vi

Total Quality Management: Paving the Road to Excellence

In our ever-changing world of global business, quality is a cornerstone of success. Organizations striving for excellence cannot afford to overlook Total Quality Management (TQM), a management philosophy centered on the continuous improvement of processes, products, and services through the involvement of all employees. 




vi

Monte Carlo Simulation — An Overview

Monte Carlo simulation helps companies understand process variability and make informed decisions. It's beneficial for quality control in manufacturing.




vi

How AI is Addressing Vital Challenges Across the Metrology Value Chain

In March 2023, after a GPT model passed a biology exam, Bill Gates noted on his blog that AI could save lives and address climate change. If AI can tackle such significant challenges, it can also help with issues faced by manufacturers, metrologists, and quality control professionals. This article will examine the challenges metrologists encounter and highlight potential AI-driven solutions in the metrology value chain.




vi

AI Brings Vision-Guided Robotics Far Beyond Pick-and-Place

As consumers demand higher-quality goods at steadily increasing volumes, the chief benefits of industrial automation — speed, accuracy, and consistency—become more important to businesses worldwide with each passing day. 




vi

ZEISS Leads IMTS Visitors on a Journey to Discover Their Superforce

ZEISS Industrial Quality Solutions is presenting a hero's journey at the 2024 International Manufacturing Technology Show (IMTS) booth #134302 in the East Hall, Level 3.




vi

MSI Viking Expands Partnership with Mahr to Include Advanced Production Metrology Systems

MSI Viking announced the expansion of its long-standing partnership with Mahr Inc.




vi

Sandvik Coromant Supports Future Leaders of Manufacturing at NAIT Awards Ceremony

Sandvik Coromant recently participated in the annual awards ceremony at the Northern Alberta Institute of Technology (NAIT).




vi

Ametek Acquires Virtek Vision International

Ametek, Inc. announced the acquisition of Virtek Vision International, a leading provider of advanced laser-based projection and inspection systems.





vi

Mastercam Appoints Elizaga as VP of Global Sales & Services

Mastercam announced the appointment of Oscar Elizaga as vice president of global sales and services.




vi

Renishaw Receives Industry Partner Award at Davis Technical College Foundation’s Annual Life-Changer Luncheon

Renishaw was recognized for committing its expertise to the CNC Machining program, as well as a host of the company's advanced manufacturing equipment.




vi

Hybrid Metrology Systems Combine Conventional Capabilities with New Technology for Higher Productivity

Metrology is the science of inspection. It includes various measurement tools such as calipers, gauges, micrometers, and vision systems, which are often used for quality control in nondestructive testing (NDT).




vi

Achieving Efficiency and Precision: The Role of Universal Shaft Measurement Machines in Modern Manufacturing

The manufacturing industry relies on precision for safety and performance. Shaft measurement instruments are crucial for ensuring the functionality of mechanical systems.




vi

Advancing Capabilities of Backlit Video Metrology

Backlit video metrology systems offer high-speed and precise inspection capabilities by analyzing digital part shadow images to determine feature position and size. Advancements in computing power and algorithms enhance precision, speed, and feature detection, while integration with part positioning systems allows for composite part images, rotating part profile examination, and rapid part sorting.




vi

Bias in Measurement Uncertainty…And Horror Movies

I kept waking up at 7:47 and also noticed the same time on the clock in the evenings. When I mentioned it to my niece, she said it happens to her too, at a different time of the day.




vi

LEVI LEVITATES A STONE FISH LIMITED EDITION PRINT

LEVI LEVITATES A STONE FISH LIMITED EDITION PRINT by James Christensen is a(n) Limited Edition. The Edition is Limited to Limited to 450 pcs




vi

Coastal View Paper

Coastal View Paper by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Coastal View Canvas

Coastal View Canvas by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Eternal Riviera Paper

Eternal Riviera Paper by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Eternal Riviera Canvas

Eternal Riviera Canvas by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Via Fiore

Via Fiore by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Villa di Mare

Villa di Mare by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Mediterranean Villa Paper

Mediterranean Villa Paper by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Mediterranean Villa Canvas

Mediterranean Villa Canvas by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Riviera Twilight Paper

Riviera Twilight Paper by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Riviera Twilight Canvas

Riviera Twilight Canvas by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Riviera Terrace Paper

