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Rapid detection of monkeypox virus and differentiation of West African and Congo Basin strains using endonuclease restriction-mediated real-time PCR-based testing

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00492B, Paper
Juan Zhou, Fei Xiao, Xiaolan Huang, Jin Fu, Nan Jia, Chunrong Sun, Min Chen, Zheng Xu, Hui Huang, Yi Wang
A novel multiplex ET-PCR assay that integrates PCR amplification, restriction endonuclease cleavage and real-time fluorescence detection was devised to diagnose MPXV infection and distinguish the Congo Basin and West Africa MPXV strains.
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Development of a label-free, sensitive gold nanoparticles-poly (adenine)aptasensing platform for colorimetric determination of aflatoxin B1 in corn

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00605D, Paper
Omid Heydari Shayesteh, Katayoun Derakhshandeh, Akram Ranjbar, Reza Mahjub, Abbas Farmany
In this work, a sensitive colorimetric bioassay method based on poly (adenine) aptamer (polyA apt) and gold nanoparticles (AuNPs) was developed to the determination of aflatoxin B1 (AFB1). The polyA...
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Heparin-stabilized gold nanoparticles embedded in graphene for the electrochemical determination of esculetin

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Anal. Methods, 2024, 16,2256-2266
DOI: 10.1039/D4AY00229F, Paper
Vinicius José da Silva, Luan Gabriel Baumgarten, Juliana Priscila Dreyer, Edson Roberto Santana, Almir Spinelli, João Paulo Winiarski, Iolanda Cruz Vieira
A conductive nanocomposite consisting of heparin-stabilized gold nanoparticles embedded in graphene was prepared for esculetin determination in tea and jam samples.
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Construction of a stable fluorescent sensor based on CsPbBr3/CdS core/shell quantum dots for selective and sensitive detection of tetracycline in ethanol

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2267-2277
DOI: 10.1039/D4AY00032C, Paper
Yang He, Yangjie Li, Han Wang, Site Luo, Haihu Yu
Construction of a stable fluorescent sensor based on CsPbBr3/CdS core/shell quantum dots for selective and sensitive detection of tetracycline in ethanol via a mechanism integrating photoinduced electron transfer.
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Characterizing a visual lateral flow device for rapid SARS-CoV-2 virus protein detection: pre-clinical and system assessment

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02075D, Paper
Natpapas Wiriyachaiporn, Jetnapang Kongrueng, Kannika Sukkuea, Rattana Tanrattanawong, Jarunee Vanichtanankul, Thanaya Saeyang, Tararat Jantra, Deanpen Japrung, Weerakanya Maneeprakorn, Suwussa Bamrungsap, Pareena Janchompoo, Ekawat Pasomsub
Analytical and pre-clinical evaluation of a visual screening lateral flow device for SARS-CoV-2 virus protein detection and its system characterization.
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Anti-aggregation colorimetric sensing of cysteine using silver nanoparticles in the presence of Pb2+

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Published On ::

Anal. Methods, 2024, 16,2378-2385
DOI: 10.1039/D4AY00351A, Paper
Lihui Mao, Yi Zhang, Huan Zhang, Huili Liu, Yong-ping Gao
In this study, an unmodified AgNPs was synthesized to prepare AgNPs-Pb2+ as a probe for colorimetric sensing of cysteine. We developed a AgNPs colorimetric method for the determination of cysteine in urine, utilizing the anti-aggregation principle.
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On-chip light sheet illumination for nanoparticle tracking in microfluidic channels

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Anal. Methods, 2024, 16,2229-2240
DOI: 10.1039/D3AY02290K, Communication
Théo Travers, Gaétan Delhaye, Martinus H. V. Werts, Denis Gindre, Matthieu Loumaigne
A simple and inexpensive method is presented to efficiently integrate light sheet illumination in a microfluidic chip for dark-field microscopic tracking and sizing of nanoparticles.
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A new colorimetric aptasensor for paraquat detection based on the designed aptamer with multiple paraquat binding sites in combination with gold nanoparticles

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2340-2348
DOI: 10.1039/D4AY00053F, Paper
Pakawat Kongpreecha, Sineenat Siri
Given paraquat's environmental health risks, there is a need for a fast and simple detection method. This study presents a novel colorimetric aptasensor with a tailored aptamer, boosting sensitivity by targeting multiple paraquat binding sites.
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A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00146J, Paper
Dumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan-Fan Ding
A fluorescence method based on Cu-triggered click reaction of azide modified CD63 aptamer and alkyne capped Pdots was developed for breast cancer derived exosome detection.
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A simple and rapid colorimetric detection of Staphylococcus Aureus relied on the distance-dependent optical properties of silver nanoparticles

