now Category construction and knowledge production in childhood studies: rethinking 'left-behind children' through the case of 'liushou children' in China. By ezproxy.scu.edu.au Published On :: Thu, 01 Aug 2024 00:00:00 -0400 Children's Geographies; 08/01/2024(AN 178911409); ISSN: 14733285Academic Search Premier Full Article CHILDREN of migrant laborers POSTCOLONIALISM PARENTS HEGEMONY FAMILIES
now From 'No' to 'Know': a heuristic for decolonizing research with youth. By ezproxy.scu.edu.au Published On :: Tue, 01 Oct 2024 00:00:00 -0400 Children's Geographies; 10/01/2024(AN 180134756); ISSN: 14733285Academic Search Premier Full Article SOCIAL science research IDENTITY (Psychology) PARTICIPANT observation RESEARCH methodology DECOLONIZATION
now There are fragments of Romani Gypsy history all over the UK – if one knows where to look By ifp.nyu.edu Published On :: Tue, 08 Oct 2024 21:42:46 +0000 The post There are fragments of Romani Gypsy history all over the UK – if one knows where to look was curated by information for practice. Full Article History
now Adult Children with Mental Illness: What Social Workers Should Know By ifp.nyu.edu Published On :: Tue, 29 Oct 2024 19:24:03 +0000 The post Adult Children with Mental Illness: What Social Workers Should Know was curated by information for practice. Full Article Video
now Co-knowledge production linking science, communities and public policy under deep uncertainty in a modern risk society in Japan By ifp.nyu.edu Published On :: Mon, 04 Nov 2024 04:56:19 +0000 The post Co-knowledge production linking science, communities and public policy under deep uncertainty in a modern risk society in Japan was curated by information for practice. Full Article Grey Literature
now Social Work England | Knowledge, skills and behaviours Our plan to bring new curriculum guidance into regulation for qualifying social work courses By ifp.nyu.edu Published On :: Mon, 04 Nov 2024 14:19:35 +0000 The post Social Work England | Knowledge, skills and behaviours Our plan to bring new curriculum guidance into regulation for qualifying social work courses was curated by information for practice. Full Article Grey Literature
now Enhancing the science–policy linkages using traditional and Indigenous knowledge By ifp.nyu.edu Published On :: Mon, 04 Nov 2024 17:03:03 +0000 The post Enhancing the science–policy linkages using traditional and Indigenous knowledge was curated by information for practice. Full Article Grey Literature
now 2025-26 National Urban Fellows Program Now Accepting Applications: Fully Funded Master’s & Leadership Development By ifp.nyu.edu Published On :: Tue, 22 Oct 2024 14:04:46 +0000 The post 2025-26 National Urban Fellows Program Now Accepting Applications: Fully Funded Master’s & Leadership Development was curated by information for practice. Full Article Funding
now Office of Justice Programs: Apply Now to our Research Assistantship Program (Closes Jan 20) By ifp.nyu.edu Published On :: Sun, 03 Nov 2024 15:02:33 +0000 The post Office of Justice Programs: Apply Now to our Research Assistantship Program (Closes Jan 20) was curated by information for practice. Full Article Funding
now Participatory topological mapping: A novel approach for exploring and communicating situated knowledge of complex socio-ecological systems By ifp.nyu.edu Published On :: Sun, 03 Nov 2024 23:59:11 +0000 Methodological Innovations, Ahead of Print. Land use change impacts on Sámi reindeer husbandry are well-documented, but existing maps often fail to capture socio-ecological relationships between herders, reindeer and nature. Conventional Geographic Information Systems (GIS) simplify these relationships, lacking local context and excluding valuable knowledge due to their rigid structure. This paper introduces participatory topological mapping, […] The post Participatory topological mapping: A novel approach for exploring and communicating situated knowledge of complex socio-ecological systems was curated by information for practice. Full Article Open Access Journal Articles
now Using Legitimation Code Theory to explore knowledge building in English medium higher education teaching: methodological challenges and innovations By ifp.nyu.edu Published On :: Tue, 05 Nov 2024 09:29:38 +0000 Volume 29, Issue 7, October 2024. Read the full article › The post Using Legitimation Code Theory to explore knowledge building in English medium higher education teaching: methodological challenges and innovations was curated by information for practice. Full Article Journal Article Abstracts
now The Bookshelf: The Little-Known History Of Violence At New England's African American Schools By www.nhpr.org Published On :: Tue, 16 Jun 2020 11:22:04 -0400 The history of school desegregation in America has long been centered around the southern United States. Full Article
now Hints of snow emerging on the weather maps By www.mprnews.org Published On :: Thu, 07 Nov 2024 22:40:00 +0000 A major November snow system has dumped tremendous snow in Colorado. The same system brings mainly rain to Minnesota this weekend. Full Article
