The Delaware Department of Health and Social Services (DHSS) and Partnership for Drug-Free Kids are collaborating to bring dedicated, science-based resources and support to Delaware families. The two entities will work together to provide innovative, digital resources and one-on-one support to parents and caregivers as they help a loved one struggling with opioids or other […]

WILMINGTON (Nov. 21, 2019) – The Delaware Department of Health and Social Services (DHSS), Partnership for Drug-Free Kids and Google have launched a first-in-the-nation partnership to bring needed resources to Delaware families looking for help online for a loved one struggling with substance use disorder. DHSS will work with Partnership and Google to identify communication […]

Let’s be honest, there is a lot of SAS content available on the web. Sometimes it gets difficult to navigate through everything to find what you need, especially if you are looking for complimentary resources. Training budgets can be limited or already used for the year, but you’re still interested [...]

Tips and resources for making the most of your SAS experience was published on SAS Users.

To help achieve public compliance with laws and regulations, officers from Feb. 3-9 made 869 public contacts and responded to 22 complaints.

To help achieve public compliance with laws and regulations, officers from Feb. 10-16 made 1,508 public contacts.

To help achieve public compliance with laws and regulations, officers from Feb. 17-23 made 1,376 public contacts and responded to 53 complaints.

To help achieve public compliance with laws and regulations, officers from Feb. 24 - March 1 made 1,812 public contacts and responded to 34 complaints.

To help achieve public compliance with laws and regulations, officers from March 2-8 made 1,351 public contacts and responded to 49 complaints.

DOVER – Delaware State Housing Authority (DSHA) is temporarily pausing application submissions for the Delaware Housing Assistance Program (DE HAP). Pausing the program will allow DSHA to explore how resources from the federal government and others may be used in the coming weeks to continue the program and respond to the ongoing high demand for […]

  A gamer’s life is a hard one. Games pop up left and right and by the dozens and really, how many games can a gamer play in the limited time that he has at his disposal? And it’s not just g...

ResourceSpace suffers from cross site scripting, html injection, insecure cookie handling, and remote SQL injection vulnerabilities. Versions 6.4.5976 and below are affected.

The Microsoft Windows kernel suffers from a 64-bit pool memory disclosure vulnerability via REG_RESOURCE_LIST registry values (CmResourceTypeDevicePrivate entries).

The Microsoft Windows kernel suffers from a 64-bit pool memory disclosure vulnerability via REG_RESOURCE_LIST registry values (videoprt.sys descriptors).

The Microsoft Windows kernel suffers from a 64-bit pool memory disclosure vulnerability via REG_RESOURCE_REQUIREMENTS_LIST registry values.

Missouri’s smallest investor-owned utility is charting a dramatically different course two years after being acquired by new owners.

The round was led by Ecosystem Integrity Fund with participation from Equinor Energy Ventures and Evergy Ventures

Missouri’s smallest investor-owned utility is charting a dramatically different course two years after being acquired by new owners.

The round was led by Ecosystem Integrity Fund with participation from Equinor Energy Ventures and Evergy Ventures

Missouri’s smallest investor-owned utility is charting a dramatically different course two years after being acquired by new owners.

Japanese chemical giant Sumitomo Chemical group has spent approximately ¥15 billion (A$177 million) on Botanical Resources Australia, a Tasmanian pyrethrum business.

Tidal energy developer Atlantis Resources remains on track to deliver power to the Scottish power grid from the MeyGen site in the coming year, according to an end-of-year statement issued by the company earlier this week.

Missouri’s smallest investor-owned utility is charting a dramatically different course two years after being acquired by new owners.

Support services for victims and witnesses, the police and other relevant authorities are stretched to the limits because of staff shortages, travel restrictions or other demands related to Covid-19.

On 15 March 2020, following the announcement by President Ramaphosa regarding South Africa’s precautionary measures that must be put in place to prevent the contraction and spread of COVID-19, South Africans came face to face with the stark re...

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The government of Indonesia wanted to improve land and water management in the Citarum River Basin, and requested assistance from the Asian Development Bank (ADB) to develop a long-term integrated water resources management (IWRM) investment program as part of its strategic road map. In December 2008, ADB approved a multitranche financing facility (MFF) for the Integrated Citarum Water Resources Management Investment Program to support the implementation of the IWRM road map in the basin. A periodic financing request was formulated to implement priority activities from the road map.