Riviera Terrace Paper by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

Riviera Terrace Canvas

Riviera Terrace Canvas by Kerry Hallam is a(n) Limited Edition. The Edition is Limited to pcs




vi

UNION FLEET PASSING VICKSBURG LIMITED EDITION PRINT

UNION FLEET PASSING VICKSBURG LIMITED EDITION PRINT by Tom Lovell is a(n) Limited Edition. The Edition is Limited to Limited to 1500 pcs




vi

Sunrise Vision

Sunrise Vision by JD Challenger is a(n) Limited Edition. The Edition is Limited to Limited Edition 400 pcs




vi

MARC DAVIS IMAGINEERING A DREAM

MARC DAVIS IMAGINEERING A DREAM by Marc Davis is a(n) Limited Edition. The Edition is Limited to LIMITED EDITION #96 OF 200 pcs




vi

Romance on the Riviera Hand Embellished Giclee on Canvas

Romance on the Riviera Hand Embellished Giclee on Canvas by James Coleman is a(n) Limited Edition. The Edition is Limited to 195 pcs




vi

The Nativity Framed Canvas

The Nativity Framed Canvas by Brian Jekel is a(n) Open Edition. The Edition is Limited to Canvas Transfer pcs




vi

Victorious Lion of Judah

Victorious Lion of Judah by C. Michael Dudash is a(n) First Issue. The Edition is Limited to Limited Edition of 3500 pcs




vi

Visionary

Visionary by Christopher Pardell is a(n) Limited Edition. The Edition is Limited to 3319 pcs




vi

Invitation to Rapture Giclee On Canvas

Invitation to Rapture Giclee On Canvas by Arian is a(n) Limited Edition. The Edition is Limited to Limited Edition of 175 pcs




vi

Visions Of Love (Platinum)

Visions Of Love (Platinum) by Brian Davis is a(n) Limited Edition. The Edition is Limited to Limited Edition of 95 pcs




vi

CSTM 2024: Reflections from Canadian Blood Services trainees, part 1

CSTM 2024: Reflections from Canadian Blood Services trainees, part 1


Tuesday, July 09, 2024 Trainees

The Canadian Society for Transfusion Medicine (CSTM) annual conference, held in partnership with Canadian Blood Services and Héma-Québec, took place on May 23-26, 2024, in Saskatoon with the theme of “Bridging transfusion communities.” 

Coinciding with CSTM, Canadian Blood Services' annual Research Day also provided a chance for Canadian Blood Services’ extended research network to collaborate, share their research, and connect. We asked two Canadian Blood Services research trainees to reflect on their experiences and key learnings from these events. Read on for their perspectives! 

This blog was prepared by Mahsa Yazdanbakhsh, a PhD candidate in Dr. Jason Acker’s lab in Edmonton, and Carina Paredes, a PhD candidate in Dr. Sandra Ramirez-Arcos' lab in Ottawa. Mahsa and Carina are recipients of Canadian Blood Services Graduate Fellowship Program as well as travel bursaries to support their attendance at these events. 

Carina (left) and Mahsa (right) are pictured attending Canadian Blood Services’ Research Day event in Saskatoon, May 2024. Photo provided by Emily Wright.

1. You both contributed as planning committee members for Research Day 2024; why were you interested in contributing in this way?  

Carina:  

I volunteered for the Research Day organizing committee because I wanted to improve skills such as leadership and organizational abilities and because I believe that actively participating at Research Day is an opportunity for us [trainees] to engage in knowledge dissemination, networking and collaboration that will support our future careers!   

The best part of participating in this event was being an active part of the organizing committee and connecting with trainees, scientists, and managers, which provided me with a great opportunity to network.   

Mahsa:  

I contributed to Research Day 2024 as a planning committee member and moderated a session of presentations. My role involved organizing speaker sessions and supporting team communication. Having attended previous Research Days, I was eager to help enhance the event and being on the planning committee gave me a deeper appreciation for the effort involved while collaborating with a dedicated team. I learned valuable skills in event planning, teamwork, and problem-solving. Additionally, it expanded my network and allowed me to connect with many professionals at Canadian Blood Services.  

It's important for trainees to be involved because it offers leadership experience and fosters a greater connection to the academic community. 

2. Did you also share your research during Research Day and/or CSTM and if so, in what ways? 

Carina:  

I was selected for a Poster presentation at CSTM and I was also able to briefly present it at Research Day. My poster was titled “Role of the efflux pump NorB in survival and increased quinolone resistance of Staphylococcus aureus grown in platelet concentrates.” Staphylococcus aureus is a round-shaped bacterium that is naturally found in the skin and mucosa of healthy humans. It is important to study because contamination of blood components with this bacterium is a major safety threat to transfusion patients. My work aims to unravel the role of a specific gene in antibiotic resistance and virulence of Staphylococcus aureus when grown in platelet components.  

“Having this opportunity to present my work allowed me to receive feedback from peers and experts from different areas of the transfusion medicine. I find this aspect of presenting and sharing my work very important especially because the feedback received will direct me to improve my work and attain stronger research outcomes.” 

Mahsa:  

I presented my research during CSTM and Research Day through a poster and a rapid trainee presentation. My poster was titled, "Osmotic Variability in Red Blood Cells from Different Blood Donor Groups." A typical red blood cell’s lifespan is 120 days. This study compared how younger and older red blood cells from frequent and non-frequent blood donors respond to osmotic changes. Osmotic changes relate to the balance of fluid within a cell. Results showed significant differences in osmotic response among different donor groups, and these results may be useful for optimizing blood product quality and functionality. 

