National Diabetes Data Group
Dec 1, 1979; 28:1039-1057
Articles

The Netherlands has witnessed a rise in far-right populism, challenging its reputation as a humanitarian haven. Yet, public fears equating immigration with a rise in religious extremism do not necessarily reflect the facts. This profile explores historical and contemporary migration in a country where population growth relies largely on immigration, and analyzes to what extent policymaking has been shaped by rising populism.

Mary M Tai
Feb 1, 1994; 17:152-154
Short Report

Kalevi Pyörälä
Mar 1, 1979; 2:131-141
Proceedings of the Kroc Foundation International Conference on Epidemiology of Diabetes and its Macrovascular Complications

Johanna M Mooy
Sep 1, 1995; 18:1270-1273
Short Report

W B Kannel
Mar 1, 1979; 2:120-126
Proceedings of the Kroc Foundation International Conference on Epidemiology of Diabetes and its Macrovascular Complications

OBJECTIVE

Preanalytical processing of blood samples can affect plasma glucose measurement because on-going glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose tolerance test (OGTT) blood samples for pregnant women from a delayed to an early centrifugation protocol. The effect of this change on the rate of gestational diabetes mellitus (GDM) diagnosis was determined.

Here's a question with three different answers. The first answer is derived from arithmetic. The second comes from common sense. The third is based on psychology.

OBJECTIVE

Impaired insulin-stimulated myocardial glucose uptake has occurred in patients with type 2 diabetes with or without coronary artery disease. Whether cardiac insulin resistance is present remains uncertain in subjects at risk for type 2 diabetes, such as individuals with impaired glucose tolerance (IGT) or those with normal glucose tolerance (NGT) and 1-h postload glucose ≥155 mg/dL during an oral glucose tolerance test (NGT 1-h high). This issue was examined in this study.

Helsinki : Department of Pharmacology and Toxicology, University of Helsinki, 1985.

Highly conserved PenI-type class A β-lactamase in pathogenic members of Burkholderia can evolve to extended-spectrum β-lactamase (ESBL), which exhibits hydrolytic activity towards third-generation cephalosporins, while losing its activity towards the original penicillin substrates. We describe three single-amino-acid-substitution mutations in the ArgS arginine-tRNA synthetase that confer extra antibiotic tolerance protection to ESBL-producing Burkholderia thailandensis. This pathway can be exploited to evade antibiotic tolerance induction in developing therapeutic measures against Burkholderia species, targeting their essential aminoacyl-tRNA synthetases.

Ebonie Slade, a senior majoring in biobehavioral health at Penn State Greater Allegheny, is the recipient of the 2020 Jackson Lethbridge Tolerance Award.

It was widely observed, following a certain event in a Connecticut elementary school on Dec. 14, 2012, that if America would tolerate the slaughter by gunfire of 20 children aged 6 and 7, it would tolerate anything. Nothing proves the truth of that observation more than our response to the coronavirus pandemic. At this moment of maximum peril, we’re tolerating the turning of workers in meatpacking plants and grocery stores, seniors in nursing homes and heedless churchgoers into sacrificial offerings to the gods of “freedom” and “choice.” Grandparents are being counseled to give up their lives “in exchange for keeping the America that all Americans love for your children and grandchildren.”...

Hydrogen sulfide (H₂S), a plant gasotransmitter, functions in the plant response to cadmium (Cd) stress, implying a role for cysteine desulfhydrase in producing H₂S in this process. Whether d-CYSTEINE DESULFHYDRASE (DCD) acts in the plant Cd response remains to be identified, and if it does, how DCD is regulated in this process is also unknown. Here, we report that DCD-mediated H₂S production enhances plant Cd tolerance in Arabidopsis (Arabidopsis thaliana). When subjected to Cd stress, a dcd mutant accumulated more Cd and reactive oxygen species and showed increased Cd sensitivity, whereas transgenic lines overexpressing DCD had decreased Cd and reactive oxygen species levels and were more tolerant to Cd stress compared with wild-type plants. Furthermore, the expression of DCD was stimulated by Cd stress, and this up-regulation was mediated by a Cd-induced transcription factor, WRKY13, which bound to the DCD promoter. Consistently, the higher Cd sensitivity of the wrky13-3 mutant was rescued by the overexpression of DCD. Together, our results demonstrate that Cd-induced WRKY13 activates DCD expression to increase the production of H₂S, leading to higher Cd tolerance in plants.

Heat stress (HS) has serious effects on plant development, resulting in heavy agricultural losses. A critical transcription factor network is involved in plant adaptation to high temperature. DEHYDRATION RESPONSIVE ELEMENT-BINDING PROTEIN2A (DREB2A) is a key transcription factor that functions in plant thermotolerance. The DREB2A protein is unstable under normal temperature and is degraded by the 26S proteasome; however, the mechanism by which DREB2A protein stability dramatically increases in response to HS remains poorly understood. In this study, we found that the DREB2A protein of Arabidopsis (Arabidopsis thaliana) is stabilized under high temperature by the posttranslational modification SUMOylation. Biochemical data indicated that DREB2A is SUMOylated at K163, a conserved residue adjacent to the negative regulatory domain during HS. SUMOylation of DREB2A suppresses its interaction with BPM2, a ubiquitin ligase component, consequently increasing DREB2A protein stability under high temperature. In addition, analysis of plant heat tolerance and marker gene expression indicated that DREB2A SUMOylation is essential for its function in the HS response. Collectively, our data reveal a role for SUMOylation in the maintenance of DREB2A stability under high temperature, thus improving our understanding of the regulatory mechanisms underlying HS response in plant cells.

