U.S. intelligence officials say a video that purports to show election fraud in Georgia is fake and the work of “Russian influence actors."

AUM hit by mark-to-market loss, inflows touch ₹Rs 41,887 cr

Sensex, Nifty, Share Prices LIVE: Gift Nifty indicates a likely 100-point gap-down opening for Nifty at 23,870 on Wednesday as global markets remain weak. Analysts cite concerns over an earnings slowdown and persistently high inflation; Jefferies India downgraded full-year earnings for 63% of the 121 large companies it covers due to economic slowing. India’s retail inflation surged to a 14-month high of 6.21% in October, with steep rises in food and metal prices potentially influencing the RBI’s December policy stance. A continued hold on rates seems likely, but analysts at AngelOne note a shallower rate-cut cycle ahead for India, mirroring the US trend. Options data signals resistance around 24,500 due to heavy call writing and support near 23,500, with a bearish put-call ratio drop to 0.52. India VIX rose to 14.60 (+2.40%), suggesting caution; however, lower volatility generally supports bullish sentiment, according to SAMCO’s Dhupesh Dhameja.

Analysts indicate significant pressure on mid-cap and small-cap sectors as a substantial portion of companies fail to meet expectations

Equity mutual funds witnessed a record inflow of Rs 41,887 crore in October, marking a surge of over 21 per cent on a month-on-month (MoM) basis, fuelled by robust investments in thematic funds. This also marks the 44th consecutive month of net inflow in the equity-oriented funds, highlighting the ever-increasing appeal of mutual funds among investors, data with the Association of Mutual Funds in India (AMFI) showed on Monday.

Retail inflation breached the Reserve Bank's upper tolerance level, soaring to a 14-month high of 6.21 per cent in October mainly on account of rising food prices. Inflation based on the consumer price index (CPI) was 5.49 per cent in September and 4.87 per cent in the year-ago month. Retail inflation trended below the RBI's upper tolerance band of 6 per cent since September last year.

‘You don’t throw down shots of liquor with Tabasco in them unless there is a lot on your mind. I would think that the same goes for people who came out to cheer Trump’

Tight end who scored 16 touchdowns for the Boilermakers is picked by the Los Angeles Rams in the fourth round.

Markus Bailey missed most of his senior season with a knee injury but he started 40 games for the Boilermakers.

A Blue Skimmer Dragonfly, photographed yesterday at Campbell's Swamp near Griffith, NSW.

Research Event

Event participants

Dr Maria Ângela Bragança, Secretary of State for Cooperation, Ministry of External Relations, Angola

Bacterial products such as lipopolysaccharides (or endotoxin) cause systemic inflammation, resulting in a substantial global health burden. The onset, progression, and resolution of the inflammatory response to endotoxin are usually tightly controlled to avoid chronic inflammation. Members of the NF-κB family of transcription factors are key drivers of inflammation that activate sets of genes in response to inflammatory signals. Such responses are typically short-lived and can be suppressed by proteins that act post-translationally, such as the SOCS (suppressor of cytokine signaling) family. Less is known about direct transcriptional regulation of these responses, however. Here, using a combination of in vitro approaches and in vivo animal models, we show that endotoxin treatment induced expression of the well-characterized transcriptional repressor Krüppel-like factor 3 (KLF3), which, in turn, directly repressed the expression of the NF-κB family member RELA/p65. We also observed that KLF3-deficient mice were hypersensitive to endotoxin and exhibited elevated levels of circulating Ly6C+ monocytes and macrophage-derived inflammatory cytokines. These findings reveal that KLF3 is a fundamental suppressor that operates as a feedback inhibitor of RELA/p65 and may be important in facilitating the resolution of inflammation.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

Epithelial cells are held together and connected by several different types of structures that form cell-cell contacts.

OM responded to the needs of people affected by Typhoon Vinta, relying on military accompaniment to reach the location and deliver aid.

Fears of deepening global slowdown due to the COVID-19 outbreak and subsequent lockdowns have spooked the markets globally, including in India.  Almost all the equity-oriented mutual fund categories registered net inflows last month.

Incoming Bank of England governor Mark Carney explains where he differs with the IMF on austerity, central bank inflation targeting and how he was made Bank of England chief even though he's Canadian.

The Kansas City Chiefs will open defence of their Super Bowl championship by hosting Houston on September 10 (Sept. 11 AEST) in the NFL’s annual kick-off game — pending developments in the coronavirus pandemic, of course.

The SANFL is set to resume without paying players, coaches or umpires.

James Harrison might be the only man in America who wasn't surprised to see Rob Gronkowski return to the NFL -- he tells TMZ Sports he knew a Gronk comeback was in the works since at least November!!! The former Steelers star says he and the future…

Global credit rating agency Fitch Ratings on Monday forecast that inflation in India would touch Reserve Bank of India's (RBI) medium term target range of two-six per cent by end 2018.

