barley and quinoa improves murine cognitive impairment induced by a high-fat diet via altering gut microbial ecology and suppressing neuroinflammation

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02704C, Paper
Fenfen Wei, Huibin Jiang, Chuang Zhu, Lingyue Zhong, Zihan Lin, Yan Wu, Lihua Song
A high-fat diet (HFD) is associated with various adverse health outcomes, including cognitive impairment and an elevated risk of neurodegenerative conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02321H, Paper
Fangyang Chen, Botao Wang, Xin Sun, Yage Wang, Ruiyan Wang, Kaikai Li
EGT intervention significantly improved D-galactose induced oxidative stress, neuroinflammation, and mitochondrial function, resulting in the alleviation of memory injury.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A mixed report card for the India-Middle East-Europe Corridor

Implementation on the northern part of the corridor, which is mostly in West Asia, is going to move slowly until the conflict subsides, while progress is faster on the eastern leg connecting the UAE and Indian ports




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The Science Quiz: AI in science, from neurons to nodes




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Neuroinflammatory response on a newly combinatorial cell–cell interaction chip

Biomater. Sci., 2024, 12,2096-2107
DOI: 10.1039/D4BM00125G, Paper
Yimeng Zhao, Xuefei Lv, Yu Chen, Chen Zhang, Di Zhou, Yulin Deng
Neuroinflammatory response on a novel combinatorial cell–cell interaction chip.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The underbelly of Europe’s digital euro

The ECB has presented this central bank digital currency, the digital euro, as a new, better alternative for citizens: free, anonymous, and reliable. But this does not convey its actual purpose




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Facebook and Instagram users in Europe can opt for less personalised ads

Facebook and Instagram users in Europe will get the option to see less personalised ads if they don’t want to pay for an ad-free subscription




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Eurofins acquires Covance’s analytical services unit for foods




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Changing of the guard at European chemical firms

BASF, Borealis, Covestro, and Solvay bring in new CEOs as they report first-quarter results




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Don’t freak out, Europe, but you might be in the middle of a mustelid uprising




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Meet the Janelia chemist crafting glowing molecular tools for neuroscientists

Luke Lavis’s lab teaches old dyes new tricks at the HHMI campus




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Europe to ban some single-use plastics

New obligations for industry as the region and other areas target the causes of marine litter




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BridgeBio launches CoA Therapeutics to treat a rare neurodegenerative disease

The startup is developing allosteric activators to increase levels of the vital metabolic molecule coenzyme A in pantothenate kinase-associated neurodegeneration




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Psychedelics forge connections between neurons

Study in rats and fruit flies suggests that these drugs could inspire better, ketamine-like antidepressants




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Alexion partners with Complement Pharma on neurodegenerative therapy




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Europe proposes big new research program




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BridgeBio licenses compounds from NeuroVive and launches Fortify Therapeutics




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Europe sweats over CO<sub>2</sub> shortage

Production at Coca-Cola is interrupted as hot weather drives surge in demand




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European firms push recycling

Chemical makers launch initiatives for recycling multilayer packaging and polystyrene




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Ineos to build first European cracker in 20 years




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How Europe’s chemical industry learned to love REACH

Supporting the chemical management law is good for competitiveness, Europe’s chemical industry now says




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Europe’s science budget set to grow despite Brexit

Horizon Europe raises stakes in global technology race




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Verge Genomics raises $32 million for machine learning-backed neuroscience drug discovery




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Making molecular movies at Europe’s powerful X-ray laser facility

Although some kinks are still being worked out, the European XFEL is now giving researchers an unprecedented view of the inner workings of molecules and materials




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European recycling initiatives press ahead




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Europa League: Israel deploys rescue planes after football fans attacked in Amsterdam




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Delhi’s dance with Europe: Capitalising on new opportunities




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PIX: Man United log first Europa League win

The win leaves United in 15th place in the Europa League standings on six points from four games.




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Covid-19: Europe begins easing lockdown measures

Tentatively, parts of Europe are emerging from lockdown, with France and Belgium joining the list of countries easing measures on Monday, amid fears of a second coronavirus wave.




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How Europe splintered over contact tracing apps

Apple and Google’s tech standard is gaining momentum against go-it-alone systems




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Eastern Europea sense opportunity in German court ruling

Experts warn EU’s legal bedrock shaken by judgment on ECB’s bond-buying programme




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Writing sounds in Carolingian Europe: the invention of musical notation / Susan Rankin, University of Cambridge

Lewis Library - ML174.R26 2018





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Coronavirus: How lockdown is being lifted across Europe

As the UK looks to lift restrictions, how do other European countries plan to re-open after lockdown?