now Scattered light showers Saturday. Snow chance next weekend? By www.mprnews.org Published On :: Fri, 08 Nov 2024 21:02:00 +0000 A weak weather system will bring scattered light rain showers this weekend. Full Article
now Renowned Indian-American behavioral economist to join Booth School of Business By www.newsindiatimes.com Published On :: Wed, 23 May 2018 10:10 -0500 Behavioral economist Sendhil Mullainathan to join Booth faculty as University Professor Full Article
now Beyoncé surprise drops live Coachella album, Netflix doc now streaming By minnesota.publicradio.orghttps Published On :: Wed, 17 Apr 2019 11:40:28 -0500 The recording of her historic 2018 performance, titled Homecoming: Live Album, includes new songs and arrives just as a documentary of the concert begins streaming on Netflix. Full Article
now ‘It’s the best week’: After being wrongly incarcerated, a Minnesota man is now free By www.mprnews.org Published On :: Wed, 13 Nov 2024 01:41:00 +0000 Edgar Barrientos-Quintana was wrongly convicted in 2009 and sentenced to life in prison without parole for the 2008 murder of Jesse Mickelson in Minneapolis. Full Article
now What to know about Tom Homan, the former ICE head returning as Trump's 'border czar' By www.mprnews.org Published On :: Mon, 11 Nov 2024 16:10:00 +0000 Homan was the acting director of Immigration and Customs Enforcement from January 2017 to June 2018, where he was a key architect of the Trump administration's controversial family separation policy. Full Article
now What to know about Kristi Noem, Trump's pick for Homeland Security secretary By www.mprnews.org Published On :: Wed, 13 Nov 2024 11:54:14 +0000 Donald Trump has selected South Dakota Gov. Kristi Noem to head the Department of Homeland Security. It's one of the biggest government agencies that will be integral to his vow to secure the border and carry out a massive deportation operation. Full Article
now What's Next, Now That N.H. Officials Have Proposed Among The Strictest PFAS Limits In The Country? By www.nhpr.org Published On :: Mon, 15 Jul 2019 20:16:52 +0000 New restrictions on PFAS and what that means for Granite State communities. These chemicals have been found in public water supplies around the state. Used for decades in such products as Teflon and Gortex, they've been linked to serious health problems, spurring communities to take action, including lawsuits. Now, after intense pressure from community activists, New Hampshire officials have proposed some of the lowest PFAS limits in the country. We'll find out what's in store now, in terms of testing, following the health effects of these chemicals, and more. Full Article
now Travel: In the middle of nowhere on Lake Superior, a city defined by industry By www.christianpost.com Published On :: Sun, 04 Aug 2024 08:41:59 -0400 “Nobody really comes here,” the waiter at my hotel said. “People only stop when they’re driving through.” I heard that a lot during my recent three-night visit to Thunder Bay on the north shore of Lake Superior in Ontario, Canada. Full Article
now Melania Trump returns as first lady: 4 things to know about her life, marriage and more By www.christianpost.com Published On :: Sat, 09 Nov 2024 08:57:54 -0500 As former President Donald Trump heads back to the White House to serve a second, non-consecutive term, his wife, former first lady Melania Trump, is returning to the national spotlight. Here are four things to know about her background, political views and marriage. Full Article
now OSU Kicks Off Football Season Full Of Unknowns By radio.wosu.org Published On :: Fri, 02 Sep 2016 12:44:38 +0000 Ohio State has rolled through most of its Big Ten games in recent years, but has taken tough criticism for a weak non-conference schedule. That changes this year, as the Buckeyes head to Norman, Oklahoma in the season's third week to take on the University of Oklahoma, a team that made the four-team postseason playoff last year. Full Article
now Do you know the signs of a contracting scam? Tips to avoid post Beryl scams By www.tdi.texas.gov Published On :: Mon, 15 Jul 2024 07:00:00 CDT Scam artists often follow a large storm or disaster. The Texas Department of Insurance (TDI) has tips to help recognize and avoid common contracting scams. Full Article
now Bones of unknown million-year-old animals found in Yakutia By english.pravda.ru Published On :: Fri, 22 Dec 2023 16:22:00 +0300 Bones of unknown animals millions of years of age were found in Yakutia. In the Churapcha region of Yakutia, archeologists found a Paleolithic human site that is believed to be at least 30,000 years old. Bones of unknown animals were found during excavation works. The radiocarbon research of the finds revealed that the found remains were from the Neogene era - a period that began 23 million years ago and ended 2.58 million years ago. Full Article Science