“Sharing research at these events provides an opportunity to disseminate findings to a broader audience within the transfusion community, which is important because the research contributes to existing knowledge in the field and has the potential to influence future research directions and clinical practice.”  

Overall, presenting at Canadian Blood Services’ Research Day and CSTM allows for collaboration, knowledge exchange, and advancements in the field of transfusion medicine, ultimately benefiting patients and health-care providers alike. 

3. How many times have you attended Research Day and CSTM and what was your favourite moment or takeaway this year?  

Carina: 

I attended Research Day and CSTM in 2023 and 2024. I really enjoyed every day of this event, but the highlight of this year was to visit the Vaccine and Infectious Disease Organization (VIDO) facilities in Saskatoon and learn more about their very interesting work. I was very pleased to listen to the keynote speakers at CSTM and their opening remarks. 

Mahsa:  

This marked my third participation in CSTM and second in Research Day, and the highlight was the reunion with familiar faces after a year! Meeting my close friend, whom I hadn't anticipated seeing at CSTM, was particularly delightful and added an extra layer of joy to the event for me. 

4. What would you say to other trainees about Research Day and/or CSTM? 

Carina:  

It’s a great opportunity for improvement and promotes learning, collaboration and innovation. It also allows us trainees to learn from each other's experiences, receive feedback from experts, and improve our individual performance. 

“I would say to other trainees: Participate, be present and get involved! As a trainee, it is important to not only present our research, but also to engage in organizational activities that will build our skill set for our future career.” 

Mahsa:  

I would encourage other trainees to actively participate in both Research Day and CSTM. Attending Research Day provides a platform to present your work and receive constructive feedback, while CSTM offers a broader networking opportunity within the transfusion community. These events offer opportunities for trainees in Canadian Blood Services’ research and education network to share research findings, receive feedback, and network with peers and experts. 

“By participating in these events, you not only contribute to the advancement of knowledge in transfusion medicine but also refine skills and establish connections that can be beneficial for your future endeavors.” 


Canadian Blood Services – Driving world-class innovation  

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.  

Related blog posts


Thursday, June 29, 2023
Abby Wolfe

Canadian Blood Services supports capacity building in transfusion medicine through the support of research and physician trainees. In this blog, trainees reflect on their experiences attending CSTM 2023 in Montreal.


Thursday, April 25, 2024
Dr. Matthew Yan

Canadian Blood Services is looking forward to connecting with members of the transfusion community at CSTM 2024, happening this May in Saskatoon! In lead-up to the event, a series of blogs will preview some of the contributions of our research and education network to CSTM 2024.


Thursday, May 16, 2024
Dr. Bill Sheffield

Canadian Blood Services is looking forward to connecting with members of the transfusion community at CSTM 2024, happening this month in Saskatoon! In this third post in a series of blogs counting down to CSTM 2024, Dr. William (Bill) Sheffield shares what he’s looking forward to about this year’s events.




vi

CSTM 2024: Reflections from Canadian Blood Services trainees, part 2

CSTM 2024: Reflections from Canadian Blood Services trainees, part 2


Tuesday, July 16, 2024 Poojan Joshi

The Canadian Society for Transfusion Medicine (CSTM) annual conference, held in partnership with Canadian Blood Services and Héma-Québec, took place on May 23-26, 2024, in Saskatoon with the theme of “Bridging transfusion communities.”

Coinciding with CSTM, Canadian Blood Services' annual Research Day also provided a chance for Canadian Blood Services’ extended research network to collaborate, share their research, and connect. Following these events, we asked Canadian Blood Services research trainees to reflect on their experiences and key learnings from the event.

This blog was prepared by Poojan Joshi, a research assistant working with Canadian Blood Services social scientists Drs. Jennie Haw and Kelly Holloway.

Dr. Jennie Haw (left), Dr. Kelly Holloway (centre) and Poojan Joshi (right) are pictured attending Research Day in Saskatoon. Photo by Emily Wright, Canadian Blood Services.

What was it like attending your first Canadian Blood Services Research Day and CSTM conference as a research assistant? 

Attending CSTM 2024 for the first time (it was also my first conference ever!) as a social science research assistant was an incredible experience for many reasons. As I listened to the various presentations and engaged with experts in the field, I was struck by the vast array of knowledge and experience attendees brought to the field of transfusion medicine. I was also humbled by the multidisciplinary collaborations that go into building and maintaining an efficient blood system. 

My background includes training in social psychology and qualitative research methods from the University of Guelph, where I developed interest in areas such as health, immigration and refugees, public and media discourse and policy. In December 2022, I had the opportunity to work on a social science research project with Dr. Kelly Holloway and Dr. Jennie Haw titled “Addressing Systemic Barriers to Donation for Donors of African and South Asian Ancestry.” This project aligned very well with my research interests and underscored the importance of applying a broader sociocultural perspective to donation practices and research. I soon realized that my diverse interests were more connected than I had originally thought as I began to understand donation as a complex social act embedded in a wide sociocultural and political context. 

