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Though we travel the world over to find the beautiful, we must carry it with us or we find it not.

Check out travel recommendations at Wanderfly!

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A Princeton University-led study has found that trees worldwide develop thicker bark when they live in fire-prone areas. The findings suggest that bark thickness could help predict which forests and savannas will survive a warmer climate in which wildfires are expected to increase in frequency.

Princeton President Christopher L. Eisgruber and 47 other American college and university presidents today sent a letter to President Trump urging him to "rectify or rescind the recent executive order closing our country's borders to immigrants and others from seven majority-Muslim countries and to refugees from throughout the world." "If left in place," the letters says, "the order threatens both American higher education and the defining principles of our country."

WASHINGTON (April 28, 2020) —  Today, the U.S. Environmental Protection Agency (EPA) and State of Indiana announced that recent air monitoring data show the city of Indianapolis, and the areas of Muncie, Lake and Porter counties are meeting federal air quality standards.

Im Dezember bricht in Wuhan eine rätselhafte Lungenkrankheit aus. Es dauert 21 Tage, bis die chinesischen Behörden den Kampf gegen die Seuche einleiten. Hätte die Corona-Pandemie verhindert werden können? Lesen Sie hier die SPIEGEL-Titelstory.

At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

At first, it was hard to hear what Turk Wendell was saying from atop his tractor.

Nearly a month after the Facebook page for The Official Quarantine Cookbook gained thousands of followers, the book is available to buy.

Games involving Notre Dame, Purdue and Indiana could have a lot at stake this season.

Now you can read all of IndyStar's sports content in one place with our free INSports app.

From Notre Dame to the Monon Bell. We rank Indiana's top 50 college football games in 2018.

Indianapolis Metropolitan Police Department are on the scene in the area of East 32nd Street and Baltimore Avenue.

Indianapolis Metropolitan Police Department are on the scene in the area of East 32nd Street and Baltimore Avenue.

Decision makers at Penske Entertainment are beginning to chart the course for a historic summer of racing at the Indianapolis Motor Speedway.

1. Earthquake of magnitude 3.5 hits Delhi-NCR  Times of India
2. Magnitude 3.4 Earthquake Strikes Delhi, Epicentre Near UP Border  News18
3. 3.5 Magnitude Earthquake Hits Delhi-NCR, no Casualty Reported  India.com
4. Breaking news live : Eathquake tremors felt in Delhi, adjoining areas  Times of India
5. Earthquake in Delhi: Tremors felt in national capital region  The Financial Express
6. View Full coverage on Google News

Apple India Website Puts Siri in Silent Mode

Justin Gaethje produces the best performance of his career to finish Tony Ferguson and win the UFC interim lightweight title at UFC 249.

Filed under: North America, United States

Continue reading Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks

Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks originally appeared on Gadling on Mon, 16 Dec 2013 15:07:00 EST. Please see our terms for use of feeds.

Four minutes and 28 seconds. That is how long it took a News24 reporter to find cigarettes – meant to be banned under Level 4 lockdown regulations – which were available for purchase at one of many places in South Africa.

French tennis chief Bernard Guidicelli admitted that Roland Garros could be staged behind closed doors.

The DML News App offers the best in news reporting.

The post VIDEO: Lindsey Graham puts Obama on notice after Justice Department swipe appeared first on Dennis Michael Lynch.

27 January 2015

Members Event

Event participants

Dr Mukulika Banerjee, Director, South Asia Centre, London School of Economics
Nandan Nilekani, Co-founder and Chairman, EkStep; Chairman, Unique Identification Authority of India (UIAI) (2009-14)
Dr Gareth Price, Senior Research Fellow, Asia Programme, Chatham House
Mihir Swarup Sharma, India Columnist, Bloomberg View; Senior Fellow, Observer Research Foundation, New Delhi
Chair: James Crabtree, Contributing Editor, Financial Times; Senior Visiting Fellow, Lee Kuan Yew School of Public Policy

6 January 2017 , Volume 93, Number 1

Nepal protested India's inauguration of a new road to China that passes through territory claimed by Kathmandu on Saturday, with police arresting dozens demonstrating close to India's embassy. Indian defence minister Rajnath Singh on Friday inaugurated via video link the 80-kilometre (50 miles) long road from Ghatiabagarh in northern Uttarakhand state to the Lipu Lekh pass high in the Himalaya. The pass is claimed by Nepal based on an 1816 treaty that defines its western border with India.

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

The dextransucrase DSR-OK from the Gram-positive bacterium Oenococcus kitaharae DSM17330 produces a dextran of the highest molar mass reported to date (∼109 g/mol). In this study, we selected a recombinant form, DSR-OKΔ1, to identify molecular determinants involved in the sugar polymerization mechanism and that confer its ability to produce a very-high-molar-mass polymer. In domain V of DSR-OK, we identified seven putative sugar-binding pockets characteristic of glycoside hydrolase 70 (GH70) glucansucrases that are known to be involved in glucan binding. We investigated their role in polymer synthesis through several approaches, including monitoring of dextran synthesis, affinity assays, sugar binding pocket deletions, site-directed mutagenesis, and construction of chimeric enzymes. Substitution of only two stacking aromatic residues in two consecutive sugar-binding pockets (variant DSR-OKΔ1-Y1162A-F1228A) induced quasi-complete loss of very-high-molar-mass dextran synthesis, resulting in production of only 10–13 kg/mol polymers. Moreover, the double mutation completely switched the semiprocessive mode of DSR-OKΔ1 toward a distributive one, highlighting the strong influence of these pockets on enzyme processivity. Finally, the position of each pocket relative to the active site also appeared to be important for polymer elongation. We propose that sugar-binding pockets spatially closer to the catalytic domain play a major role in the control of processivity. A deep structural characterization, if possible with large-molar-mass sugar ligands, would allow confirming this hypothesis.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

Almost five years ago, lawmakers on a bipartisan committee of Parliament agreed unanimously to amend the law to give the Independent Commission of Investigations (INDECOM) the power to arrest and prosecute cops. That proposed amendment, which was...

This edited volume develops a pragmatic approach to the engagement of highly skilled members of the diaspora for the benefit of their countries of origin. The book, edited by a World Bank senior economist, is based on empirical work in middle-income and high-income economies.

This report provides an overview of several commonly used translation and interpretation technologies. It aims to assist language access practitioners in understanding and identifying which systems would best meet their agency’s language access needs.

The number of U.S. residents deemed Limited English Proficient (LEP) has increased substantially in recent decades, consistent with the growth of the U.S. foreign-born population. This brief offers analysis on the number, share, growth, and linguistic diversity of LEP individuals in the United States from 1990 to 2010 at the national, state, and metropolitan-area levels.

New research demonstrates an extreme form of inattentional blindness in which we fail to see the unexpected

There’s much more to visual perception than meets the eye. What we see is not merely a matter of patterns of light falling on the retina, but rather is heavily influenced by so-called ‘top-down’ brain mechanisms, which can alter the visual information, and other types of sensory information, that enters the brain before it even reaches our conscious awareness.

Related: Memory contaminates perception | Mo Costandi

Related: Language boosts invisible objects into visual awareness | Mo Costandi

The economic crisis of 2008 hit Spain with a disproportionate effect on those in temporary work, revealing underlying gaps in the policy framework meant to support the inclusion of both immigrants and other vulnerable individuals in the Spanish labor market. This report assesses how well recent reforms are filling these gaps and helping immigrants and other disadvantaged workers move into middle-skilled jobs.

A new program is giving bicycles to Indigenous youth who move to Winnipeg for school to help them get around the city as they pursue their studies.