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Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity

RSC Med. Chem., 2024, 15,3711-3727
DOI: 10.1039/D4MD00584H, Research Article
Sara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-Dias
A series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors

RSC Adv., 2024, 14,36352-36369
DOI: 10.1039/D4RA07074G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. Covey
Photoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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SF: we have been repeatedly impressed by how resourceful GLS is in the European market

GLS and SF, China's largest integrated logistics service provider, are excited to announce a bilateral network partnership.




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Ochama Expands in Europe

Ochama, the European omni-channel retail brand of JD.com, Inc. (also known as JINGDONG), has announced the launch of a new automated warehouse in Poland.








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10 best winter hiking holidays in Europe for snowshoeing, winter sun and mountain climbs

From trekking the foothills of Mont Blanc to snowshoeing in Oulanka National Park, here are some of the best European trails to tread this winter




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Call for a review of services for people with neurological disorders




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A real opportunity to improve neurology services in England




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Australian neuroscientist given two year suspended sentence for falsifying Parkinson's research




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Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons

A unique population of ventral tegmental area (VTA) neurons co-transmits glutamate and GABA. However, the circuit inputs to VTA VGluT2+VGaT+ neurons are unknown, limiting our understanding of their functional capabilities. By coupling monosynaptic rabies tracing with intersectional genetic targeting in male and female mice, we found that VTA VGluT2+VGaT+ neurons received diverse brainwide inputs. The largest numbers of monosynaptic inputs to VTA VGluT2+VGaT+ neurons were from superior colliculus (SC), lateral hypothalamus (LH), midbrain reticular nucleus, and periaqueductal gray, whereas the densest inputs relative to brain region volume were from the dorsal raphe nucleus, lateral habenula, and VTA. Based on these and prior data, we hypothesized that LH and SC inputs were from glutamatergic neurons. Optical activation of glutamatergic LH neurons activated VTA VGluT2+VGaT+ neurons regardless of stimulation frequency and resulted in flee-like ambulatory behavior. In contrast, optical activation of glutamatergic SC neurons activated VTA VGluT2+VGaT+ neurons for a brief period of time at high frequency and resulted in head rotation and arrested ambulatory behavior (freezing). Stimulation of glutamatergic LH neurons, but not glutamatergic SC neurons, was associated with VTA VGluT2+VGaT+ footshock-induced activity and inhibition of LH glutamatergic neurons disrupted VTA VGluT2+VGaT+ tailshock-induced activity. We interpret these results such that inputs to VTA VGluT2+VGaT+ neurons may integrate diverse signals related to the detection and processing of motivationally salient outcomes.




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Monocyte Invasion into the Retina Restricts the Regeneration of Neurons from Müller Glia

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.




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Deciphering Peripheral Taste Neuron Diversity: Using Genetic Identity to Bridge Taste Bud Innervation Patterns and Functional Responses

Peripheral taste neurons exhibit functional, genetic, and morphological diversity, yet understanding how or if these attributes combine into taste neuron types remains unclear. In this study, we used male and female mice to relate taste bud innervation patterns to the function of a subset of proenkephalin-expressing (Penk+) taste neurons. We found that taste arbors (the portion of the axon within the taste bud) stemming from Penk+ neurons displayed diverse branching patterns and lacked stereotypical endings. The range in complexity observed for individual taste arbors from Penk+ neurons mirrored the entire population, suggesting that taste arbor morphologies are not primarily regulated by the neuron type. Notably, the distinguishing feature of arbors from Penk+ neurons was their propensity to come within 110 nm (in apposition with) different types of taste-transducing cells within the taste bud. This finding is contrary to the expectation of genetically defined taste neuron types that functionally represent a single stimulus. Consistently, further investigation of Penk+ neuron function revealed that they are more likely to respond to innately aversive stimuli—sour, bitter, and high salt concentrations—as compared with the full taste population. Penk+ neurons are less likely to respond to nonaversive stimuli—sucrose, umami, and low salt—compared with the full population. Our data support the presence of a genetically defined neuron type in the geniculate ganglion that is responsive to innately aversive stimuli. This implies that genetic expression might categorize peripheral taste neurons into hedonic groups, rather than simply identifying neurons that respond to a single stimulus.