This understanding allowed me to view the presentations, posters, and plenary sessions of Research Day and CSTM 2024 through a social science lens. In doing so, I appreciated the impact that social science has on many aspects of the blood system, from donor to recipient, and the critical role it plays in addressing current and future complex challenges.

“Since joining Canadian Blood Services as a full-time research assistant in September 2023, I’ve gained a deeper understanding of the role of social science in transfusion medicine. 

Under the excellent mentorship of Drs. Kelly Holloway and Jennie Haw, I have developed a profound appreciation for the intersection of these fields and the critical insights social science can bring to transfusion medicine.” 

Thinking about Research Day specifically, what learnings or ideas have the presentations sparked for you?

Dr. Chantale Pambrun’s opening remarks highlighted the importance of the blood operator and how research plays a crucial role in improving transfusion medicine and health, as well as several challenges and opportunities ahead. One significant area where social science has played a key role is in donor policies and changes in deferral criteria. Dr. Mindy Goldman’s presentation noted that because donor policies impact blood safety, public perception, and product availability, a multidisciplinary approach is required to balance donor and recipient safety with the maintenance of an adequate supply.

Dr. Kelly Holloway’s presentation on the lived experiences of immunoglobulin recipients demonstrated the importance of incorporating patient stories to advance our understanding of health and inspire positive change. Immunoglobulin products (Ig) are manufactured from plasma and may be needed by patients with immunodeficiencies or autoimmune and alloimmune disorders

What was the most memorable moment from the CSTM 2024 program this year and what reflections did you take away from it?  

Dr. Jennie Haw’s presentation on the systemic barriers to blood donation experienced by donors of African and South Asian ancestry was memorable for me, as it illustrated the strengths and commitment of diverse communities in donating blood and plasma, highlighting the need to address the barriers they face. As I am actively involved in this project, it was powerful to see this perspective of social science shared with experts.

Another memorable session was the plenary on Indigenous health and well-being in Northern Saskatchewan. Presentations by Rena Sutherland, Janet Tootoosis, and Jack Janvier highlighted key considerations for transfusion medicine, such as trust, relationship-building, community engagement, and patient-centred care. They discussed the challenges of providing transfusions in remote areas and emphasized the importance of collaboration, expertise, resources, and clear communication.

The session also addressed the impact of colonialism, including residential schools, ongoing racism, and the exclusion of Indigenous holistic health views to provide guidance on effectively engaging Indigenous communities using a strengths-based approach. Social science research is crucial in these areas as it helps build and maintain trust through community engagement, ensuring inclusive and culturally safe care for donors and recipients. 

“My time at CSTM 2024 was more than just an academic exercise; it was a recognition of the inseparability of social science from the field of transfusion medicine. The talks and discussions illustrated how societal factors are connected to health outcomes and donor policies.”  

I am excited to carry this knowledge forward to the 2024 International Society of Blood Transfusion conference in June, where I hope to take my learning from a Canadian context and expand it by engaging with international experts in transfusion medicine. By fostering interdisciplinary collaborations and supporting innovative approaches, we can ensure that our blood systems not only operate efficiently but also resonate with the voices and needs of all communities.

Read more about social science and diversity in the blood system in these articles on blood.ca:


Canadian Blood Services – Driving world-class innovation 

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.  

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.  

Related blog posts


Tuesday, July 09, 2024
Trainees

Canadian Blood Services research trainees reflect on the 2024 Canadian Society for Transfusion Medicine (CSTM) conference and their experience as planning committee members for Canadian Blood Services’ Research Day.


Thursday, May 02, 2024
Dr. Jennie Haw

Canadian Blood Services is looking forward to connecting with members of the transfusion community at CSTM 2024, happening this May in Saskatoon! In this second post in a series of blogs counting down to CSTM 2024, Dr. Jennie Haw shares her insights in lead-up to the event.


Thursday, June 29, 2023
Abby Wolfe

Canadian Blood Services supports capacity building in transfusion medicine through the support of research and physician trainees. In this blog, trainees reflect on their experiences attending CSTM 2023 in Montreal.




vi

Driving excellence: The Centre for Blood Research and Canadian Blood Services renew collaboration to advance blood science education and training

Driving excellence: The Centre for Blood Research and Canadian Blood Services renew collaboration to advance blood science education and training


Tuesday, July 30, 2024 Kaitlyn Chuong

This blog was originally prepared by CBR communications and programs coordinator Kaitlyn Chuong and former Canadian Blood Services knowledge broker Dr. Travis Sztainert, with edits provided by Abby Wolfe. 

After more than 20 years, the Centre for Blood Research (CBR) and Canadian Blood Services are proud to share that they have renewed their collaboration agreement which supports education, training and knowledge mobilization for the next generation of trainees and researchers in blood science and transfusion at CBR.  

