In a groundbreaking study, researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases--two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord. After years of investigating the diseases' underlying mechanisms, the research team has identified an existing FDA-approved drug that could significantly improve quality of life for affected patients and their families.

In a groundbreaking study, researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases--two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord. After years of investigating the diseases' underlying mechanisms, the research team has identified an existing FDA-approved drug that could significantly improve quality of life for affected patients and their families.

Event Begins: Thursday, November 14, 2024 3:00pm
Location: Randall Laboratory
Organized By: Interdisciplinary QC/CM Seminars

In this talk, I will explore the emergent physics resulting from the complex interaction between real-space and momentum-space topology in strongly correlated quantum materials, with a particular focus on skyrmions. Using quantum Hall and quantum spin Hall insulators as key examples, I will explain the mechanisms behind skyrmion formation through electron doping in these correlated and gapped topological systems. We provide a detailed analysis of the phase diagrams and the formation of skyrmion lattices within the Kane-Mele-Hubbard model, supported by calculations from both the unrestricted real-space Hartree-Fock and density matrix renormalization group methods. In these systems, the doped electron and skyrmion form a composite object whose density is governed by the doped electron density. This electron-skyrmion bound state is stabilized by the coupling between the orbital magnetization of the Chern band and the emergent magnetic flux generated by the skyrmion. Moreover, we find that doping induces quantum anomalous Hall crystals, which exhibit quantized Hall conductance and broken translational symmetry. Our theory offers an intrinsic mechanism for the experimentally observed robust quantum anomalous Hall insulator over an extended doping range near a filling factor of ν = 1 in twisted transition metal moiré superlattices.

Reference: Miguel Gonçalves and Shi-Zeng Lin, arXiv:2407.12198

Short-bio:
Shizeng Lin completed his Ph.D. at the National Institute for Materials Science and the University of Tsukuba in Japan. After earning his Ph.D., he joined Los Alamos National Laboratory (LANL) in 2011, initially as a postdoctoral researcher in the Theoretical Division. In 2014, he was appointed as a scientist at LANL. He is also currently affiliated with the Center for Integrated Nanotechnology at LANL, one of the five Nanoscale Science Research Centers funded by the U.S. Department of Energy. Lin’s research primarily focuses on theoretical studies of novel quantum materials, with a particular emphasis on systems characterized by correlation and topology. He received the LANL Laboratory-Directed Research and Development Program Early Career Award in 2017 and the LANL Fellows Prize for Outstanding Research in 2024.

Event Begins: Thursday, November 14, 2024 3:00pm
Location: Off Campus Location
Organized By: Center for Middle Eastern and North African Studies

This presentation focuses on the importance of studying contemporary Gulf states. The definition of contemporary in this context considers the period starting from the early 1990s. The reason for this has to do with the collapse of the Soviet Union, regional changes like the invasion of Kuwait and its consequences, and the wider Middle Eastern regional consequences. The presentation also looks at the patterns that emerged in all Gulf states at the same time in different contexts: political, economic, and social.

Mahjoob Zweiri is a professor of contemporary politics and Middle Eastern history with a focus on Iran and the Gulf region. He was the director of the Gulf Studies Center at Qatar University from 2018 to 2024 and the head of the humanities department from 2011 to 2016. Before joining Qatar University in 2010, Zweiri was a senior researcher in Middle Eastern politics and Iran at the Center for Strategic Studies, University of Jordan. From March 2003 to December 2006, he was a research fellow and then director of the Centre for Iranian Studies in the Institute for Middle Eastern and Islamic Studies at Durham University. Zweiri has more than 95 publications in the areas of Iran, contemporary Middle Eastern history and politics, Gulf studies, social sciences in universities of the future, and artificial intelligence’s role in social sciences. In addition to Arabic, he is fluent in Farsi and English. Zweiri is the founder and editor of the *Journal of Gulf Studies*, published by Intellect, and editor of the book series *Contemporary Gulf States*. Currently, he is a visiting professor at the University of Michigan.

Register and attend over Zoom: https://myumi.ch/pkJWz.