The project’s key objective was to demonstrate an innovative integrated ecosystem and water resources management that will improve the environmental conditions in the Baiyangdian Basin in Hebei province, southwest of Beijing. It focused on the need to conserve Baiyangdian Lake—one of the most important and vulnerable ecosystems in the People’s Republic of China (PRC). It would also contribute to achieving the goals of the Baoding municipality’s Eleventh Five-Year Environmental Protection Plan.

ADB is proposing a project to deliver climate adaptive solutions for water resources management and modernize outdated irrigation and drainage systems within the Amu Darya and selected reaches of the Zarafshan irrigation system.

ADB signed an agreement today to provide $8.32 million in financing to the Government of Pakistan to enable vital preparatory work ahead of a series of major projects to enhance water availability and increase agricultural...

Scotland is committed to be a carbon-neutral society by 2040 and has achieved the important initial step of decarbonizing power production. However, more ambitious measures are required to fully decarbonize all of the electricity, transport and heating sectors.

We explore the potential to use low-carbon GeoEnergy resources and bioenergy combined with Carbon Capture and Storage (BECCS) in the Midland Valley area to decarbonize the Scottish economy and society. The Midland Valley has a long history of geological resource extraction and, as a result, the geology of the region is well characterized.

Geothermal energy and subsurface energy storage have the potential to be implemented. Some of them, such as gravity and heat storage, could re-use the redundant mining infrastructure to decrease investment costs. Hydrogen storage could be of particular interest as the Midland Valley offers the required caprock–reservoir assemblages. BECCS is also a promising option to reduce overall CO₂ emissions by between 1.10 and 4.40 MtCO₂ a^–1. The Midland Valley has enough space to grow the necessary crops, but CO₂ storage will most likely be implemented in North Sea saline aquifers. The studied aspects suggest that the Midland Valley represents a viable option in Scotland for the exploitation of the majority of low-carbon GeoEnergy resources.

Thematic collection: This article is part of the ‘Early Career Research’ available at: https://www.lyellcollection.org/cc/SJG-early-career-research

Surgical procedures are performed in the United States in a wide variety of clinical settings and with variation in clinical outcomes. In May 2012, the Task Force for Children’s Surgical Care, an ad hoc multidisciplinary group comprising physicians representing specialties relevant to pediatric perioperative care, was convened to generate recommendations to optimize the delivery of children’s surgical care. This group generated a white paper detailing the consensus opinions of the involved experts. Following these initial recommendations, the American College of Surgeons (ACS), Children’s Hospital Association, and Task Force for Children’s Surgical Care, with input from all related perioperative specialties, developed and published specific and detailed resource and quality standards designed to improve children’s surgical care (https://www.facs.org/quality-programs/childrens-surgery/childrens-surgery-verification). In 2015, with the endorsement of the American Academy of Pediatrics (https://pediatrics.aappublications.org/content/135/6/e1538), the ACS established a pilot verification program. In January 2017, after completion of the pilot program, the ACS Children’s Surgery Verification Quality Improvement Program was officially launched. Verified sites are listed on the program Web site at https://www.facs.org/quality-programs/childrens-surgery/childrens-surgery-verification/centers, and more than 150 are interested in verification. This report provides an update on the ACS Children’s Surgery Verification Quality Improvement Program as it continues to evolve.

There is increasing interest in developing diagnostics that discriminate individual mutagenic mechanisms in a range of applications that include identifying population-specific mutagenesis and resolving distinct mutation signatures in cancer samples. Analyses for these applications assume that mutagenic mechanisms have a distinct relationship with neighboring bases that allows them to be distinguished. Direct support for this assumption is limited to a small number of simple cases, e.g., CpG hypermutability. We have evaluated whether the mechanistic origin of a point mutation can be resolved using only sequence context for a more complicated case. We contrasted single nucleotide variants originating from the multitude of mutagenic processes that normally operate in the mouse germline with those induced by the potent mutagen N-ethyl-N-nitrosourea (ENU). The considerable overlap in the mutation spectra of these two samples make this a challenging problem. Employing a new, robust log-linear modeling method, we demonstrate that neighboring bases contain information regarding point mutation direction that differs between the ENU-induced and spontaneous mutation variant classes. A logistic regression classifier exhibited strong performance at discriminating between the different mutation classes. Concordance between the feature set of the best classifier and information content analyses suggest our results can be generalized to other mutation classification problems. We conclude that machine learning can be used to build a practical classification tool to identify the mutation mechanism for individual genetic variants. Software implementing our approach is freely available under an open-source license.

