wit

3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3 + 2]-cycloaddition with arynes: synthesis of substituted 3-vinyl-1,2-benzisoxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00391H, Communication
Alexander A. Lukoyanov, Svetlana A. Aksenova, Andrey A. Tabolin, Alexey Yu. Sukhorukov
3-Halo-1,2-oxazine N-oxide derivatives act as surrogates of vinyl nitrile oxides in tandem [3 + 2]-cycloaddition/[3 + 2]-cyclofragmentation with arynes leading to benzisoxazoles.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




wit

Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00432A, Paper
Peng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Kewen Tang, Yu Liu
2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur...
The content of this RSS Feed (c) The Royal Society of Chemistry




wit

TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00302K, Communication
Qiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo Zhao
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




wit

K2CO3-Mediated (3+3-1) Annulation of 1,3-Acetonedicarboxylates with 2-Fluoro-1-nitroarenes: Synthesis of Indoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00488D, Paper
Meng-Yang Chang, Chin-Huey Ho, Hsing-Yin Chen
The K2CO3-mediated one-pot reaction of 1,3-acetonedicarboxylates with 2 equiv. of substituted 2-fluoro-1-nitrobenzenes has been developed to synthesize various 2,3-dicarboxylate indoles via a tandem (3 + 3 − 1) annulation pathway....
The content of this RSS Feed (c) The Royal Society of Chemistry




wit

Getting Started with CSS Shapes: Wrapping content around custom paths

Using CSS Shapes we can create experiences that we have never been able to create on the web before.




wit

Rolling out Public Key Pinning with HPKP Reporting




wit

Cabin crew with an invisible cape 

Being a cabin crew member is not a mere job, but an ineffable life experience




wit

Navigating newer disruptions with maximum agility

Focusing on hyper-personalisation, using the right communication tools and platforms, engaging with the customers at the right time and place will give a much-needed fillip to the industry




wit

Compliance with regulation: Staying ahead is key




wit

OpenAI builds first chip with Broadcom and TSMC, scales back foundry ambition

OpenAI is working with Broadcom and TSMC to build its first in-house chip designed to support its artificial intelligence systems, per sources




wit

ChatGPT will now work as a search engine as OpenAI partners with some news outlets

OpenAI is launching a ChatGPT-powered search engine that could put the artificial intelligence company in direct competition with search giant Google




wit

Transformation Stories #4 A New Podcast Interview With Me (Rob Larsen)

Check out yours truly on an episode of Atlas Systems’ Transformation Stories. A hands-on leader and change-maker with 20 years of experience, Rob Larsen remains at the forefront of software-led innovation – in financial services and the larger enterprise world. In this all-new conversation with Atlas Systems, Larsen offers insights into finding the right pace […]




wit

Drugs regulator finds 49 samples not of standard quality, manufacturers asked to withdraw their products

Four spurious drugs were also found and action has been initiated against the makers, the DCGI said




wit

AIIMS-Bibinagar to boost tuberculosis care in Telangana with aerial aid

Inaugurated virtually by Prime Minister Narendra Modi, the drone service is part of a series of health projects designed to enhance access to essential services in remote and underserved areas




wit

What is breast density and how is it associated with cancer? Explained

Breast density matters because of two main reasons: it may make it harder to detect signs of cancer on a mammogram, and it is linked with an increased risk of breast cancer




wit

Air passenger with suspected mpox symptoms isolated at Tiruchi govt. hospital

When contacted, a senior hospital official told The Hindu that the patient’s blood sample has been sent for further testing




wit

Tiruchi man with mpox symptoms: Sample has returned negative, says Tamil Nadu Health Minister

The man, who had returned from Sharjah on October 31, was found to have fever during screening on arriving at the Tiruchi airport.




wit

'I have danced with Sushmita Sen!'

'She got really close, and I was like, oh Miss Universe and me dancing!'




wit

'I don't like people messing with me'

'Television actors are people who play with fire.'




wit

'Bhansali teaches you without a danda'

'When you walk on to a Sanjay Leela Bhansali set, it is complete surrender. You have to become a sponge.'





wit

'Comparisons With Vicky Used To Irritate'

'That comparison, "Oh look at Vicky, do you also see yourself being that successful in life?"' 'Vicky has seen a lot and done a lot and he is where he is. I feel really happy about it.''But I have my own journey.'





wit

Creating a sunrise alarm with the LIFX lightbulb

If you’re unfamiliar with LIFX it’s basically a smart wifi enabled led lightbulb. Lifx recently released a Ruby gem to communicate with it and give it instructions. With winter looming in the southern hemisphere and the sun being up for what feels like 4 seconds at that time of year it’s really hard to get … Continue reading "Creating a sunrise alarm with the LIFX lightbulb"




wit

UITableView in JavaScript, list view with re-usable cells using flexbox

If you’re familiar with iOS development you will know that a UITableView is very efficient when displaying a list of data. A simplification of what it does is display enough cells to fill the viewport plus a few more either side. As you scroll it re-uses cells that are now out of the viewport so … Continue reading "UITableView in JavaScript, list view with re-usable cells using flexbox"




wit

Changing content type of a file in a FormData request with cURL

The other day I had to test an API response based on a file having the incorrect Content-Type of a FormData PUT request. After some digging in cURL I found the -F & --form flag to set the file and its content type. If you don’t specify the content type it will be inferred from … Continue reading "Changing content type of a file in a FormData request with cURL"




wit

How I built my earthin24 twitter bot

At work my team have recently taken over a golang app. To learn a new language I like to build something that keeps my interest and by the nature of exploring something of interest you tend to cover way more surface area of a language this way. 🌏 12pm 25th August – 12pm 26th August … Continue reading "How I built my earthin24 twitter bot"




wit

Halomax marks 22 Years of leadership in the lighting industry with a focus on innovation and sustainability

