Salamanders are typically elusive animals and adept at hiding, but National Zoo visitors will have a chance to see a variety of different amphibian species […]

The post National Zoo Opens New Home for Appalachian Salamanders appeared first on Smithsonian Insider.

After decades of attempts, Smithsonian Conservation Biology Institute (SCBI) scientists and researchers at Cornell University have become the first to successfully use in vitro fertilization […]

The post Smithsonian-Cornell Partnership produces First Domestic Puppies by In Vitro Fertilization appeared first on Smithsonian Insider.

Snowstorms and blizzards send people to raid supermarkets and prepare their homes for days of staying indoors, but how do the animals at the Smithsonian’s […]

The post What happens at the National Zoo when it snows? appeared first on Smithsonian Insider.

New fossils found in Northeastern China have revealed a remarkable evolutionary coincidence: an extinct group of insects known as Kalligrammatid lacewings (Order Neuroptera) share an […]

The post Remarkable butterfly look-alike lived 50 million years before butterflies appeared appeared first on Smithsonian Insider.

With over 138 million collection objects, 2.1 million library volumes, and 137,000 cubic feet of archives, the stories of how our collections have made their […]

The post Seventeen Objects for 170 Years (Happy Birthday to us!) appeared first on Smithsonian Insider.

Perhaps puppies cuddling in the snow makes winter’s bite not so unpleasant? In one of his most charming designs, Japanese artist Isoda Koryūsai (1735–1790) depicted […]

The post Snow puppies appeared first on Smithsonian Insider.

The 11 farthest known stars in our galaxy are located about 300,000 light-years from Earth, well outside the Milky Way’s spiral disk. New research by […]

The post Farthest Milky Way stars might be ripped from another galaxy appeared first on Smithsonian Insider.

In conflicts between predators and prey, speed is a decided advantage, and evolution has given the trap-jaw ant a distinct advantage with spring-loaded jaws that […]

The post Locked and loaded: unique trigger design fires this ant’s snapping jaws appeared first on Smithsonian Insider.

“Probably no genus of birds in the American avifauna has received the amount of attention that has been bestowed upon the turkeys…there has been no […]

The post Happy Thanksgiving! Here are 25 fun turkey-related objects in Smithsonian collections! appeared first on Smithsonian Insider.

Flitting swiftly through the darkness above the tropical forest canopy in Central and South America, a group of cute little bats with dog-like faces have […]

The post More sky puppies! Scientists discover two new species of dog-faced bat appeared first on Smithsonian Insider.

Flying through the air? Check. Surviving snake bites? Check. One of the most adorable creatures on earth? Absolutely! Do you think you know everything about […]

The post This Squirrel Appreciation Day we have a few surprising squirrely facts for you appeared first on Smithsonian Insider.

Every day, astronomers at the Harvard-Smithsonian Center for Astrophysics depend on computers to help them solve the mysteries of the universe, just as they did […]

The post Underpaid women “computers” mapped the universe in the 19th century appeared first on Smithsonian Insider.

Scott J. Neal, Qingxiang Zhou, and Francesca Pignoni

The specification of organs, tissues and cell types results from cell fate restrictions enacted by nuclear transcription factors under the control of conserved signaling pathways. The progenitor epithelium of the Drosophila compound eye, the eye imaginal disc, is a premier model for the study of such processes. Early in development, apposing cells of the eye disc are established as either retinal progenitors or support cells of the peripodial epithelium (PE), in a process whose genetic and mechanistic determinants are poorly understood. We have identified Protein Phosphatase 2A (PP2A), and specifically a STRIPAK-PP2A complex that includes the scaffolding and substrate-specificity components Cka, Strip and SLMAP, as a critical player in the retina-PE fate choice. We show that these factors suppress ectopic retina formation in the presumptive PE and do so via the Hippo signaling axis. STRIPAK-PP2A negatively regulates Hpo kinase, and consequently its substrate Wts, to release the transcriptional co-activator Yki into the nucleus. Thus, a modular higher-order PP2A complex refines the activity of this general phosphatase to act in a precise specification of cell fate.

Xian Hu, Salma Jalal, Michael Sheetz, Oddmund Bakke, and Felix Margadant

Despite progress made in confocal microscopy, even fast systems still have insufficient temporal resolution for detailed live cell volume imaging, such as tracking rapid movement of membrane vesicles in three-dimensional space. Depending on the shortfall, this may result in undersampling and/or motion artifacts that ultimately limit the quality of the imaging data. By sacrificing detailed information in the Z-direction, we propose a new imaging modality that involves capturing fast "projections" from the field of depth which shortens imaging time by approximately an order of magnitude as compared to standard volumetric confocal imaging. With faster imaging, radiation exposure to the sample is reduced, resulting in less fluorophore photobleaching and potential photodamage. The implementation minimally requires two synchronized control signals that drive a piezo stage and trigger the camera exposure. The device generating the signals has been tested on spinning disk confocals and instant structured-illumination-microscopy (iSIM) microscopes. Our calibration images show that the approach provides highly repeatable and stable imaging conditions that enable photometric measurements of the acquired data, in both standard live imaging and super-resolution modes.

