1. ICMR partners with Bharat Biotech International Limited for developing indigenous coronavirus COVID-19 vacc...  Zee News
2. Bharat Biotech to lead monoclonal antibodies project for Covid-19 therapy  The Financial Express
3. Bharat Biotech to lead project on monoclonal antibodies therapy for COVID-19  The New Indian Express
4. ICMR teams up with Bharat Biotech to develop Covid-19 vaccine  Times of India
5. CSIR approves project to develop human monoclonal antibodies that can neutralize COVID-19 in patients  Times Now
6. View Full coverage on Google News

ICMR teams up with Bharat Biotech to develop COVID-19 vaccine  The Financial ExpressView Full coverage on Google News

The wildfire disaster that struck Fort McMurray, Alberta, Canada in May 2016 destroyed more than 2,400 structures and created insured losses of more than $3.5 billion. The incident captured the hearts and minds of the media and citizens the world over,

This survey from goo Ranking looked at what Japanese considered was the tastiest menu item at McDonald’s. My first visit to a McDonald’s was in Germany to get a salad, then a cafe latte in a McCafe in Macau (McAu?) in lieu of going to a casino as part of a package tour. My first […]

A team of Princeton chemists has identified a way to tag a protein's nearest molecular neighbors, enabling the precise mapping of their micro-environment. This could open new avenues to cancer treatment and other drug therapies.

Responding to a challenge that tragic necessity has thrown to countless research labs around the world, a team from the Department of Chemistry will deploy its new cell mapping technology to shed light on the molecular interplay between COVID-19 and its host. The team is collaborating with Princeton molecular biologists who study viruses.

ABTA accused of acting like a quasi-regulator

So far, nearly 80 per cent of its passengers have rebooked

We study the trade-offs faced by Internet Service Providers (ISPs) that serve as platforms through which consumers access both television and internet services. As online streaming video improves, these providers may respond by attempting to steer consumers away from streaming video toward their own TV services, or by attempting to capture surplus from this improved internet content. We augment the standard mixed bundling model to demonstrate the trade-offs the ISP faces when dealing with streaming video, and we show how these trade-offs change with the pricing options available to the ISP. Next, we use unique household-level panel data and the introduction of usage-based pricing (UBP) in a subset of markets to measure consumers' responses and to evaluate quantitatively the ISP's trade-offs. We find that the introduction of UBP led consumers to upgrade their internet service plans and lower overall internet usage. Our findings suggest that while steering consumers towards TV services is possible, it is likely costly for the ISP and therefore unlikely to be profitable. This is especially true if the ISP can offer rich pricing menus that allow it to capture some of the surplus generated by a better internet service. The results suggest that policies like UBP can increase ISPs' incentive to maintain open access to new internet content.

This paper proposes a new methodology for estimating teacher value-added. Rather than imposing a normality assumption on unobserved teacher quality (as in the standard empirical Bayes approach), our nonparametric estimator permits the underlying distribution to be estimated directly and in a computationally feasible way. The resulting estimates fit the unobserved distribution very well regardless of the form it takes, as we show in Monte Carlo simulations. Implementing the nonparametric approach in practice using two separate large-scale administrative data sets, we find the estimated teacher value-added distributions depart from normality and differ from each other. To draw out the policy implications of our method, we first consider a widely-discussed policy to release teachers at the bottom of the value-added distribution, comparing predicted test score gains under our nonparametric approach with those using parametric empirical Bayes. Here the parametric method predicts similar policy gains in one data set while overestimating those in the other by a substantial margin. We also show the predicted gains from teacher retention policies can be underestimated significantly based on the parametric method. In general, the results highlight the benefit of our nonparametric empirical Bayes approach, given that the unobserved distribution of value-added is likely to be context-specific.

Legacy buildings of Los Angeles County Museum of Art are being torn apart for a new Peter Zumthor design. The planned gallery interiors remain a mystery.

Why would a former LACMA curator, a former Getty Museum director and artist Lauren Bon join the jury for an architectural competition to remake LACMA when demolition has begun for the Peter Zumthor plan?

From the moment the Los Angeles County Museum of Art unveiled the latest version of its new design, critics have piled on.

An anonymous donor is funding design competition prizes for global firms' alternatives to Peter Zumthor's plan for Los Angeles County Museum of Art

In Beverly Hills, a two-story home once owned by Ed McMahon that Donald Trump vowed to save from foreclosure is asking $6.795 million.

The coronavirus canceled the Hollywood event that was expected to draw about 33,000 admissions. The "Special Home Edition" can reach millions.

Trung tâm Lưu trữ Quốc gia tại TPHCM vừa khai mạc triển lãm ngày 'Thống nhất non sông' kỷ niệm 45 năm ngày 30/04/1975-2020. Ảnh từ trang Facebook của ông Trần Hữu Phúc Tiến.

"When we do start back, everybody will be off the same amount of time," McMillan says.

