Queen Elizabeth wore a neon green outfit to her 90th birthday party. What could go wrong? Oh right, the internet...

Corporate diversity initiatives have focused primarily on skin color, ethnicity, and gender thus far, but age should also be imperative.  Aside from it being an overlooked and unmonitored protected category, workforce demographics project a talent shortage for all diversity groups under 40. In the coming months, IBM could face hundreds of lawsuits (and/or a class […]

The post How tech giants have been getting away with Age Discrimination appeared first on DiversityJobs.com.

Frosty Entertainment via Eneba has 50-Day of Game Pass Ultimate via Xbox Live Gold Conversion for ~$7.75 when you follow the instructions below.

Note, this offer is for Current/Existing Game Pass Ultimate Members only. Expired/New users can redeem up to 3-Years worth of Xbox Live Gold codes and convert their Xbox Live Gold membership to 2-Years of Game Pass Ultimate by joining Ultimate Membership. (3:2 Ratio)
 
Deal Instructions:

• Click here to visit the product page
• Click Buy Now and go to cart
• Click on "Got discount code?" and apply code GoldUS
• Proceed to checkout
• Select payment method PayPal/Credit Card (service fees will be applied here)
• End-price should be ~$7.75
  • Note, price is subject to change by a few cents due to currency exchange rate volatility.
• Redeem code on Microsoft Store or on your Xbox Console/App
• Your Game Pass Ultimate membership will be extended for 50 days per each code.

About Game Pass Ultimate

• Includes Xbox Live Gold and Xbox Game Pass with over 100 high-quality games to play with friends on console, PC, phones, and tablets, plus an EA Play membership, all in one membership. (see the current list here)

Melon Game via Eneba has 13-Months Xbox Game Pass Ultimate Subscription via Xbox Live Gold Conversion (Digital Delivery) on sale starting from ~$56 when you follow the instructions below.

• Note: Offer valid for New or Expired Xbox Game Pass Ultimate subscribers only. For current/active Game Pass Ultimate Members, check this thread.

Deal Instructions:

• Click here to visit the 3-Month Xbox Live Gold Membership product page.
• Click 'Buy Now' on the product page
• In cart, add 5x additional units to your cart (for a total of 6x 3-Month Subscription Cards)
• Click on "Got discount code?" and apply code GoldUS
• Proceed to checkout with 6x 3-Month Xbox Live Gold Membership subscriptions
• Select PayPal or Credit Card as your payment method
  • Note, a service fee will apply here
• Your total should be ~$44.64 (price might vary slightly due to currency exchange volatility)
• Next, click here to redeem your 6x 3-Months Xbox Live Gold codes to your Microsoft account
  • Note: Opt out of 'Recurring billing'
• Next, Join Xbox Game Pass Ultimate by purchasing a 1-Month subscription from GCMGAMES via Eneba for ~$11.14 (price after service fee).
• Next, click here to redeem your 1-Month Xbox Game Pass Ultimate code to your Microsoft account
• You will be prompted to upgrade your Xbox Live Gold to Game Pass Ultimate with a 3:2 conversion. You will have 12+1 month of Game Pass Ultimate after conversion.
• Final total price for 13-Month Game Pass Ultimate membership after conversion should be ~$56

GCMGames via Eneba has Xbox Game Pass Ultimate: 3 Month Subscription (Digital Delivery - Stackable) on sale for around $26.99 when you follow the instructions below:

Deal Instructions:

• Go to product page
• Click on Buy Now.
• Click on "Got discount code?" under "Total Price" and apply discount code XGPUUS
• Proceed to checkout.
• Total price after service/payment fees should be around $26.99

Note: Codes are stackable, you can stack up to three years.

Half off select accessories via verizon up. Elite 2 controller 89.99

 

https://www.verizon.com/featured/verizon-up/?cjdata=MXxOfDB8WXww&URL=https%3A%2F%2Fwww.verizon.com%2Ffeatured%2Fverizon-up%2F&CMP=afc_h_p_cj_oth_fios_2022_04&

Eneba offers 50-Day of Xbox Game Pass Ultimate via Xbox Game Pass Core Conversion for around $11.05 when you follow the instructions below.

• Note, this offer is for Current/Existing Game Pass Ultimate Members only.