Event Begins: Thursday, November 14, 2024 12:00pm
Location: Palmer Commons
Organized By: DCMB Tools and Technology Seminar

This presentation will be held in 2036 Palmer Commons. There will also be a remote viewing option via Zoom.

Belimo Americas was the recipient of the Atlantic Canada Mechanical Exhibitors (ACME) Innovation Award for its Belimo Energy Valve™. The Energy Valve is a two-way pressure independent control valve that optimizes, documents, and proves water coil performance.

Индийская компания DRDO провела испытания новой крылатой ракеты большой дальности LRLACM.

A 47-year-old man in southern Alberta is facing human trafficking charges among other offences dating back two decades.

Manitoba RCMP have identified the body of a man pulled from the Red River in September as a 29-year-old who was reported missing.

Teachers and staff at an elementary school in Vanderhoof, B.C., have received what RCMP are calling 'disturbing' letters. They arrived just weeks after a rainbow crosswalk in the same community was targeted for vandalism.

PESHAWAR: Khyber Pakhtunkhwa Chief Minister Ali Amin Khan Gandapur on Wednesday said his government is committed to providing maximum opportunities to girls to excel in education and sports.

He said that perseverance was key to success in life and that striving forward with determination and high spirits ultimately led to success.

He was speaking at the concluding ceremony of All Pakistan Inter-Boards Girls Cricket and Tennis Championship held at the Board of Intermediate and Secondary Education, Peshawar, according to a statement issued from the chief minister’s secretariat on Wednesday.

The competitions commenced on Nov 9, featuring teams from KP and various other educational boards from across the country.

Mr Gandapur welcomed the participants from other provinces and emphasised the importance of organising sports alongside academic activities.

“The purpose of holding such events is to polish the skills of our youth, and get them prepared for practical life ahead,” the statement quoted Mr Gandapur as saying. “Challenges are part of the journey to success and should be faced head-on,” he added.

“A person becomes great when he dreams big,” he said while quoting PTI founder Imran Khan, adding that one must set ambitious goals and move forward with courage.

The chief minister congratulated the Lahore Board’s cricket team on its victory, and affirmed the importance of investing in youth.

Mr Gandapur also announced cash prizes of Rs50,000 for each participating team.

He also distributed trophies and shields among the players.

In tennis, the Lahore Board secured the first position followed by Mardan, while Peshawar Board and Punjab Board of Technical Education, Lahore, shared the third position.

Similarly, the Lahore Board clinched the first position in the cricket tournament, while Peshawar remained the runner-up.

The chief minister also inaugurated a newly-constructed gymnasium at the Peshawar BISE, which has been established at a cost of Rs160 million. The facility includes boxing, karate, taekwondo, wrestling rings, a table tennis court and a fitness gym.

Published in Dawn, November 14th, 2024

Mounties say they've arrested three men in Surrey, B.C., believed to be tied to a transnational organized crime group connected to Mexican drug cartels, while four others suspected of trafficking large quantities of drugs were arrested in Burnaby, B.C. 

Hi sir Suppose a registered person receives Security services from a CompanyThe Company is unregistered under GST Will the RCM provisions applicable on this transaction Please adviseThanks

Andhra Pradesh Chief Minister N. Chandrababu Naidu has put brakes on a proposal to undertake uranium exploration in the Kappatralla reserve forest area in Kurnool district, offering relief to agitating villagers.

Karnataka Chief Minister Siddaramaiah on Wednesday expressed confidence that Congress party would win by-elections in all three constituencies of the state.

The Indian government launched the official website for the 18th Pravasi Bharatiya Divas Convention, a key platform for engaging with the Indian diaspora worldwide. The convention, scheduled for January 8-10, 2025, will focus on the diaspora's contribution to a developed India.

1. Won’t back off from ‘Pharma Village’, says Telangana CM’s brother  The Siasat Daily
2. Lagcherla: KTR named in remand report  Deccan Chronicle
3. Ex-BRS MLA held over mob attack on Vikarabad collector  Hindustan Times
4. Video | Violence Over Land Row In Telangana Chief Minister's Constituency, 55 Detained  NDTV
5. Govt. charges BRS with hatching conspiracies to stall development projects for political gains  The Hindu

The YSR Congress Party Government led by Y S Jagan Mohan Reddy has given stage - I approvals for conducting explorations in the region to assess the availability of uranium

Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme

Stock ends at ₹253.50 against IPO price of ₹289 on BSE

Converting to a headless CMS requires more work than you might think. These tips will help you avoid some common pitfalls.