Pacers coach Nate McMillan is hoping to be in the final days of a stay-at-home order, and he's letting players know they need to be ready to return.

'Last Dance' brings back memories of tough 90's NBA for Pacers coach Nate McMillan

Pacers coach Nate McMillan is hoping to be in the final days of a stay-at-home order, and he's letting players know they need to be ready to return.

'Last Dance' brings back memories of tough 90's NBA for Pacers coach Nate McMillan

'Last Dance' brings back memories of tough 90's NBA for Pacers coach Nate McMillan

ICMR teams up with Bharat Biotech to develop Covid-19 vaccine  Times of IndiaView Full coverage on Google News

RCMP in Saskatchewan dealt with a total of 104 complaints related to COVID-19 public health orders from May 1 to May 7.

velocityconf: What Is the Risk That Amazon Will Go Down (Again)? http://t.co/DgnfQynjcM Thank you @bergstrom_johan for the awesome #velocityconf post.

Theme Cruise to Panama (Shakespeare at Sea / MacMania)

Nucleoside analogues are a valuable experimental tool. Incorporation of these molecules into newly synthesized DNA (i.e. pulse-labeling) is used to monitor cell proliferation or to isolate nascent DNA. Some of the most common nucleoside analogues used for pulse-labeling of DNA in cells are the deoxypyrimidine analogues 5-ethynyl-2'-deoxyuridine (EdU) and 5-ethynyl-2'-deoxycytidine (EdC). Click chemistry enables conjugation of an azide molecule tagged with a fluorescent dye or biotin to the alkyne of the analog, which can then be used to detect incorporation of EdU and EdC into DNA. The use of EdC is often recommended because of the potential cytotoxicity associated with EdU during longer incubations. Here, by comparing the relative incorporation efficiencies of EdU and EdC during short 30-min pulses, we demonstrate significantly lower incorporation of EdC than of EdU in noninfected human fibroblast cells or in cells infected with either human cytomegalovirus or Kaposi's sarcoma-associated herpesvirus. Interestingly, cells infected with herpes simplex virus type-1 (HSV-1) incorporated EdC and EdU at similar levels during short pulses. Of note, exogenous expression of HSV-1 thymidine kinase increased the incorporation efficiency of EdC. These results highlight the limitations when using substituted pyrimidine analogues in pulse-labeling and suggest that EdU is the preferable nucleoside analogue for short pulse-labeling experiments, resulting in increased recovery and sensitivity for downstream applications. This is an important discovery that may help to better characterize the biochemical properties of different nucleoside analogues with a given kinase, ultimately leading to significant differences in labeling efficiency of nascent DNA.

Marilyn Goudreault
Jan 1, 2009; 8:157-171
Research

Jeffrey C. Silva
Jan 1, 2006; 5:144-156
Research

Nucleoside analogues are a valuable experimental tool. Incorporation of these molecules into newly synthesized DNA (i.e. pulse-labeling) is used to monitor cell proliferation or to isolate nascent DNA. Some of the most common nucleoside analogues used for pulse-labeling of DNA in cells are the deoxypyrimidine analogues 5-ethynyl-2'-deoxyuridine (EdU) and 5-ethynyl-2'-deoxycytidine (EdC). Click chemistry enables conjugation of an azide molecule tagged with a fluorescent dye or biotin to the alkyne of the analog, which can then be used to detect incorporation of EdU and EdC into DNA. The use of EdC is often recommended because of the potential cytotoxicity associated with EdU during longer incubations. Here, by comparing the relative incorporation efficiencies of EdU and EdC during short 30-min pulses, we demonstrate significantly lower incorporation of EdC than of EdU in noninfected human fibroblast cells or in cells infected with either human cytomegalovirus or Kaposi's sarcoma-associated herpesvirus. Interestingly, cells infected with herpes simplex virus type-1 (HSV-1) incorporated EdC and EdU at similar levels during short pulses. Of note, exogenous expression of HSV-1 thymidine kinase increased the incorporation efficiency of EdC. These results highlight the limitations when using substituted pyrimidine analogues in pulse-labeling and suggest that EdU is the preferable nucleoside analogue for short pulse-labeling experiments, resulting in increased recovery and sensitivity for downstream applications. This is an important discovery that may help to better characterize the biochemical properties of different nucleoside analogues with a given kinase, ultimately leading to significant differences in labeling efficiency of nascent DNA.

Gregory McMichael and his son, Travis, were charged with murder and aggravated assault in relation to the shooting death of Ahmaud Arbery in February.