Deal Instructions:

• Click here to visit the product page.
• Click Buy Now and go to cart.
• Apply discount code XGPC
• Select payment method PayPal/Credit Card (service fees will be applied here)
• Proceed to checkout with end-price of ~ $11.05
• Click here to redeem your 3-Month Xbox Live Gold Membership code(s).
• You will be prompted to extend your Game Pass Ultimate by 50 days. The renewal date should be the same as your Xbox Game Pass Ultimate plus 50 days (Maximum 36 months).

About Game Pass Ultimate:

• Xbox Game Pass Ultimate Membership includes Xbox Live Gold and Xbox Game Pass with over 100 high-quality games to play with friends on console, PC, phones, and tablets, plus an EA Play membership, all for one low price.

Welcome to the first episode of the Internet Musician Podcast! Show notes for Episode #1: Subscribe to the Internet Musician Podcast with iTunes: The first episode of The Internet Musician Podcast, hosted by indie artist and internet music marketing junkie Brian Hartzog (http://www.brianhartzog.net).  In this introductory episode, Brian introduces himself, his indie music credentials and […]

A misspelling of former President Donald Trump's name occurred on an optional ballot review screen in Virginia, prompting an unfounded claim on social media of "election fraud." The error was a typo that appeared only on the ballot review screen, not on actual ballots, and would not affect any votes, election officials said.

The post Typo in Trump’s Name on Ballot Review Screen Is Not ‘Election Fraud’ appeared first on FactCheck.org.

I had email FOMO. I could be making a million dollars a year from my subscriber list! I read email marketing advice like it was porn — people say it can happen but I don’t think it really does happen. Finally I capitulated and started collecting data. The best insight from that data set is […]

The post Why am I subscribed to Penelope’s Substack? appeared first on Penelope Trunk Careers.

1. Wir produzieren keine Eiscreme (journalist.de, Jacob Goldmann (Pseudonym)) In seinem Essay “Wir produzieren keine Eiscreme” beschreibt Jacob Goldmann, ein Pseudonym eines Lokaljournalisten, wie wirtschaftliche Interessen zunehmend redaktionelle Entscheidungen beeinflussen. Als ein Beispiel nennt er die Berichterstattung über die Nosferatu-Spinne, die aufgrund der hohen Klickzahlen zu einer Überflutung des Nachrichtenangebots geführt habe. Goldmann argumentiert, dass […]

When my brother, Thom Atkins, visited last fall, he showed me (and a few quilting buddies) his new method for designing and constructing "scrappy improv wall quilts," a technique that turned out to be a lot of fun for me, especially given my long history with an improvisational, intuitive approach to bead embroidery.

Basically, what we did was to empty our bags or boxes of scraps onto a large table and start pawing through them, pulling out ones that appealed to us at that moment. For me it was all about color - red, magenta, fuchsia, with hints of pink, golden-yellow, orange, lavender, and dark green. All of the fabrics were in my scrap box. We had two days of Thom's demonstrations and guidance. During that time, each of us in our small group produced a unique and very pleasing "piece" or "block," measuring roughly 18 x 21 inches, the size of a fat quarter.

One of my red scraps, cut in a nice arc at one end, was the start of it all because I liked the shape and the color. Next I picked up a small strip of yellow, and held it behind the arc of red. Ooooh! Nice enough to repeat. The scrap of orange/red batik was large enough to cut a similar arc, and the strip of yellow was long enough to go behind that one too. These two arcs formed the basis of my piece.

You can see the two arcs above; the lower right was the first. The yellow strip was only about 3" wide, not enough to go all the way around the arcs, but I cut two shapes that would echo the top of each of the arcs. I layered the remaining scraps from that on top of the arcs along the vertical edges of the design. Then I put a dark green scrap behind the arcs and the yellow, which set them off nicely. The rest was just filling to the edges of the quilt with more scraps, including fussy-cut leaves and flowers.

The next step was to glue it all together along the 1/4" seam overlap, working in layers from bottom to top, and cutting away the excess fabric from the underside after each piece is glued. Cutting away the excess fabric leaves a double layer of fabric only at the seams; the rest is a single layer. The glue is Elmer's School Glue, Disappearing Purple, as shown below. It is an organic stick glue, relatively easy to sew through, repositionable, (in case you change your mind), and purple when first applied, drying to transparent (so you can see where exactly you are putting it).