now Will US implode from within now? By english.pravda.ru Published On :: Thu, 07 Jan 2021 12:54:00 +0300 A reader wrote: On Wednesday, January 6, Republican supporters tried to prevail outgoing president wish to remain in the White House by hook or crook has exposed the democratic norms of mighty America. The majority that has elected Joe Biden as next president of United States are watching and repenting why they tollerated such an unscrupulous man. Acts of his Vice President Pence have also open the eyes of people that he is acting more loyal than the king and supporting Trump desire to perpetuate in power even after his defeat shows the early signs that the process of US imploding from within has been ignited. Vice President and a handful of Republicans are adding fuel to fire and claiming the popular votes and electoral votes have been stolen by misleading the innocent simple voters by giving wrong information. We in the third world feel sorry for poor US voters now working on the same recipe of crippling normal working of state apparatus by street demonstration and sit-ins as CIA operatives use to spread in other countries not following on their dotted lines. Full Article Opinion
now Nexi now offers Tap to pay on iPhone for merchants in Italy with Nexi SoftPOS By www.retailtechnologyreview.com Published On :: Tue, 13 Nov 1460 17:17:45 -0001 Nexi, the European PayTech, now enables merchants in Italy to accept in-person contactless payments seamlessly and securely with Tap to Pay on iPhone, and will continue to expand the availability of Tap to Pay on iPhone to its customers in Europe where the service is available. Full Article EPoS Systems Data Capture Payment Technology
now Russia now strikes Odessa ports almost every day By english.pravda.ru Published On :: Mon, 14 Oct 2024 21:13:00 +0300 The Russian Aerospace Forces interrupted active ship traffic in Odessa ports. Ballistic missile strikes on the Odessa port infrastructure take place almost every day since October 6. The first strike was carried out on a vessel at sea on September 12. Afterwards, Russian Iskander missiles hit Shui Spirit container ships flying the Panamanian flag, the Paresa flying the flag of Saint Kitts and Nevis. The 22nd berth in the Yuzhny port and the 10th berth in the Odessa port were also hit. On October 14, the Belize-flagged NS Moon and Palau-flagged Optima dry cargo ships were damaged. The latter vessel was reported to have been damaged a week ago. Local authorities also confirmed damage to a pilot boat and a grain warehouse. Three servicemen were killed. Full Article Incidents
now Leeches can now be used to treat Parkinson's and epilepsy By english.pravda.ru Published On :: Fri, 03 Mar 2023 16:50:00 +0300 Scientists have made a breakthrough in the field of bioelectronics by successfully injecting gel polymers inside leeches and zebrafish, which organized themselves into functional electrodes. The study was published in Science journal. It was revealed that when the gel molecules came in contact with enzymes inside an animal's body, they became electrically conductive. This innovation could lead to better treatments for people with neurological conditions such as Parkinson's and epilepsy by allowing scientists to stimulate areas of the body with an external voltage. Professor Magnus Berggren at the Laboratory for Organic Electronics, LOE, at Linköping University, Sweden, noted that for decades, they have tried to create electronics that mimic biology, but now they let biology create the electronics for them. Full Article Health
now Shorten life: food habits that lead to the grave have become known By english.pravda.ru Published On :: Wed, 19 Apr 2023 00:46:00 +0300 Experts at the Mayo Clinic have identified certain eating habits that can shorten one's lifespan, revealing that even foods that are considered healthy can have a negative impact. According to their research, it's best to avoid consuming too many diet drinks as they often contain sugar substitutes that can be harmful. Furthermore, inadequate water intake can also speed up the aging process and lead to poor health. Juices with high sugar content should also be consumed in moderation, with natural alternatives being the preferable option. Frequent consumption of soda can lead to rapid weight gain and excessive cholesterol production. Full Article Health
now Do You Know What the Biggest Risk Factors for Pancreatic Cancer Are? By www.newswise.com Published On :: Tue, 12 Nov 2024 14:50:23 EST Full Article
now Do You Know What the Biggest Risk Factors for Pancreatic Cancer Are? By www.newswise.com Published On :: Tue, 12 Nov 2024 14:50:23 EST Full Article
now You Don't Want to Know How Maraschino Cherries Are Made By recipes.howstuffworks.com Published On :: Tue, 20 Feb 2024 18:43:02 -0500 The expression "the cherry on top" refers to a very good thing. You may think differently once you learn how maraschino cherries are actually made. Full Article
now What Is Boba? Everything to Know About Bubble Tea By recipes.howstuffworks.com Published On :: Tue, 30 Apr 2024 10:19:10 -0400 You're not alone if you've ever found yourself wondering, "What is boba?" This food trend has taken the drink market by storm, enchanting tea enthusiasts and curious foodies alike. Full Article