The collaboration agreement which is administered by Innovation and Portfolio Management at Canadian Blood Services has recently been extended for three more years to 2027. This agreement formalizes the next iteration of this long-standing partnership and is the result of continued commitment from both organizations to improve blood research.  

This partnership emerged in response to recommendations made following Canada’s public inquiry into the contaminated blood crisis of the 1980s and 1990s. Thus, to address a recognized gap in transfusion science knowledge, in 2002, a group of visionary blood researchers at the University of British Columbia (UBC) established Canada’s first interdisciplinary blood research centre — an entirely unique and valuable resource for established and emerging blood scientists. With its creation, the CBR brought together a wide range of multi-talented investigators to develop highly specialized labs to study blood and transfusion science. Since its inception, the CBR has grown to include more than 35 basic science, applied science, social science and clinical investigators in 12 departments, representing 6 faculties at UBC, with a focus on advancing knowledge of transfusion science and medicine in the lab and in the clinic.  

"We are delighted to extend our partnership with the Centre for Blood Research through 2027. This renewal highlights our shared commitment to advancing education, training, and research in transfusion science. Together, we aim to drive innovation and improve transfusion practices, ensuring a safer and more effective future for the Canadian blood system." 

Dr. Chantale Pambrun
Senior Medical Director, Innovation & Portfolio Management 

“The long-term relationship of Canadian Blood Services and the CBR has been nothing less than fantastic! By combining resources and sharing knowledge, education and research outputs, this unique partnership has resulted in more rapid and meaningful advances that are recognized locally, nationally and internationally. The entire transfusion medicine community has benefitted and will continue to do so.”  

Dr. Ed Conway
Director of the Centre for Blood Research

The partnership of Canadian Blood Services was integral to creating the Centre for Blood Research, providing essential start-up funding and continuing to support infrastructure for the centre and its training and education programs. Several Canadian Blood Services scientists are active members within the Centre for Blood Research including senior scientist Dr. Ed Pryzdial and adjunct scientists Dr. Ed Conway, Dr. Hongshen Ma and Dr. Jay Kizhakkedathu

Learn more about some of the research these scientists and members of their labs undertake in our previous R.E.D. blogs and videos:  

The CBR is grateful for Canadian Blood Services’ continuous support, without which its many educational, training and research programs would not be possible. This includes, for example, CBR’s Graduate Award Program and Summer Studentship Program, as well as the CBR's weekly seminar series and the annual Earl W. Davie and Norman Bethune symposia. 


Canadian Blood Services – Driving world-class innovation  

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.   

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. 

Related blog posts


Tuesday, June 25, 2024
Guest Author

The Centre for Blood Research (CBR) Norman Bethune Symposium gathers scientists, clinicians, healthcare professionals, and trainees to discuss advancements in the field of blood research. The 12th Annual event, held in April 2024, consisted of expert talks on thalassemia, thrombocytopenia, sickle cell disease, and other bleeding disorders, demonstrating the breadth of ongoing research.


Tuesday, May 14, 2024
Abby Wolfe

The 2024 Canadian Blood Services’ Lay Science Writing Competition is open for submissions from research trainees in Canadian Blood Services’ research network until Friday, June 14, 2024. The theme this year is: “Connecting science with society”. Additional competition details available in this post!


Wednesday, February 21, 2024
Dr. Travis Sztainert

In this blog post, read about the 2023 Earl W. Davie Symposium held at the Centre for Blood Research (CBR) - a research event that brings together scientists, medical doctors, healthcare professionals, and trainees in the field of blood research and beyond.




vi

Canadian Blood Services discovery research lab contributes to new knowledge on neutrophils

Canadian Blood Services discovery research lab contributes to new knowledge on neutrophils


Thursday, August 29, 2024 Abby Wolfe

Dr. Donald R. Branch’s work as a discovery scientist at Canadian Blood Services focuses on immunotherapy, seeking to further enhance understanding of the cellular and molecular mechanisms involved in autoimmune diseases. Based in Toronto, Dr. Branch’s laboratory develops models of rheumatoid arthritis, Alzheimer’s disease, immune thrombocytopenia (ITP) and multiple sclerosis in mice. These models are particularly useful in examining how cells affected by these conditions respond to current therapeutic agents like intravenous immunoglobulin – a blood product made from human plasma commonly known as IVIg – and investigating potential alternative therapeutics.  

Over the years, Dr. Branch’s lab research findings have included the discovery of a special reagent that makes identification of antibodies easier by “zapping" autoantibodies,answers around unexpected side effects of IVIg therapy, and insights around recipients’ responses to bone marrow transplantation. It has also earned him numerous awards and accolades, including four from AABB, the Association for the Advancement of Blood & Biotherapies.

Dr. Don Branch, Canadian Blood Services senior scientist

New knowledge about neutrophils

Recently, contributions from Dr. Branch’s lab helped a U.K.-based team of researchers discover new information about how neutrophil function and activity is regulated. Neutrophils are a type of white blood cell that are part of the body’s normal immune response. A person’s neutrophil levels may be affected by infections as well as chronic or acute illnesses. Patients who have very low neutrophil counts and/or persistent infections may receive a boost to their neutrophil levels via granulocyte transfusion therapy. However, in some diseases, overactivation of neutrophils can also create an inflammatory environment and harm healthy tissue.