SAVANNAH—Gregory and Travis McMichael have been arrested and charged with murder and aggravated assault in connection with the February killing of Ahmaud Arbery, the Georgia Bureau of Investigation announced Thursday. According to police, the white father and son, 64 and 34, chased Arbery, a 25-year-old black man, after he ran by Travis McMichael’s home in the Satilla Shores neighborhood of Brunswick on Feb. 23. He was unarmed and jogging at the time. “This is a start towards victory,” Thea Brooks, Arbery’s aunt, told The Daily Beast on Thursday. “This only the beginning though, but this is what we were all hoping for.”The McMichaels said they believed Arbery was a burglar responsible for a series of break-ins in their neighborhood and that they pursued him in their pickup truck while armed with a shotgun and a .357 magnum. The GBI alleges the McMichaels confronted Arbery, and that Travis shot him. A local prosecutor previously indicated a third man, William Bryan, took part in the chase and filmed the incident.‘It’s Murder’: This Shooting of an Unarmed Black Man Is Roiling GeorgiaAt least two shots hit the 25-year-old, the Glynn County Coroner’s Office told The Daily Beast last week.Video that Brooks said depicted her nephew’s death elicited a furious reaction nationwide, and residents of the area protested the initial failure to prosecute a case on Tuesday.“It’s murder. It’s heartbreaking to even look at. The whole city has seen it,” Brooks told The Daily Beast after the video was released this week.The Georgia NAACP echoed her words in a Thursday response to the McMichaels’ arrest: “The murderers of Ahmaud Arbery have been arrested.”Gregory McMichael, a former cop and investigator with a local prosecutor’s office, previously told The Daily Beast he “never would have gone after someone for their color.” He also said the “closest version of the truth” about the incident was captured in a letter effectively clearing him and his son that was written by a prosecutor who recused himself from the case, George Barnhill. McMichael also admitted he had no direct evidence that Arbery was a thief. “But he’s the guy who’s there without permission,” he said from behind the closed front door of his son’s home.The owner of an unfinished home just down the street from Travis McMichael's home, Larry English, told The Daily Beast earlier this week that he had surveillance footage that appeared to show Arbery stopping to look at the foundation of his still-under-construction home. While Gregory McMichael claimed to police that Arbery had been caught on surveillance video, it was not immediately clear what video he was referring to. English told The Daily Beast he had no knowledge of the McMichaels seeing his surveillance footage. McMichael’s ties to law enforcement helped fuel a haze of suspicion around the killing from the beginning. Barnhill was one of two area prosecutors who looked into the incident before recusing themselves. A third prosecutor—District Attorney Tom Durden—sought a GBI probe ahead of the arrests this week.Read more at The Daily Beast.Got a tip? Send it to The Daily Beast hereGet our top stories in your inbox every day. Sign up now!Daily Beast Membership: Beast Inside goes deeper on the stories that matter to you. Learn more.

Helen talks about new research on prevention of recurrent VTE - and Carl things the evidence goes further, and we can extend prophylaxis for a year. 13.00 - CRP testing for antibiotic prescription in COPD exacerbations, should we start doing it in primary care settings - and what will that mean. We also hear from Chris Butler, one of the...

The Member States of the United Nations convened in December to adopt the Global Compact for Safe, Orderly, and Regular Migration (GCM). Ahead of the adoption, this side event in Marrakech (open only to those with GFMD credentials) considered the coordination and mechanisms most needed to achieve the commitments laid out in the GCM.

Northrop Grumman received a $123.5 million contract modification Friday to integrate the Department of Navy Large Aircraft Infrared Countermeasures system onto aircraft for the U.S. military and two allied governments.

The ADA said it believes a new policy from the Centers for Medicare and Medicaid could be “detrimental” to the millions of adults who rely on Medicaid for dental care.

The American Dental Association and American Academy of Pediatric Dentistry filed comments Feb. 28 on the Centers for Medicare and Medicaid Services’ proposed 2021 notice of benefit and payment parameters for the Affordable Care Act.

The ADA, Organized Dentistry Coalition, and many state dental associations are asking the U.S. Department of Health and Human Services and Centers for Medicare & Medicaid Services to release funding from the Coronavirus Aid, Relief and Economic Security Act Provider Relief Fund to assist dental Medicaid providers.

The Centers for Medicare & Medicaid Services announced May 5 the agency has created a new Frequently Asked Questions page to aid state Medicaid and Children’s Health Insurance Program agencies in their response to the COVID-19 pandemic.

McMillan, Peter -- Travel.

London : Rebman, 1910.

London : Rebman, 1903.

Valencia : M. Alufre, 1886.

Guanyang Wang.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1690--1706.

Abstract:
Uniform sampling of binary matrix with fixed margins is an important and difficult problem in statistics, computer science, ecology and so on. The well-known swap algorithm would be inefficient when the size of the matrix becomes large or when the matrix is too sparse/dense. Here we propose the Rectangle Loop algorithm, a Markov chain Monte Carlo algorithm to sample binary matrices with fixed margins uniformly. Theoretically the Rectangle Loop algorithm is better than the swap algorithm in Peskun’s order. Empirically studies also demonstrates the Rectangle Loop algorithm is remarkablely more efficient than the swap algorithm.