Thom's method is a type of raw edge applique, typically accomplished with heat-fusible web, such as "wonder under." The typical method, given a complex, layered design such as mine, would have resulted in a thick, stiff, multi-layer surface, which would be difficult to quilt, even with a machine. In Thom's method, there is no web, and in most places only one or two layers of fabric. Like all raw edge techniques, the raw edges must be sewn down, and the resulting quilts are not very suitable for bed quilts unless there is heavy stitching over the raw edges (for example, dense, zig-zag, machine stitching).

After gluing my original (shown above) quilt top, I assembled the quilt, using a spray glue to layer the backing, batting and top. The next step was to stitch along the "seams," the overlapping, glued edge of each piece. From there, it was up to each of us as to how to finish the quilt, perhaps with machine quilting, such as stippling or contour stitches, or perhaps with beading, all of which Thom does on his quilts.

A couple of months went by after getting to the unfinished stage shown above. I liked it, but didn't know what to do with it, until one day when I was at our Senior Center, getting foot care from a trained nurse who comes a couple times a week to help those who need it. Her treatment room, about the size of a walk-in closet, has no windows. Her client faces the door to the room, a plain, wooden door.  "That door needs a quilt," I told her. The rest is history; my scrappy improv quilt, Eclipse,  hangs there now.

Only first I had to finish it. Above is the finished quilt, Eclipse. Below I'll tell you some of the finishing steps and about how I transformed it from looking flat and ordinary to sharp and textured using embroidery embellishments. Please click on the photo so you can see the details!

You might have noticed that the finished quilt is longer (better suited for hanging on a door) than the original piece. That was a challenge, although less than you might expect, because Thom had demonstrated for us how he sometimes extends the size of his quilts. In short, I roughly planned out the addition, the mock-up shown below, then created it using the same process and scraps as the original piece.


I used fusible "tape" made for butt-joining pieces of batting, to add a new piece of batting to the bottom edge of batting on the original (upper) part of the quilt. The horizontal strip of striped fabric overlaps the two parts of the quilt and the joined batting underneath. As you can see below, I added a fussy-cut flower over the striped fabric to break up the horizontal strip and visually join the two parts.


Confession time... I'm not good at machine quilting, and don't even have a proper quilting foot for my old machine (1972 Pfaff). I tried stitching around the fussy cut flowers to secure the glued edges, but failed miserably. What to do? Ah, hand-sew with embroidery stitches and floss? Yes! It took a few tries, but eventually I found stitch and thread combinations that worked.

It looked so good that I decided to add stitching and knots to the yellow arcs next. Wow! That popped the eclipse look! In the photo below, you can see bits of all the embroidery stitches I added. Not only does the embroidery provide embellishment and emphasis, it also further quilts the piece. Click the photo to see the detail and better read the stitch identification.


Here are two more detail photos of the finished quilt (without the text boxes).



Lots of fun, and I like the results! Will I do another one? Well, right now I've finally returned to my hexie project, where I'm likely to remain for many months, but after that, scrappy improv may be just what I need!

Bamako is a 2006 film directed by Abderrahmane Sissako, first released at the 2006 Cannes Film Festival on 21 May and in Manhattan by New Yorker Films on 14 February 2007. The film depicts a trial taking place in Bamako, the capital of Mali, amid the daily life that is going on in the city. In the midst of that trial, two sides argue whether the World Bank and International Monetary Fund are guided by special interest of developed nations, or whether it is corruption and the individual nations' mismanagement, that is guilty of the current financial state of many poverty-stricken African countries as well as the rest of the poor undeveloped world. The film even touches on European colonization and discusses how it plays a role in shaping African societies and their resulting poverty and issues.