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Lifehope Transit Challenge: God’s heart for Europe

OM Lifehope coordinates the Transit Challenge, sending out teams all over Europe to love, serve and proclaim Christ.




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Loving the Most Hated People in Europe

Work of OM Romania among the Roma population




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Progress along Europe’s waterways

OM's Riverboat will bring the gospel to six ports in three European countries over the course of three months, starting in December 2017.




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OM Europe steps out to reach youth

European youth more than ever need good relationships with adults, says OM Europe’s Empowering Kids&Youth team, who focus on positively impacting Europe’s next generation.




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Bus4Life begins sixth European tour

Bus4Life begins its sixth year serving churches and OM teams across Central and Eastern Europe.




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More wheels to Europe

After years of dreaming and praying, OM Finland purchases a new vehicle to replace the old Bus4Life, opening more opportunities to reach Eastern Europe.




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Ready to reach Europe

OM field leader Martin believes Belgium has a strategic part to play, with OM, in helping grow a church planting movement in Europe.




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Fox News AI Newsletter: AI developers discover 'Donald Trump neuron', expert says

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.



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  • fnc
  • Fox News
  • fox-news/columns/artificial-intelligence-newsletter
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Spanish fans voted C Ronaldo for the European MVP

UEFA announced the 2013 best player in Europe three candidate list in the recently, the core of Ribery three time Champions Bayern will PK Messi C rom.. "Marca" fans in the investigation of the C Luo



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{Occult Infiltration of the Roman Catholic Church} The Revised Roman Empire - The Medici Family [generally considered the most Occult family of Medieval Europe] - Other Prominent Medici were *Pope Leo X (1475-1521); Pope Clement VII (1478-1534); Catherine

Medici, an Italian family of merchants and bankers who ruled the republic of Florence through economic power and personal influence. By their patronage of the arts they made Florence the center of the Italian Renaissance. The Medici were created dukes of Florence by Holy Roman Emperor Charles V in 1531, and grand dukes of Tuscany by Emperor Maximilian II in 1575. The last Medici grand duke was deposed by the Austrians in 1737. Important members of the Medici family included the following. Giovanni De' Medici: (1360-1429) established the family fortune and made himself ruler of Florence's merchant oligarchy. Cosimo De' Medici: (1389-1464), his son, used his banking business to gain political power and led Florence in a long period of prosperity and artistic achievement. Lorenzo the Magnificent: (1449-1492), grandson of Cosimo, gained fame as a statesman and patron of arts and letters. He was recognized as a poet himself and was largely responsible for the Tuscan dialect becoming the national speech of Italy. Cosimo (I) the Great: (1519-1574) succeeded to the dukedom in 1537 and ruled as a despot. He restored the duchy of Tuscany by conquering the other republics that had been part of it.



  • Christian Church History Study
  • 2. 313 A.D. to 1521 A.D. - Revised Rome and the Holy Roman Empire

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Johannes Gutenberg - His early training was in goldsmithing - Gutenberg had the idea of utilizing techniques of metalworking, such as casting, punch-cutting, and stamping, for the mass production of books. European books at this time were hand written by

Johannes Gutenberg was born into a noble family of the city of Mainz, Germany. His early training was in goldsmithing. In 1428, he moved to Strasbourg for political reasons, where he remained for over 20 years. It was in Strasbourg that he probably made his first experiments with moveable type. -- Gutenberg had the idea of utilizing techniques of metalworking, such as casting, punch-cutting, and stamping, for the mass production of books. European books at this time were hand written by scribes in a gothic script with many flourishes and ligatures (interconnected letter pairs). To reproduce this "look" Gutenberg fashioned a font of over 300 characters, far larger than the fonts of today. To make this possible, he invented the variable-width mold, and perfected the blend of lead, antimony, and tin used by type foundries up to the present century. -- Many years of Gutenberg's life are lost to history, but by 1450 he was back in Mainz at work on a printing press. Between 1450 and 1455, while preparing to produce a large folio Latin Bible, Gutenberg is thought to have printed a number of smaller books, a calendar, and a papal Letter of Indulgence. The Bible of 42 lines, the oldest surviving printed book in the western world, was completed by August 15, 1456, and while it is now credited to Gutenberg, he appears to have been relieved of his supervisory position, and his press, before the time of its publication. In fact, no printed material was ever credited to Gutenberg during his lifetime. -- Gutenberg is also believed to have worked on the Catholicon of Johannes de Janua, an enormous encyclopedia: 748 pages in two columns of 66 lines each. In later years, he received a position as a courtier to the archbishop of Mainz, and was buried in the town's Franciscan church.