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02189K, Paper
Ngoc Anh Thu Phan, Hoang Men Nguyen, Cam Duyen Thi Vo, Toi Vo Van, Phuoc Long Truong
The quick and accurate diagnosis of pathogens has appeared as a pressing issue in clinical diagnostics, environmental monitoring, and food safety. The current assays are suffering from limited capacities in...
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Quantifying platinum binding on protein-functionalized magnetic microparticles using single particle-ICP-TOF-MS

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00268G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Veronica C. Bradley, Benjamin T. Manard, Lyndsey Hendriks, Daniel R. Dunlap, Amber N. Bible, Ada Sedova, Patricia Saint-Vincent, Brian C. Sanders, Hunter B. Andrews
This work describes an analytical procedure, single particle-inductively coupled plasma-time-of-flight-mass spectrometry (SP-ICP-TOF-MS), that was developed to determine the platinum binding efficiency of protein-coated magnetic microparticles.
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Proximity hybridization based “turn-on” DNA tweezer for accurate and enzyme-free small extracellular vesicles analysis

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00487F, Paper
Jinlin Wu, Xi Mei, Xiaoqin Zhan, Fang Liu, Dongfang Liu
Small extracellular vesicles (sEVs) are a type of extracellular vesicles that carry many types of molecular information. The identification of sEVs is essential for the non-invasive detection and treatment of...
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The preparation of a boronate affinity-based controlled oriented imprinting coating on a silica nanoparticle surface for the separation and purification of shikimic acid in herbal medicine

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00219A, Paper
Yumin Yang, Daojin Li, Bingqian Liu
Shikimic acid (SA) is one of the most effective drugs against the A (H1N1) virus and has high medicinal value.
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Three-dimensional hotspot structures constructed from nanoporous gold with a V-cavity and gold nanoparticles for surface-enhanced Raman scattering

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Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00348A, Paper
Yang Xu, Yan Wu, Jianjun Wei, Yuanyu Zhao, Peili Xue
A nanoporous gold V-shaped resonant cavity (NPGVRC) structure constructed with plasmonic resonance coupling effect. The NPGVRC has excellent SERS performance and 3D hotspot properties.
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Monolith stationary phases prepared via cyclic anhydride ring-opening polymerization as tunable platforms for chromatographic applications

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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00251B, Paper
Ahmad Aqel, Ayman Ghafr, A. Yacine Badjah-Hadj-Ahmed, Zeid Abdullah ALOthman
Polymer monolithic stationary phases were prepared based on a cyclic anhydride as a reactive and tunable platform via ring-opening post-polymerization using primary amines; octadecylamine and benzylamine. The characterization techniques indicated...
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QR codes for security in vehicles

By www.thehindubusinessline.com
Published On :: Tue, 03 Sep 2013 16:32:33 +0530


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Clarity of vision: On eye drops for presbyopia and ‘claims’

By www.thehindu.com
Published On :: Tue, 17 Sep 2024 00:15:00 +0530

A useful drug is undone by fantastic claims about its efficacy


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It is an offence: On Supreme Court clarification on online content on child sex abuse

By www.thehindu.com
Published On :: Wed, 25 Sep 2024 00:10:00 +0530

Court has done well to clarify law on online content showing child sex abuse


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​Mad doctrine: On Russia’s revision of its nuclear doctrine

By www.thehindu.com
Published On :: Mon, 30 Sep 2024 00:10:00 +0530

Any threat of use of nuclear weapons must be viewed seriously 


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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
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Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists

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Published On ::

RSC Med. Chem., 2024, 15,3616-3624
DOI: 10.1039/D4MD00306C, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. Sheldrake
Cyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.
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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00608A, Research Article
Sunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo Mathew
A total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.
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Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials

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Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis

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Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article
Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
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Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
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A novel approach for the synthesis of the cyclic lipopeptide globomycin

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00685B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Samantha J. Bann, Stephen A. Cochrane
Lipid swapping: a new approach for the synthesis of globomycin that allows for facile lipid diversification.
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Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
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Data crucial for building climate resilience, says ISRO scientist

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 19:40:51 +0530


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Plea to include ‘panneer karumbu’ in Pongal gift hamper

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 19:41:17 +0530


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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 18:56:40 +0530

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa


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620: Cloudflare #HotDrama, Auth, and Prototyping Thoughts

By shoptalkshow.com
Published On :: Mon, 17 Jun 2024 08:27:24 +0000

Show DescriptionWe dive a bit deeper into the Cloudflare drama of the past couple of weeks, Instagram ads vs Cara art, what to do about Auth in your app, pre-negging any sponsorships, prototyping and feedback on projects, and ideas for future topics. Listen on Website →Links Cloudflare took down our website after trying to force […]


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628: Tending to RSS Feeds, Code Hike’s Fine Markdown, and Cloudflare R2

By shoptalkshow.com
Published On :: Mon, 12 Aug 2024 07:04:48 +0000

Doc told me to travel but there's COVID on the planes, Dave's got a 2x life update, how often do you manage or prune your RSS feed subscriptions, checking in on Code Hike and their fine grained Markdown approach, JavaScript decorators use case, and using Cloudflare R2 for image storage.


