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Meet Cyclone: A Monitoring Tool That Watches for Waves of Immune Response

A new algorithm detects when immunotherapies create surges of T cell responses in melanoma patients.



  • News
  • News & Opinion

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A Neural Thermostat Sets the Intensity of Immune Responses

Specialized neurons in the brainstem and vagus nerve provide potential therapeutic targets for treating inflammatory disorders.




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DC residents begin effort to recall Councilman Charles Allen over response to crime

Washington, D.C., Councilman Charles Allen is facing a recall effort led by a former government worker, who cited that the representative of Ward 6 should be more focused on curbing crime.




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Nats second baseman Danny Espinosa to the 15-day disabled list

The locker sat empty in the happy clubhouse, its contents packed away and its occupant gone. Danny Espinosa has been a key contributor to the Nationals since his first promotion from the minor leagues late in the 2010 season. He has played 390 games for Washington, most of them at second base. But on Tuesday he was absent, a glaring void next to his normal spot alongside teammate Ian Desmond’s stall. Around the room loud music blasted from the stereo system after a thrilling 3-2 comeback win over the New York Mets on Tuesday night. Espinosa wasn’t there to enjoy it.




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Nats second baseman Danny Espinosa undergoes MRIs

Nationals second baseman Danny Espinosa underwent MRIs on both his left shoulder and his right wrist on Wednesday.




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After an Inlander article about her links to conspiracy theory websites, Rep. Jenny Graham responds with profanity, threats and another conspiracy website

State Rep. Jenny Graham (R-Spokane) called me on my cellphone the day the Inlander published my story about her unwittingly linking to conspiracy theory posts on Facebook. I called her back immediately — while she was still leaving a voicemail — and was greeted with two blasts of profanity. "You cocksucker!…



  • News/Local News

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Pete Davidson 'Really Excited' for Elon Musk's 'SNL' Hosting Gig Despite Fellow Cast's Criticisms

The 'Trainwreck' actor is looking forward to the upcoming episode which will see the Tesla boss as a host although some of his co-stars are seemingly not happy with the casting.



  • tv
  • Saturday Night Live
  • Pete Davidson;Elon Musk

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Morgan Wallen Excluded From Billboard Music Awards Despite 6 Nods After N-Word Scandal

According to Dick Clark Productions, the 'Whiskey Glasses' singer will not be 'performing, presenting or accepting' any possible trophies at the 2021 music awards show.




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The Weeknd Remains Uninterested in Joining Grammys Despite Changes in Nomination Process

The 'Blinding Lights' hitmaker still refuses to be a part of the Grammys although he commends the organization for shutting down nomination review committees.




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Josh Duggar to Be Released From Prison Despite Allegations of Him Possessing 65 Child Porn Pics

While he is not allowed to return to his family home, the former '19 Kids and Counting' star is reportedly granted unlimited contact with his six children as long as his wife Anna Duggar is present.




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Tristan Thompson's Legal Team Sends Sydney Chase Cease and Desist Twice Despite Her Denial

The Instagram model, who previously claimed that she had hooked up with the basketball player, denies reports which say that the NBA star has slapped her with a legal notice.




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YFN Lucci Isn't a 'Gang Member' Despite Being Indicted for Racketeering, Attorney Insists

Just months after being released from prison on his murder charge, the 'Everyday We Lit' rapper reportedly will be ordered back to jail as he is named in a 105-count racketeering indictment.




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Pete Davidson 'Really Excited' for Elon Musk's 'SNL' Hosting Gig Despite Fellow Cast's Criticisms

The 'Trainwreck' actor is looking forward to the upcoming episode which will see the Tesla boss as a host although some of his co-stars are seemingly not happy with the casting.



  • tv
  • Saturday Night Live
  • Pete Davidson;Elon Musk

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Josh Duggar to Be Released From Prison Despite Allegations of Him Possessing 65 Child Porn Pics

While he is not allowed to return to his family home, the former '19 Kids and Counting' star is reportedly granted unlimited contact with his six children as long as his wife Anna Duggar is present.