  • Christian Church History Study
  • 2. 313 A.D. to 1521 A.D. - Revised Rome and the Holy Roman Empire

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Wikipedia: Johannes Gutenberg (1398 - February 3, 1468) was a blacksmith, goldsmith, printer and publisher who probably introduced movable type to Europe, and is likely to have developed the earliest European printing press - He is sometimes said to have

Gutenberg's printing technology spread rapidly throughout Europe, and may well have been refined and perfected by others. The process quickly replaced most of the manuscript methods of book-production throughout the world. Woodblock printing and manuscript rubrication continued to be used to supplement Gutenberg's printing process. His first major work using his printing methods was the Gutenberg Bible. -- Legacy: Although Gutenberg was financially unsuccessful in his lifetime, the printing technologies spread quickly, and news and books began to travel across Europe much faster than before. It fed the growing Renaissance, and since it greatly facilitated scientific publishing, it was a major catalyst for the later scientific revolution. The capital of printing in Europe shifted to Venice, where visionary printers like Aldus Manutius ensured widespread availability of the major Greek and Latin texts. The claims of an Italian origin for movable type have also focused on this rapid rise of Italy in movable-type printing. This may perhaps be explained by the prior eminence of Italy in the paper and printing trade. Additionally, Italy's economy was growing rapidly at the time, facilitating the spread of literacy. Christopher Columbus had a geographical book (printed by movable types) bought by his father. That book is in a Spanish museum. Finally, the city of Mainz was sacked in 1462, driving many (including a number of printers and punch cutters) into exile. -- **Printing was also a factor in the Reformation. Martin Luther's 95 Theses were printed and circulated widely; subsequently he issued broadsheets outlining his anti-indulgences position (certificates of indulgences were one of the first items Gutenberg had printed). The broadsheet contributed to development of the newspaper. -- In the decades after Gutenberg, many conservative patrons looked down on cheap printed books; books produced by hand were considered more desirable. Today there is a large antique market for the earliest printed objects. Books printed prior to 1500 are known as incunabula. There are many statues of Gutenberg in Germany, including the famous one by Bertel Thorvaldsen (1837) in Mainz, home to the eponymous Johannes Gutenberg University of Mainz and the Gutenberg Museum on the history of early printing. The later publishes the Gutenberg-Jahrbuch, the leading periodical in the field. Project Gutenberg [www.gutenberg.org], the oldest digital library [of FREE eBooks], commemorates Gutenberg's name. In 1961 the Canadian philosopher and scholar Marshall McLuhan entitled his pioneering study in the fields of print culture, cultural studies, and media ecology, The Gutenberg Galaxy: The Making of Typographic Man. Gutenberg remains a towering figure in the popular image. In 1999, the A&E Network ranked Gutenberg the No. 1 most influential person of the second millennium on their "Biographies of the Millennium" countdown. In 1997, Time-Life magazine picked Gutenberg's invention as the most important of the second millennium. In space, he is commemorated in the name of the asteroid 777 Gutemberga. A French opera on his life, by Philippe Manoury, was staged in Strasbourg in September 2011.



  • Christian Church History Study
  • 2. 313 A.D. to 1521 A.D. - Revised Rome and the Holy Roman Empire

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The Real History of the Crusades - The crusades are quite possibly the most misunderstood event in European history - Most of what passes for public knowledge about it is either misleading or just plain wrong -- Whether we admire the Crusaders or not, it

