MUNICH, Germany – HARMAN International, a wholly-owned subsidiary of Samsung Electronics Co., Ltd. focused on connected technologies for automotive, consumer and enterprise markets, today announced the opening of its first Experience Store in Europe....

As the world gets warmer, animals whose sex is determined by temperature are finding cool ways to control their own fate. But can they adapt in time?

At Unseen Amsterdam, striking images of a melting glacier are stirring visitors to action

A Backstage Pass with Christopher Dragon: Creating that HARMAN Experience at the World's Largest Technology Show Around the world, many companies are preparing to close out the year, but for HARMAN, it’s time to head to Las Vegas once again for the...

From the mealtimes you keep and the speed at which you eat to your choice of dining companions, how you eat has a big impact on your health and waistline

As the world gets warmer, animals whose sex is determined by temperature are finding cool ways to control their own fate. But can they adapt in time?

A mother who was given a 50 percent survival chance and her newborn baby were discharged from hospital on Monday (May 4) after both fighting COVID-19.

Title: Many Adults Delay Getting Help for Eating Disorders
Category: Health News
Created: 4/21/2020 12:00:00 AM
Last Editorial Review: 4/22/2020 12:00:00 AM

Title: Defeating Dandruff
Category: Health News
Created: 4/28/2012 11:00:00 AM
Last Editorial Review: 4/30/2012 12:00:00 AM

Title: Health Tip: Avoid Emotional Eating
Category: Health News
Created: 5/2/2013 8:35:00 AM
Last Editorial Review: 5/2/2013 12:00:00 AM

Title: Statin Users Eating More Bad Food Than a Decade Ago, Study Shows
Category: Health News
Created: 4/25/2014 12:35:00 PM
Last Editorial Review: 4/28/2014 12:00:00 AM

Title: Start Healthy Eating Habits Early to Head Off Obesity in Kids
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/29/2015 12:00:00 AM

Title: Expert Offers Advice on Treating Corns, Calluses
Category: Health News
Created: 4/24/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM

Title: Heat Beats Cold for Treating Jellyfish Stings
Category: Health News
Created: 4/29/2016 12:00:00 AM
Last Editorial Review: 4/29/2016 12:00:00 AM

Title: Cooking at Home Means Eating Better, Spending Less
Category: Health News
Created: 4/30/2017 12:00:00 AM
Last Editorial Review: 5/1/2017 12:00:00 AM

Title: Eating Gluten-Free Without a Medical Reason?
Category: Health News
Created: 5/2/2017 12:00:00 AM
Last Editorial Review: 5/3/2017 12:00:00 AM

Title: Eating Fish in Moderation During Pregnancy Benefits Fetus: Study
Category: Health News
Created: 3/20/2020 12:00:00 AM
Last Editorial Review: 3/23/2020 12:00:00 AM

Title: Health Tip: Treating Chicken Skin
Category: Health News
Created: 1/30/2020 12:00:00 AM
Last Editorial Review: 1/30/2020 12:00:00 AM

ABSTRACT

The global stress response controlled by the alternative sigma factor RpoS protects enteric bacteria from a variety of environmental stressors. The role of RpoS in other, nonenteric bacteria, such as the opportunistic pathogen Pseudomonas aeruginosa, is less well understood. Here, we employed experimental social evolution to reveal that cooperative behavior via secreted public goods is an important function in the RpoS response of P. aeruginosa. Using whole-genome sequencing, we identified rpoS loss-of-function mutants among isolates evolved in a protein growth medium that requires extracellular proteolysis. We found that rpoS mutants comprise up to 25% of the evolved population and that they behave as social cheaters, with low fitness in isolation but high fitness in mixed culture with the cooperating wild type. We conclude that rpoS mutants cheat because they exploit an RpoS-controlled public good produced by the wild type, the secreted aminopeptidase PaAP, and because they do not carry the metabolic costs of expressing PaAP and many other gene products in the large RpoS regulon. Our results suggest that PaAP is an integral part of a proteolytic sequence in P. aeruginosa that permits the utilization of protein as a nutrient source. Our work broadens the scope of stress response functions in bacteria.

IMPORTANCE Bacterial stress responses are generally considered protective measures taken by individual cells. Enabled by an experimental evolution approach, we describe a contrasting property, collective nutrient acquisition, in the RpoS-dependent stress response of the opportunistic human pathogen P. aeruginosa. Specifically, we identify the secreted P. aeruginosa aminopeptidase (PaAP) as an essential RpoS-controlled function in extracellular proteolysis. As a secreted "public good," PaAP permits cheating by rpoS mutants that save the metabolic costs of expressing RpoS-controlled genes dispensable under the given growth conditions. Proteolytic enzymes are important virulence factors in P. aeruginosa pathogenesis and constitute a potential target for antimicrobial therapy. More broadly, our work contributes to recent findings in higher organisms that stress affects not only individual fitness and competitiveness but also cooperative behavior.

