A copper(II) dimer with the deprotonated anion of 2-bromo­nicotinic acid (2-BrnicH), namely, tetrakis(μ-2-bromonicotinato-κ2O:O')bis[aquacopper(­II)](Cu—Cu), [Cu2(H2O)2(C6H3BrNO2)4] or [Cu2(H2O)2(2-Brnic)4], (1), was prepared by the reaction of copper(II) chloride dihydrate and 2-bromo­nicotinic acid in water. The copper(II) ion in 1 has a distorted square-pyramidal coordination environment, achieved by four carboxyl­ate O atoms in the basal plane and the water mol­ecule in the apical position. The pair of symmetry-related copper(II) ions are connected into a centrosymmetric paddle-wheel dinuclear cluster [Cu⋯Cu = 2.6470 (11) Å] via four O,O'-bridging 2-bromo­nicotinate ligands in the syn-syn coordination mode. In the extended structure of 1, the cluster mol­ecules are assembled into an infinite two-dimensional hydrogen-bonded network lying parallel to the (001) plane via strong O—H⋯O and O—H⋯N hydrogen bonds, leading to the formation of various hydrogen-bond ring motifs: dimeric R22(8) and R22(16) loops and a tetra­meric R44(16) loop. The Hirshfeld surface analysis was also performed in order to better illustrate the nature and abundance of the inter­molecular contacts in the structure of 1.

The asymmetric units of the title compounds, namely, catena-poly[[(1,4,8,11-tetra­aza­cyclo­tetra­decane-κ4N1,N4,N8,N11)nickel(II)]-μ-1,3-bis­(3-carboxyl­ato­prop­yl)tetra­methyl­disiloxane-κ2O:O'], [Ni(C10H24O5Si2)(C12H24N4)]n (I), and catena-poly[[[(1,4,8,11-tetra­aza­cyclo­tetra­decane-κ4N1,N4,N8,N11)nickel(II)]-μ-4-({[(3-carb­oxy­prop­yl)di­methyl­sil­yl]­oxy}di­methyl­sil­yl)butano­ato-κ2O:O'] per­chlorate], {[Ni(C10H25O5Si2)(C12H24N4)]ClO4}n (II), consist of one (in I) or two crystallographically non-equivalent (in II) centrosymmetric macrocyclic cations and one centrosymmetric dianion (in I) or two centrosymmetric monoanions (in II). In each compound, the metal ion is coordinated by the four secondary N atoms of the macrocyclic ligand, which adopts the most energetically stable trans-III conformation, and the mutually trans O atoms of the carboxyl­ate in a slightly tetra­gonally distorted trans-NiN4O2 octa­hedral coordination geometry. The crystals of both types of compounds are composed of parallel polymeric chains of the macrocyclic cations linked by the anions of the acid running along the [101] and [110] directions in I and II, respectively. In I, each polymeric chain is linked to four neighbouring ones by hydrogen bonding between the NH groups of the macrocycle and the carboxyl­ate O atoms, thus forming a three-dimensional supra­molecular network. In II, each polymeric chain contacts with only two neighbours, forming hydrogen bonds between the partially protonated carb­oxy­lic groups of the bridging ligand. As a result, a lamellar structure is formed with the layers oriented parallel to the (1overline{1}1) plane.

Aminoacyl-tRNA synthetases (ARSs) play essential roles in protein biosynthesis as well as in other cellular processes, often using evolutionarily acquired domains. For possible cooperativity and synergistic effects, nine ARSs assemble into the multi-tRNA synthetase complex (MSC) with three scaffold proteins: aminoacyl-tRNA synthetase complex-interacting multifunctional proteins 1, 2 and 3 (AIMP1, AIMP2 and AIMP3). X-ray crystallographic methods were implemented in order to determine the structure of a ternary subcomplex of the MSC comprising aspartyl-tRNA synthetase (DRS) and two glutathione S-transferase (GST) domains from AIMP2 and glutamyl-prolyl-tRNA synthetase (AIMP2GST and EPRSGST, respectively). While AIMP2GST and EPRSGST interact via conventional GST heterodimerization, DRS strongly interacts with AIMP2GST via hydrogen bonds between the α7–β9 loop of DRS and the β2–α2 loop of AIMP2GST, where Ser156 of AIMP2GST is essential for the assembly. Structural analyses of DRS–AIMP2GST–EPRSGST reveal its pivotal architecture in the MSC and provide valuable insights into the overall assembly and conditionally required disassembly of the MSC.