Malês portrays the difficult living conditions of Black men and women in 19th-century Bahia, fighting against extreme racism, poverty, and religious intolerance. The film features a prominent cast, including Rocco and Camila Pitanga, Wilson Rabelo, Bukassa Kabengele, Samira Carvalho, Rodrigo de Odé, Heraldo de Deus, and Patricia Pillar, along with the director Antonio Pitanga. The script is written by Manuela Dias, and the cinematography is by Pedro Farkas. The film, based on historical facts, depicts the Malês Revolt, the largest organized uprising by enslaved people in Brazilian history. The insurrection mobilized the enslaved and free Black population through the streets of Salvador against slavery in 1835. Led by Muslim Africans, called Malês, the rebellion took place at the end of Ramadan, celebrated in January by Islam. After the revolt’s failure, the demonstrators were severely punished, and repression against Black people in Brazil increased. In the feature, Antonio Pitanga plays Pacífico Licutan, one of the leaders of the uprising, who emphasized the importance of participation from different tribes and religions for the revolt’s success and the end of slavery. The film also presents other participants of the revolt, such as Anuna (Rodrigo dos Santos), Manuel Calafate (Bukassa Kabengele), Vitério Sule (Heraldo de Deus), and Luis Sanim (Thiago Justino), along with fictional characters who portray real-life dramas, such as Dassalu (Rocco Pitanga), Sabina (Camila Pitanga), and Abayome (Samira Carvalho).

OnlyFans has emerged as a platform where creativity and intimacy intertwine, offering a personalized experience unlike any other. This blog post unveils the crème de la crème of OnlyFans creators, those who have mastered the art of captivating audiences with their unique content. Prepare to be enticed by a world where exclusivity meets allure, as ... Read more

The post Top OnlyFans Creators You Must Subscribe To appeared first on Star Two.

7-minute video shows you how to use the Repeat Signage designer screen to insert controls, e.g. picture control, to create flexible, dynamic, digital signage presentations for display screens.

Receba as principais notícias, análises e áudios produzidos pelas nossas equipes em São Paulo e Londres e seja o primeiro a saber dos fatos mais importantes e interessantes no Brasil e no mundo.

By Julianna Frieman Republican senators competing for the majority leader position vowed Sunday to address President-elect Donald Trump’s demands ahead of his inauguration. Trump revealed Sunday that the Senate leader of his GOP majority must support recess appointments to assure his Cabinet positions be confirmed expeditiously and unobstructed. The three senators contending for the leadership […]

The post GOP Senate Majority Leader-Hopefuls Scramble To Address Trump Demands Ahead Of Inauguration appeared first on Liberty Unyielding.

Elite players are taking fewer shots from further out. What is behind the trend and is it harming the game?

If you’re an entrepreneur nurturing your own company to a full-blown success, you are always looking for insights and ideas to take your business to the next level, right? But you’re probably super busy as well, and don’t always have the time to figure out where you should be looking for those insights.

If you run an eCommerce website, you may prefer to use a graphic as the call-to-action button for your subscription-style products or services. Below you can find a number of different subscription buttons suitable for use on a website’s landing page or the product page. Want some Buy Now button or Add to Cart button […]

The post Subscription Button Graphics for eCommerce Websites appeared first on Tips and Tricks HQ.

Meta Platforms is rolling out enhanced privacy and parental controls for Instagram accounts of users under 18 in a significant overhaul aimed at addressing growing concerns around the negative effects of social media.

TL;DR: Get 37% off this touchscreen infotainment system with CarPlay and Android Auto compatibility. 

Elon, who?? Okay, maybe Teslas have cool infotainment systems, but you don't have to pay crazy prices for an over-hyped screen—just grab one of these CarPlay displays for your old beater. — Read the rest

The post Teslas suck! What you really need is this whizz-bang CarPlay screen appeared first on Boing Boing.

Five years ago I was posting a lot to a publication called NewCo Shift, which is now offline. I got ahold of the archives, and found this review, which hasn’t lost any of its relevance – in fact, it kind of reads like it was written last week.  Everyone in tech loves Yuval Noah Harari. … Continue reading "From the Archive: Tech Must Get Over Its Superman Complex, Or We’re All Screwed"

Just because you’re paranoid, it doesn’t mean you’re wrong. And for any supporters of President-elect Donald Trump who feel that they’ve been unfairly targeted by the government, but were summarily […]

The post Fired FEMA Worker Reveals Discrimination Against Trump Supporters Was Even Worse Than First Reported appeared first on The Western Journal.