now Say Goodbye to Hyerim-NVee Duo :( (for now!) By world.kbs.co.kr Published On :: 2024-11-06 +09:00 Saying goodbye is never easy! NVee joins DJ Hyerim for one last livestream session before she heads off on her well-deserved baby leave. Together, they chat about what K-pop idols do during their...[more...] Full Article Economy&It
now BGS geological data sets now available on Ordnance Survey hub - Ground Engineering By news.google.com Published On :: Mon, 03 Jun 2024 07:00:00 GMT BGS geological data sets now available on Ordnance Survey hub Ground Engineering Full Article
now UK Minerals Yearbook 2023 now available to download - British Geological Survey By news.google.com Published On :: Tue, 04 Jun 2024 11:09:40 GMT UK Minerals Yearbook 2023 now available to download British Geological Survey Full Article
now World Mineral Production 2018 to 2022 is now available - British Geological Survey By news.google.com Published On :: Tue, 09 Apr 2024 14:26:00 GMT World Mineral Production 2018 to 2022 is now available British Geological Survey Full Article
now AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography By journals.iucr.org Published On :: 2024-03-07 Macromolecular crystallography generally requires the recovery of missing phase information from diffraction data to reconstruct an electron-density map of the crystallized molecule. Most recent structures have been solved using molecular replacement as a phasing method, requiring an a priori structure that is closely related to the target protein to serve as a search model; when no such search model exists, molecular replacement is not possible. New advances in computational machine-learning methods, however, have resulted in major advances in protein structure predictions from sequence information. Methods that generate predicted structural models of sufficient accuracy provide a powerful approach to molecular replacement. Taking advantage of these advances, AlphaFold predictions were applied to enable structure determination of a bacterial protein of unknown function (UniProtKB Q63NT7, NCBI locus BPSS0212) based on diffraction data that had evaded phasing attempts using MIR and anomalous scattering methods. Using both X-ray and micro-electron (microED) diffraction data, it was possible to solve the structure of the main fragment of the protein using a predicted model of that domain as a starting point. The use of predicted structural models importantly expands the promise of electron diffraction, where structure determination relies critically on molecular replacement. Full Article text
now New insights into the domain of unknown function (DUF) of EccC5, the pivotal ATPase providing the secretion driving force to the ESX-5 secretion system By journals.iucr.org Published On :: 2024-05-28 Type VII secretion (T7S) systems, also referred to as ESAT-6 secretion (ESX) systems, are molecular machines that have gained great attention due to their implications in cell homeostasis and in host–pathogen interactions in mycobacteria. The latter include important human pathogens such as Mycobacterium tuberculosis (Mtb), the etiological cause of human tuberculosis, which constitutes a pandemic accounting for more than one million deaths every year. The ESX-5 system is exclusively found in slow-growing pathogenic mycobacteria, where it mediates the secretion of a large family of virulence factors: the PE and PPE proteins. The secretion driving force is provided by EccC5, a multidomain ATPase that operates using four globular cytosolic domains: an N-terminal domain of unknown function (EccC5DUF) and three FtsK/SpoIIIE ATPase domains. Recent structural and functional studies of ESX-3 and ESX-5 systems have revealed EccCDUF to be an ATPase-like fold domain with potential ATPase activity, the functionality of which is essential for secretion. Here, the crystal structure of the MtbEccC5DUF domain is reported at 2.05 Å resolution, which reveals a nucleotide-free structure with degenerated cis-acting and trans-acting elements involved in ATP binding and hydrolysis. This crystallographic study, together with a biophysical assessment of the interaction of MtbEccC5DUF with ATP/Mg2+, supports the absence of ATPase activity proposed for this domain. It is shown that this degeneration is also present in DUF domains from other ESX and ESX-like systems, which are likely to exhibit poor or null ATPase activity. Moreover, based on an in silico model of the N-terminal region of MtbEccC5DUF, it is hypothesized that MtbEccC5DUF is a degenerated ATPase domain that may have retained the ability to hexamerize. These observations draw attention to DUF domains as structural elements with potential implications in the opening and closure of the membrane pore during the secretion process via their involvement in inter-protomer interactions. Full Article text
