id Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3800-3816DOI: 10.1039/D4MD00585F, Research ArticleMarwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-KarmalawyNovel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3695-3703DOI: 10.1039/D4MD00546E, Research ArticleMiyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke DemizuA novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id U.S. oil industry urges Trump to ditch Biden climate policies By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:27:45 +0530 Full Article Business
id Vodafone Idea narrows Q2 loss to ₹7,176 crore By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:56:55 +0530 Full Article Business
id SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:49:14 +0530 Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities Full Article Mangaluru
id Incessant rains cause landslides on Tirumala ghat road By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:56:12 +0530 Full Article Andhra Pradesh
id RLDA invites bids for commercial land use in Tirupati railway station By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:29:31 +0530 The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side Full Article Andhra Pradesh
id Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:25:39 +0530 Full Article Andhra Pradesh
id India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 09:20:06 +0530 In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months Full Article Real Estate
id Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 11:31:53 +0530 The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling Full Article News
id Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:50:51 +0530 GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations Full Article Health
id Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36352-36369DOI: 10.1039/D4RA07074G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. CoveyPhotoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Synthesis of MOF-supported Pt catalyst with high electrochemical oxidation activity for methanol oxidation By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36370-36377DOI: 10.1039/D4RA06393G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Merve Akin, Hatice Kars, Muhammed Bekmezci, Aysenur Aygun, Mert Gul, Guray Kaya, Fatih SenIn this study, Pt and Pt@Ti-MOF NPs catalysts were synthesized by chemical reduction method. Ti-MOF structure was synthesized using the solvothermal method, and the effect of Ti-MOF on methanol oxidation was investigated.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
id Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:45:12 +0530 Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka Full Article Karnataka
id Karnataka bypolls: A few residents of Savanur boycott polling in Shiggaon Assembly constituency By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:31:09 +0530 Some families at Dandinpet in Savanur boycotted the bypolls over not being given record of occupancy rights to them. Full Article Karnataka
id ED’s investigation into MUDA case is based on false allegations, says Siddaramaiah By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:12:55 +0530 Full Article Karnataka
id Only education can empower women: Siddaramaiah By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:33:50 +0530 Full Article Karnataka
id Karnataka to roll out e-khatas for all properties in GPs, ULBs to avoid fictitious transactions By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:13:49 +0530 Full Article Karnataka
id Pakistan should stop playing cricket with India, says Rashid Latif By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:49:54 +0530 The Pakistan Cricket Board (PCB) has written to ICC asking for written confirmation from the BCCI for India's inability to travel to Pakistan for the tournament Full Article Cricket
id Pacers Koushik, Vidyadhar run through Uttar Pradesh By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:46:00 +0530 Duo shares eight wickets to roll the opposition over for 89; debutant Shrijith’s unbeaten 68 steadies a rocking ship for the visitors as they eke out a 38-run lead Full Article Cricket
id Siddhant Banthia sails past Siddharth Vishwakarma in ITF men’s tennis tournament By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:37:44 +0530 Siddhant Banthia broke serve dropping one point, and served out at love in the next game, to gain a stranglehold over the proceedings. He ran up a 5-1 lead in the second set before closing it out without any trouble Full Article Sport
id India's middle class tightens its belt, squeezed by food inflation By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:50:09 +0530 Slowing urban spending over the past three to four months has not only hurt the earnings of largest consumer goods firms Full Article Economy
id Allison Transmission to double Chennai facility with $100 mn+ investment amid rising global demand By www.thehindubusinessline.com Published On :: Thu, 14 Nov 2024 07:33:39 +0530 The expansion aims to double the facility’s size, creating 167 new jobs, and enhance production capacity for automatic transmissions in response to growing global demand Full Article Companies
id Delhi HC sets aside Centre’s order cancelling U.S.-based professor’s OCI card By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:10:09 +0530 On the govt.’s allegation of his being involved in “anti-India activities”, the court says the notice lacks specific details or evidence supporting these claims Full Article Delhi
id Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:20:29 +0530 The attacker, Vignesh, was reportedly frustrated over the treatment given to his mother, who was diagnosed with Hodgkin’s Lymphoma in an advanced stage Full Article Chennai
id Residents raise concerns over water quality and odour from Vellalore dump yard By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:22:04 +0530 Full Article Coimbatore
id Permission of State govt. required for bringing elephants from outside: Kerala HC By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:23:10 +0530 Full Article Kochi
id The globally-acclaimed Candlelight Concert is now in Chennai. Listen to classical and contemporary music at Museum Theatre, amidst thousands of candles By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:12:01 +0530 The first concert on November 15 will feature tunes from Tamil and Hindi films, followed by tributes to Coldplay, Mozart, Queen, and Abba in the upcoming months Full Article Life & Style
id Yet another incident of doctor being attacked By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:22:03 +0530 Full Article Chennai
id U.T. seeks Centre’s nod to implement Smart Meter Project with post-paid plan option By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:27:15 +0530 There is stiff resistance from various quarters for the pre-paid Smart Meter Project. It will be difficult to introduce the prepaid functionality at the beginning stages of the implementation, says Minister for Home A. Namassivayam in his memorandum submitted to Union Minister for Power Manohar Lal Khattar Full Article Puducherry
id BJP leaders to live with people living alongside Musi river By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:41 +0530 Full Article Telangana
id Barcelona’s Fati sidelined with hamstring injury By www.thehindu.com Published On :: Thu, 14 Nov 2024 01:20:00 +0530 Fati is set to miss the club’s Champions League match against French side Brest on November 26, as well as La Liga matches against Celta Vigo, Las Palmas, Mallorca and Real Betis Full Article Football
id Tilak’s maiden ton, Abhishek’s 50 fire India to 219/6 against South Africa in 3rd T20I By www.thehindu.com Published On :: Thu, 14 Nov 2024 01:34:36 +0530 Tilak Varma got ample backing from Abhishek Sharma who made a brisk 50 after SA skipper Aiden Markram invited the visitors to bat first. Full Article Cricket
id Fifty years ago | Tamil Nadu omnibus tax increase held valid By www.thehindu.com Published On :: Thu, 14 Nov 2024 04:35:00 +0530 Full Article Archives
id Tackling diabetes epidemic By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:00:00 +0530 An India free of diabetes-related complications is eminently possible, if lifestyle changes are made Full Article Open Page
id Pakistan court acquits Imran Khan, his close aides in Section 144 violation case By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:02:42 +0530 The dismissal of the case against Khan comes as a kind of relief for someone who has been incarcerated since August last year Full Article World
id South India science drama festival on Thursday and Friday By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:04:59 +0530 Full Article Bengaluru
id Donald Trump meets Joe Biden in White House; both pledge smooth transition By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:05:43 +0530 In a brief meeting, the two leaders assured the nation of a peaceful transition of power on January 20, 2025. Full Article U.S. Elections
id U-shaped flyover on IT corridor nearing completion By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:01:19 +0530 Full Article Tamil Nadu
id Constable killed in accident By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:13:16 +0530 Full Article Karnataka
id Police arrest man for employing, abusing 11-year-old domestic help in Noida society By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:58:38 +0530 Full Article Delhi
id BJP councillor nominated presiding officer for mayoral polls, AAP raises objections By www.thehindu.com Published On :: Thu, 14 Nov 2024 01:08:46 +0530 Mayoral elections today; ruling party says L-G should have considered either incumbent Mayor or most senior councillor for role to ensure fairness; AAP in habit of casting aspersions, says BJP Full Article Delhi
id After Uddhav Thackeray calls EC biased for checking his bags, Eknath Shinde releases videos of his bags being checked By www.thehindu.com Published On :: Thu, 14 Nov 2024 02:21:50 +0530 Eknath Shinde’s luggage was being checked at the Palghar police ground helipad as part of Standard Operating Procedures (SOPs) Full Article Mumbai
id In Beed, Independent candidates on strong footing against party nominees By www.thehindu.com Published On :: Thu, 14 Nov 2024 05:43:54 +0530 Candidates who rebelled against party diktat stand out with strong support at the ground level and also have high chances of winning the seat Full Article Maharashtra Assembly
id Karnataka rolls out APAAR ID for schoolchildren By www.thehindu.com Published On :: Thu, 14 Nov 2024 06:20:00 +0530 Critics questioned the need for a new ID, given that students in the State are already assigned Student Achievement Tracking System IDs Full Article Karnataka
id Mother, sister arrested for suicide of 32-year-old Pakshikere resident seek bail By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:00:00 +0530 Full Article Mangaluru
id Catering services should only be provided by those having trade licence, says association By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:00:00 +0530 Full Article Mangaluru