ABSTRACT

Patients with COVID-19 infection are at risk of acute respiratory disease syndrome (ARDS) and death. The tissue receptor for COVID-19 is ACE2, and higher levels of ACE2 can protect against ARDS. Angiotensin receptor blockers and statins upregulate ACE2. Clinical trials are needed to determine whether this drug combination might be used to treat patients with severe COVID-19 infection.

In order to establish sustainable heat loading (heat removal and storage) in abandoned flooded mine workings it is important to understand the geomechanical impact of the cyclical heat loading caused by fluid injection and extraction. This is particularly important where significantly more thermal loading is planned than naturally occurs. A simple calculation shows that the sustainable geothermal heat flux from abandoned coal mines can provide less than a tenth of Scotland's annual domestic heating demand. Any heat removal greater than the natural heat flux will lead to heat mining unless heat storage options are also considered.

As a first step, a steady-state, fully saturated, 2D coupled hydromechanical model of a generalized section of pillar-and-stall workings has been created. Mine water rebound was modelled by increasing the hydrostatic pressure sequentially, in line with monitored mine water-level data from Midlothian, Scotland. The modelled uplift to water-level rise ratio of 1.4 mm m^–1 is of the same order of magnitude (1 mm m^–1) as that observed through interferometric synthetic aperture radar (InSAR) data in the coalfield due to mine water rebound. The modelled magnitude of shear stress at the pillar corners, as a result of horizontal and vertical displacement, is shown to increase linearly with water level. Mine heat systems are expected to cause smaller changes in pressure than those modelled but the results provide initial implications on the potential geomechanical impacts of mine water heat schemes which abstract or inject water and heat into pillar-and-stall coal mine workings.

Thematic collection: This article is part of the SJG Collection on Early-Career Research available at: https://www.lyellcollection.org/cc/SJG-early-career-research

Background:

In 2015, Vyvanse (lisdexamfetamine) became the first Food and Drug Administration (FDA)-approved treatment for binge-eating disorder (BED), a condition first recognized by the DSM–V in 2013. Because pharmaceutical companies use continuing medical education (CME) to help sell drugs, we explored possible bias in CME modules on BED.

Methods:

We utilized a qualitative thematic analysis research approach to identify and classify patterns in CME activities focusing on BED.

Results:

We identified 27 online CME activities on BED in 2015. All were funded by Shire, which manufactures lisdexamfetamine. Seven of 16 presenters disclosed financial ties with Shire. Twenty-nine slides recurred in at least 2 CME modules, and 12 slides were repeated in 5 or more modules. Diagnosis-related themes included: BED is a real, treatable disease; BED is highly prevalent but often missed; BED can occur in anyone; BED results in poor quality of life; many patients with BED are obese; and BED makes losing weight difficult. Treatment-related themes included: lisdexamfetamine is highly effective; topiramate is limited by substantial adverse effects; and other therapeutic options for BED are inferior to lisdexamfetamine because they do not cause weight loss. Although amphetamines can cause addiction, myocardial infarction, stroke, and death, no module mentioned these serious adverse effects.

Conclusions:

It seems that CME is being used to promote lisdexamfetamine for weight loss (a contraindicated use) and to highlight benefits of lisdexamfetamine while underplaying the risks.

Stiff person syndrome (SPS) is a rare neurologic disorder characterized by progressively worsening rigidity and spasms of the axial and limb muscles. Dyspnea has been recently recognized as a common symptom in SPS,¹ and life-threatening respiratory crises have been occasionally reported and suspected to be responsible for sudden death in these patients.^2,3 The pathophysiologic mechanisms of these respiratory manifestations remain unclear. Some authors have hypothesized that rigidity and/or spasm of the muscles of the trunk could prevent normal rib cage movements and excursion of the diaphragm.¹

Asja Guzman, Rachel C. Avard, Alexander J. Devanny, Oh Sang Kweon, and Laura J. Kaufman

The study of cancer cell invasion in 3D environments in vitro has revealed a variety of invasive modes, including amoeboid migration, characterized by primarily round cells that invade in a protease- and adhesion-independent manner. Here, we delineate a contractility-dependent migratory mode of primarily round breast cancer cells that is associated with extensive integrin-mediated extracellular matrix (ECM) reorganization that occurs at membrane blebs, with bleb necks sites of integrin clustering and integrin-dependent ECM alignment. We show that the spatiotemporal distribution of blebs and their utilization for ECM reorganization is mediated by functional β1 integrin receptors and other components of focal adhesions. Taken together, the work presented here characterizes a migratory mode of primarily round cancer cells in complex 3D environments and reveals a fundamentally new function for membrane blebs in cancer cell invasion.