Their extensive product range includes downlighters, profile lights, and step lights for residential interiors, as well as decorative and office lighting for commercial spaces.




wit

OnePlus 13 launched with Snapdragon 8 Gen 4 SoC: Price details, battery and other specifications

While the OnePlus 13 has only been revealed in China so far, speculations are that it will arrive on the global market in the coming months. In India, the phone is expected to be launched in January 2025.




wit

Empowering Pharma with AI, Analytics: Accelerating Drug Discovery, Optimizing Healthcare Outcomes By Rajesh Munirathnam

While AI is making significant strides in healthcare, it is also transforming other industries, such as insurance.




wit

Magic once more with Surabhi

‘Maya Bazar’ and ‘Pataala Bhairavi’ attracted a lot of theatre lovers, says Velcheti Subrahmanyam.




wit

Maria’s journey with Shakti

German dancer-choreographer uses dance to connect the woman with her wild side




wit

When the dancer sketched with her feet

Lasya’s fitting tribute to her father Narasimhachari.




wit

In dialogue with nature

The fourth edition of Ignite! Festival of Contemporary Dance provided a platform where diverse contemporary dance practices were made accessible to a large number of audiences




wit

In step with changing beats

The art of nattuvangam has undergone a sea change. Archana Nathan speaks to exponents to find out what this means for the classical form




wit

Learning to live with competition

One does not have to run the rat race; there are other ways to handle corporate life




wit

Making peace with the present

Transient experiences matter more than milestones




wit

'Withholding' a problem in relationship building




wit

Manipur to compensate farmers hit by ethnic violence with ₹38-crore package 

Farmers are afraid to go to the fields because of sporadic firing by armed miscreants from higher grounds 




wit

What are the regulations with respect to rice prices? | Explained

What are the measures the government is taking to bring down the increasing price of rice?




wit

Farmers’ income will be increased with innovative schemes: Himachal CM Sukhvinder Singh Sukhu

‘We intend to bring a revolutionary change in the agriculture sector with a special focus on promoting animal husbandry,’ Sukhvinder Singh Sukhu tells the hill State’s milk producers




wit

Centre sends train with 1,600 tonnes onions to Delhi to ease prices

The Centre added that shipments by rail rake to Lucknow and Varanasi will be scheduled in next few days




wit

‘We are with you’: 22 East London housing estates stand in solidarity with Grenfell

A gesture of love and solidarity from estates and communities in East London to Grenfell and their local community.




wit

‘Migration will become a human right’ – interview with Mohsin Hamid

The author of The Reluctant Fundamentalist talks to Graeme Green about extremism, the refugee crisis and feeling at home in the past.




wit

Ask LukeW: PDF Parsing with Vision Models

Over the years, I've given more than 300 presentations on design. Most of these have been accompanied by a slide deck to illustrate my points and guide the narrative. But making the content in these decks work well with the Ask Luke conversational interface on this site has been challenging. So now I'm trying a new approach with AI vision models.

To avoid application specific formats (Keynote, PowerPoint), I've long been making my presentation slides available for download as PDF documents. These files usually consist of 100+ pages and often don't include a lot of text, leaning instead on visuals and charts to communicate information. To illustrate, here's of few of these slides from my Mind the Gap talk.

In an earlier article on how we built the Ask Luke conversational interface, I outlined the issues with extracting useful information from these documents. I wanted the content in these PDFs to be available when answering people's design questions in addition to the blog articles, videos and audio interviews that we were already using.

But even when we got text extraction from PDFs working well, running the process on any given PDF document would create many content embeddings of poor quality (like the one below). These content chunks would then end up influencing the answers we generated in less than helpful ways.

To prevent these from clogging up our limited context (how much content we can work with to create an answer) with useless results, we set up processes to remove low quality content chunks. While that improved things, the content in these presentations was no longer accessible to people asking questions on Ask Luke.

So we tried a different approach. Instead of extracting text from each page of a PDF presentation, we ran it through an AI vision model to create a detailed description of the content on the page. In the example below, the previous text extraction method (on the left) gets the content from the slide. The new vision model approach (on the right) though, does a much better job creating useful content for answering questions.

Here's another example illustrating the difference between the PDF text extraction method used before and the vision AI model currently in use. This time instead of a chart, we're generating a useful description of a diagram.

This change is now rolled out across all the PDFs the Ask Luke conversational interface can reference to answer design questions. Gone are useless content chunks and there's a lot more useful content immediately available.

Thanks to Yangguang Li for the dev help on this change.




wit

Look book, with love

Here are the latest looks to steal from the fashion week...




wit

Grand Prix with a difference

This year around, the Watch Oscars threw up some surprises by independent watchmakers




wit

Menswear: say it with flowers

The time has come for men to stop and smell the roses. And wear them, while they are at it




wit

A flower in time: Chronographs with a softer touch

Latest floral chronographs to add a bit of drama and fantasy to your attire




wit

Keeping time in the skies with the Aviator 8 Mosquito

The iconic pilot’s watch returns with the Aviator 8 Mosquito —- and it’s better than before