The European Commission has proposed an integrated EU approach to stop profits from trading minerals being used to fund armed conflicts. The package of measures aims to make it more difficult for armed groups in conflict-affected and high-risk areas to finance their activities through the mining of and trade in minerals.

This workshop focused on how to comply with international regulations on conflict-free gold supply chains and how to make the most of the OECD Due Diligence Guidance for Responsible Supply Chains of Minerals from Conflict-Affected and High-Risk Areas.

Focused mainly on the Democratic Republic of the Congo, this report takes stock of 5 years of implementation of national and international programmes and initiatives designed to operationalise the recommendations of the OECD Due Diligence Guidance on Responsible Supply Chains of Minerals from Conflict-Affected and High-Risk Areas in the Great Lakes Region of Central Africa.

Despite a small aid budget, Iceland stands out among donors for its commitment to supporting the poorest countries and using its expertise in areas like renewable energy, land restoration and gender equality for aid programmes that advance global goals, according to a new OECD report.

This paper examines how three multilateral environmental agreements (MEAs) incorporate transparency into their regulatory regimes: CITES (endangered species, especially tropical timber), the Basel Convention (hazardous e-waste), and the Kimberley Process (conflict diamonds)

New research points to the role of field-of-study mismatch in explaining the long-term effects of cyclical labour market shocks. It suggests that policy effort ought to be directed not just towards the NEETs, but also towards youth who find employment during recessions, given their higher risk of prolonged field-of-study mismatch and lower wages if mismatch is accompanied by overqualification.

This chapter analyses how skills are used at work, why skills use matters for workers and economies and its key determinants. It draws on data for the 28 OECD countries participating in the Survey of Adult Skills.

OECD work on the independence of regulators and how to protect them from undue influence. Information includes new data from a survey of 48 regulators across the world.

This Forum took stock of the key challenges and trends in regulating money in politics; identify emerging risks and opportunities; shape a common understanding of the policy options ahead and trade-offs in enhancing fairness, integrity and transparency in decision making including in the realm of political finance; and mobilise partners to work together and promote synergies in the future agenda.

South Africa must take urgent steps to proactively investigate and prosecute foreign bribery. No foreign bribery cases have been prosecuted since South Africa joined the Convention in 2007. The 4 on-going investigations – out of only 10 allegations that have surfaced to date – are also far from reaching the prosecution stage, according to a new report by the OECD Working Group on Bribery.

Parents’ level of education still greatly influences that of their children: individuals are 4.5 times more likely to attend higher education if one of their parents has a higher education degree than if both their parents have below upper secondary education.

Results from the OECD Programme for International Student Assessment (PISA) show that, among countries with a comparatively high gross domestic product (GDP) per capita, the amount spent on education is less important than how those resources are used.

A new book reveals how the very wealthy are shaping US society more than is commonly realised

It makes no sense to aim for a high rate in order to create jobs

1. Rare inflammatory syndrome linked to Covid-19 kills 3 kids in New York, says governor Andrew Cuomo  Hindustan Times
2. Children infected with COVID-19 are developing new symptoms similar to Kawasaki disease  WION
3. COVID-19: Cases surpass 4 million worldwide, New York children die from related inflammation  CGTN
4. New York looking further into emerging COVID-19 issue affecting children  The Daily News Online
5. 'Every parent's nightmare': New York is investigating the death of a 5-year-old child from an illness linked t  Business Insider India
6. View Full coverage on Google News

Australia's most popular airline Qantas has released the names of the most watched movies, box sets and comedies on its inflight entertainment system ahead of the new year.

Three children in New York have died and 73 more cases have been reported of a rare inflammatory syndrome exhibiting symptoms similar to Kawasaki disease or toxic shock-like syndrome.

Dave Aspden asked Lancashire garage owner Gary Faulkner for a free exhaust to be fitted on his Vauxhall Cavalier. The garage agreed but Mr Aspden never booked and was told he had to wait.

More and more of us are drawing inspiration from high-end hotels. Even Harry and Meghan seem to be at it, modelling their marital home, according to reports, on Soho Farmhouse in Oxfordshire.

Justin Gaethje delivered the performance of his career to inflict a brutal beating on Tony Ferguson and set up a mouth-watering showdown with Khabib Nurmagomedov for the lightweight title. 

Tarun Jain and Revathy Suryanarayana explore the link between vernacular language use in schools and educational achievement using data from large-scale historical events in South India.

Acute poverty linked to armed conflict and displacement is a major reason for the growing number of commercial sex workers in Manipur. Drug abuse too is common, further impacting those turning to the world's oldest profession. Thingnam Anjulika Samom reports.