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The post Fundamentals for Creating a Shoppable Interactive Video for eCommerce appeared first on e-Learning Feeds.

But can you still write "BOOBS" on it?

Some black holes are way bigger than we can explain, and they may have come from supermassive stars that formed by devouring the other stars around them

Because we don't have enough on our plates as it is, now we've got 'murder hornets' flying around the United States. Murder hornets (actually Asian Giant Hornets, but that name didn't strike enough fear into the masses) have a sting powerful enough that China recommends medical treatment if stunk more than ten times, and emergency treatment if stung more than 30. *pours out a little liquor for Macaulay Culkin in My Girl*. And where is his glasses?! He can't see without his glasses! Put his glasses on! Here's a video of Coyote Peterson getting stung by one (the Japanese Giant Hornet was previously believed to be a subspecies of the Asian Giant Hornet, but has since been recategorized as a color morph). This is a video of a praying mantis eating a Giant Asian hornet until it's just a pile of limbs. So yeah, praying mantises -- start breeding them. And make sure to selectively breed them too so we can produce them bigger and bigger until they're preying on us because the way things are going how is that not how this ends? Keep going for the video while I surround my Animal Crossings town with preying mantises to protect my villagers and keep my five-star rating (okay, three).

High salt intake seems to impair the immune cells in humans that fight bacteria because of a side effect of the hormones that help get rid of salt

Over time, trash that has been floating in the ocean gets covered in algae and other micro-organisms

Follow our live Covid-19 updates HERE Coronavirus: The symptoms

Follow our live Covid-19 updates HERE Coronavirus: The symptoms

With elite sport across the globe on pause due to the coronavirus pandemic, Americans are turning to competitive eating to fill the void.

RAF plane still awaiting go-ahead for flight to Turkey to collect supplies

A nurse from New Zealand who cared for Boris Johnson as he battled coronavirus says he "absolutely needed" intensive care treatment after his symptoms worsened.

The trade association for the national potato industry in Belgium has urged the population to keep eating chips during lockdown to help support farmers.

Not for one Spanish TV anchor, whose video-chat blunder might have cost him his relationship.

The closure of cafes and restaurants in Rome due to the coronavirus outbreak means seagulls have had to change their habits and start eating rats, zoologists claim.

The state accuses the ride-hailing apps of flouting a labor law by classifying drivers as independent contractors instead of employees.

If Peter Turchin is right, we face the end of a 300-year cycle, as did previous far-flung empires. 

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Other researchers have rejected the findings and say dog owners do not need to be concerned

A couple of days ago Alison Roman, critic and food enthusiast gave an interview directly trashing Chrissy Teigen’s approach to business. “What Chrissy Teigen has done is so crazy to me. She had a successful cookbook. And then it was like Boom, the line at Target. Boom, now she has an Instagram page that has […]

The post Alison Roman Is Eating Her Words, Apologizing To Chrissy Teigen appeared first on Chart Attack.

Cybertip.ca, an online sexual exploitation of children tipline, says it saw a 66 per cent spike in reports in April.

Newly revealed Twin Galaxies defamation suit has been quietly proceeding for months.

Waking up without a hangover after a night of getting plastered is the world saying: here, have one on me

Brace yourself. That is the first thing that enters one’s head after a heavy night out, before the eyes are even open. Sometimes, listing nausea or a banging in the brain is what wakes us in the first place. We all know that if someone invented a cure for hangovers – and boy, have they tried – that person would be very rich indeed. Or worshipped as a deity. Most likely both.

It doesn’t matter if it has been one too many after work drinks or cracking open a second bottle of wine with one’s partner… the consequences of over-indulgence patiently lie in wait.

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The once mighty northern cod stocks' growth is stalled according to DFO science. Ecosystem conditions including a lack of food are contributing factors. Fish harvesters say in the bigger picture though, the numbers are moving in the right direction.

Whether or not the Ingrams were cheating on 'Who Wants to Be a Millionaire?', the resulting outrage was rooted in the same dynamics that have come to dominate social discourse in the years since, says Adam White