A MULTI — STOREY development planned for western Sydney has been approved despite years of resistance from council and residents.

WashingtonLa Pamela va a comprar al supermercat dues vegades a la setmana. La carn, el pollastre i l’arròs són alguns dels productes que no poden faltar a la nevera del seu apartament de Washington D.C. Explica que compra la vedella de la millor qualitat: “Això implica que gastaré més. via Pocket

The inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns of intracellular calcium signals. Mutations in IP3Rs have been increasingly associated with many debilitating human diseases such as ataxia, Gillespie syndrome, and generalized anhidrosis. However, how these mutations affect IP3R function, and how the perturbation of as-sociated calcium signals contribute to the pathogenesis and severity of these diseases remains largely uncharacterized. Moreover, many of these diseases occur as the result of autosomal dominant inheritance, suggesting that WT and mutant subunits associate in heterotetrameric channels. How the in-corporation of different numbers of mutant subunits within the tetrameric channels affects its activities and results in different disease phenotypes is also unclear. In this report, we investigated representative disease-associated missense mutations to determine their effects on IP3R channel activity. Additionally, we designed concatenated IP3R constructs to create tetrameric channels with a predefined subunit composition to explore the functionality of heteromeric channels. Using calcium imaging techniques to assess IP3R channel function, we observed that all the mutations studied resulted in severely attenuated Ca2+ release when expressed as homotetramers. However, some heterotetramers retained varied degrees of function dependent on the composition of the tetramer. Our findings suggest that the effect of mutations depends on the location of the mutation in the IP3R structure, as well as on the stoichiometry of mutant subunits assembled within the tetrameric channel. These studies provide insight into the pathogenesis and penetrance of these devastating human diseases.

Gurmeet K. Bakshi, Jyoti Garg and Gabriela Olteanu
Math. Comp. 93 (), 3027-3058.
Abstract, references and article information

A small group of science teachers in Missouri is using the coronavirus as a teachable moment that's aligned to the Next Generation Science Standards.

Nonprofit housing developers wanting to renovate or build homes for Delawareans to purchase can now apply for the Catalyst Fund program through the Delaware State Housing Authority (DSHA).

Alpine F1 team will make switch to Mercedes-Benz AMG power units in 2026 Agreement lasts until at least 2030 Former supplier Renault is ending F1 power unit program to focus on EV technology The Alpine Formula 1 team on Tuesday announced plans to switch to power units and gearboxes from Mercedes-Benz AMG starting in 2026, when F1 is due to...

Sony Interactive Entertainment in its financial results announced it has shipped 65.5 million PlayStation 5 consoles as of September 30, 2024.

With 65.5 million PlayStation 5 consoles shipped through the end of June that means 3.8 million units were shipped from July to September. This is down 1.1 million (-22.45%) from the same quarter in 2023 when 4.9 million units were shipped.

For reference, the PlayStation 4 had shipped 4.2 million units in the same quarter for a lifetime total of 67.7 million units shipped as of September 30, 2017. This puts the PS5 behind shipped PS4 units by 2.2 million units.

There were a total of 77.7 million games sold on the PlayStation 5 and PlayStation 4 for the quarter. This is up 10.1 million from 67.6 million during the same period a year earlier. Digital sales accounted for 70 percent of software sales.

There were 5.3 million first-party games sold across the PlayStation 5 and PlayStation 4. This is up 0.6 million from 4.7 million a year ago.

There were 116 million monthly active users on the PlayStation Network, an increase of nine million from 107 million a year ago. Sony did not disclose the number of PlayStation Plus subscribers. It was at 47.4 million at the end of March 2023.

Sony's Game & Network Services Segment for the quarter ending September 30, 2024, reported revenue increased 244.5 billion yen ($1.60 billion) year-over-year to 2,973.4 billion yen ($19.46 billion), while operating income increased 142.0 billion yen ($0.93 billion) to 389.3 billion yen ($2.55 billion).

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463014/ps5-ships-655-million-units-as-of-september-2024/

Publisher Sony Interactive Entertainment and developer Team Asobi in Sony's latest earnings report have announced Astro Bot has sold over 1.5 million units as of November 3, 2024.

Astro Bot released for the PlayStation 5 on September 6.

Our own Lee Mehr gave the game an 8.5 out of 10 in his review and said "As an ode to PlayStation, Astro Bot succeeds at meaningfully infusing its history; as an all-ages theme park, it succeeds by infusing each location with an overwhelming sense of joyous wonder most often felt in Nintendo platformers, but with a level of technical sophistication not yet seen from its hardware."

Read details on the game below:

Join ASTRO on a supersized space adventure.

When the PlayStation 5 mothership is attacked by ASTRO’s long-standing galactic nemesis, scrambling its wires and scattering the crew throughout space, only ASTRO can make things right! Setting off on his biggest mission yet, he needs your help to rescue the stranded crew and rebuild the mothership.