M. Pinar and M. A. Penalva

TRAnsport Protein Particle (TRAPP) complexes regulate membrane traffic. TRAPPII and TRAPPIII share a core hetero-heptamer, also denoted TRAPPI. In fungi TRAPPIII and TRAPPII mediate GDP exchange on RAB1 and RAB11, respectively, regulating traffic across the Golgi, with TRAPPIII also activating RAB1 in autophagosomes. Our finding that Aspergillus nidulans TRAPPII can be assembled by addition of a TRAPPII-specific subcomplex onto core TRAPP prompted us to investigate the possibility that TRAPPI/TRAPPIII already residing in the Golgi matures into TRAPPII to determine a RAB1-to-RAB11 conversion as Golgi cisternae progress from early Golgi to TGN identity. By time-resolved microscopy we determine that the TRAPPII reporter Trs120/TRAPPC9 is recruited to existing TGN cisternae slightly before RAB11 arrives, and resides for~45 sec on them before cisternae tear off into RAB11 secretory carriers. Notably, the core TRAPP reporter Bet3/TRAPPC3 was not detectable in early Golgi cisternae, being instead recruited to TGN cisternae simultaneously with Trs120/TRAPPC9, indicating en bloc recruitment of TRAPPII to the Golgi and arguing strongly against the TRAPP maturation model.

In the battle against invasive species, giant commercial ships are on the front lines. But even when they follow the rules, one of their best […]

The post Battle against invasive marine species comes up short as global shipping surges appeared first on Smithsonian Insider.

On Monday, Aug. 21, beginning shortly after 9 a.m. Pacific Time, the sky will darken across North America as the moon’s orbit carries it between […]

The post Enrich your solar eclipse experience with this new app! appeared first on Smithsonian Insider.

A novel approach for finding and evaluating structural models of small metallic nanoparticles is presented. Rather than fitting a single model with many degrees of freedom, libraries of clusters from multiple structural motifs are built algorithmically and individually refined against experimental pair distribution functions. Each cluster fit is highly constrained. The approach, called cluster-mining, returns all candidate structure models that are consistent with the data as measured by a goodness of fit. It is highly automated, easy to use, and yields models that are more physically realistic and result in better agreement to the data than models based on cubic close-packed crystallographic cores, often reported in the literature for metallic nanoparticles.

The post Salamanders: The Hidden Jewels of Appalachia appeared first on Smithsonian Insider.

The post With the recent hatching of two Cuban crocodiles, the National Zoo just got a little snappier! appeared first on Smithsonian Insider.

If a supernova vaporized Earth’s ozone layer, what would happen to life in the ocean? Smithsonian biologist Pat Neale shows how UV rays could harm […]

The post If a supernova vaporized our ozone layer, what would happen to life on Earth? appeared first on Smithsonian Insider.

myVolcano is a crowd-sourcing app that enables you to share your photographs and descriptions of volcanic hazards, as well as collecting samples and measurements of […]

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The Smithsonian’s National Museum of Natural History released a new mobile app “Skin and Bones” Jan. 13. The free app is available for download in […]

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Judy Garland’s iconic ruby slippers from “The Wizard of Oz” are one of the most popular attractions at the National Museum of American History. But […]

The post Crowdfunding campaign to restore Ruby Slippers surpasses mark appeared first on Smithsonian Insider.

Happy Holidays from the Smithsonian’s National Air and Space Museum!

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Smithsonian staff gathered on Thursday, June 1 outside the National Museum of African American History and Culture to show their support and listen to Director […]

The post Smithsonian staff rally to support African American History Museum after noose incident appeared first on Smithsonian Insider.

 The zoo extends the collecting mission of the Smithsonian into the realm of the living. From the Series: Stories From the Vault: Random? http://bit.ly/2gfy5hO

The post Keeping zoo animals happy, healthy appeared first on Smithsonian Insider.

The post Happy Holidays from Smithsonian’s National Zoo appeared first on Smithsonian Insider.

Power App is a Google Chrome extension that has a description of "This extension configures your Default Search to Power App (searchpowerapp.com)".

This article was published first at Remove the Power App Chrome Extension

If searches from a browser's address bar and possibly search engines are being redirected through the site https://searchpowerapp.com/, then you most likely have a browser extension or addon installed that is causing these redirects. Some extension will cause all of the searches from your browser's address bar to redirect through https://searchpowerapp.com/, which eventually redirects to Yahoo.com.

This article was published first at Remove the Searchpowerapp.com Search Redirect

The Windows Defender Browser Protection tech support scam is a fake web site alert that states that Windows Defender Browser Extension detected someone to hack your bank account.

This article was published first at Remove the Windows Defender Browser Protection Tech Support Scam

Flash App+ is a Google Chrome extension that has a description of "This extension configures your Default Search to Flash App+ (searchpowerapp.com)".

This article was published first at Remove the Flash App+ Chrome Extension

The post Introducing Leafsnap, an electronic field guide to North America trees run on a mobile phone app appeared first on Smithsonian Insider.

Bird species in rainforest fragments in Brazil that were isolated by deforestation first disappeared and then reappeared during the next quarter-century.

The post “Extinct” birds reappear in rainforest fragments in Brazil appeared first on Smithsonian Insider.