A headless CMS is a content services platform accessed via APIs, supporting omnichannel content delivery to a broad range of devices.

Fustic, M; Nair, R; Wetzel, A; Siddiqui, R; Mathews, W; Wust, R; Bringue, M; Radovic, J. Palaeogeography, Palaeoclimatology, Palaeoecology vol. 564, 110187, 2020 p. 1-17, https://doi.org/10.1016/j.palaeo.2020.110187
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200671.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200671.jpg" title="Palaeogeography, Palaeoclimatology, Palaeoecology vol. 564, 110187, 2020 p. 1-17, https://doi.org/10.1016/j.palaeo.2020.110187" height="150" border="1" /></a>

How do you see the Rockies utilizing Ryan McMahon this season? Beat reporter Thomas Harding answers this question and more from fans in the latest Rockies Inbox.

Ryan McMahon and the Rockies hope the struggles of 2018 lead to an immediate payoff. McMahon is a prime competitor for regular starts at second base, and those will come his way if he realizes potential for power and run production.

FOOD OUTLET IS PAYING GST AT 5% WITH NO ITC CLAIM. NOW AFTER 1ST OCTOBER RCM ON RENT PAID IS TO BE PAID BY THE RESTAURANT @ 18%. SO CAN HE CLAIM RCM CREDIT OR NOT

The Election Commission (EC) officials on Wednesday inspected bag of Maharashtra Chief Minister Eknath Shinde during his Palghar visit. A couple of days ago, EC officials frisked Uddhav Thackeray's helicopter, after which, Shiv Sena UBT chief accused the EC of being

In a surprising turn of events during Prime Minister Narendra Modi's visit to Darbhanga, Bihar, Chief Minister Nitish Kumar left the audience and PM Modi himself stunned when he attempted to touch the Prime Minister's feet. This incident, which occurred at

Sunknowledge is the only RCM partner trusted by both payors and providers, offering comprehensive healthcare solutions.

Mannheim/Germany-based eutecma gmbh is expanding its presence on the North American continent.

W oprogramowaniu Concept Intermedia S@M CMS wykryto 3 podatności różnego typu (CVE-2024-3800, CVE-2024-3801 oraz CVE-2024-3816).

W oprogramowaniu Edito CMS wykryto podatność CVE-2024-4836 pozwalającą na pobieranie plików konfiguracyjnych.

With a daily readership of over 1 000 000, AeroTime Hub offers breaking aviation industry news, while thousands attend major conferences, shows and concerts managed by AIR Convention and Seven Live. ... Avia Solutions Group delivers prime aviation services to keep air transportation running smooth and steady. Are you here to join the mission?

Some months back I joined both ACM and IEEE Computer Society and I'm definitely a better human being now. Most won't notice, I guess. And you can take that any way you want to.

De Fin-S Fish van Lunker City is een echte classieke shad voor het vissen op baars en snoekbaars. Een softbait met een dun, maar diep body profiel en een vorkstaartje.

competition carbon insteekhengel silstar 950 cm lengte 8 delig nieuwstaatin bijbehorende originele hengelhoes 100% geen haarscheurtjes e.dverkeerd werkelijk nog in nieuwstaat helemaal compleet met doppen en ogendit is een zeer dure carbon hengelvissport hengelsport zeevissen karpervissen wit vis vereniging

This exciting session of Grand Rounds focused on rapid identification of emerging infectious diseases. As our world increases in interconnectivity of both technology and people, the rapid identification of emerging infectious diseases becomes more important for disease treatment, control, and prevention.Earn Free CME's, CNEs, CEUs, CPE with "Explaining the Unexplained" CDC Video- Expires January 21, 2014. 

Published at LXer: AAEON SRG-CM4 is an IoT gateway based on the Raspberry Pi Compute Module 4 (CM4) with 1GB to 8GB of RAM and 8GB to 32GB of eMMC storage, all powered by the Broadcom BCM2711...