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Ryan Reynolds Has Cheeky Response to 'Mortal Kombat 2' Johnny Cage Casting Rumors

The 'Green Lantern' actor puts together his reactions to fans' speculation that he will be taking on the role in the sequel and his cellular service provider Mint Mobile beating out its competitors in one tweet.




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Jodie Turner-Smith 'Gave It All' During 'Without Remorse' Filming Despite Being Pregnant

The 'Queen and Slim' actress talks about the challenges of filming her new action movie, claiming her pregnancy added 'a layer of complexity' to her role.




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Danny Huston Recalls Desperation to Impress Director Father With Own Skills

Serving behind the lens for the first time in 20 years, 'The Last Photograph' helmer looks back at time time his legendary father John Huston gave one of his first lessons in directing.




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eSpeak-NG: A Compact TTS Solution for Apple Devices

In this episode, Ida Grace introduces eSpeak-NG, a compact open-source software text-to-speech synthesizer available on the App Store for iPhone, iPad, and Mac. Developed by Yury Popov, eSpeak-NG supports over 100 languages and accents. It is built upon the original eSpeak engine created by Jonathan Duddington. The app acts as a compatibility layer between the eSpeak NG library and Apple VoiceOver, enhancing accessibility for users with visual impairments.

eSpeak-NG on the App Store
https://apps.apple.com/us/app/espeak-ng/id6444089174

transcription:
Disclaimer: This transcript is generated by AIKO, an automated transcription service. It is not edited or formatted, and it may not accurately capture the speakers’ names, voices, or content.

Hello AppleVis.

This is Ida again and I'm back with another demonstration.

This one is somewhat by request, so thank you for the person who requested this podcast.

They said that they really wanted a demonstration of this app, so I hope that this is satisfactory.

I am doing a demonstration today of the eSpeak NG app.

This app will add the eSpeak synthesizer to VoiceOver for anybody who wants it.

There are settings that you have to change within the app, or that you can change within the app if you want to, and then you can go into the actual VoiceOver settings to start using eSpeak.

Right now I'm using Daniel, which is not an eSpeak voice, but I will select an eSpeak voice throughout this demonstration.

So I am in the app right now, and the first thing you get...

It says eSpeak NG.

It's eSpeak NG, Daniel.

Learn how to pronounce words, please.

Anyway, so this is the name of the app.

So the first button you come to, if I swipe to the right here, that button allows you to set up what languages you want VoiceOver to have available to you in the eSpeak app.

So if I go in here...

First thing you see is back, of course.

You can search in that field for a specific voice and language.

Okay, I deselected that one because that is not my user-preferred language.

As you can tell by Daniel, he is English UK, not English US, so I deselected that.

But in order to do that, I had to keep going to the right.

Let me show you.

So under user-preferred, the only thing that seems to be there is English United States.

Whether it's selected or not, you can double-tap to select and deselect it.

Under this system heading, it gives you all the languages.

And the only one in here for English right now is English UK because I deselected the English United States.

So that means that when we go into the VoiceOver settings, the eSpeak United States English voices will not be available because I deselected that one.

Because I personally think that United States English eSpeak sounds very bad, which I will demonstrate in a moment.

But you have all of these languages that you can, of course, choose what language is your preferred language in this languages listed below may be poorly supported by VoiceOver and might be broken at all.

They are available in spoken content.

Okay, so that's a little disclaimer about the eSpeak app and the VoiceOver languages that it supports.

Okay, so then it's just going…




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Celebrated war correspondent to speak at Press Club

Veteran of numerous conflicts appearing in Birmingham lunch date.




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Library of Birmingham unveils Shakespeare-inspired collection

New community-curated exhibition opens in the Shakespeare Memorial Room.




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Shakespeare Im.Print unveiled

New exhibition opens in the Shakespeare Memorial Room.







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Shakespeare goes green

Great Big Green Week launches at Shakespeare’s New Place





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"Stranger things have happened, especially in driver's education class."

So I read a children's book as a kid in the 1980s that used the title quote as a running gag. Can anybody identify it? It may or may not have been a guide to surviving school. It was almost certainly a paperback from a Scholastic book order. (I had thought it was by Jovial Bob Stine, but no book of his that the Internet knows of seems to fit. It might have been bundled with one of his books, though?)