Make the most of ASTRO’s new power-ups, handcrafted to level up your immersion: from springy punches and rockets all the way to a giant sponge!

Buckle up for some epic PlayStation camaraderie, join forces with your favorite PlayStation icons and show the universe that small is mighty in this fresh new ASTRO adventure, exclusive to PlayStation 5 consoles!

Features:

• Embark on a galactic quest and explore more than 50 planets in search of ASTRO’s lost crew.
• Dash, swing, and rocket-punch your way through this journey, with all-new power-ups.
• Feel the world come to life via your DualSense wireless controller.
• Team up with iconic PlayStation heroes to save the galaxy!

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463015/astro-bot-sales-top-15-million-units/

IT firms units want WHF for more employees for a longer period, developers are concerned about losing customers for office space

Bigger than the total yearly consumer shipments in 2019

Total PC shipments witness a record 14.8 million units during Jan-Dec 2021

Opposing curbs, traditional sweeteners body BHAKTI says Centre should not be swayed by false narratives

Antigent tests said to produce more false negatives

This initiative aims to enhance rapid medical assistance, particularly in remote areas, and align with global healthcare standards

The automaker had dispatched 62,276 units in the same month last year.

Including exports, the total SUV sales were 55,571 units. The domestic sales for Commercial Vehicles stood at 28812 units

The company exported 8,688 motorcycles during the month

Perambalur district allocated Rs.2.85 crore subsidy for poultry development

Vedanta Limited plans to expand its subsidiary Bharat Aluminium Company Limited (BALCO) and the Athena Chhattisgarh Power Plant Project

The Tamil Nadu government has announced relaxations allowing industries, particularly export units, to resume operations with standard operating procedure as suggested by the Union government.

1. NDMA issues guidelines for restarting manufacturing units  Top Live News
2. Govt issues new guidelines for restarting industries after lockdown  Livemint
3. Consider Week 1 As Trial: Government On Industry Restart Post Lockdown  NDTV
4. NDMA issues guidelines on restarting manufacturing industries post lockdown  Economic Times
5. 'Consider 1st Week Test Run Period': Post Vizag Tragedy, Govt Issues Rules to Reopen Industries After Loc...  Todaynewspaper
6. View Full coverage on Google News

The project is estimated at about NIS 30 million.

: Communicating across its nine factories and setting up milk collection points are some of the steps taken by dairy products major Thirumala as per COVID-19 guidelines for manufacture, to ensure supply does not get affected, a top official said. Thirumala was acquired by France-based dairy group Lactalis in 2014 and the company produces dairy products across nine manufacturing units in southern states. Thirumala CEO Christophe Jouin said the company had taken precautions by communicating across factories, setting up milk collection points and issuing safety guidelines to employees. "The first step was to carry out checking of temperatures of employees before they enter the factory and maintaining social distancing norms during daily work, among others," he told PTI. The entire process, from the collection of milk till the distribution, has been enhanced and totally protected with the help of intensive comunication done well in advance, he said. The company collects milk ..

Skoda Octavia RS 245 deliveries have commenced in the country. The company has started to deliver the performance sedan as the nation-wide lockdown has been eased at select cities including Bengaluru.

Hyundai India recently announced that it will be restarting its operations in India from the 6th of May 2020. The company has slowly started to reopen dealerships across India in a phase-wise manner, as per the government's lockdown relaxation guidelines in many parts of the country.

Hyundai India has announced that they have resumed production operations at their facility in Sriperumbudur, Chennai. The manufacturing facility of Hyundai has been shut since the 23rd of March 2020, amidst COVID-19 pandemic.

Honda Motorcycles & Scooters India (HMSI) has announced that the company has registered 0 units of domestic sales in the month of April 2020. The zero units of retail sales are due to the current COVID-19 pandemic, which has put the country under lockdown.

TVS Motor Company has announced that they have registered 0 units of sales in the month of April 2020. The company shut down all its operations on the 23rd of March 2020, just a day before the lockdown began.

Chennai based motorcycle manufacturer, Royal Enfield, has registered 91 units in sales for the month of April 2020, even with a suspension in production activities because of the Covid-19 pandemic.

Bajaj Auto has released its sales report for the month of April 2020 in India. Unsurprisingly, the company has announced 0 units of domestic sales in the country during the last month. This was due to the nationwide lockdown, amidst the COVID-19 pandemic.

Bihar chief minister Nitish Kumar on Saturday asked state’s chief secretary Deepak Kumar to take necessary steps to create employment opportunities for returning migrant workers as per the outcome of their skill survey.

Following the formula of graded relaxation of the lockdown, the State government has allowed garment factories located outside containment zones to c

The Karnataka government has allowed garment units in red zones but outside containment zones to resume operations with 33% work force.

Buyer orders one Pixel 4 online, Google delivers 10 units by mistake

Gas leak fallout: CPCB asks industrial units across India to go for safety and hazard audit before resuming operations

Around 75% pharma units operational in Gujarat: FDCA

Garment units can open in red zones in Karnataka