WASHINGTON – Today, the U.S. Environmental Protection Agency (EPA) announced the 2019 winners of the national WasteWise awards. EPA is recognizing the outstanding accomplishments of 11 WasteWise partner organizations.

Sheboygan County, Wis. – Today, the U.S.

WASHINGTON (April 28, 2020) —  Today, the U.S. Environmental Protection Agency (EPA) and State of Indiana announced that recent air monitoring data show the city of Indianapolis, and the areas of Muncie, Lake and Porter counties are meeting federal air quality standards.

Im Dezember bricht in Wuhan eine rätselhafte Lungenkrankheit aus. Es dauert 21 Tage, bis die chinesischen Behörden den Kampf gegen die Seuche einleiten. Hätte die Corona-Pandemie verhindert werden können? Lesen Sie hier die SPIEGEL-Titelstory.

Das Elektroauto Citroën DS3 E-Tense nutzt die gleiche Technik wie Opel Corsa und Peugeot 208. Um sich abzuheben, gibt es ein Feuerwerk an Designdetails - die manchmal nerven. Eine Ausfahrt.

Folgen der Corona-Grenzschließungen: Beim Bundesamt für Migration und Flüchtlinge sind in den ersten Monaten dieses Jahres offenbar fast ein Drittel weniger Asylanträge gestellt worden als im Vorjahreszeitraum.

Ein Missbrauchsvorwurf gegen Joe Biden stürzt die US-Demokraten ins Dilemma. Seine Kritiker sagen: Würde er an den Standards gemessen, die er selbst aufgestellt hat, müsste er seine Kandidatur zurückziehen.

Fußball-Zweitligist Dynamo Dresden muss nach positiven Corona-Fällen für zwei Wochen in Quarantäne. Das könnte den Plan zur Fortsetzung der Saison gefährden. Denn die Chancengleichheit ist jetzt kaum noch gegeben.

Die einen befürworten Schutzmaßnahmen, die anderen protestieren vehement: Rhetoriker Olaf Kramer erklärt, warum die Coronakrise für heftige gesellschaftliche Spannungen sorgt - und wie wir miteinander reden sollten.

Chicago: They were there when you were born and they’re there for you now. Mothers are first responders to any sickness or heartache that their kids have. They don’t come with sirens blaring, but have rescued us when we had a high fever, or tummy ache in the middle of the night.

Every day should be Mother’s Day, because without mothers, none of us would exist. But today is the national holiday, designated 106 years ago by President Woodrow Wilson — a time when cards, flowers, chocolates and breakfast in bed typically accompany the kind words we send mom’s way.

A disabled Brooklynite who ran afoul of Department of Buildings officials by renting out his home to Airbnb users triumphed last week when a Manhattan judge ordered the city to repay his $4,375 fine and cover any additional costs and payouts in his battle with the de Blasio administration. The decision ended a legal battle pitting Stanley “Skip” Karol against the city that began with an anonymous phone call back in July 2018.

Investigators are using additional video footage to reconstruct the February afternoon that Ahmaud Arbery was fatally shot in a quiet southern Georgia neighborhood.

He may have just welcomed a new baby, but Elon Musk can still act like one himself.

Investigators are using additional video footage to reconstruct the February afternoon that Ahmaud Arbery was fatally shot in a quiet southern Georgia neighborhood.

He may have just welcomed a new baby, but Elon Musk can still act like one himself.

A disabled Brooklynite who ran afoul of Department of Buildings officials by renting out his home to Airbnb users triumphed last week when a Manhattan judge ordered the city to repay his $4,375 fine and cover any additional costs and payouts in his battle with the de Blasio administration. The decision ended a legal battle pitting Stanley “Skip” Karol against the city that began with an anonymous phone call back in July 2018.

Hucks, cases, mud, roots, and full commitment by all the riders. And tea drinking. Of course.
( Comments: 9 )

Metropolitan Police Federation chairman says planned 14-day strategy is unenforceable

Top 10 scorers in Purdue men's basketball history

The road to Indianapolis: Why Colts fell in love with Michael Pittman Jr.

When a famed Egyptian actor revealed his daughter had transitioned, the reaction was unconventional.

Long-time Slashdot reader blackbearnh writes: Since the COVID-19 pandemic has made Personal Protective Equipment worth it's weight in gold, Makers have been trying to help bridge the gap. While sewn masks have been the most common solution, the 3D printing community has been pitching in as well. The Montana Mask has been one of the most popular designs... Thursday, the group Make the Masks announced that the design files and STLs to print the mask have been released under the GNU General Public License v3, allowing anyone to print, sell, remix or improve the design, as long as they conform to the license. Importantly, the GPLv3 includes an international non-exclusive patent grant, meaning that even if the inventors decide to apply for a patent, it will not restrict anyone from using the design.

Read more of this story at Slashdot.

The road to Indianapolis: Why Colts fell in love with Michael Pittman Jr.

As tests increase on the Island of Montreal, the city announced Saturday that 33 more people have died and 420 new cases have been confirmed in the past 24 hours.

COVID-19 has been more prevalant in Quebec's women than men, unlike many other of the world's regions according to data published by the Quebec Institute of Public Health on Saturday.

BBC Sport marks Dennis Bergkamp's birthday by looking back at his brilliant winning goal for the Netherlands against Argentina at the 1998 World Cup.

German football will be the first to restart in Europe - here's your guide to following it.