Grasses are among the most resilient plants, and some can survive prolonged desiccation in semiarid regions with seasonal rainfall. However, the genetic elements that distinguish grasses that are sensitive versus tolerant to extreme drying are largely unknown. Here, we leveraged comparative genomic approaches with the desiccation-tolerant grass Eragrostis nindensis and...

Gabriela Montejo-Kovacevich, Simon H. Martin, Joana I. Meier, Caroline N. Bacquet, Monica Monllor, Chris D. Jiggins, and Nicola J. Nadeau

Microclimatic variability in tropical forests plays a key role in shaping species distributions and their ability to cope with environmental change, especially for ectotherms. Nonetheless, currently available climatic datasets lack data from the forest interior and, furthermore, our knowledge of thermal tolerance among tropical ectotherms is limited. We therefore studied natural variation in the microclimate experienced by tropical butterflies in the genus Heliconius across their Andean range in a single year. We found that the forest strongly buffers temperature and humidity in the understorey, especially in the lowlands, where temperatures are more extreme. There were systematic differences between our yearly records and macroclimate databases (WorldClim2), with lower interpolated minimum temperatures and maximum temperatures higher than expected. We then assessed thermal tolerance of 10 Heliconius butterfly species in the wild and found that populations at high elevations had significantly lower heat tolerance than those at lower elevations. However, when we reared populations of the widespread H. erato from high and low elevations in a common-garden environment, the difference in heat tolerance across elevations was reduced, indicating plasticity in this trait. Microclimate buffering is not currently captured in publicly available datasets, but could be crucial for enabling upland shifting of species sensitive to heat such as highland Heliconius. Plasticity in thermal tolerance may alleviate the effects of global warming on some widespread ectotherm species, but more research is needed to understand the long-term consequences of plasticity on populations and species.

Events with extreme temperatures and humidity are occurring twice as often now as they were 40 years ago

-- Read more on ScientificAmerican.com

The America that condones mass murder of children is allowing the coronavirus to spread.

Researchers found that temperature extremes previously thought to be rare have been recorded more than 1,000 times in 40 years.

Events with extreme temperatures and humidity are occurring twice as often now as they were 40 years ago

-- Read more on ScientificAmerican.com

Researchers found that temperature extremes previously thought to be rare have been recorded more than 1,000 times in 40 years.

The leaked video of Rishi Kapoor in the ICU has enraged Bollywood. Industry folk consider it a violation of privacy and have demanded a probe. Singer and minister Baabul Supriyo reportedly said,  "Hospitals should have a zero tolerance policy for such acts and the person concerned may well be sacked for good."

Reacting to such forwarded video clip, several celebrities including Arjun Kapoor, Karan Wahi and Mini Mathur called out the hospital for staff negligence. Without mentioning the particular leaked video, Arjun wrote: "The choice is not to post something is sometimes as important as to be the first to post something. Images have a lot of power lest we forget.

"Sometimes humanity and empathy must prevail over being first to embrace use of sly voyeuristic material presented to you."

Actor Karan Wahi admitted that he too saw the video and decided to delete it immediately, rather than share it among others as he found it disturbing. Karan said: "There's a forward that a ward boy or someone from the hospital has shot of Rishi Kapoor in his hospital just before he passed. I saw it. And think it's a gross violation of his privacy. If you receive it, delete it rather than forward it further."

He added: "Actors are also human beings. Please do not forward or post them just to be the first one. Have some respect."

Actress-anchor Mini Mathur urged people to "stop the insensitivity". She tweeted: "Just came across a disgusting, completely invasive video of Rishi sir on WhatsApp in hospital actually titled "last video of RK" obviously shot by a hospital staff member. I know humanity is at sea at the moment but can we PLEASE STOP THIS INSENSITIVITY and not be party to this?"

Mini also tagged Mumbai Police to take strict actions against the offender. "If you see a video like this on any group can you please insist that it's taken down??? Can we stop this vicarious celeb goggling even when they are indisposed and unaware? It should be a legal offence @MumbaiPolice and met with the strictest action," Mini added.

The management at Sir HN Reliance Foundation Hospital, where Rishi Kapoor breathed his last, issued a statement on Friday saying they would investigate the leak and circulation of videos featuring the actors mortal.

A Facebook post on the hospital's official page reads: "A message from Sir H.N. Reliance Foundation Hospital's management. #RespectForLife.

"It has come to our attention that a video of one of our patients is surfacing on digital media platforms. At Sir H.N. Reliance Foundation Hospital, patient confidentiality and privacy is of utmost importance to us and we strongly condemn such actions. The hospital management is investigating the incident and strict action will be taken against the perpetrators."

Several netizens have questioned the morality of hospital staff, assuming they shot the videos since there is no question of outsiders amid the lockdown.

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Intolerance row

Intolerance Row

IEEE Computer Society

IEEE Computer Society

IEEE / Institute of Electrical and Electronics Engineers Incorporated

IEEE Computer Society

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