The research has been published in the high-impact scientific journal, Nature. This publication has filled a gap in knowledge about the mechanisms involved in maintaining balance between neutrophils’ infection-fighting power and inflammation-causing potential. As Dr. Branch describes: “This research by Dr. Brown and team shows that the myeloid inhibitory C-type lectin enzyme, which is known as MICL, controls neutrophil activity in rheumatoid arthritis. It is likely that MICL also regulates neutrophil activity in general. This suggests that if therapeutics can be designed to target MICL, they may be useful in controlling inflammation and infection. It is a fundamental finding that will change our understanding of the biology of neutrophils.”  

Discovery research, like the study to which Don and Ruqayyah contributed, is essential to improving patient care in the long run. New biomedical insights are essential to crafting new drugs and new therapeutic approaches in a rational way.

Dr. William (Bill) Sheffield, Canadian Blood Services senior scientist and associate director of research

Discovery research expertise leads to new collaboration  

The special mouse model that Dr. Branch’s lab uses is known as K/BxN. In this model, two mouse populations are selectively bred to produce offspring whose genetic material carry an antibody that destroys bone cartilage. An arthritis-causing serum containing this destructive antibody can then be obtained from the mice for use as a reagent in research. This process is termed “serum-transfer arthritis” and has been used by many investigators in the study of treatments that may alleviate the condition. 

Knowledge of Dr. Branch’s lab’s expertise in this area prompted a connection to the team of researchers at the Universities of Exeter and Aberdeen in the U.K. for this study. Says Dr. Branch, “In 2021, I supported a successful application to Canadian Blood Services’ Blood Efficiency Accelerator Program (BEAP) by Dr. Maria Fernandes, a researcher from  Héma-Québec who works with neutrophils. Through this collaboration, Dr. Fernandes was aware that I work on rheumatoid arthritis with K/BxN mice, and she also knew that Dr. Gordon Brown in the U.K. was looking to collaborate with a researcher in this area for some planned neutrophil research. My lab, which included postdoctoral fellow Dr. Ruqayyah Almizraq at the time, contributed to Dr. Brown’s research by providing the sera from our K/BxN mice. With this sera, Dr. Brown and his collaborators were able to induce rheumatoid arthritis and show that it could be resolved by removing the inhibition of a specific enzyme.”  

Science that is never boring

The Branch lab is currently using these same mouse models to investigate whether a recombinant protein called IgG1 Fc hexamer could be an effective replacement for IVIg in the treatment of autoimmune conditions like rheumatoid arthritis and ITP. While early results are promising, continued work is needed. In fact, back in 2018, Dr. Branch was asked in a previous R.E.D. blog post to describe what he found to be the most exciting part of science. Reflecting on the same question now, he reiterates that his response still rings true after 50 years in the field:   

The most exciting part of science is that when you do good science, you get more questions than you get answers, which means it is never boring. There is no end to imagination; new ideas, theories, experiments and discoveries occur often and provide a level of excitement to which many other professions cannot attest.

Dr. Donald (Don) Branch, Canadian Blood Services senior scientist


Canadian Blood Services – Driving world-class innovation 

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.   

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. 

Related blog posts


Tuesday, March 28, 2023
Aldis Brennan

Dr. Donald Branch, Canadian Blood Services senior scientist, has received the Dale A. Smith Memorial Award for his discovery of the ZZAP reagent. This award, from the Association for the Advancement of Blood & Biotherapies (AABB), recognizes the application of technology to the practice of transfusion medicine or biotherapies.


Thursday, March 16, 2023
Beth Binnington, Senior Research Assistant

Students from the Undergraduate Pathology Alliance at Western University posed insightful questions to researchers during an interactive visit to the research laboratory of Dr. Donald Branch, Canadian Blood Services senior scientist in February 2023.


Wednesday, February 28, 2018
Dr. Kendra Hodgkinson

For this instalment of “Meet the researcher”, we met with Dr. Donald Branch, a scientist at Canadian Blood Services who studies infectious diseases and immunology. How long have you been with Canadian Blood Services? I started with the Canadian Red Cross at the Edmonton Blood Centre in December 1985...




vi

And the winner of the first Canadian Blood Services Dana Devine Award is…

And the winner of the first Canadian Blood Services Dana Devine Award is…


Tuesday, September 17, 2024 Aldis Brennan


Dr. Melika Loriamini! 

This new award, in honour of Dr. Dana Devine, supports early career scientists in a field related to transfusion science and medicine, blood banking and blood biotherapies. It is awarded in collaboration with the Canadian Society for Transfusion Medicine’s at their annual conference. 