In this article, a method is presented to estimate a new local quality measure for 3D cryoEM maps that adopts the form of a `local resolution' type of information. The algorithm (DeepRes) is based on deep-learning 3D feature detection. DeepRes is fully automatic and parameter-free, and avoids the issues of most current methods, such as their insensitivity to enhancements owing to B-factor sharpening (unless the 3D mask is changed), among others, which is an issue that has been virtually neglected in the cryoEM field until now. In this way, DeepRes can be applied to any map, detecting subtle changes in local quality after applying enhancement processes such as isotropic filters or substantially more complex procedures, such as model-based local sharpening, non-model-based methods or denoising, that may be very difficult to follow using current methods. It performs as a human observer expects. The comparison with traditional local resolution indicators is also addressed.

Serial crystallography is a powerful technique in structure determination using many small crystals at X-ray free-electron laser or synchrotron radiation facilities. The large diffraction data volumes require high-throughput software to preprocess the raw images for subsequent analysis. ClickX is a program designated for serial crystallography data preprocessing, capable of rapid data sorting for online feedback and peak-finding refinement by parameter optimization. The graphical user interface (GUI) provides convenient access to various operations such as pattern visualization, statistics plotting and parameter tuning. A batch job module is implemented to facilitate large-data-volume processing. A two-step geometry calibration for single-panel detectors is also integrated into the GUI, where the beam center and detector tilting angles are optimized using an ellipse center shifting method first, then all six parameters, including the photon energy and detector distance, are refined together using a residual minimization method. Implemented in Python, ClickX has good portability and extensibility, so that it can be installed, configured and used on any computing platform that provides a Python interface or common data file format. ClickX has been tested in online analysis at the Pohang Accelerator Laboratory X-ray Free-Electron Laser, Korea, and the Linac Coherent Light Source, USA. It has also been applied in post-experimental data analysis. The source code is available via https://github.com/LiuLab-CSRC/ClickX under a GNU General Public License.

The section of the Bilbao Crystallographic Server (http://www.cryst.ehu.es) dedicated to subperiodic groups includes a new tool called LSITESYM for the study of materials with layer and multilayer symmetry. This new program, based on the site-symmetry approach, establishes the symmetry relations between localized and extended crystal states using representations of layer groups. The efficiency and utility of the program LSITESYM is demonstrated by illustrative examples, which include the analysis of phonon symmetry in Aurivillius compounds and in van der Waals layered crystals MoS2 and WS2.

Timing was critical because female giant pandas ovulate only once a year. A short period of two to three days around ovulation is the only time she is able to conceive. Gestation typically lasts from 90 to 185 days.

The post Smithsonian scientists give giant pandas a helping hand at reproduction appeared first on Smithsonian Insider.

For more than three decades JoGayle Howard dedicated her life and work to reproducing endangered species.

The post JoGayle Howard, National Zoological Park pioneer in reproductive biology, dies appeared first on Smithsonian Insider.

A new study by Florida State University and Smithsonian Institution biologists shows that bleaching events brought on by rising sea temperatures are having a detrimental […]

The post Study: Bleaching events impair long-term coral reproduction appeared first on Smithsonian Insider.

California’s Channel Islands are located dozens of miles west of the state’s coast and surrounded by Pacific waters, yet they too are experiencing the same […]

The post Drought slows wildlife reproduction on California’s Channel Islands appeared first on Smithsonian Insider.

Four years after conservationists relocated 570 desert tortoises (Gopherus agassizii) in California from a threatened habitat to a new nearby location, the tortoises outwardly appeared […]

The post Smithsonian Study shows relocated desert tortoises reproduce at lower rate appeared first on Smithsonian Insider.

Representatives from academies and research organizations around the world sent messages of condolence and support to members, officials and staff of the U.S. National Academies in the wake of terrorist attacks on the World Trade Center and the Pentagon. The following are excerpts from some of these messages.

The United States should ban human reproductive cloning aimed at creating a child.

Although most people who receive and manage Social Security benefits on behalf of other individuals perform their duties well.

In response to alarming evidence of high rates of depression and suicide among U.S. health care workers, the National Academy of Medicine is launching a wide-ranging “action collaborative” of multiple organizations to promote clinician well-being and resilience.

While computational reproducibility in scientific research is generally expected when the original data and code are available, lack of ability to replicate a previous study -- or obtain consistent results looking at the same scientific question but with different data -- is more nuanced and occasionally can aid in the process of scientific discovery, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

Imagine giving one recipe to 10 different chefs and getting 10 completely different results. This inconsistency could be due to any number of factors — variables that cannot be controlled, omission of details, or shortcomings in design and execution.