now Comparison of two crystal polymorphs of NowGFP reveals a new conformational state trapped by crystal packing By journals.iucr.org Published On :: 2024-09-02 Crystal polymorphism serves as a strategy to study the conformational flexibility of proteins. However, the relationship between protein crystal packing and protein conformation often remains elusive. In this study, two distinct crystal forms of a green fluorescent protein variant, NowGFP, are compared: a previously identified monoclinic form (space group C2) and a newly discovered orthorhombic form (space group P212121). Comparative analysis reveals that both crystal forms exhibit nearly identical linear assemblies of NowGFP molecules interconnected through similar crystal contacts. However, a notable difference lies in the stacking of these assemblies: parallel in the monoclinic form and perpendicular in the orthorhombic form. This distinct mode of stacking leads to different crystal contacts and induces structural alteration in one of the two molecules within the asymmetric unit of the orthorhombic crystal form. This new conformational state captured by orthorhombic crystal packing exhibits two unique features: a conformational shift of the β-barrel scaffold and a restriction of pH-dependent shifts of the key residue Lys61, which is crucial for the pH-dependent spectral shift of this protein. These findings demonstrate a clear connection between crystal packing and alternative conformational states of proteins, providing insights into how structural variations influence the function of fluorescent proteins. Full Article text
now Crystal structure and Hirshfeld surface analysis of 3,3'-[ethane-1,2-diylbis(oxy)]bis(5,5-dimethylcyclohex-2-en-1-one) including an unknown solvate By journals.iucr.org Published On :: 2024-05-17 The title molecule, C18H26O4, consists of two symmetrical halves related by the inversion centre at the mid-point of the central –C—C– bond. The hexene ring adopts an envelope conformation. In the crystal, the molecules are connected into dimers by C—H⋯O hydrogen bonds with R22(8) ring motifs, forming zigzag ribbons along the b-axis direction. According to a Hirshfeld surface analysis, H⋯H (68.2%) and O⋯H/H⋯O (25.9%) interactions are the most significant contributors to the crystal packing. The contribution of some disordered solvent to the scattering was removed using the SQUEEZE routine [Spek (2015). Acta Cryst. C71, 9–18] in PLATON. The solvent contribution was not included in the reported molecular weight and density. Full Article text
now Fast nanoscale imaging of strain in a multi-segment heterostructured nanowire with 2D Bragg ptychography By journals.iucr.org Published On :: 2024-02-01 Developing semiconductor devices requires a fast and reliable source of strain information with high spatial resolution and strain sensitivity. This work investigates the strain in an axially heterostructured 180 nm-diameter GaInP nanowire with InP segments of varying lengths down to 9 nm, simultaneously probing both materials. Scanning X-ray diffraction (XRD) is compared with Bragg projection ptychography (BPP), a fast single-projection method. BPP offers a sufficient spatial resolution to reveal fine details within the largest segments, unlike scanning XRD. The spatial resolution affects the quantitative accuracy of the strain maps, where BPP shows much-improved agreement with an elastic 3D finite element model compared with scanning XRD. The sensitivity of BPP to small deviations from the Bragg condition is systematically investigated. The experimental confirmation of the model suggests that the large lattice mismatch of 1.52% is accommodated without defects. Full Article text
now Neural network analysis of neutron and X-ray reflectivity data incorporating prior knowledge By journals.iucr.org Published On :: 2024-03-31 Due to the ambiguity related to the lack of phase information, determining the physical parameters of multilayer thin films from measured neutron and X-ray reflectivity curves is, on a fundamental level, an underdetermined inverse problem. This ambiguity poses limitations on standard neural networks, constraining the range and number of considered parameters in previous machine learning solutions. To overcome this challenge, a novel training procedure has been designed which incorporates dynamic prior boundaries for each physical parameter as additional inputs to the neural network. In this manner, the neural network can be trained simultaneously on all well-posed subintervals of a larger parameter space in which the inverse problem is underdetermined. During inference, users can flexibly input their own prior knowledge about the physical system to constrain the neural network prediction to distinct target subintervals in the parameter space. The effectiveness of the method is demonstrated in various scenarios, including multilayer structures with a box model parameterization and a physics-inspired special parameterization of the scattering length density profile for a multilayer structure. In contrast to previous methods, this approach scales favourably when increasing the complexity of the inverse problem, working properly even for a five-layer multilayer model and a periodic multilayer model with up to 17 open parameters. Full Article text