Mitochondria are specialized compartments that produce requisite ATP to fuel cellular functions and serve as centers of metabolite processing, cellular signaling, and apoptosis. To accomplish these roles, mitochondria rely on the genetic information in their small genome (mitochondrial DNA) and the nucleus. A growing appreciation for mitochondria's role in a myriad of human diseases, including inherited genetic disorders, degenerative diseases, inflammation, and cancer, has fueled the study of biochemical mechanisms that control mitochondrial function. The mitochondrial transcriptional machinery is different from nuclear machinery. The in vitro re-constituted transcriptional complexes of Saccharomyces cerevisiae (yeast) and humans, aided with high-resolution structures and biochemical characterizations, have provided a deeper understanding of the mechanism and regulation of mitochondrial DNA transcription. In this review, we will discuss recent advances in the structure and mechanism of mitochondrial transcription initiation. We will follow up with recent discoveries and formative findings regarding the regulatory events that control mitochondrial DNA transcription, focusing on those involved in cross-talk between the mitochondria and nucleus.

Mitsunori Fukuda
Jun 1, 2008; 7:1031-1042
Research

Timothy J. Griffin
Apr 1, 2002; 1:323-333
Research

Linn Fagerberg
Feb 1, 2014; 13:397-406
Research

HIV Type 1 (HIV-1) and simian immunodeficiency virus (SIV) display differential replication kinetics in macrophages. This is because high expression levels of the active host deoxynucleotide triphosphohydrolase sterile α motif domain and histidine-aspartate domain–containing protein 1 (SAMHD1) deplete intracellular dNTPs, which restrict HIV-1 reverse transcription, and result in a restrictive infection in this myeloid cell type. Some SIVs overcome SAMHD1 restriction using viral protein X (Vpx), a viral accessory protein that induces proteasomal degradation of SAMHD1, increasing cellular dNTP concentrations and enabling efficient proviral DNA synthesis. We previously reported that SAMHD1-noncounteracting lentiviruses may have evolved to harbor RT proteins that efficiently polymerize DNA, even at low dNTP concentrations, to circumvent SAMHD1 restriction. Here we investigated whether RTs from SIVmac239 virus lacking a Vpx protein evolve during in vivo infection to more efficiently synthesize DNA at the low dNTP concentrations found in macrophages. Sequence analysis of RTs cloned from Vpx (+) and Vpx (−) SIVmac239–infected animals revealed that Vpx (−) RTs contained more extensive mutations than Vpx (+) RTs. Although the amino acid substitutions were dispersed indiscriminately across the protein, steady-state and pre-steady-state analysis demonstrated that selected SIVmac239 Vpx (−) RTs are characterized by higher catalytic efficiency and incorporation efficiency values than RTs cloned from SIVmac239 Vpx (+) infections. Overall, this study supports the possibility that the loss of Vpx may generate in vivo SIVmac239 RT variants that can counteract the limited availability of dNTP substrate in macrophages.

Deplatforming Trump puts big tech under fresh scrutiny Expert comment NCapeling 22 January 2021

The response of digital platforms to the US Capitol riots raises questions about online content governance. The EU and UK are starting to come up with answers.

The ‘deplatforming’ of Donald Trump – including Twitter’s announcement that it has permanently banned him due to ‘the risk of further incitement of violence’ after the riots in the US – shows once more not only the sheer power of online platforms but also the lack of a coherent and consistent framework for online content governance.

Taking the megaphone away from Trump during the Capitol riots seems sensible, but was it necessary or proportionate to ban him from the platform permanently? Or consistent with the treatment of other ‘strongmen’ world leaders such as Modi, Duterte and Ayatollah Ali Khamenei who have overseen nationalistic violence but whose accounts remain intact?

Such complex decisions on online expression should not made unilaterally by powerful and unregulated tech actors, but instead should be subject to democratic oversight and grounded in the obligations of states and responsibilities of companies under international human rights law.

The speed and scale of digital information has left governments across the world struggling with how to tackle online harms such as hate speech, extremist content and disinformation since the emergence of mass social media 15 years ago.

The US’s hallowed approach to the First Amendment, under which speech on public issues – even hate speech – occupies the highest rank and is entitled to special protection, has contributed to a reluctance to regulate Silicon Valley’s digital platforms. But the irony is that by not regulating them, the government harmed freedom of expression by leaving complex speech decisions in the hands of private actors.

