JE Hixson
Mar 1, 1990; 31:545-548
Articles

Amid the ongoing civil unrest in Haiti due to gang violence, levels of internal displacement have soared. Mass internal displacements in Haiti have led to a host of adverse consequences. This includes a disruption of schooling, increased levels of violence and exploitation, and limited access to essential services such as healthcare. Just last week, clashes […]

Title: 9 Vitamins That May Help With Vaginal Dryness
Category: Health and Living
Created: 8/3/2022 12:00:00 AM
Last Editorial Review: 8/3/2022 12:00:00 AM

Title: Vaginal or C-Section, Method of Childbirth Won't Affect a Couple's Sex Life Later
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

The orexigenic gut peptide ghrelin is an endogenous ligand for the growth hormone secretagogue receptor type 1a (GHSR1a). Systemic ghrelin administration has previously been shown to increase gastric motility and emptying. While these effects are known to be mediated by the vagus nerve, the cellular mechanism underlying these effects remains unclear. Therefore, the purpose of the present study was to investigate the signaling mechanism by which GHSR1a inhibits voltage-gated Ca²⁺ channels in isolated rat gastric vagal afferent neurons using whole-cell patch-clamp electrophysiology. The ghrelin pharmacological profile indicated that Ca²⁺ currents were inhibited with a log (Ic₅₀) = –2.10 ± 0.44 and a maximal inhibition of 42.8 ± 5.0%. Exposure to the GHSR1a receptor antagonist (D-Lys3)-GHRP-6 reduced ghrelin-mediated Ca²⁺ channel inhibition (29.4 ± 16.7% vs. 1.9 ± 2.5%, n = 6, P = 0.0064). Interestingly, we observed that activation of GHSR1a inhibited Ca²⁺ currents through both voltage-dependent and voltage-independent pathways. We also treated the gastric neurons with either pertussis toxin (PTX) or YM-254890 to examine whether the Ca²⁺ current inhibition was mediated by the Gα_i/o or Gα_q/11 family of subunits. Treatment with both PTX (Ca²⁺ current inhibition = 15.7 ± 10.6%, n = 8, P = 0.0327) and YM-254890 (15.2 ± 11.9%, n = 8, P = 0.0269) blocked ghrelin’s effects on Ca²⁺ currents, as compared with control neurons (34.3 ± 18.9%, n = 8). These results indicate GHSR1a can couple to both Gα_i/o and Gα_q/11 in gastric vagal afferent neurons. Overall, our findings suggest GHSR1a-mediated inhibition of Ca²⁺ currents occurs through two distinct pathways, offering necessary insights into the cellular mechanisms underlying ghrelin’s regulation of gastric vagal afferents.

Digital Extremes has released the next big update for Warframe in the form of The Lotus Eaters update. This update …

Continue reading "‘Warframe’ Prologue Quest for Warframe 1999 The Lotus Eaters and Sevagoth Prime Now Available"

Even as winter takes hold in the Arctic, sea ice there is growing sluggishly. In Antarctica, summer’s arrival has driven sea ice to near-record lows.

Dr Aluvihare

Highlights: Vaginal estrogen during prolapse surgery did not improve the outcomes of post-operative prolapse M

Vaginal thrush is a yeast infection that is generally harmless and treated with medication. It is a common infection, with 3 in every 4 women of reproductive age likely to be affected (!--ref1--).

A monthly vaginal ring containing the antiretroviral drug dapivirine - an HIV prevention method that has been approved in several African countries and

Oxford : Routledge, 2006.

Farmers associated with as many as 16 farmer outfits from the States Punjab, Haryana, Himachal Pradesh, Rajasthan, Uttar Pradesh, and Uttarakhand would be participating

A poor harvest could force the Centre to import wheat, palm oil, sunflower oil and soybean oil

Athens, Georgia : University Of Georgia Press, 2008.

Academic qualifications wise, Sri Vaghul was a B. Com. But his knowledge, curiosity, and keenness to apply technology in the bank’s business and processes was so much ahead of his times! - S. Raman, Former CMD, Canara Bank

The youngest son of Mukesh Ambani, Asia’s richest man, has married his longtime girlfriend in what many have dubbed the wedding of the year attended by global celebrities, business tycoons and politicians, highlighting the billionaire’s staggering wealth and rising clout

Spanning seven acres, the resort features landscaped gardens, a swimming pool, and a multi-cuisine restaurant, making it ideal for families seeking relaxation and exploration.

The teaser of director Sujeeth and Pawan Kalyan’s ‘They call him OG’ reveals an action entertainer set in Mumbai

Popular religions have tried to open the eyes of the deprived masses but there appears to be seemingly inexplicable appreciation of the rich by the poor and the middle-class

Actor Vijay seems to be targeting both the BJP and the DMK 

New Zealand ended day two with an overall lead of 143, which might look small but even a target in the vicinity of 150 will pose serious challenge for the Indian batters

In conducting the feast and ceremonies, families spend as if there is no tommorow

The pilgrimage will begin on December 15, 2024 and conclude on January 5, 2025

Get set for 72 hours of biker bonding at the Royal Enfield Rider Mania

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

More and more indicators are spelling out the scale of economic damage being wreaked by Covid-19 and the containment measures taken to tackle it, writes Robert Shortt.

China's central bank said on Sunday it will step up counter-cyclical adjustments to support the economy and make monetary policy more flexible to fend off financial risks.

This year celebrities across the globe have kicked off 2020 with a bang, showcasing their washboard stomachs in a series of head-turning ensembles on the red carpet. 

The singer, 23, displayed her daring sense of style as she attended the BRIT Awards afterparty at the InterContinental Hotel in London on Tuesday

If you raise the price of your product and offer a discount on the higher price, some people will get taken in by such 'sales'. The WTO has just pulled off this kind of scheme, says Devinder Sharma.

Eric Peterman, Mindaugas Valius, and Rytis Prekeris

During mitotic cell division, the actomyosin cytoskeleton undergoes several dynamic changes that play key roles in progression through mitosis. While the regulators of cytokinetic ring formation and contraction are well-established, proteins that regulate cortical stability during anaphase and telophase have been understudied. Here, we describe a role for CLIC4 in regulating actin and actin-regulators at the cortex and cytokinetic cleavage furrow during cytokinesis. We first describe CLIC4 as a new component of the cytokinetic cleavage furrow that is required for successful completion of mitotic cell division. We also demonstrate that CLIC4 regulates the remodeling of sub-plasma membrane actomyosin network within the furrow by recruiting MST4 kinase and regulating ezrin phosphorylation. This work identifies and characterizes new molecular players involved in regulating cortex stiffness and blebbing during late stages of cytokinetic furrowing.

From Texas and Colorado through the Midwest, South and East Coast, tornadoes are tearing through the U.S.

Non-native earthworms are damaging hardwood forests; one University of Minnesota group is working to clear up the misconception that they're always harmless.