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Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators

RSC Med. Chem., 2024, 15,3800-3816
DOI: 10.1039/D4MD00585F, Research Article
Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-Karmalawy
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3880-3888
DOI: 10.1039/D4MD00414K, Research Article
Phuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. Vo
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00661E, Review Article
Avijit Kumar Das
The detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...
The content of this RSS Feed (c) The Royal Society of Chemistry




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U.S. oil industry urges Trump to ditch Biden climate policies




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Vodafone Idea narrows Q2 loss to ₹7,176 crore




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SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka

Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities




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Incessant rains cause landslides on Tirumala ghat road




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RLDA invites bids for commercial land use in Tirupati railway station

The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side




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Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan




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India’s office leasing soars 41% in 2024 amid rent hikes, supply crunch, and GCC growth: Cushman & Wakefield

In an interview to businessline, Cushman & Wakefield’s Veera talks about commercial space leasing outlook, trends, and rental and supply trends for the coming months




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Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional

The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling




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Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar

GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations




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Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors

RSC Adv., 2024, 14,36352-36369
DOI: 10.1039/D4RA07074G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. Covey
Photoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of MOF-supported Pt catalyst with high electrochemical oxidation activity for methanol oxidation

RSC Adv., 2024, 14,36370-36377
DOI: 10.1039/D4RA06393G, Paper
Open Access
Merve Akin, Hatice Kars, Muhammed Bekmezci, Aysenur Aygun, Mert Gul, Guray Kaya, Fatih Sen
In this study, Pt and Pt@Ti-MOF NPs catalysts were synthesized by chemical reduction method. Ti-MOF structure was synthesized using the solvothermal method, and the effect of Ti-MOF on methanol oxidation was investigated.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur

Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka




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Karnataka bypolls: A few residents of Savanur boycott polling in Shiggaon Assembly constituency

Some families at Dandinpet in Savanur boycotted the bypolls over not being given record of occupancy rights to them.




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ED’s investigation into MUDA case is based on false allegations, says Siddaramaiah




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Only education can empower women: Siddaramaiah




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Karnataka to roll out e-khatas for all properties in GPs, ULBs to avoid fictitious transactions




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Pakistan should stop playing cricket with India, says Rashid Latif

The Pakistan Cricket Board (PCB) has written to ICC asking for written confirmation from the BCCI for India's inability to travel to Pakistan for the tournament




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Pacers Koushik, Vidyadhar run through Uttar Pradesh

Duo shares eight wickets to roll the opposition over for 89; debutant Shrijith’s unbeaten 68 steadies a rocking ship for the visitors as they eke out a 38-run lead




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Siddhant Banthia sails past Siddharth Vishwakarma in ITF men’s tennis tournament

Siddhant Banthia broke serve dropping one point, and served out at love in the next game, to gain a stranglehold over the proceedings. He ran up a 5-1 lead in the second set before closing it out without any trouble




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India's middle class tightens its belt, squeezed by food inflation

Slowing urban spending over the past three to four months has not only hurt the earnings of largest consumer goods firms




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Allison Transmission to double Chennai facility with $100 mn+ investment amid rising global demand

The expansion aims to double the facility’s size, creating 167 new jobs, and enhance production capacity for automatic transmissions in response to growing global demand




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Delhi HC sets aside Centre’s order cancelling U.S.-based professor’s OCI card

On the govt.’s allegation of his being involved in “anti-India activities”, the court says the notice lacks specific details or evidence supporting these claims




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Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock

The attacker, Vignesh, was reportedly frustrated over the treatment given to his mother, who was diagnosed with Hodgkin’s Lymphoma in an advanced stage




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Residents raise concerns over water quality and odour from Vellalore dump yard




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Permission of State govt. required for bringing elephants from outside: Kerala HC




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The globally-acclaimed Candlelight Concert is now in Chennai. Listen to classical and contemporary music at Museum Theatre, amidst thousands of candles

The first concert on November 15 will feature tunes from Tamil and Hindi films, followed by tributes to Coldplay, Mozart, Queen, and Abba in the upcoming months



  • Life & Style

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Yet another incident of doctor being attacked 




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U.T. seeks Centre’s nod to implement Smart Meter Project with post-paid plan option

There is stiff resistance from various quarters for the pre-paid Smart Meter Project. It will be difficult to introduce the prepaid functionality at the beginning stages of the implementation, says Minister for Home A. Namassivayam in his memorandum submitted to Union Minister for Power Manohar Lal Khattar




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BJP leaders to live with people living alongside Musi river




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Barcelona’s Fati sidelined with hamstring injury

Fati is set to miss the club’s Champions League match against French side Brest on November 26, as well as La Liga matches against Celta Vigo, Las Palmas, Mallorca and Real Betis




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Tilak’s maiden ton, Abhishek’s 50 fire India to 219/6 against South Africa in 3rd T20I

Tilak Varma got ample backing from Abhishek Sharma who made a brisk 50 after SA skipper Aiden Markram invited the visitors to bat first.




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Fifty years ago | Tamil Nadu omnibus tax increase held valid




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Tackling diabetes epidemic

An India free of diabetes-related complications is eminently possible, if lifestyle changes are made




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Pakistan court acquits Imran Khan, his close aides in Section 144 violation case

The dismissal of the case against Khan comes as a kind of relief for someone who has been incarcerated since August last year




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South India science drama festival on Thursday and Friday




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Donald Trump meets Joe Biden in White House; both pledge smooth transition

In a brief meeting, the two leaders assured the nation of a peaceful transition of power on January 20, 2025.




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U-shaped flyover on IT corridor nearing completion




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Constable killed in accident




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Police arrest man for employing, abusing 11-year-old domestic help in Noida society




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BJP councillor nominated presiding officer for mayoral polls, AAP raises objections

Mayoral elections today; ruling party says L-G should have considered either incumbent Mayor or most senior councillor for role to ensure fairness; AAP in habit of casting aspersions, says BJP




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After Uddhav Thackeray calls EC biased for checking his bags, Eknath Shinde releases videos of his bags being checked

Eknath Shinde’s luggage was being checked at the Palghar police ground helipad as part of Standard Operating Procedures (SOPs)




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In Beed, Independent candidates on strong footing against party nominees

Candidates who rebelled against party diktat stand out with strong support at the ground level and also have high chances of winning the seat




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Karnataka rolls out APAAR ID for schoolchildren

Critics questioned the need for a new ID, given that students in the State are already assigned Student Achievement Tracking System IDs




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Mother, sister arrested for suicide of 32-year-old Pakshikere resident seek bail




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Catering services should only be provided by those having trade licence, says association