now Gay And Bisexual Men Are Now Allowed To Donate Blood In England, Scotland And Wales By www.scpr.org Published On :: Wed, 16 Jun 2021 02:20:11 -0700 Gay and bisexual men in England, Scotland, and Wales can now donate blood, plasma and platelets under certain circumstances without having to wait three months, the National Health Service announced this week.; Credit: Wilfredo Lee/AP Jaclyn Diaz | NPRGay and bisexual men in England, Scotland, and Wales can now donate blood, plasma and platelets under certain circumstances, the National Health Service announced this week in a momentous shift in policy for most of the U.K. Beginning Monday, gay men in sexually active, monogamous relationships for at least three months can donate for the first time. The move reverses a policy that limited donor eligibility on perceived risks of contracting HIV/AIDs and other sexually transmitted infections. The new rules come as the U.K. and other countries around the world report urgent, pandemic-induced blood supply issues. Donor eligibility will now be based on each person's individual circumstances surrounding health, travel and sexual behaviors regardless of gender, according to the NHS. Potential donors will no longer be asked if they are a man who has had sex with another man, but they will be asked about recent sexual activity. Anyone who has had the same sexual partner for the last three months can donate, the NHS said. "Patient safety is at the heart of everything we do. This change is about switching around how we assess the risk of exposure to a sexual infection, so it is more tailored to the individual," said Ella Poppitt, Chief Nurse for blood donation at NHS Blood and Transplant, in a statement. "We screen all donations for evidence of significant infections, which goes hand-in-hand with donor selection to maintain the safety of blood sent to hospitals." People who engage in anal sex with a new partner or multiple people or who have recently used PrEP or PEP (medication used to prevent HIV infection) will have to wait three months to donate - regardless of their gender. Why did the U.K. make this change? The NHS moved to alter its blood donation eligibility rules following a review by the FAIR (For the Assessment of Individualised Risk) steering group. The panel determined an individualized, gender-neutral approach to determining who can donate blood, platelets, and plasma is fairer and still maintains the safety of the U.K.'s blood supply. The findings were accepted in full by the government last December. Researchers will continue to monitor the impact of the donor selection changes for the next 12 months to determine if more changes are needed, NHS said. What is the policy in the U.S.? Despite efforts by advocates to change regulations in the U.S, the ability for gay and bisexual men to donate blood is still restricted. A ban on gay and bisexual blood donors has been in effect since the early 1980s when fears about HIV/AIDS were widespread. The Food and Drug Administration's current policy states a man who has sex with another man in the previous three months can't donate. Federal rules previously made such donors wait 12 months before giving blood, but due to low blood supplies during the pandemic the federal government changed the policy in April. The Red Cross said they are participating in a pilot study funded by the FDA using behavior-based health history questionnaires, similar to those used in the U.K. Copyright 2021 NPR. To see more, visit https://www.npr.org. This content is from Southern California Public Radio. View the original story at SCPR.org. Full Article
now Pfizer's COVID Vaccine In Teens And Myocarditis: What You Need To Know By www.scpr.org Published On :: Thu, 17 Jun 2021 10:40:13 -0700 A teen gets a dose of Pfizer's COVID-19 vaccine at Holtz Children's Hospital in Miami on May 18. Nearly 7 million U.S. teens and pre-teens (ages 12 through 17) have received at least one dose of a COVID-19 vaccine, so far, the CDC says.; Credit: Eva Marie Uzcategui/Bloomberg via Getty Images Joanne Silberner | NPRIt's been a little more than a month since adolescents as young as 12 became eligible in the United States to receive the Pfizer vaccine against COVID-19, and nearly all reports have been positive: The vaccine is very effective in this age group, and the vast majority of kids experience mild side effects, if any — the same sore arm or mild flu-like symptoms seen among adults who get the shot. The Centers for Disease Control and Prevention has recommended that everyone 12-years-old and older get vaccinated against COVID-19, and the rollout is well underway: According to the CDC, nearly 7 million U.S. teens and pre-teens (ages 12 through 17) have received at least one dose of a COVID-19 vaccine, so far. Still, soon after the FDA authorized the use of Pfizer's vaccine in young people, federal agencies began receiving reports of mild chest pain or other signs of possible heart inflammation (known as myocarditis) in a very small percentage of recently vaccinated teens. CDC director Rochelle Walensky said at a White House briefing Friday that there have been more than 300 cases of heart inflammation reported among more than 20 million teens and young adults who have received one of the vaccines made by Moderna or Pfizer. She said that in the "vast majority" of