Reactive oxygen and nitrogen species have been implicated in many biological processes and diseases, including immune responses, cardiovascular dysfunction, neurodegeneration, and cancer. These chemical species are short-lived in biological settings, and detecting them in these conditions and diseases requires the use of molecular probes that form stable, easily detectable, products. The chemical mechanisms and limitations of many of the currently used probes are not well-understood, hampering their effective applications. Boronates have emerged as a class of probes for the detection of nucleophilic two-electron oxidants. Here, we report the results of an oxygen-18–labeling MS study to identify the origin of oxygen atoms in the oxidation products of phenylboronate targeted to mitochondria. We demonstrate that boronate oxidation by hydrogen peroxide, peroxymonocarbonate, hypochlorite, or peroxynitrite involves the incorporation of oxygen atoms from these oxidants. We therefore conclude that boronates can be used as probes to track isotopically labeled oxidants. This suggests that the detection of specific products formed from these redox probes could enable precise identification of oxidants formed in biological systems. We discuss the implications of these results for understanding the mechanism of conversion of the boronate-based redox probes to oxidant-specific products.

Site-specific recombinases, such as Cre, are a widely used tool for genetic lineage tracing in the fields of developmental biology, neural science, stem cell biology, and regenerative medicine. However, nonspecific cell labeling by some genetic Cre tools remains a technical limitation of this recombination system, which has resulted in data misinterpretation and led to many controversies in the scientific community. In the past decade, to enhance the specificity and precision of genetic targeting, researchers have used two or more orthogonal recombinases simultaneously for labeling cell lineages. Here, we review the history of cell-tracing strategies and then elaborate on the working principle and application of a recently developed dual genetic lineage-tracing approach for cell fate studies. We place an emphasis on discussing the technical strengths and caveats of different methods, with the goal to develop more specific and efficient tracing technologies for cell fate mapping. Our review also provides several examples for how to use different types of DNA recombinase–mediated lineage-tracing strategies to improve the resolution of the cell fate mapping in order to probe and explore cell fate–related biological phenomena in the life sciences.

BackgroundUrinary tract infections (UTIs) are one of the most common bacterial infections managed in general practice. Many women with symptoms of uncomplicated UTI may not benefit meaningfully from antibiotic treatment, but the evidence base is complex and there is no suitable shared decision-making resource to guide antibiotic treatment and symptomatic care for use in general practice consultations.AimTo develop an evidence-based, shared decision-making intervention leaflet to optimise management of uncomplicated UTI for women aged <65 years in the primary care setting.Design and settingQualitative telephone interviews with GPs and patient focus group interviews.MethodIn-depth interviews were conducted to explore how consultation discussions around diagnosis, antibiotic use, self-care, safety netting, and prevention of UTI could be improved. Interview schedules were based on the Theoretical Domains Framework.ResultsBarriers to an effective joint consultation and appropriate prescribing included: lack of GP time, misunderstanding of depth of knowledge and miscommunication between the patient and the GP, nature of the consults (such as telephone consultations), and a history of previous antibiotic therapy.ConclusionConsultation time pressures combined with late symptom presentation are a challenge for even the most experienced of GPs: however, it is clear that enhanced patient–clinician shared decision making is urgently required when it comes to UTIs. This communication should incorporate the provision of self-care, safety netting, and preventive advice to help guide patients when to consult. A shared decision-making information leaflet was iteratively co-produced with patients, clinicians, and researchers at Public Health England using study data.

Background:

The success of multisite collaborative research relies on effective data collection, harmonization, and aggregation strategies. Data Coordination Centers (DCC) serve to facilitate the implementation of these strategies. The utility of a DCC can be particularly relevant for research on rare diseases where collaboration from multiple sites to amass large aggregate datasets is essential. However, approaches to building a DCC have been scarcely documented.

The COVID-19 pandemic has placed unprecedented pressure on societies worldwide, given the pandemic's rapid, often deadly spread. In health care, the pandemic has raised the pressing question of how society should allocate scarce resources during a crisis.

The newly launched #SmithsonianEdu campaign highlights 1.7 million online tools geared specifically toward students and teachers

Read our live coronavirus updates HERE Health Secretary said his 'heart goes out' to the families of NHS workers killed during outbreak Facing backlash for calling protective equipment for healthcare workers a 'precious resource' Sir Keir Starmer waded into row, calling Mr Hancock's comments 'insulting'

'We have seen this before.' Global health scholars have issued a clarion call about the needless loss of life expected because of a foreseeable prospect of 'slow and inadequate access to supplies' to control COVID-19 in sub-Saharan Africa. They say what is unfolding now is similar to when lifesaving diagnostics and treatments came to the region long after they were available elsewhere.