Levine is making the rounds to make the case for baseball in the time of the coronavirus pandemic.

Former Mayo boss Frank Browne - now coaching Galway - believes it's time for those involved in Mayo football to bury the hatchet for the good of the players

A look behind the scenes at the creation of the GT LTS from development to racing with the GT Factory Racing team.
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In this pandemic, we need an emergency increase in the number of green cards issued to immigrants with critically required skills.

Angels pitcher Andrew Heaney struggled against the Houston Astros in 2018, and he's irate not only at the sign stealing but because players haven't apologized.

Levine is making the rounds to make the case for baseball in the time of the coronavirus pandemic.

New analyses show that cheating didn't help the Astros, and may have hurt their record

The Dodgers are tired of talking about what the Houston Astros did in 2017. They're excited about what lies ahead for the team this season.

The Houston Astros cheated and Mike Fiers shined the brightest light on their scheme, LZ Granderson writes.

Levine is making the rounds to make the case for baseball in the time of the coronavirus pandemic.

Japreece Dean finishes with 16 points and eight assists and Michaela Onyenwere added 15 points and 11 rebounds in UCLA's 77-54 win over Utah.

Want to entertain more at home and be ready for drop-in guests? Then you need extra seating. Here are some solutions.

Doctors caring for the sickest COVID-19 patients are trying new ways to attack the coronavirus. One theory is that they have blood clots in their lungs.

The San Francisco Bay Area has seen consecutive weekly declines in the number of new coronavirus cases. Southern California has seen the pace increase.

This is no time for LAPD to "manage" public anger. It is a time to come clean.

Disneyland is closed -- but that hasn't stopped fans from building their own theme park rides and attractions in their homes and backyards.

When doctors are given N95 masks but the nurses who frequently come into contact with sick patients do not, you know something's wrong.

Neil Lennon is worried Celtic will run out of time to complete the transfer of Greg Taylor.

VIRGIN Media and O2 are to merge to create a £31billion media and telecoms giant, their parent firms have announced. Liberty Global and Telefonica - the owners of Virgin Media and O2 respectively - had confirmed on Monday that they were in discussions over a possible combination.

2020-03-27 -

An anonymous reader quotes a report from NPR: As hospitals were overrun by coronavirus patients in other parts of the world, the Army Corps of Engineers mobilized in the U.S., hiring private contractors to build emergency field hospitals around the country. The endeavor cost more than $660 million, according to an NPR analysis of federal spending records. But nearly four months into the pandemic, most of these facilities haven't treated a single patient. Public health experts said this episode exposes how ill-prepared the U.S. is for a pandemic. They praised the Army Corps for quickly providing thousands of extra beds, but experts said there wasn't enough planning to make sure these field hospitals could be put to use once they were finished. "It's so painful because what it's showing is that the plans we have in place, they don't work," said Robyn Gershon, a professor at New York University's School of Global Public Health. "We have to go back to the drawing board and redo it." But the nation's governors -- who requested the Army Corps projects and, in some cases, contributed state funding -- said they're relieved these facilities didn't get more use. They said early models predicted a catastrophic shortage of hospital beds, and no one knew for sure when or if stay-at-home orders would reduce the spread of the coronavirus. "All those field hospitals and available beds sit empty today," Florida Gov. Ron DeSantis, a Republican, said last month. "And that's a very, very good thing." Michigan Gov. Gretchen Whitmer, a Democrat, said: "These 1,000-bed alternate care sites are not necessary; they're not filled. Thank God." Senior military leaders also said the effort was a success -- even if the beds sit empty.

Read more of this story at Slashdot.

Officer Frank Hernandez has been involved in at least three on-duty shootings, including one where the city's Police Commission found fault with his actions.

Dani Bereznay, one of the fastest esports Formula 1 drivers in the world, talks about taking on real-life F1 drivers.

As “The Rise of Skywalker” opens, here's a look back at how the series created so many memorable ones.

Submit your visual art here. We'll publish some of the submissions.

oscon: Community Management Training - strategic planning, creating buzz, handling conflict + more http://t.co/eHz9h6VfnU @jonobacon #oscon

The Amateur Traveler talks to Ira Bernstein about two lesser visited cities in Italy - Turin and Bologna. Turin has the reputation as the Detroit of Italy because of its long association with Fiat but that nickname does not express the beauty of the city, the warmth of its people nor the quality of its wine. Bologna has a reputation for good food in a country known for its good food which may be one of the reasons that Bologna is known as "the fat". The city is the home of bolognese sauce and lasagna. It also lays claim to one of the oldest if not the oldest university in Europe. Ira takes us on a tour of surprising museums (like the largest Egyptian museum outside Cairo), pivotal history and of course wonderful food. 