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Desperately Seeking URC-1160 (Sorry, Susan)

My Spectrum (formerly TWC) cable box works via RF with a particular remote that comes with it in some areas. Not mine. I've got the IR remote and need the other sort. Can't find it on Amazon or eBay... I've visited the Spectrum offices in my area (Portland, ME) and have been told that, in my area, the new cable box I have (the Spectrum 201-T, which is actually the Technicolor WorldBox) does not ship with its regular, RF-capable remote, the URC-1160. In some parts of the country, however, it does.

I've searched online to find a replacement--no dice. I've also called Spectrum, to see if they will send me one, and I was told that they can only request a new remote, not specify what sort. They shipped me another IR remote.

How can I get my hands on one of these URC-1160s?




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Despite The Pandemic, Atlanta United Returns To The Pitch

Atlanta United is the first professional sports team from Georgia to return to play during the coronavirus pandemic. Major League Soccer suspended play in March less than a month into the season. GPB Sports' Jon Nelson joined GPB All Things Considered host Rickey Bevington to explain why Saturday night's soccer match will be anything but normal.




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By salishsea in "Respecfully agree to disagree" on Ask MeFi

I actually got paid to do this.

For three years (from 1996 to 1999) I worked as a Public Information and Consultation Advisor for the Federal Treaty Negotiation Office in British Columbia. It was essentially my job to talk to angry and racist non-native people about the land claims settlements we, the federal government, were negotiating with First Nations.

One thing that helped me do this job was a story I heard Utah Phillips tell at the 1997 Vancouver Folk Music Festival. Seems one day he was told of an old cowboy in New Mexico who was dying. This old cowboy had ridden on some of the last cattle drives on the Great Plains in the 1800s and had scores of songs in his head about that time. Utah made an effort to go visit him on his death bed way out in the desert. When he got to the cowboy's cabin, a nurse answered the door, said he was expected and asked him to wait in the sitting room while she got the cowboy ready for the visitor.

The cowboy was an avid reader and had many hundreds of books. As he was waiting Utah scanned the shelves and saw what was what. He was surprised and shocked to see tract after tract from the John Birch Society, a virulent right wing political movement that clashed deeply with Utah's own hard left politics. Utah reflected on the predicament he was in. Here was this cowboy full of all of these songs, and there was this irresolvable political gap between them.

But thinking on it more, Utah realized that the REASON the cowboy had so many political books is that he didn't actually KNOW much about politics. In fact if he were to ask the old man about politics, he knew the old man would only give him lies, stuff that he didn't believe but that was recited out of the books. Utah Phillips noted that there was not one book on cowboys or cowboy music on the book shelves, and that's what Utah was there for. He entered the bedroom of the dying cowboy and passed a lovely day trading songs and stories of the cattle drives of the 19th century.

In conclusion Utah said "You know, if you talk to people about what they know, they will always tell you the truth."

That line stayed with me as I ventured in cowboy country shortly afterwards. I was meeting with a group of loggers and ranchers in Williams Lake, in the interior of British Columbia and they were a hard crew. Every month we met and every month they told me that they didn't want any land claims settlements with the "goddamn Indians" in their area. One guy, a man I'll call Bob used to go on and on about "you can't make deals with Indians, they can't be trusted, they're no good with their word..." That sort of thing.

Now I am Aboriginal myself, and this rankled after a while. But keeping Utah's words in mind I challenged Bob one day and said, "Bob, you know, I'm Indian and I'm trustworthy and you can make deals with me. I know for a fact that what you're saying is bullshit. It's lies. So I'm not going to ask you about Indians anymore. Instead I'm going to talk to you about something you do know about, and that is logging. Why don't you take me out to see your operation?"

Bob agreed and the next day I met him at 5:00am with a thermos of coffee and a box of Tim Hortons and we climbed into his F350 and headed out into the Cariboo Mountains. We drove for two hours and the whole time we talked about logging and what it's like being in the business, what kind of markest he was trying to develop, and how much he loved his new machinery He talked about his new feller-buncher like he was a dad with a newborn. Gone was the intransigent racist and here beside me was an interesting man, telling me the truth about what he loved.