When we think about the Middle Ages, it is easy to view Europe in light of what it became rather than what it was. The colossus of the medieval world was Islam, not Christendom. The Crusades are interesting largely because they were an attempt to counter that trend. But in five centuries of crusading, it was only the First Crusade that significantly rolled back the military progress of Islam. It was downhill from there. When the Crusader County of Edessa fell to the Turks and Kurds in 1144, there was an enormous groundswell of support for a new Crusade in Europe. It was led by two kings, Louis VII of France and Conrad III of Germany, and preached by St. Bernard himself. It failed miserably. Most of the Crusaders were killed along the way. Those who made it to Jerusalem only made things worse by attacking Muslim Damascus, which formerly had been a strong ally of the Christians. In the wake of such a disaster, Christians across Europe were forced to accept not only the continued growth of Muslim power but the certainty that God was punishing the West for its sins. Lay piety movements sprouted up throughout Europe, all rooted in the desire to purify Christian society so that it might be worthy of victory in the East. ... Yet, even while these close shaves were taking place, something else was brewing in Europe-something unprecedented in human history. The Renaissance, born from a strange mixture of Roman values, medieval piety, and a unique respect for commerce and entrepreneurialism, had led to other movements like humanism, the Scientific Revolution, and the Age of Exploration. Even while fighting for its life, Europe was preparing to expand on a global scale. The Protestant Reformation, which rejected the papacy and the doctrine of indulgence, made Crusades unthinkable for many Europeans, thus leaving the fighting to the Catholics. In 1571, a Holy League, which was itself a Crusade, defeated the Ottoman fleet at Lepanto. Yet military victories like that remained rare. The Muslim threat was neutralized economically. As Europe grew in wealth and power, the once awesome and sophisticated Turks began to seem backward and pathetic-no longer worth a Crusade. The "Sick Man of Europe" (the Ottoman Empire) limped along until the 20th century [WWI], when he finally expired, leaving behind the present mess of the modern Middle East.



  • Christian Church History Study
  • 2. 313 A.D. to 1521 A.D. - Revised Rome and the Holy Roman Empire

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Wikipedia: Family name, Last Name - In Ireland, the use of surnames have a very old history - Ireland was the first country in Europe to use fixed surnames - As noted in the Annals, the first recorded fixed surname was Ó Cleirigh which recorded the d

In England, the introduction of family names is generally attributed to the Normans and the Domesday Book of 1086. Documents indicate that surnames were first adopted among the feudal nobility and gentry, and only slowly spread to the other parts of society. Some of the early Norman nobility arriving in England during the Norman Conquest differentiated themselves by affixing 'de' (of) in front of the name of their village in France. This is what is known as a territorial surname, a consequence of feudal landownership. In medieval times in France, such a name indicated lordship, or ownership, of the village. But some early Norman nobles in England chose to drop the French derivations and call themselves instead after their new English holdings. -- True surnames, in the sense of hereditary appellations, date in England from about the year 1000. Largely they were introduced from Normandy, although there are records of Saxon, surnames prior to the Norman Conquest. By the end of the twelfth century hereditary names had become common in England. But even as late as 1465 they were not universal. During the reign of Edward V (between April and June, 1483) a law was passed to compel certain Irish to adopt surnames as **a method to track and control them more: "They shall take unto them a Surname, either of some Town, or some Colour, as Black or Brown, or some Art or Science, as Smyth or Carpenter, or some Office, as Cooke or Butler." (ramsdale.org/surname.htm)



  • Christian Church History Study
  • 2. 313 A.D. to 1521 A.D. - Revised Rome and the Holy Roman Empire

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Ancient Saracens - Saracen was a term used by the ancient Romans to refer to a people who lived in desert areas in and around the Roman province of Arabia, and who were distinguished from Arabs - In Europe during the Middle Ages the term was expanded to i