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Unsuccessful malls on the verge of closure

By www.thehindu.com
Published On :: Fri, 04 Sep 2015 15:40:22 +0530

Poor management practices have resulted in many malls across the country becoming unviable spaces.


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A premium for cleanliness

By www.thehindu.com
Published On :: Fri, 26 Feb 2016 15:16:24 +0530

If you’re looking at buying a home, take a pick from one of India’s cleanest cities.


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F1: Piastri on pole as McLaren in front

By www.rediff.com
Published On ::

McLaren are leading the constructor's championship but are only 29 points ahead of Ferrari, with Leclerc an obvious threat and team mate Carlos Sainz qualifying fifth and Mercedes' George Russell sixth.


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Ferrari's Leclerc fined for swearing

By www.rediff.com
Published On ::

Stewards at the Brazilian race summoned Leclerc on Friday, acting on a report from the governing FIA's media delegate and after reviewing a written transcript.


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Superlative Class

By www.thehindubusinessline.com
Published On :: Sat, 05 Oct 2024 08:33:00 +0530

The EQS SUV reinvigorates Mercedes-Benz’s game in the all-electric segment


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The (E-) Class of 2024

By www.thehindubusinessline.com
Published On :: Sat, 26 Oct 2024 06:18:00 +0530

A new E-Class is here and it promises to be better than before. How’s that even possible?


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Bengaluru startup develops new tech for battery recycling, begins production

By www.thehindubusinessline.com
Published On :: Sun, 27 Oct 2024 18:13:56 +0530

Li-ion battery recycler Metastable Materials launches commercial ops


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India seeks $70 million from Climate Investment Funds

By www.thehindubusinessline.com
Published On :: Sun, 27 Oct 2024 18:22:57 +0530

India looks to accelerate proposed ‘renewable energy integration programme’


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Trump presidency casts long shadow over climate summit 

By www.thehindubusinessline.com
Published On :: Sun, 10 Nov 2024 19:27:32 +0530

The return of the climate denier as head of the world’s biggest greenhouse gas emitter threatens to throw net-zero negotiations into disarray once again


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ADB increases climate finance after US, Japan give world's first sovereign guarantees

By www.thehindubusinessline.com
Published On :: Mon, 11 Nov 2024 10:38:46 +0530


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Police rule out communal angle in clash near Jahangirpuri temple

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 00:15:57 +0530


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India's climate policies expected to reduce CO2 emissions by around 4 billion tonnes by 2030: Report

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 18:34:50 +0530

The study by Delhi-based independent think tank Council on Energy, Environment and Water (CEEW) said policies for India's power, residential and transport sectors have already saved 440 million tonnes of carbon dioxide (MtCO2) between 2015 and 2020.


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Kejriwal gives clarion call to sarpanchs in Punjab to wipe out curse of drugs

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 20:56:50 +0530

Opposition says AAP government has ‘mishandled and mismanaged’ every aspect of State administration


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ARRL Opening Late on Friday, Nov. 8 and Closed on Veterans Day, Nov. 11

By www.arrl.org
Published On :: Thu, 07 Nov 2024 13:42:00 -0600

 ARRL® The National Association for Amateur Radio® has two closures coming up for our headquarters in Newington, Connecticut:

ARRL will be closed on Friday morning, November 8, 2024, for an employee meeting. During the short closure, members are encouraged to use the ARRL website, www.arrl.org, for membership renewals, publication purchases, and to access most benefits, services, and programs. T...


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Code is a new form of government: Clive Thompson

By www.thehindubusinessline.com
Published On :: Wed, 10 Jun 2020 16:33:11 +0530

The tech journalist and author of Coders explains how programmers have such a huge impact in our everyday lives


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Clicks and baits: The Instagram story

By www.thehindubusinessline.com
Published On :: Sun, 09 Aug 2020 21:28:16 +0530


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Cleaning the Augean stables

By www.thehindubusinessline.com
Published On :: Sun, 16 Aug 2020 20:41:54 +0530

Urjit Patel’s book is a tongue-in-cheek comment on the futility of bad-loan recovery in Indian banking


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