When we got out to the cut block where his crew was working, he radioed them in and they came down to get coffee and donuts. Of the 12 guys he had working for him, six were First Nations. I laughed when I met them and asked them if they knew Bob's opinions on the trustworthiness of Indians. "Oh yeah," One of them laughed. "He's an old blowhard!"

But Bob countered by saying that THESE guys were great, that they had been with him for coming on 20 years. THEY were different.

We laughed. Really hard. We talked for a while about what THESE guys felt about land claims and they all had different opinions. Respect arose in the space of nuance and reflection.

So many people parrot opinions. In fact opinions are so often just a front for something else, the yawning abyss of ignorance. Very few people hold fixed opinions about things that matter deeply to them. Instead the hold nuanced and thoughtful interests. That's not to say that I wouldn't claw your eyes out if you hurt my child, but that's different from having an opinion on Tiger Woods or abortion or whether or not Obama is doing a good job. Most of us aren't Tiger, a pregnant woman facing a choice or the President. Most opinions are shallow, and the holder of them guards their superficiality with outrage and emotion to prevent you from getting close and discovering nuance. People hold opinons out of fear or loyalty. But when it comes to something you really care about, it's less about an opinion and more about the nuanced, many layered, complex fabric of knowledge, practical, theoretical, aspirational and emotional

From that day on, I never again talked to Bob about First Nations people, but he became a very involved person in our advisory committee because he had a piece of his heart staked in the process. I came to respect him very much, even though he continued to blow hard against my rookie colleagues and say stupid racist things that somewhere he must have believed. He did it just to put them off guard, to protect his own vulnerabilities and mask his fear. I came to respect what lay beneath the opinion, which was a real fear that land claims would ruin his logging operation. I dismissed the racism but respected Bob and what was really at stake for him. And I think he came to respect me too.

It was the best job I ever had.




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Chicago Mayor Lori Lightfoot On Her City's Response To Unrest Over Police Violence

Copyright 2020 NPR. To see more, visit SCOTT SIMON, HOST: Police reform is the issue that made a lawyer named Lori Lightfoot a political presence in Chicago when she was head of the Chicago Police Board. Of course, she is now Mayor Lightfoot of Chicago and said this week that police misconduct and brutality, quote, "tarnish the badge." Mayor Lightfoot joins us now. Mayor Lightfoot, thanks for being with us. LORI LIGHTFOOT: It's my pleasure, Scott. SIMON: You've led investigations into brutality cases when you were head of the police board and the CPD's Office of Professional Standards. Must also be said that as an attorney in private practice, you represented some police officers. How difficult is police reform? LIGHTFOOT: Well, having seen this issue from a lot of different angles - I also prosecuted corrupt police officers when I was a federal prosecutor. So I've been around this issue for a long time, and really, it comes down to this. You can have all the policies that you want,




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Mourners Pay Respects To Rayshard Brooks At Martin Luther King Jr.'s Church

Updated 7:41 p.m. ET Mourners came to pay their respects to Rayshard Brooks at a public viewing in Atlanta Monday. The Black man was shot and killed during an encounter with white police officers earlier this month after he was discovered asleep in a car at a fast-food restaurant. The viewing was held at the historic Ebenezer Baptist Church where civil rights leader Martin Luther King Jr. was a co-pastor. The funeral service, scheduled for 1 p.m. ET on Tuesday, will also take place at the church. Brooks' death on June 12 added to the fury and anger already felt by demonstrators protesting against systemic racism and police brutality in Atlanta and across the nation. Many of the protests were prompted by the death of George Floyd in custody of Minneapolis police in May. Atlanta-based movie and television mogul Tyler Perry is reported to be covering funeral costs for the family. As NPR reported over the weekend , Clark Atlanta University has also offered full scholarships for his




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Despite Shortfalls And Delays, U.S. Testing Czar Says Efforts Are Mostly 'Sufficient'