Meanwhile at the other extreme is the growing number of illiberal and authoritarian governments using a combination of vague laws, censorship, propaganda, and internet blackouts to severely restrict online freedom of expression, control the narrative and, in some cases, incite atrocities.

Regulation is on the way

The happy medium – flexible online content regulation providing clarity, predictability, transparency, and accountability – has until now been elusive. But even before the deplatforming of Trump, 2021 was set to be the year when this approach finally gained some traction, at least in Europe.

The EU’s recently-published draft Digital Services Act puts obligations on dominant social media platforms to manage ‘systemic risks’, for example through requirements for greater transparency about their content decisions, algorithms used for recommendations, and online advertising systems.

The UK will shortly publish its Online Safety Bill, which will establish a new regulatory framework for tackling online harms, including the imposition of a duty of care and codes of conduct on Big Tech, to be overseen by an independent regulator (Ofcom).

Both proposals are based on a ‘co-regulatory’ model under which the regulator sets out a framework substantiated with rules by the private sector, with the regulator performing a monitoring function to ensure the rules are complied with.

Both also draw on international human rights standards and the work of civil society in applying these standards in relation to the online public square, with the aim of increasing control for users over what they see online, requiring transparency about tech companies’ policies in a number of areas, and strengthening the accountability of platforms when they fall foul of the regulation.

The procedure for both proposals has also been inclusive, involving extensive multi-stakeholder consultations with civil society organizations and Big Tech, and the proposals will be subject to scrutiny in 2021, notably from the EU and UK parliaments.

Both proposals are at an early stage, and it remains to be seen whether they go far enough – or indeed will have a chilling effect on online platforms. But as an attempt to initiate a dialogue on globally coherent principles, they are positive first steps. They also provide food for thought for the new Joe Biden administration in the US as it turns its attention to the regulation of Big Tech.

For some time civil society – most prominently David Kaye, the former UN Special Rapporteur on freedom of expression and opinion – have called for content regulation to be informed by universal international human rights law standards.

The EU and UK are peculiarly well-placed to take the lead in this area because European countries have for decades been on the receiving end of judgments from the European Court of Human Rights on the appropriate limits to freedom of expression in cases brought under the European Convention on Human Rights.

In deciding these cases, the court has to balance the right to freedom of expression against the restrictions imposed – for example in the context of incitement to violence, political debate, and satire. Deciding where to draw the line on what can and cannot be expressed in a civilised society which prizes freedom of expression is inevitably a difficult exercise.

International human rights law provides a methodology that inquires whether the interference to freedom of expression was prescribed by law and pursues a legitimate aim, and also whether it was necessary in a democratic society to achieve those aims – including whether the interference was necessary and proportionate (as for example in Delfi AS v Estonia, which involved a news portal failing to take down unlawful hate speech).

To be effective, online content regulation has to bite on tech companies, which is a challenge given the internet is global but domestic law normally applies territorially. The EU’s proposals have an extraterritorial element as they apply to any online platforms providing services in the EU regardless of where the platform is headquartered.

Further, both the EU and UK want to give the regulator strong enforcement powers – it is proposed for example that Ofcom will have powers to fine platforms up to ten per cent of their turnover for breaches.

Although the proposals would not apply directly to the deplatforming of Trump which occurred in the US, the philosophy behind the EU and UK approach is likely to have an impact beyond European shores in promoting a co-regulatory model that some of the bigger tech companies have been inviting for some time, reluctant as they are to ‘play God’ on content moderation decisions without reference to any regulatory framework.

In the absence of regulation, the standards of tech platforms such as Facebook and Twitter have already evolved over time in response to pressure from civil rights groups, users, and advertisers, including updated policies on protecting civic conversation and hate speech.

Facebook has also set up an independent Oversight Board, whose members include leading human rights lawyers, to review decisions on content including – at its own request – the decision to indefinitely suspend Trump from Facebook and Instagram. Decisions on the Board’s first tranche of cases are expected imminently.

Gatekeeper status is key

Online content regulation also needs to address the role of Big Tech as the ‘digital gatekeepers’, because their monopoly power extends not just to editorial control of the news and information we consume, but also to market access.