A new report from the National Academies of Sciences, Engineering, and Medicine urges systemic action to change the culture in STEMM (science, technology, engineering, mathematics, and medicine) to address the underrepresentation of women in these fields.

Home State restaurant sells groceries to stay afloat in reaction to the coronavirus on April 16, 2020 in Los Angeles, California. ; Credit: Amy Sussman/Getty Images

This Friday, California will take the first steps toward easing its statewide stay-at-home order.

In Stage 2 of Newsom’s reopening plan, lower risk workplaces like schools, childcare facilities, retail businesses (curbside pickup) and offices where working remotely is not possible will be allowed to reopen. For counties and cities, the reopening will be slightly adjusted according to regional demands. Los Angeles Mayor Eric Garcetti has announced that some low risk businesses will be allowed to reopen this Friday, as will city-owned hiking trails and golf courses (excluding Runyon Canyon). In Orange County, many beaches have already been reopened. The county has also seen some businesses open up in defiance of Governor Newsom’s stay-at-home order.

Today, California restaurants are submitting a plan to Governor Newsom to reopen sit-down service with safeguards.Under these guidelines, only family members or people who live together would sit at the same table. Buffets, salad bars and shared bread baskets would be out. Salt and pepper shakers could be replaced by bottles of hand sanitizer. And meals could arrive from food servers sheathed in face masks.

What will the partial reopening look like in Southern California? And how will reopening progress in the weeks ahead? We speak with an epidemiologist, restaurant industry advocate, barber and hair salon advocate and economics commentator to learn more.

With files from the Associated Press

Guests:

Richard Jackson, M.D., pediatrician, epidemiologist and professor emeritus at the UCLA Fielding School of Public Health, he’s served in many leadership positions with the California Health Department, including as the State Health Officer, for nine years he served as director of the CDC’s National Center for Environmental Health

Jot Condie, president & CEO of the California Restaurant Association, an advocacy organization for the restaurant industry that has submitted an reopening plan for the restaurant industry today to Governor Gavin Newsom

Ted D. Nelson, president and CEO of the Professional Beauty Federation of California, which represents barbers and salon professionals; the organization says it will sue California Governor Gavin Newsom this week over the statewide stay-at-home order

Greg Ip, chief economics commentator for the The Wall Street Journal; he tweets @greg_ip

This content is from Southern California Public Radio. View the original story at SCPR.org.

A map of science could assist research planning strategies by helping to identify emerging topics. The map — which is based on links to almost 20 million scientific articles that have been published over the past 16 years — clusters and links scientific disciplines by citation-based relationships and serves as a highly detailed and scalable infographic. The authors hope it will be used by research planners to help distinguish — and potentially forecast — the research areas in science which have longevity, and also those which are innovative.

A new study suggests gaps exist in the treatment of depression with many individuals who screen positive for the mental health disorder not receiving treatment, according to an article published online by JAMA Internal Medicine.

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People who are annoyed by environmental noise are also more likely to suffer from depression and anxiety, a new, large-scale study from Germany suggests. The results do not prove that noise causes mental health issues but suggest a possible link, which the study’s authors are exploring further. Of all the types of noise considered in the study, aircraft noise was reported to be the most annoying.

Oysters exposed to polystyrene microplastics produced fewer offspring, which were also smaller and slower growing than offspring from unexposed oysters, according to recent research. The researchers say their study adds to growing evidence of the harm caused by microplastic pollution and can help stakeholders to take action on plastic debris entering the oceans to limit its long-term impact on marine life.

After Tropical Depression 19W moved ashore in central Vietnam NASA-NOAA's Suomi NPP satellite passed over the system and found some powerful thunderstorms over Thailand, Vietnam and Laos capable of dropping heavy rainfall.

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There has been a mixed response to Local Agenda 21 (LA21) across Europe, but a new study from the Basque Country in Spain has identified factors that contribute to a successful LA21 strategy. These are a local entrepreneurial presence, joint problem-solving and joint decision-making by local government members.

Low oxygen levels (‘hypoxia’) are a pressing concern for marine and freshwater ecosystems worldwide, and this may deteriorate as ocean temperatures rise. Hypoxia causes stress in organisms, which can cause reproductive impairments that persist across generations — even the offspring that have never been exposed to hypoxia. Previous studies discovered that hypoxia can disrupt sex hormones, resulting in birth defects and affecting reproduction of male fish over several generations. This study shows how hypoxia can also affect female marine medaka (Oryzias melastigma) over multiple generations — and thus may pose a significant threat to the sustainability of natural fish populations worldwide.