cases, the inflammation went away. An expert advisory committee to the health agency is expected to review the cases in more depth at a meeting Friday. So, in the meantime, should parents of teens hesitate to have their kids vaccinated against COVID-19? Vaccine experts and the American Academy of Pediatrics say no, don't hesitate. It's good for doctors and patients to be aware that there might be a connection between the mRNA vaccines and heart inflammation, and to report to their pediatrician anything they see in that first week after vaccination. But it is also important, the CDC notes, to recognize that even if this does turn out to be an extremely rare side effect of the vaccine, "most patients who received care responded well to medicine and rest and quickly felt better." And the serious risks of COVID -19 — even for young healthy people — outweigh the risks of any possible side effects from the vaccine. Here are some questions you may have, and what's known: What exactly is myocarditis? Myocarditis is an inflammation of the heart muscle, and pericarditis, also being investigated, is an inflammation of the sac around the heart. Long before the pandemic, thousands of cases of myocarditis were diagnosed in the U.S. and around the world each year, often triggered by the body's immune response to infections. SARS-CoV-2 can trigger it, and so can cold viruses, and staph and strep and HIV. Other causes include toxins and allergies. Symptoms include chest pain and shortness of breath. It's often mild enough to go unnoticed, but a full-blown case in adults can cause arrhythmias and heart failure that require careful treatment with multiple medications, and several months of strict rest. In a case study of seven teenagers who got myocarditis following vaccination published last week in the journal Pediatrics, all seven got better after routine treatment with anti-inflammatory drugs. Pediatric cardiologist Dr. Stuart Berger of the Northwestern University Feinberg School of Medicine, a spokesperson for the American Academy of Pediatrics, says vaccine-related myocarditis in teens is not all that worrisome. "Although they appear with some symptoms of chest pain, and maybe some findings on EKGs, all of the cases we've seen have been on the mild end of the spectrum," he says. So, what's the concern? Several hundred reports about the inflammation have been filed with the federal government's Vaccine Adverse Event Reporting System (VAERS); that's a repository of reports sent in by health professionals and patients about any health events they spot in the hours or days after vaccinations. Many of the events reported turn out to be coincidental — not caused by a vaccine. The database is just meant as a starting point for further investigation and not proof of cause and effect. But as NPR's Geoff Brumfiel noted this week, "when millions of people are vaccinated within a short period, the total number of these reported events can look big." That said, anecdotes reported by doctors in medical journals and reports to VAERS suggest that both of the mRNA vaccines authorized for use in the U.S. — the Pfizer and Moderna vaccines — might slightly increase the incidence of myocarditis in young people. In 2003, a report in the New England Journal of Medicine estimated the background incidence of myocarditis to be 1.13 cases in 100,000 children per year. Paul Offit, professor of pediatrics at the Children's Hospital of Philadelphia and a member of a Food and Drug Administration vaccine advisory committee says there likely is a causal link between the heart inflammation some doctors are seeing in these teens and the second dose of vaccine. "I think it's real," he says, but hastens to add that the effect is exceedingly small – based on the data collected so far, maybe one in 50,000 vaccinees between the ages of 16 and 39. "And the good news is at least so far it looks to be transient and self-resolving." Still, maybe I should wait to get my teen vaccinated and see how this plays out? Uhm, no, according to several vaccine experts contacted by NPR. And this is where a little math comes in handy. "Take a stadium full of 100,000 people between the ages of 16 and 39, which is the subset that appears to be at greater risk," Offit says. "Vaccinate all of them, and two might get myocarditis." But if you don't vaccinate any of the 100,000, he estimates that about 1,300 would eventually get COVID-19. And those numbers are likely to increase this winter. About one in 1,000 children who get COVID-19 have gone on to develop a condition called MIS-C (multisystem inflammatory syndrome in children), says Offit, and most of those kids have had some level of myocarditis. In addition, the new coronavirus has directly caused myocarditis in some children and adults. Which of the two stadiums in Offit's metaphor would have more cases of myocarditis — the vaccinated children or unvaccinated kids — is not known precisely. But Offit says he suspects it would be the unvaccinated group. And there's no doubt that 1,000 unvaccinated children would suffer more COVID-19-related illnesses. "A choice not to