The decision of Apple, Google, and Amazon to stop hosting right-wing social network Parler after it refused to combat calls for violence during the US Capitol riots was understandable in the circumstances, but also underlined the unilateral ability of Big Tech to decide the rules of the market.

Again, it is Europe where efforts are underway to tackle this issue: the EU’s draft Digital Market Act imposes obligations on online gatekeepers to avoid certain unfair practices, and the UK’s new Digital Markets Unit will have powers to write and enforce a new code of practice on those technology companies with ‘substantial and enduring’ market power.

In the US, Biden’s team will be following these developments with interest, given the growing bipartisan support for strengthening US antitrust rules and reviving antitrust enforcement. The EU’s recently published proposals for an EU-US tech agenda include a transatlantic dialogue on the responsibility of tech platforms and strengthened cooperation between antitrust authorities on digital markets.

Ultimately a consistent – and global – approach to online content is needed instead of fragmented approaches by different companies and governments. It is also important the framework is flexible so that it is capable of applying not only to major democracies but also to countries where too often sweeping state regulation has been used as a pretext to curtail online expression online.

The pursuit of a pluralistic framework tailored to different political and cultural contexts is challenging, and international human rights law cannot provide all the answers but, as a universal framework, it is a good place to start. The raft of regulatory measures from the EU and UK means that, regardless of whether Trump regains his online megaphone, 2021 is set to be a year of reckoning for Big Tech.

The Implication of Greater Use of Investment Screening 26 June 2020 — 9:00AM TO 10:30AM Anonymous (not verified) 11 February 2021 Online

What is driving the trend towards greater use of investment screening by nation states and regional economic groupings?

• How is the COVID-19 crisis affecting this trend?
• What will the economic implications be?
• Will this help or hinder inclusivity and transparency in investment governance?
• Is there a role for international safeguards and/or international coordination of national/regional approaches to investment screening?

This event is part of the Inclusive Governance Initiative, which is examining how to build more inclusive models and mechanisms of global governance fit for purpose in today’s world.

Facebook's power under scrutiny as Trump ban upheld Expert comment NCapeling 6 May 2021

Keeping Donald Trump’s Facebook ban in place shows the vast power social media platforms hold, raising questions of whether that power is appropriately used.

Kate Jones

From a human rights perspective, the Oversight Board’s decision is a strong one, and not at all surprising. The board decided Facebook was right to suspend the former president’s access to post content on Facebook and Instagram, but not indefinitely.

It found Donald Trump’s posts violated Facebook’s community standards because they amounted to praise or support of people engaged in violence and that, applying a human rights assessment, Facebook’s suspension of Trump was a necessary and proportionate restriction of his right to freedom of expression.

However the board also found Trump’s indefinite suspension was neither in conformity with a clear Facebook procedure nor consistent with its commitment to respect human rights. Its decision requires Facebook to make a new decision on the future of Donald Trump’s account, grounded in its rules.

While opinions on this result will differ, the increased call for clear and accessible rules and respect for human rights in their implementation that the Oversight Board brings to Facebook’s operations is welcome.

But the Oversight Board’s powers are limited to content moderation – Facebook declined to answer the board’s questions about amplification of Trump’s posts through the platform’s design decisions and algorithms. This limitation on the board’s role should be lifted. It is in content amplification, not just content moderation, that Facebook should face scrutiny and accountability for the sake of the human rights of its users.

Fundamentally, human rights is not a veneer which can mask or legitimize underlying power dynamics or public policy – those still fall to be assessed for themselves.

The Trump/Facebook saga does highlight the vast power Facebook and other major social media platforms have over political discussion and persuasion. Through granting or denying, or through amplifying or quietening the voices of political figures, Facebook has the power to shape politics, electorates, and democratic processes. Improving content moderation through the Oversight Board, although important, does little to constrain that power.

Facebook itself, unlike a government, has no accountability to the general public, and the Oversight Board must not distract us from the need for a full conversation about the extent to which Facebook’s power is appropriately held and properly wielded.

Emily Taylor

This decision marks a coming of age for Facebook’s content moderation process. For years, decisions to take down content or ban users have been opaque, conducted by a human workforce that Facebook and other platforms have been hesitant to acknowledge. The platforms have also been worried that being seen to exercise an editorial function might put at risk the legal protections which prevent the platforms being held responsible for user-generated content.