“I truly appreciate the Committee for the recognition and I'm so proud that I'm the first person to win the Dana Devine Award,” Dr. Loriamini says. “When I walked into the conference, I felt like I was famous because everyone knew who I was. It was a great feeling that all the work, all the hard work, during these years that I did, it's now acknowledged, and everyone knows it.” 

Dr. Loriamini began her career in medical laboratory science in Iran, obtaining a Bachelor of Science degree before immigrating to Canada. She completed a second Bachelor’s degree, this time in biomedical science from York University, and went on to enroll in the laboratory medicine and pathobiology PhD program at the University of Toronto. While completing her education, Dr. Loriamini worked as a Medical Laboratory Technologist at LifeLabs and the William Osler Hospital. 

As part of her PhD, Dr. Loriamini worked with Canadian Blood Services Senior Scientist Dr. Donald Branch which she says allowed her to “acquire expertise in the fields of transfusion medicine and immunology and we were able to publish various articles.” 

In fact, it was Dr. Branch who first sent her the application for the award and told her he thought she was a strong candidate. 

“I want to say thanks to Dr. Branch, who was my supervisor. Actually, thank you is not enough,” Dr. Loriamini says. “He taught me how to think as a scientist and how to become a scientist. I truly appreciate him. He always trusted me.” 

Dr. Loriamini’s research focused on developing a new drug to help people who have autoimmune cytopenias — a cluster of conditions which causes your immune system to attack your own healthy blood cells. She was able to identify a potential drug which is expected to undergo clinical trials in the future.

In addition to receiving the Canadian Blood Services Dana Devine Award, Dr. Loriamini has also been recognized with the Canadian Blood Services Graduate Fellowship Program award in 2019 and 2021, the AABB Outstanding Abstract Award for Trainees as a Fellow/Post-Doctoral Student in 2022, the SGS travel award from the University of Toronto in 2022, the Best Poster for Translation/Basic research award from Hematology Academic Day in 2023, and the Best Poster for Infectious Diseases, Inflammation, and Immunology award from the 2023-Laboratory Medicine & Pathobiology Research Conference. 

Dr. Loriamini is now a Clinical Practice Leader at Humber River Health in Toronto which allows her to bring her research to a clinical setting. Congratulations Dr. Melika Loriamini! 


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.  

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.

Related blog posts


Wednesday, January 24, 2024
Dr. Travis Sztainert

Read about the new Canadian Blood Services Dana Devine Award program. This blog post, written by the Centre for Blood Research (CBR) includes reflections from individuals who worked with Dr. Devine.


Thursday, June 29, 2023
Abby Wolfe

Canadian Blood Services supports capacity building in transfusion medicine through the support of research and physician trainees. In this blog, trainees reflect on their experiences attending CSTM 2023 in Montreal.


Thursday, April 02, 2020
Dr. Geraldine Walsh

Congratulations to the recipients of funding recently awarded through the Centre for Innovation’s BloodTechNet Award Program and Graduate Fellowship Program. This funding supports innovators in education and graduate students conducting research in the field of transfusion science.




vi

Canadian Blood Services research engineer applies network modelling techniques and mentorship skills to benefit Canada’s Lifeline

Canadian Blood Services research engineer applies network modelling techniques and mentorship skills to benefit Canada’s Lifeline


Tuesday, October 22, 2024 Dr. Emily Freeman

Dr. John Blake is a research engineer at Canadian Blood Services and a Professor in the Department of Industrial Engineering at Dalhousie University. Based in Halifax, Nova Scotia, Dr. Blake and his trainees use engineering principles and various computer-based optimization techniques to inform large scale decisions at Canadian Blood Services.  

Applying network modelling to biologics  

To some, it may be surprising to learn that there is such opportunity to integrate engineering into the health-care focused setting of Canadian Blood Services. However, as Dr. Blake explains, the same engineering principles that apply to the development and quality assurance of other products also apply to biologics such as blood, stem cells and organs. One of these classic engineering approaches currently applied to improving operations at Canadian Blood Services is network modelling.  

Network modelling is a computer-based method that creates a virtual representation of objects and their relation to each other. The resulting models are particularly useful for maintaining adaptability in the collection of blood donations, as well as the distribution and inventory management strategies that allow Canadian Blood Services to remain a safe and reliable provider of life-saving products. 

Dr. Blake making friends while walking the Camino de Santiago in Spain

Contributing to efficiency and sustainability in Canada’s Lifeline  

For Dr. Blake’s team, modelling is not about the data acquired but rather how they can turn existing data into real life change. Part of this approach is ensuring that Canadian Blood Services is asking the right questions when it comes to allocating resources. For example, Dr. Blake has worked on models to assess how changing stem cell donor recruitment will affect the number of matches for Canadian patients. By modelling things such as recruitment approaches, Dr. Blake’s work assists Canadian Blood Services to consistently identify ways to improve Canada’s Lifeline.

Recently, Dr. Blake has also been applying this method to optimize the number and location of mobile and permanent donor facilities across the nation. This redesign of the donation facility network will address the growing demand for donations by bringing Canadian Blood Services’ facilities closer to the donors. 