get a vaccine is not a choice to avoid myocarditis," he says. "It's a choice to take a different risk — and I would argue a more serious one" — of developing a bad case of COVID-19 or long-COVID or COVID-caused myocarditis. Are the experts advising their own kids in this age group to get vaccinated? Yes. "I understand people having concerns," says Dr. Judith Guzman-Cottrill. She's a parent and professor of pediatric infectious diseases at the Oregon Health and Science University, as well as the senior author on a small study that came out this month in the journal Pediatrics. In the report, Guzman-Cottrill and her colleagues analyzed the cases of seven boys around the country who developed myocarditis within four days of receiving the Pfizer-BioNTech vaccine. She and her family recently faced the vaccination decision for her own 13-year-old daughter — and said a whole-hearted yes to the shot. Guzman-Cottrill suspects there may turn out to be a slightly increased risk of heart inflammation from vaccination in young people, but she and her co-authors note in the Pediatrics report that a direct cause-and-effect connection — even in these seven cases — has yet to be established. And she's impressed that despite the millions of doses that have so far been delivered to teens, no clear and serious post-vaccination problems have shown up. "The emergency departments and urgent care clinics are not filled with teenagers complaining of chest pain," she says. She's treated unvaccinated teens who developed severe myocarditis from an infection with the COVID-19 virus, and others who developed COVID-19 pneumonia and respiratory failure. Seeing those teens struggle — teens who lacked the powerful immune protection the vaccine provides — was enough for her to suggest vaccination to her daughter, who got her second vaccination earlier this week. "She saw it as a pathway back to a normal post pandemic life," Guzman-Cottrill says. And that's where public health comes in. "We really need a highly vaccinated student body when kids return to the classroom this fall," says Guzman-Cottrill, "so we don't see surges in COVID-19 cases." Joanne Silberner, a former health policy correspondent for NPR, is a freelance journalist living in Seattle. Copyright 2021 NPR. To see more, visit https://www.npr.org. This content is from Southern California Public Radio. View the original story at SCPR.org. Full Article
now New Report Finds Major US Metro Areas, Greater Los Angeles Among Them, Are More Segregated Now Than 30 Years Ago By www.scpr.org Published On :: Wed, 30 Jun 2021 09:31:22 -0700 People rest while riding a Los Angeles Metro Rail train amid the coronavirus pandemic on April 1, 2020 in Los Angeles, California.; Credit: Mario Tama/Getty Images AirTalkDespite the racial reckoning going on in America right now, and despite the fact that attitudes towards race, inclusion and representation are different now than they were 30 years ago, new research from UC Berkeley shows that a large majority of American metro areas are more segregated now than they were in 1990. The new report from Berkeley’s Institute covers a number of topic areas, but among the key findings were from the national segregation report component of the project, which found Los Angeles to be the sixth-most segregated metro area with more than 200,000 people. Today on AirTalk, we’ll talk with the lead researcher on the new report and a local historian to talk about how we see the findings of the report play out in Southern California. Guests: Stephen Menendian, assistant director and director of research at the Othering & Belonging Institute at UC Berkeley, which works to identify and eliminate the barriers to an inclusive, just, and sustainable society in order to create transformative change; he tweets @SMenendian Eric Avila, professor of history, urban planning, and Chicano/a studies at UCLA This content is from Southern California Public Radio. View the original story at SCPR.org. Full Article
now Get to know CVO: Erin Lysne, VALT and… the ghost of VALT? By www.usgs.gov Published On :: Mon, 4 Nov 2024 13:49:40 EST At the Cascades Volcano Observatory, staff use technical skills and creativity to solve complex problems and innovate for the future. Erin personifies the cleverness, craftsmanship and creativity that makes volcano science meaningful and FUN! Full Article
now Get to know CVO: Maciej Obryk and the USGS debris-flow flume By www.usgs.gov Published On :: Mon, 11 Nov 2024 16:09:26 EST At the Cascades Volcano Observatory, staff use technical skills and creativity to solve complex problems and innovate for the future. Maciej’s experiments are too large for the observatory, so he travels 3 hours southeast of CVO to the HJ Andrews Experimental Forest in Blue River, Oregon to study debris flows. Full Article
now 5 Reasons Why SMBs Can Now Adopt Virtualization By www.itsecurity.com Published On :: Fri, 11 Jun 2010 23:57:01 +0000 On-Demand Webinar > Watch Now!>> SPONSORED BY: VM6 SoftwareWatch this FREE on-demand webinar now and you’ll discover:Why virtualization is important How to achieve a scala... Full Article