When the Oversight Board was first posited, observers questioned whether a body funded by Facebook could properly exercise a legitimate appeals function. Now there is a reasoned decision which partly supports the decision to de-platform a serving president, but also takes issue with the indefinite nature of the ban.

Facebook specifically asked the Oversight Board to consider specific challenges involved when the person involved is a political leader. The board concluded that Trump’s ‘status as head of state with a high position of trust not only imbued his words with greater force and credibility but also created risks that his followers would understand they could act with impunity’. The storming of the US Capitol and role President Trump played in stirring up the violence underlined that political leaders’ words can motivate others to take harmful actions.

Just as the events of January 6 remain shocking, it remains shocking that private platforms have exercised the power to curb the speech of a US president. It also remains shocking that the platforms sat back and took no action over the previous four years, but waited until the final days of the transition.

The board’s decision is an evolution in private-sector content moderation, with a diverse board giving a reasoned opinion on a Facebook decision. But to fully comply with the principles of open justice, board decisions should include more detail on the individuals who have made the decision – at present, it appears all members of the board review the decision but it is not clear which individuals were involved in its drafting, or that they were clear from conflicts. If the process is to gain respect as a truly independent oversight on the platform’s decisions, greater transparency over the identity of decision-makers will be needed.

Mark Zuckerberg expressed concern about Facebook becoming an arbiter of truth or free speech and, overall, the difficulty of having private companies managing the application of fundamental rights on their platforms has not been solved. Just because companies have the financial resources to do it, does not mean they necessarily should.

Yet no other international governance or arbitration system has emerged to handle the complexities of platform power over speech. In the context of that vacuum, the Oversight Board’s decision is a welcome step.

Hepatocyte nuclear factor-1β (HNF-1β) is a tissue-specific transcription factor that is required for normal kidney development and renal epithelial differentiation. Mutations of HNF-1β produce congenital kidney abnormalities and inherited renal tubulopathies. Here, we show that ablation of HNF-1β in mIMCD3 renal epithelial cells results in activation of β-catenin and increased expression of lymphoid enhancer–binding factor 1 (LEF1), a downstream effector in the canonical Wnt signaling pathway. Increased expression and nuclear localization of LEF1 are also observed in cystic kidneys from Hnf1b mutant mice. Expression of dominant-negative mutant HNF-1β in mIMCD3 cells produces hyperresponsiveness to exogenous Wnt ligands, which is inhibited by siRNA-mediated knockdown of Lef1. WT HNF-1β binds to two evolutionarily conserved sites located 94 and 30 kb from the mouse Lef1 promoter. Ablation of HNF-1β decreases H3K27 trimethylation repressive marks and increases β-catenin occupancy at a site 4 kb upstream to Lef1. Mechanistically, WT HNF-1β recruits the polycomb-repressive complex 2 that catalyzes H3K27 trimethylation. Deletion of the β-catenin–binding domain of LEF1 in HNF-1β–deficient cells abolishes the increase in Lef1 transcription and decreases the expression of downstream Wnt target genes. The canonical Wnt target gene, Axin2, is also a direct transcriptional target of HNF-1β through binding to negative regulatory elements in the gene promoter. These findings demonstrate that HNF-1β regulates canonical Wnt target genes through long-range effects on histone methylation at Wnt enhancers and reveal a new mode of active transcriptional repression by HNF-1β.

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Dr Sam Geall

Torin Greenwood, Jonathan Kariv and Noah Williams
Math. Comp. 93 (), 2959-2983.
Abstract, references and article information

Constantin Carle and Marlis Hochbruck
Math. Comp. 93 (), 2611-2641.
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Math is often described as the science of patterns, which makes it a natural subject to help in the study of the underlying causes of patterns found in nature, for example, bands of vegetation that often occur on gently sloped terrains in certain near-desert ecosystems worldwide. We are starting to learn more about these bands' common properties by using mathematical models built on data, such as rainfall totals and the curvature of the terrain. Mary Silber talks about these mathematical models of vegetation bands.

Christian Weiss
Theor. Probability and Math. Statist. 111 (), 199-209.
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