Early and medieval Christian literature: Eusebius and Epiphanius Scholasticus, in their Christian histories, place Saracens east of the Gulf of Aqaba but beyond the Roman province of Arabia and mention them as Ishmaelites through Kedar; thus, they are outside the promise given to Abraham and his descendants through Isaac and also therefore, in Christian theology, beyond a privileged place in the family of nations or divine dispensation. The Jews viewed them as pagans and polytheists in ancient times and in later Christian times they became associated with cruel tyrants from early Christian history such as: Herod the Great, Herod Antipas and Agrippa I. Christian writings, such as those by Origen, viewed them as heretics who had to be brought into the orthodox fold. To the Christian Saint Jerome the Arabs, who were also considered in Christian theology as Ishmaelites, were also seen to fit the definition of Saracens; pagan tent-dwelling raiders of the lands on the eastern fringes of the Roman empire. -- The term Saracen carried the connotation of people living on the fringes of settled society, living off raids on towns and villages, and eventually became equated with both the "tent-dwelling" Bedouin as well as sedentary Arabs. Church writers of the period commonly describe Saracen raids on monasteries and their killing of monks. The term and the negative image of Saracens was in popular usage in both the Greek east as well as the Latin west throughout the Middle Ages. With the advent of Islam, in the Arabian peninsula, during the seventh century among the Arabs, the term's strong association with Arabs tied the term closely with not just race and culture, but also the religion. The rise of the Arab Empire and the ensuing hostility with the Byzantine Empire saw itself expressed as conflict between Islam and Christianity and the association of the term with Islam was further accentuated both during and after the Crusades. -- John of Damascus, in a polemical work typical of this attitude described the Saracens in the early 8th century thus: There is also the people-deceiving cult (threskeia) of the Ishmaelites, the forerunner of the Antichrist, which prevails until now. It derives from Ishmael, who was born to Abraham from Hagar, wherefore they are called Hagarenes and Ishmaelites. And they call them Saracens, inasmuch as they were sent away empty-handed by Sarah; for it was said to the angel by Hagar: "Sarah has sent me away empty-handed" (cf. Book of Genesis xxi. 10, 14).



  • Christian Church History Study
  • 2. 313 A.D. to 1521 A.D. - Revised Rome and the Holy Roman Empire

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King Charlemagne (742 - 814 A.D.) the "Father of Europe" - The greatest of medieval kings was born in 742 A.D., at a place unknown, he was of German blood and speech - To the medieval mind, only King Arthur vied with Charlemagne as the finest ex

King Charlemagne: The greatest of medieval kings was born in 742, at a place unknown. He was of German blood and speech, and shared some characteristics of his people- strength of body, courage of spirit, pride of race, and a crude simplicity many centuries apart from the urbane polish of the modern French. He had little book learning; read only a few books- but good ones; tried in his old age to learn writing, but never quite succeeded; yet he could speak old Teutonic and literary Latin, and understood Greek. In 771 Carloman II died, and Charles at twenty-nine became sole king. Two years later he received from Pope Hadrian II an urgent appeal for aid against the Lombard Desiderius, who was invading the papal states. Charlemagne besieged and took Pavia, assumed the crown of Lombardy, confirmed the Donation of Pepin, and accepted the role of protector of the Church in all her temporal powers. -- Returning to his capital at Aachen, he began a series of fifty-three campaigns- nearly all led in person- designed to round out his empire by conquering and Christianizing Bavaria and Saxony, destroying the troublesome Avars, shielding Italy from the raiding Saracens, and strengthening the defenses of Francia against the expanding Moors of Spain. The Saxons on his eastern frontier were pagans; they had burned down a Christian church, and made occasional incursions into Gaul; these reasons sufficed Charlemagne for eighteen campaigns (772-804), waged with untiring ferocity on both sides. Charles gave the conquered Saxons a choice between baptism and death, and had 4500 Saxon rebels beheaded in one day; after which he proceeded to Thionville to celebrate the nativity of Christ. -- The empire [of Europe] was divided into counties, each governed in spiritual matters by a bishop or archbishop, and in secular affairs by a comes (companion- of the king) or count. A local assembly of landholders convened twice or thrice a year in each provincial capital to pass upon the government of the region, and serve as a provincial court of appeals. The dangerous frontier counties, or marches, had special governors- graf, margrave, or markherzog; Roland of Roncesvalles, for example, was governor of the Breton march. All local administration was subject to missi dominici- "emissaries of the master"- sent by Charlemagne to convey his wishes to local officials, to review their actions, judgments, and accounts; to check bribery, extortion, nepotism, and exploitation, to receive complaints and remedy wrongs, to protect "the Church, the poor, and wards and widows, and the whole people"from malfeasance or tyranny, and to report to the King the condition of the realm; the Capitulare missorum establishing these emissaries was a Magna Carta for the people, four centuries before England's Magna Carta for the aristocracy. That this capitulary meant what it said appears from the case of the duke of Istria, who, being accused by the missi of divers injustices and extortions, was forced by the King to restore his thievings, compensate every wronged man, publicly confess his crimes, and give security against their repetition. ... (Charlemagne) had four successive wives and five mistresses or concubines. His abounding vitality made him extremely sensitive to feminine charms; and his women preferred a share in him to the monopoly of any other man. His harem bore him some eighteen children, of whom eight were legitimate. -- The ecclesiastics [priests] of the court and of Rome winked leniently at the Moslem [Muslim] morals of so Christian a king. He was now head of an empire far greater than the Byzantine, surpassed, in the white man's world, only by the realm of the Abbasid caliphate. But every extended frontier of empire or knowledge opens up new problems. Western Europe had tried to protect itself from the Germans by taking them into its civilization; but now Germany had to be protected against the Norse and the Slavs. The Vikings had by 800 A.D. established a kingdom in Jutland, and were raiding the Frisian coast. Charles hastened up from Rome, built fleets and forts on shores and rivers, and stationed garrisons at danger points. In 810 the king of Jutland invaded Frisia and was repulsed; but shortly thereafter, if we may follow the chronicle of the Monk of St. Gall, Charlemagne, from his palace at Narbonne, was shocked to see Danish pirate vessels in the Gulf of Lyons. Perhaps because he foresaw, like Diocletian, that his overreaching empire needed quick defense at many points at once, he divided it in 806 among his three sons- Pepin, Louis, and Charles. But Pepin died in 810, Charles in 811; only Louis remained, so absorbed in piety as to seem unfit to govern a rough and treacherous world. Nevertheless, in 813, at a solemn ceremony, Louis was elevated from the rank of king to that of emperor, and the old monarch uttered his nunc dimittis: "Blessed be Thou, O Lord God, Who hast granted me the grace to see with my own eyes my son seated on my throne!" -- Death: Four months later, wintering at Aachen, he was seized with a high fever, and developed pleurisy. He tried to cure himself by taking only liquids; but after an illness of seven days he died, in the forty-seventh year of his reign and the seventy-second year of his life (814 A.D.). He was buried under the dome of the cathedral at Aachen, dressed in his imperial robes. Soon all the world called him Carolus Magnus, Karl der Grosse, Charlemagne; and in 1165 A.D., when time had washed away all memory of his mistresses, the Church which he had served so well enrolled him among the blessed.



