Parents in Tasmania are struggling to access speech pathology treatment for their children because NDIS funding has caused an explosion in demand for services.

Victorian agriculture authorities are investigating allegations of cruelty at the Bridgewater Poultry Farm, after footage released by Animal Liberation appeared to show workers mistreating chickens they were culling.

Footage from a Victorian poultry farm, released by animal activists, appears to show workers stretching the necks of chickens and throwing them onto a concrete floor.

A specialist family drug court is set up for the first time in regional Victoria in a bid to address a horrific trend in parental drug abuse.

Software developed with the help of Alice Spring medical staff and Indigenous people from remote communities is set to break down the language barrier and ease the stress of patients undergoing dialysis treatment.

What's driving Australian families overseas to gamble on "magical" stem cell treatments at sky-high prices?

Nic Dolbel wanted to improve the skin under her eyes, but a cosmetic laser treatment left her with lingering pain and what she says felt like "third-degree burns".

(United States Ninth Circuit) - In a petition for review challenging an Objection Letter sent by the EPA regarding draft permits for water reclamation plants in El Monte and Pomona, California, the petition is dismissed for lack of subject matter jurisdiction where neither 33 U.S.C. section 1369(b)(1)(E) nor (F) of the Clean Water Act provided the court with subject matter jurisdiction to review the Objection Letter.

"If you’re gonna do it, get the good stuff."

The post MEGADETH's Dave Mustaine Said Cannabis Helped With His Cancer Treatments appeared first on Metal Injection.

The Effects of Left-Turn Traffic-Calming Treatments on Conflicts and Speeds in Washington, D.C. , released by the Insurance Institute for Highway Safety

Use of Surface Treatments to Extend Pavement Life: A Case Study on US 301, Sussex County, Virginia , released by the Virginia Department of Transportation

One of the most fascinating things about planet Earth is the way that life shapes the Earth and the Earth shapes life. We only have to look back to the Great Oxygenation Event (GOE) of 2.4 billion years ago to see how lifeforms have shaped the Earth. In that event, phytoplanktons called cyanobacteria pumped the …

Continue reading "New Data Show How Phytoplankton Pumps Carbon Out of the Atmosphere at an Enormous Scale"

The post New Data Show How Phytoplankton Pumps Carbon Out of the Atmosphere at an Enormous Scale appeared first on Universe Today.

Tiny meteorites that fell to Earth 2.7 billion years ago suggest that the atmosphere at that time was high in carbon dioxide, which agrees with current understanding of how our planet's atmospheric gases changed over time.

For obvious reasons, there has been a lot of attention paid to work going into developing vaccines that could prevent Covid-19 infection, and drugs that could treat it. In particular, there has been some excitement about new animal trial data for remdesivir, a drug developed by Gilead Sciences. Gilead's share price rose nearly 10% on the day the trial data were announced.
It will be some time yet before the safety and efficacy of remdesvir is established, if ever (it's worth noting that it was tried, unsuccessfully, as a treatment for Ebola). And since I started work on this post…

Immunosuppression continues to be a necessary component of transplantation, despite its association with a multitude of adverse effects. Numerous efforts have been made to circumvent the need for immunosuppression by using various techniques to achieve donor hyporesponsiveness. In this issue of the JCI, Morath et al. take this endeavor forward. Prior to transplantation, the researchers infused recipients with donor-modified immune cells and achieved immunologic hyporesponsiveness. This successful phase I trial also provides a possible avenue for achieving transplantation without the requisite immunosuppression.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

At the Smarter Cities Forum in Shanghai today, IBM announced a collaboration with South China's largest hospital, Guang Dong Hospital of Traditional Chinese Medicine, to apply new analytics technology to help doctors uncover trends and new knowledge about disease treatment from thousands of anonymous Electronic Medical Records (EMR)The tool will also enable clinicians to perform empirical studies on the efficacy of certain traditional Chinese treatments.

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