The following article, California Sheriff Refuses to Arrest People Defying Stay-at-Home Order: “There cannot be a new normal”, was first published on 100PercentFedUp.com.

Riverside, California Sheriff Chad Bianco spoke to the Riverside Board of Supervisors on May 5th to say that he will not enforce the stay-at-home order in California. He tells people who are afraid of contracting the coronavirus that they should stay home if they want to. Bianco continues with the suggestion that any business owner […]

Continue reading: California Sheriff Refuses to Arrest People Defying Stay-at-Home Order: “There cannot be a new normal” ...

Members Event

Event participants

G John Ikenberry, Albert G Milbank Professor of Politics and International Affairs, Princeton University; Eastman Professor, Balliol College, Oxford
Chair: Dr Robin Niblett, Director, Chatham House

7 October 2014

Research Event

Event participants

Professor Amitav Acharya, Professor, School of International Service, American University
Chair: Professor Michael Cox, Professor of International Relations, London School of Economics; Associate Fellow, Americas Programme, Chatham House

Invitation Only Research Event

Event participants

Ambassador Linda Thomas-Greenfield, Assistant Secretary of State for African Affairs, US Department of State
Chair: Dame Rosalind Marsden, Associate Fellow, Africa Programme, Chatham House

Research Event

Event participants

Christopher K Johnson, Senior Adviser; Freeman Chair in China Studies, Center for Strategic and International Studies
Chair: Dr Michal Meidan, Associate Fellow, Asia Programme, Chatham House 

Members Event

Event participants

Professor Kerry Brown, Director, Lau China Institute, King's College London; Associate Fellow, Asia Programme, Chatham House
Chair: Isabel Hilton OBE, Founder and Editor, Chinadialogue

Members Event

Event participants

Dr Mukulika Banerjee, Director, South Asia Centre, London School of Economics
Nandan Nilekani, Co-founder and Chairman, EkStep; Chairman, Unique Identification Authority of India (UIAI) (2009-14)
Dr Gareth Price, Senior Research Fellow, Asia Programme, Chatham House
Mihir Swarup Sharma, India Columnist, Bloomberg View; Senior Fellow, Observer Research Foundation, New Delhi
Chair: James Crabtree, Contributing Editor, Financial Times; Senior Visiting Fellow, Lee Kuan Yew School of Public Policy

6 January 2017 , Volume 93, Number 1

Reiterlied posted a photo:

A tribute to Pirates I made last year when winter was coming to an end.

(You can find the blog post I wrote last year at Stuck in Plastic: www.stuckinplastic.com/2019/04/week-17-ching-shih/)

The investigation into the fatal shooting in Brunswick, Georgia, will also look at a neighbor of suspects Gregory and Travis McMichael who recorded video of the incident, authorities said.

Ousted vaccine expert Rick Bright said he is "frustrated at our inability to be heard as scientists."

The White House has halted talks with Congress over any further coronavirus stimulus package as it waits for more information about how U.S. state reopenings affect the economy, White House top economic adviser Larry Kudlow told reporters on Friday. The Senate and House of Representatives have already passed four major bills to address the novel coronavirus outbreak, including three aimed at stabilizing the economy as most Americans have sheltered in place and unemployment has soared.

The government said it's distributing the promising coronavirus drug, remdesivir, to some hard-hit states. Eventually, all 50 states should get it.

Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes recognized by cytotoxic T lymphocytes (CTLs) has hindered the utilization of CD8+ T-cell–mediated immunity and has precluded the development of effectively diversified epitope-based vaccination approaches. In particular, an HPAIV H5N1 CTL-recognized epitope based on the peptide MHC-I–β2m (pMHC-I) complex has not yet been designed. Here, screening a collection of selected peptides of several HPAIV strains against a specific pathogen-free pMHC-I (pBF2*1501), we identified a highly-conserved HPAIV H5N1 CTL epitope, named HPAIV–PA123–130. We determined the structure of the BF2*1501–PA123–130 complex at 2.1 Å resolution to elucidate the molecular mechanisms of a preferential presentation of the highly-conserved PA123–130 epitope in the chicken B15 lineage. Conformational characteristics of the PA123–130 epitope with a protruding Tyr-7 residue indicated that this epitope has great potential to be recognized by specific TCRs. Moreover, significantly increased numbers of CD8+ T cells specific for the HPAIV–PA123–130 epitope in peptide-immunized chickens indicated that a repertoire of CD8+ T cells can specifically respond to this epitope. We anticipate that the identification and structural characterization of the PA123–130 epitope reported here could enable further studies of CTL immunity against HPAIV H5N1. Such studies may aid in the development of vaccine development strategies using well-conserved internal viral antigens in chickens.

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca2+ ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Here, we report crystal structures at 1.8–2.3 Å resolutions of the CRD of murine dendritic cell-immunoactivating receptor (DCAR, or Clec4b1), the CLR that binds phosphoglycolipids such as acylated phosphatidyl-myo-inositol mannosides (AcPIMs) of mycobacteria. Using mutagenesis analysis, we identified critical residues, Ala136 and Gln198, on the surface surrounding the ligand-binding site of DCAR, as well as an atypical Ca2+-binding motif (Glu-Pro-Ser/EPS168–170). By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches. We also observed a hydrophobic groove extending from the ligand-binding site that is in a suitable position to interact with the lipid portion of whole AcPIMs. These results suggest that the hydroxyl group-binding ability and hydrophobic groove of DCAR mediate its specific binding to pathogen-derived phosphoglycolipids such as mycobacterial AcPIMs.