  • Christian Church History Study
  • 2. 313 A.D. to 1521 A.D. - Revised Rome and the Holy Roman Empire

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Wiens WCs unter den dreckigsten in Europa

Wiens öffentliche Toiletten sind laut einer auf Google-Rezensionen basierenden Auswertung des britischen Sanitärhändlers Showers to you europaweit unter den schmutzigsten. Sie belegen den sechsten Platz im Ranking.


orf.at




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Medexus gets Health Canada nod to market tumor imaging material Gleolan for neurosurgery




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Revelwood Expands Award-Winning Workday Adaptive Planning Business in Europe

Revelwood, the Workday Adaptive 2023 Solution Provider of the Year – Americas, is expanding to companies in Europe.




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Pacific Holidays Inc. Unveils Top Notch European Vacation Packages

Pacific Holidays Inc. just released a new line of exciting European vacations. The vacation plans culminate years of research into the travel industry and customer experience.




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International Lawyers Network Shortlisted for "Network of the Year" at The Lawyer European Awards 2024

The International Lawyers Network (ILN) has been shortlisted for "Network of the Year" at The Lawyer European Awards 2024, recognizing its excellence and commitment to providing high-quality legal services globally. This marks yet another milestone for ILN, which was previously honored with the title of Global Law Firm Network of the Year in 2021.




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GrECo and MAI combine forces in Central and Eastern Europe

Specialist insurance broker GrECo acquires 100% of MAI CEE Ltd., a major risk, insurance and employee benefits consultant in CEE.




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Sportworld Launches Innovative, Data-Driven FAST Channels for EURO 2024 Worldwide

Sportworld, the innovative sports streaming platform, offers fans worldwide a unique EURO 2024 experience with its own channels, an interactive prediction game, the integration of a live ticker, and the aggregation of all program information and highlight clips in one place.