Public health experts generally agree that, in spite of improvements, the U.S. still falls short on the testing needed to combat the COVID-19 pandemic. The official who oversees the country's testing efforts, however, maintains the U.S. is doing well on testing now and will soon be able to expand testing greatly using newer, point-of-care tests that deliver quick results. In an interview with NPR's Morning Edition , Adm. Brett Giroir pointed out the U.S. is currently conducting more than 700,000 tests a day. He argued that some parts of the country are already conducting enough tests to contain outbreaks. "We know that in areas of the country right now that have appropriate mitigation, that the testing we have is sufficient. We know right now that the testing we have is dense enough that we can detect very sensitively where there's going to be a problem," the assistant secretary for health in the Department of Health and Human Services told NPR. A recent analysis for NPR by Harvard




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Shakespearean Sonnet Machine

The Shakespearean Sonnet Machine is a slighty pointless little randomiser app that spits out endless variations of Shakespeare's 154 sonnets. (Well, not quite endless, but there should be 562,448,656 different ones in there if you're patient enough to keep reloading.)

[Link




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tbh: Reckoning with Israel / Artists As First Responders

Today, we hear how one Bay Area Jewish teenager is trying to make sense of generations of conflict. Then, how should artists respond when destruction and death are streamed daily to our phones?




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La respuesta del Gobierno es torpe y excesiva: Libreros

Jairo Libreros habla sobre la respuesta del gobierno frente al informe de la ONU




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En 2020 esperamos ver buenos resultados en términos de empleo: MinTrabajo

El Ministro de trabajo habla sobre las cifras de desempleo en Colombia




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Especial de navidad: el significado de las tradiciones

Expertos hablaron del significado y origen de tradiciones como la noche de velitas; el árbol de navidad; el pesebre y el nacimiento de Jesús.




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Cierre de cuentas a Trump: ¿censura o responsabilidad de las redes?




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¿Qué esperar del futuro de las relaciones Colombia-Estados Unidos?

Panelistas creen que cambio de Gobierno es una oportunidad para Colombia en temas como la consolidación de la paz y el medioambiente.




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¿Responde la nueva tributaria a las necesidades que tiene el país?

Panelistas debatieron con base en los pocos puntos que se conocen de la tributaria; creen que hace falta un enfoque en reactivación y generación de empleo.




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La reforma tributaria en la política: ¿qué esperar del Congreso?

Panelistas consideran que texto de la reforma va a sufrir una serie de cambios en el legislativo; también reconocen los esfuerzos del gobierno para equilibrar la balanza.




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Diálogo tras protestas: ¿cómo lograr espacios de consenso?

Panelistas consideran que es clave evitar la estigmatización para tener un diálogo que al tiempo sea abierto a distintos sectores de la sociedad




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Seis meses después ¿cómo avanza la vacunación en el mundo?

Cinco expertos internacionales analizaron de acuerdo con sus experiencias, los avances, retos y problemas presentados durante la vacunación.




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Tras la llegada de Castillo a la presidencia, ¿qué le espera a Perú?

Expertos consideran que difícilmente llegará la calma al país y plantean que el principal reto será la gobernabilidad de Castillo ante el Congreso.




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Episodio 4- Hora2022: Coalición de la Esperanza

Cuatro figuras de la coalición plantearon que el centro es una propuesta de economía de mercado; respeto del Estado de derecho y recuperación de la seguridad.




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Problema en seguridad no se soluciona con comandos especiales: Lucas Gómez

El gerente de Fronteras planteó que se debe ser responsable y no caer en el escenario de estigmatización cuando la criminalidad no tiene pasaporte




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¿Qué le espera a Colombia en el litigio contra Nicaragua en La Haya?

Panelistas creen que el proceso se debe blindar de la polarización política; confían en la defensa del gobierno y ven imposible un diálogo con Nicaragua.




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Atentado en Cúcuta, ¿quiénes son los responsables de la violencia?

Panelistas consideran que una tropa desmoralizada es una de las causas, otros creen que hay relación con la falta de inteligencia y refuerzo de la seguridad por parte de las Fuerzas Militares.




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Coalición Centro Esperanza estuvo en debate de Coaliciones de Caracol Radio

En el marco del proyecto Hora 2022, se llevó a cabo la segunda jornada de debate con los candidatos de la Coalición Centro Esperanza.