At a cost of $7.5 million a patient, they were 16 very expensive field hospitals. Yet, according to NPR, those hospitals are now “stand[ing] down.” You probably remember them from headlines early in the pandemic: makeshift medical centers being assembled at breakneck speed by companies contracted by the Army Corps of Engineers in anticipation of…

The post After Treating Barely Any Patients for a Massive $7.5 Million Each, 16 Emergency COVID Hospitals Are Standing Down appeared first on The Western Journal.

T-type (Cav3) Ca2+ channels are important regulators of excitability and rhythmic activity of excitable cells. Among other voltage-gated Ca2+ channels, Cav3 channels are uniquely sensitive to oxidation and zinc. Using recombinant protein expression in HEK293 cells, patch clamp electrophysiology, site-directed mutagenesis, and homology modeling, we report here that modulation of Cav3.2 by redox agents and zinc is mediated by a unique extracellular module containing a high-affinity metal-binding site formed by the extracellular IS1–IS2 and IS3–IS4 loops of domain I and a cluster of extracellular cysteines in the IS1–IS2 loop. Patch clamp recording of recombinant Cav3.2 currents revealed that two cysteine-modifying agents, sodium (2-sulfonatoethyl) methanethiosulfonate (MTSES) and N-ethylmaleimide, as well as a reactive oxygen species–producing neuropeptide, substance P (SP), inhibit Cav3.2 current to similar degrees and that this inhibition is reversed by a reducing agent and a zinc chelator. Pre-application of MTSES prevented further SP-mediated current inhibition. Substitution of the zinc-binding residue His191 in Cav3.2 reduced the channel's sensitivity to MTSES, and introduction of the corresponding histidine into Cav3.1 sensitized it to MTSES. Removal of extracellular cysteines from the IS1–IS2 loop of Cav3.2 reduced its sensitivity to MTSES and SP. We hypothesize that oxidative modification of IS1–IS2 loop cysteines induces allosteric changes in the zinc-binding site of Cav3.2 so that it becomes sensitive to ambient zinc.

Normally when creating a digital file, such as a picture, much more information is recorded than necessary-even before storing or sending. The image on the right was created with compressed (or compressive) sensing, a breakthrough technique based on probability and linear algebra. Rather than recording excess information and discarding what is not needed, sensors collect the most significant information at the time of creation, which saves power, time, and memory. The potential increase in efficiency has led researchers to investigate employing compressed sensing in applications ranging from missions in space, where minimizing power consumption is important, to MRIs, for which faster image creation would allow for better scans and happier patients. Just as a word has different representations in different languages, signals (such as images or audio) can be represented many different ways. Compressed sensing relies on using the representation for the given class of signals that requires the fewest bits. Linear programming applied to that representation finds the most likely candidate fitting the particular low-information signal. Mathematicians have proved that in all but the very rarest case that candidate-often constructed from less than a tiny fraction of the data traditionally collected-matches the original. The ability to locate and capture only the most important components without any loss of quality is so unexpected that even the mathematicians who discovered compressed sensing found it hard to believe. For More Information: "Compressed Sensing Makes Every Pixel Count," What's Happening in the Mathematical Sciences, Vol. 7, Dana Mackenzie.

Researcher: Christopher Butson, Scientific Computing and Imaging Institute, University of Utah. Christopher Butson talks about work he's done to help treat Parkinson's disease.

Joseph B. Nelson
Aug 1, 2017; 30:171-174
From Research to Practice

Katherine S. O’Neal
Nov 1, 2016; 29:249-252
Pharmacy and Therapeutics

Amy P. Campbell
May 1, 2017; 30:76-81
From Research to Practice

T-type (Cav3) Ca2+ channels are important regulators of excitability and rhythmic activity of excitable cells. Among other voltage-gated Ca2+ channels, Cav3 channels are uniquely sensitive to oxidation and zinc. Using recombinant protein expression in HEK293 cells, patch clamp electrophysiology, site-directed mutagenesis, and homology modeling, we report here that modulation of Cav3.2 by redox agents and zinc is mediated by a unique extracellular module containing a high-affinity metal-binding site formed by the extracellular IS1–IS2 and IS3–IS4 loops of domain I and a cluster of extracellular cysteines in the IS1–IS2 loop. Patch clamp recording of recombinant Cav3.2 currents revealed that two cysteine-modifying agents, sodium (2-sulfonatoethyl) methanethiosulfonate (MTSES) and N-ethylmaleimide, as well as a reactive oxygen species–producing neuropeptide, substance P (SP), inhibit Cav3.2 current to similar degrees and that this inhibition is reversed by a reducing agent and a zinc chelator. Pre-application of MTSES prevented further SP-mediated current inhibition. Substitution of the zinc-binding residue His191 in Cav3.2 reduced the channel's sensitivity to MTSES, and introduction of the corresponding histidine into Cav3.1 sensitized it to MTSES. Removal of extracellular cysteines from the IS1–IS2 loop of Cav3.2 reduced its sensitivity to MTSES and SP. We hypothesize that oxidative modification of IS1–IS2 loop cysteines induces allosteric changes in the zinc-binding site of Cav3.2 so that it becomes sensitive to ambient zinc.