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Grünenthal and Averitas Pharma announce completion of recruitment for Phase III clinical trial with QUTENZA® in post-surgical neuropathic pain

- The Phase III trial AV001 aims to evaluate QUTENZA® in post-surgical neuropathic pain (PSNP), a debilitating complication of surgery occurring after approximately 10 percent of all surgical procedures[1], thus affecting more than 3 million people with surgical procedures per year in the U.S.[2]




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GEMA files model action to clarify AI providers' remuneration obligations in Europe




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Unseasonably Speaking – Stefan Zweig, Brexit and the meaning of Europe

The Austrian novelist Stefan Zweig was once among the most popular and most translated writers in the world. English Heritage's widely criticised refusal to commemorate his residence in London provides an entry point into a discussion on the role of the intellectual, Brexit, and the meaning of Europe.

The post Unseasonably Speaking – Stefan Zweig, Brexit and the meaning of Europe appeared first on Three Monkeys Online Magazine.




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EuroBSDCon 2024 presentations

EuroBSDCon 2024 [in Dublin, Ireland] has now ended, and slides for many of the OpenBSD developer presentations are now available in the usual place.

Video of the individual presentations can be expected somewhat later. In the meantime, OpenBSD-related presentations [including those from non-developers] can be found in the recordings of the "Foyer B" streams.

In addition, there was a full day PF tutorial with some updates to the publicly available slides.




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Projekt DNS4EU – współpraca na europejskim poziomie

DNS4EU to element strategii cyberbezpieczeństwa opublikowanej przez Komisję Europejską. Celem projektu jest wprowadzenie prywatnego i bezpiecznego publicznego resolvera DNS w ramach Unii Europejskiej, co przyczyni się do budowania niezależności w obszarze usług cyfrowych.




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41. civil servant proudly - ISP-Europe Archive

Simplyukgadgets Forums, . photos, internet search engine and free downloads. ... Back to Search Results Google Alert results for: simplyukgadgets. ...




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21. succor - ISP-Europe Archive

simply uk gadgets, Esempio tesineandofferta regali enna. Simply video poker game Uk Gadgets, siti di Simply Uk Gadgets, . ...




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Outstanding Leaders Exhibit More Than Just Emotional Intelligence--They Have These 7 Traits, According to Neuroscience

The topic of emotional intelligence (EQ) continues to dominate leadership conversations. Rightly so. However, in a Harvard Business Review (HBR) article that highlighted research by Daniel Goleman and Richard Boyatzis (experts on the topic), EQ is only the beginning.

Whereas EQ has an emphasis on individual psychology, there is a more relationship-based version called social intelligence. Social Intelligence, as defined by Goleman and Boyatizis, is a set of interpersonal competencies built on specific neural circuits and responses that inspire others to be effective. In other words, based on neuroscience and biology, there are certain leadership behaviors that elicit positive emotional responses in your team members.

complete article




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The Grain Analysis Market is dominated by Europe, as per Maximize Market Research.

(EMAILWIRE.COM, October 28, 2024 ) Grain Analysis Market overview Grain Analysis Market refers to the process of evaluating grain for impurities like mycotoxins and pesticide residue, as well as quality and safety, during distribution, storage to minimize waste. Grain Analysis Market drivers Increased...




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Neuromorphic Computing Market Expected to Reach $1,325.2 million by 2030

(EMAILWIRE.COM, October 28, 2024 ) The neuromorphic computing market size is expected to reach USD 1,325.2 million by 2030 growing at a compound Annual Growth Rate (CAGR) of 89.7%, from USD 28.5 million in 2024. The globalization of neuromorphic computing would further gain its momentum based on...




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European Smart Home Market Worth $29.24 Billion by 2029 Growing at a CAGR of 5.7%

(EMAILWIRE.COM, October 29, 2024 ) The European Smart Home Market was USD 22.11 billion in 2024 and is expected to reach up to USD 29.24 billion by 2029 growing at a CAGR of 5.7 %. Owing to high internet usage and common accessibility to smartphones, the consumers have been easily able to connect...




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The Automotive Adaptive Front Lighting Market is LED by Europe, as per Maximize Market Research.

(EMAILWIRE.COM, October 30, 2024 ) Growing vehicle manufacturing is driving the need for enhanced lighting systems worldwide. Increased visibility during nighttime decreases accidents, prompting more stringent regulations and greater consumer demand for these safety systems. Adaptive headlights are...