“I have waited my entire career for a problem of this type – it is truly a once in a lifetime opportunity.”

Dr. John Blake, Canadian Blood Services Research Engineer

Securing the future of Canada’s Lifeline  

To sustain a safe and effective blood system in Canada for years to come, network modelling and optimization is a never-ending process. This is one of the reasons that Dr. Blake is committed to securing the future of transfusion and transplantation systems by training and mentoring the next generation of engineers. In fact, seeing his former students join Canadian Blood Services and dedicate their talents to improving the future of Canada’s Lifeline is one of Dr. Blake’s proudest achievements.  

One of Dr. Blake’s former students, Matt Nelson, is now an industrial engineer at Canadian Blood Services.  

“In my role, I use systematic thinking to build and run complex models; collect and analyze the required data; produce useful results; and explain these results to non-technical leaders on a regular basis,” Matt says. Recently, Matt contributed to the launch and expansion of pathogen-reduced platelets, a new product that was implemented across Canadian Blood Services production sites starting in 2022. The implementation of pathogen-reduced platelets has provided an additional layer of safety for recipients by reducing the risk of potential transfusion-transmitted pathogens without compromising the quality of the component. Matt credited Dr. Blake in helping him develop the necessary skills he now dedicates to safeguarding Canada’s Lifeline:  

“Dr. Blake was the professor who introduced me to the uses of simulation to understand complex non-linear systems. This type of system is very common in situations that have a lot of variability – like the blood system – and simulation allows for exploration of the response of the system to changes.” 

Matt Nelson, Canadian Blood Services Industrial Engineer

Over the years, Dr. Blake’s ongoing modelling work and mentorship activities have also led to many recognitions and awards, but he is most proud of being recognized as Professor of the Year by Dalhousie Undergraduate students, and with awards for his contributions to the Canadian Operational Research Society. He has even the earned the distinction of being Dalhousie’s first engineer to be awarded grant funding from the tri-council agency, Social Sciences and Humanities Research Council (SSHRC). 

“I am proud to work on projects that have a measurable impact on people’s health and well-being,” Dr. Blake says. “I am forever grateful to Dr. Dana Devine for first giving me the opportunity to serve Canadians in this role at Canadian Blood Services.” 


Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.   

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.  

Related blog posts


Tuesday, March 29, 2022
Marie-Soleil Smith

This post was written by Marie-Soleil Smith, PhD Candidate in Dr. Hélène Côté’s Lab at the University of British Columbia, and edited by Dr. Geraldine Walsh, knowledge broker at Canadian Blood Services. It originally appeared on the Centre for Blood Research blog in March 2022.


Monday, January 22, 2018
Dr. Geraldine Walsh

For the latest instalment of “Meet the researcher” we chatted with Dr. John Blake, Canadian Blood Services’ research engineer and also known as “the numbers guy”.


Wednesday, June 13, 2018
Jenny Ryan

On June 5, Canadian Blood Services was honoured to accept the Canadian Operational Research Society's Omandt Solandt Award at a reception in Halifax, Nova Scotia. Michelle Rogerson, Director, Supply Chain (Atlantic), Canadian Blood Services, accepted the award on behalf of the organization. About...




vi

Robot that watched surgery videos performs with skill of human doctor




vi

Divided Nation: Study Shows Most Trump Voters See American Values Under Siege, Deepening Psychological Rift




vi

Mental Fatigue Makes Brain Areas ‘Fall Asleep,’ Leading to More Aggressive Behavior



  • Brain & Behavior

vi

Light Pollution Disrupts Bee Sleep Patterns, Threatening Vital Pollinators



  • Life & Non-humans

vi

Utilizing MapleSim to Improve Assisted Living Devices

A research team from York University have been working on developing more practical and streamlined devices to assist humans with everyday movements, such as standing and sitting. The objective was to determine if energy could be regenerated in prosthetic devices during these movements, similar to the way in which hybrid electric vehicles recover waste heat from braking and convert it into useable energy.




vi

New Version of Maple T.A. Offers Enhanced Connectivity, Workflow among Other Features

Maplesoft™, a leader in software products for technical education and research, today announced an update to its popular testing and assessment tool, Maple T.A.™. Maple T.A. is a powerful online testing and assessment system designed especially for courses involving mathematics, making it ideal for science, technology, engineering, and mathematics (STEM) courses.




vi

MapleSim 2016.2 Improves Modeling Workflow and Tool Chain Connectivity

The latest release of MapleSim has arrived, carrying with it some major updates to the software such as visualization improvements, revision control and new options for toolchain connectivity.




vi

Maplesoft Releases Online Courseware Environment for STEM

Maplesoft today released Möbius, a hands-on learning tool focused on science, technology, engineering and mathematics education. The online courseware environment provides an interactive platform for students to explore STEM concepts, visualize problems and solutions, and receive real-time assessment feedback.