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Assessing the danger of war: parallels and differences between Europe in 1914 and East Asia in 2014

12 November 2014 , Volume 90, Number 6

Joachim Krause




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An enzyme-based protocol for cell-free synthesis of nature-identical capsular oligosaccharides from Actinobacillus pleuropneumoniae serotype 1 [Enzymology]

Actinobacillus pleuropneumoniae (App) is the etiological agent of acute porcine pneumonia and responsible for severe economic losses worldwide. The capsule polymer of App serotype 1 (App1) consists of [4)-GlcNAc-β(1,6)-Gal-α-1-(PO4-] repeating units that are O-acetylated at O-6 of the GlcNAc. It is a major virulence factor and was used in previous studies in the successful generation of an experimental glycoconjugate vaccine. However, the application of glycoconjugate vaccines in the animal health sector is limited, presumably because of the high costs associated with harvesting the polymer from pathogen culture. Consequently, here we exploited the capsule polymerase Cps1B of App1 as an in vitro synthesis tool and an alternative for capsule polymer provision. Cps1B consists of two catalytic domains, as well as a domain rich in tetratricopeptide repeats (TPRs). We compared the elongation mechanism of Cps1B with that of a ΔTPR truncation (Cps1B-ΔTPR). Interestingly, the product profiles displayed by Cps1B suggested processive elongation of the nascent polymer, whereas Cps1B-ΔTPR appeared to work in a more distributive manner. The dispersity of the synthesized products could be reduced by generating single-action transferases and immobilizing them on individual columns, separating the two catalytic activities. Furthermore, we identified the O-acetyltransferase Cps1D of App1 and used it to modify the polymers produced by Cps1B. Two-dimensional NMR analyses of the products revealed O-acetylation levels identical to those of polymer harvested from App1 culture supernatants. In conclusion, we have established a protocol for the pathogen-free in vitro synthesis of tailored, nature-identical App1 capsule polymers.




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Call for a review of services for people with neurological disorders




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A real opportunity to improve neurology services in England




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Australian neuroscientist given two year suspended sentence for falsifying Parkinson&#039;s research




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The Role of Civil Society in EU Migration Policy: Perspectives on the European Union&#039;s Engagement in its Neighborhood

Civil society provides a crucial link between governments and the communities they represent—infusing policy processes with grassroots knowledge to which governments may not otherwise have access. Looking at the European Union’s efforts to engage with civil society in its “neighborhood,” this report examines the benefits, challenges, and mechanisms to building dialogue and cooperation on migration and development.




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Immigration and Competitiveness: Responding to Global Challenges in the European Union and United States

Showcasing joint research by MPI and the European University Institute and funded by the European Commission, this event featured discussion on some of the most promising reform proposals on both sides of the Atlantic. Speakers discuss the project’s comparative research, which draws on MPI’s longstanding experience advising European and North American governments on immigration.




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Scientists, Managers, and Tourists: The Changing Shape of European Mobility to the United States

European dominance in U.S. immigration flows has decreased significantly since World War II, a result of economic, demographic, and policy trends on both sides of the Atlantic. Today, migration from European Union Member States to the United States, while small, is characterized by a substantial numbers of European scientists, professionals, and businesspeople.




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Stem cells from schizophrenics produce fewer neurons

New research shows that a genetic mutation associated with schizophrenia alters the process of cellular differentiation, disturbing the balance of neurons and glia in the brain

Stem cells obtained from patients with schizophrenia carry a genetic mutation that alters the ratio of the different type of nerve cells they produce, according to a new study by researchers in Japan. The findings, published today in the journal Translational Psychiatry, suggest that abnormal neural differentiation may contribute to the disease, such that fewer neurons and more non-neuronal cells are generated during the earliest stages of brain development.

Schizophrenia is a debilitating mental illness that affects about 1 in 100 people. It is known to be highly heritable, but is genetically complex: so far, researchers have identified over 100 rare genetic variations and dozens of mutations associated with increased risk of developing the disease.

Related: Brain’s immune cells hyperactive in schizophrenia

Related: Turning urine into brain cells | Mo Costandi

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Moving Up or Standing Still? Access to Middle-Skilled Work for Newly Arrived Migrants in the European Union

The global economic crisis and changing migration patterns in Europe bring up questions about how well immigrants are able to find employment and progress into better jobs over time. This overview report caps a series of six country case studies evaluating the employment outcomes for foreign-born workers during their first decade in the Czech Republic, France, Germany, Spain, Sweden, and the United Kingdom.




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Better Work for Immigrants: Tackling Joblessness and Stunted Progression in the European Union

This day-long conference in Brussels, co-sponsored by the International Labour Office and the European Commision’s Directorate-General for Employment, Social Affairs, and Inclusion, focuses on the dynamics by which migrants get stuck in low-skilled work, and the role of training and employment services in helping them progress in their occupations.




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Aiming Higher: Policies to Get Immigrants into Middle-Skilled Work in Europe

This report is the final one in an MPI-International Labour Office series that examines the employment prospects of migrants in the EU (focusing on the case-study countries of the Czech Republic, France, Germany, Spain, Sweden, and the United Kingdom), as well as the effectiveness of integration and workforce development policies in helping these workers overcome barriers and ascend out of low-skilled work.




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Better Work for Immigrants: Tackling Joblessness and Stunted Progression in the European Union

A day-long conference in Brussels, co-sponsored by the International Labour Office and the European Commision’s Directorate-General for Employment, Social Affairs, and Inclusion, where panelists discuss the dynamics by which migrants get stuck in low-skilled work, and the role of training and employment services in helping them progress in their occupations. The conference concludes a project and series of reports prepared on the Labor Market Integration of New Arrivals in Europe