US also marked a slew of issues in India’s digital trade including those in the ecommerce policy.

Bumblebees are negatively affected by the insecticide azadirachtin even at concentrations 50 times lower than the recommended levels used by farmers, recent laboratory experiments have revealed. No males hatched in laboratory colonies that were fed on recommended levels of the pesticide and, even at concentrations 50 times lower, the males that did hatch were deformed, and there were significantly fewer compared to an untreated colony.

Wild plants closely related to crops, or ‘crop wild relatives’, contain genes that could be useful for developing resilient crop varieties and are, therefore, important for food security. This global study quantified their conservation status and availability for breeding. The researchers found major gaps in gene-bank stocks, with over 70% of crop wild relative species identified as ‘high priority’ for conservation action. The researchers say systematic efforts are needed to protect crop wild relatives for future plant breeding, including both protection in gene banks and local conservation.

Agri-environment schemes (AES) have been implemented throughout Europe to mitigate against the negative effects of agricultural intensification. Although these schemes have shown positive effects on the abundance and richness of certain species and taxa, the impact of AES on reproduction of target species at the local and landscape scale is poorly understood. This large-scale study looked for the effect of selected AE measures on bumblebee reproduction. Results indicate that bumblebee reproduction is significantly higher on sown flower patches when compared to conventional management. Although the increase is most pronounced at the plot scale, higher reproduction was found in landscapes surrounding larger sown plots (at least one hectare) compared to smaller sown plots.

Farmers could help to maintain populations of bees and other pollinators by sowing inexpensive seed mixes on their land, a new study suggests. Researchers surveyed pollinators visiting study plots in Berkshire, UK, and explored how sowing different seed mixes and using different management techniques affected the flowers produced and the pollinators visiting them.

Anti-depressant drugs can affect the behaviour of wild animals in ways which may reduce their survival, new research has shown. The researchers fed half a group of starlings fluoxetine (commonly produced as ‘Prozac’) at concentrations they would be likely to encounter in the wild, if they fed on invertebrates contained in the waste water at treatment plants. Those fed the anti-depressant showed reduced feeding rates compared to the rest of the group, possibly putting their survival at risk.

Aeration is an effective means of eliminating antidepressants from landfill leachate, a new study finds. The concentrations of five different drugs were reduced by this treatment process, which could be an effective means of tackling the growing problem of pharmaceutical infiltration into aquatic environments.

This study assessed the effects of herbicides on non-target plants in Denmark and Canada. The findings showed that some plants are more sensitive to herbicides in the reproductive stages of their life cycle and can experience delays in flowering and reduced seed production. The authors say future ecological assessments should consider reproductive outcomes.

Environmental specimen banks (ESBs) first emerged in the 1960s and are now essential to environmental management across the globe. ESBs sample and archive environmental specimens and can be used to identify the distributions of chemicals within ecosystems and trace their exposure over time. This study uses the German ESB to illustrate their potential for chemicals monitoring in the EU.

SASOL has adopted telepresence for collaboration between far-flung executives in Europe, North America and Africa. Running over the BT IP Connect global network it also enables federation with customers and suppliers. The solution’s earned Alec’s team a special recognition award from the CEO for bringing the company’s One SASOL philosophy and vision vibrantly to life

Every year some of the world’s best young musicians would jet into London to audition for a bursary with the Southbank Sinfonia. Simon Over wanted to cut down on those thousands of air miles and hours in transit. He also didn’t want to miss out on youngsters who couldn’t afford the fare.

Grey is having some charging troubles, Myke questions the benefit of courses, and they both talk about how they use the Apple Pencil.

Zillow will also be partnering with RE/MAX Executive, Century 21 Vanguard, Stephen Cooley Real Estate Group - Keller Williams and IDEAL Realty when Zillow Offers launches in Charlotte this year

The R.W. Lindholm Residence is the newest, but certainly not the first, Wright-designed structure to be relocated in its entirety.

Video: Getting enough shut-eye really matters for children, and those who are poor need it the most.

As the first plug-in electric vehicles come to the mass market, companies that design and sell car chargers are battling for market share.

Why people are protesting the Dakota Access Pipeline.

Untreated, unfiltered water is a pricey new trend that many are buying into — even though "raw" water could really cause you some harm.

Why aren't women counted in most exercise studies? Their periods tend to mess up the data.

Researchers discover that an overwhelming number of older adults with low vitamin D levels suffer from depression.

Good looking pants that protect your valuables.