(University of Houston) A new set of recommendations for health care workers on the front lines, to help them make decisions on how to treat the most critical COVID-19 patients, those with severe lung or heart failure, has been published.

The SAS Stored Process Server does not create a detailed log file by default. However, you can create a detailed SAS Stored Process Server log file (that will contain information about all of the code that was executed) by using this approach. AUTO

Marriage vows are one thing, but the public service Code of Conduct, that's serious.

T-type (Cav3) Ca2+ channels are important regulators of excitability and rhythmic activity of excitable cells. Among other voltage-gated Ca2+ channels, Cav3 channels are uniquely sensitive to oxidation and zinc. Using recombinant protein expression in HEK293 cells, patch clamp electrophysiology, site-directed mutagenesis, and homology modeling, we report here that modulation of Cav3.2 by redox agents and zinc is mediated by a unique extracellular module containing a high-affinity metal-binding site formed by the extracellular IS1–IS2 and IS3–IS4 loops of domain I and a cluster of extracellular cysteines in the IS1–IS2 loop. Patch clamp recording of recombinant Cav3.2 currents revealed that two cysteine-modifying agents, sodium (2-sulfonatoethyl) methanethiosulfonate (MTSES) and N-ethylmaleimide, as well as a reactive oxygen species–producing neuropeptide, substance P (SP), inhibit Cav3.2 current to similar degrees and that this inhibition is reversed by a reducing agent and a zinc chelator. Pre-application of MTSES prevented further SP-mediated current inhibition. Substitution of the zinc-binding residue His191 in Cav3.2 reduced the channel's sensitivity to MTSES, and introduction of the corresponding histidine into Cav3.1 sensitized it to MTSES. Removal of extracellular cysteines from the IS1–IS2 loop of Cav3.2 reduced its sensitivity to MTSES and SP. We hypothesize that oxidative modification of IS1–IS2 loop cysteines induces allosteric changes in the zinc-binding site of Cav3.2 so that it becomes sensitive to ambient zinc.

BMJ Voices is a collection of readers’ experiences of working in the NHS. For this, The BMJ is seeking short audio submissions from UK listeners. These submissions will be published on thebmj.com. Patrick Keating, a GP from Enfield, is concerned that small practices are under pressure to increase list size, but aren't able to muster resources to...

2.46 million people in England have osteoarthritis of the hip, and many of those go on to eventually have a hip replacement - which is now widely considered one of the most commonly performed and successful operations in the world. Jessamy Bagenal, clinical fellow with The BMJ, talks to Nick Aresti, a specialist registrar in trauma and...

Thankfully, electrical injuries are relatively uncommon - but that means that lack of evidence regarding the management of patients who have been electrocuted, which can cause concern for clinicians when these patients present. In this podcast, Cath Brizzel, clinical editor for The BMJ, is joined by one of the authors of a clinical update on the...

In the UK - type 2 diabetes now affects between 5-10% of the population - and accounts for around 10% of our total NHS budget. For the individuals affected, treatments are effective at helping control glucose levels - however, the sequela associated with the disease - vascular problems, and a life expectancy that’s 6 years shorter - are still an...

Assessing young people with possible eating disorders can be complex for a variety of reasons. Building a therapeutic relationship with a young person with a possible eating disorder and their family is key to enabling a thorough assessment and ongoing management, but it introduces difficult issues regarding confidentiality and risk. In this...

Talk Evidence is back, with your monthly take on the world of EBM with Duncan Jarvies and GPs Carl Heneghan (also director for the Centre of Evidence Based Medicine at the University of Oxford) and Helen Macdonald (also The BMJ's UK research Editor). This month Carl talks about evidence that restricting your diet might improve health at a...

The NHS Practitioner Health Programme - once only for doctors in London, now it’s being rolled out across the NHS to provide the largest, publicly funded, comprehensive physician health service, in the world. However, while helping the individual is essential, systemic change needs to be made to support doctors in our healthcare system. Clare...

Giving staff the confidence to speak out is important in healthcare - It's a key aspect of the WHO patient safety checklist, decreasing incidence of medical error, but it's also important to stop incidents of harassment and abuse which undermine staff and increase burnout. Creating that culture is a difficult task, but two hospitals in the...

Evan M. Benjamin
Jul 1, 2004; 22:137-138
Case Studies