[The New Humanitarian] Bahir Dar, Amhara -- 'I have been in the jungle, struggling for my people.'

Inositol 1,4,5-triphosphate receptor type 1 (ITPR1) is an endoplasmic reticulum–bound intracellular inositol triphosphate receptor involved in the regulation of intracellular calcium. Pathogenic variants in ITPR1 are associated with spinocerebellar ataxia (SCA) types 15/16 and 29 and have recently been implicated in a facial microsomia syndrome. In this report, we present a family with three affected individuals found to have a heterozygous missense c.800C > T (predicted p.Thr267Met) who present clinically with a SCA29-like syndrome. All three individuals presented with varying degrees of ataxia, developmental delay, and apparent intellectual disability, as well as craniofacial involvement—an uncommon finding in patients with SCA29. The variant was identified using clinical exome sequencing and validated with Sanger sequencing. It is presumed to be inherited via parental germline mosaicism. We present our findings to provide additional evidence for germline mosaic inheritance of SCA29, as well as to expand the clinical phenotype of the syndrome.

Pressure from 10 clubs could change the AFL’s competitive balance mechanism.

While initial rumors suggested that Kinberg’s trilogy might continue the iconic Skywalker Saga, insiders have clarified that the upcoming series will chart new territory within the ‘Star Wars’ universe

Mumbai (AFP) Nov 2, 2024
Indian security forces killed three suspected militants in two separate firefights in disputed Kashmir, the army and a senior police official said Saturday. Muslim-majority Kashmir has been divided between rivals India and Pakistan since their independence from British rule in 1947 and is home to a long-running insurgency. The first firefight broke out after Indian troops moved to check

Mar 12, 2024

After a century of rebellion, South America experienced a rapid decline in revolts in the early 1900s. Historical narratives and an analysis of a comprehensive new dataset show that the decrease stemmed in large part from the expansion and professionalization of the region’s militaries, which were driven by an export boom and the threat of interstate conflict. 

Yemen's Houthi rebels launched an attack near a commercial vessel in the Red Sea, claiming to target American warships amidst ongoing regional conflicts.

Houthi rebels launched drones and missiles at US Navy warships in the Red Sea, but the attacks were unsuccessful, according to the Pentagon.

The newly suspended leaders include -- Shamkant Saner, Rajendra Thakur, Aba Bagul, Manish Anand, Suresh Kumar Jethliya, Kalyan Borade, and Chandrapaul Chauksey.

London : Nick Hern Books, 2023.

London ; New York : Birbeck Law, 2009.

After successful stints in Jamai Raja and Ek Hazaaron Mein Meri Behna Hai, Nia Sharma faces fresh challenges in Fear Factor: Khatron Ke Khiladi.

Amit Shah holds discussion with alliance leaders Eknath Shinde, Devendra Fadnavis and Ajit Pawar

Maharashtra Deputy CM admits that there will be friendly fights in some seats, though BJP is trying to help rebel withdraw their names; BJP, Sena wll support Amit Thackeray of the MNS for the Mahim seat

Devendra Fadnavis is contesting from the Nagpur South-West Assembly constituency in the upcoming Maharashtra election

Despite agrarian distress, unemployment levels, these may not become poll issues, say experts; key to power will likely be decided by Vidarbha region where both Congress and BJP are directly pitted against each other

This wave of dissent poses a fresh challenge for both the ruling Mahayuti coalition and the opposition Maha Vikas Aghadi (MVA) alliance. Today was the last day for withdrawal of nominations

SAD leader Balwinder Bhundur said the eight leaders had actively colluded with the party’s enemies to create divisions in the party and weaken it

Recent Houthi attacks has again drawn attention to the Yemeni rebels and raised questions about their goals and strategies

After Syrian rebel shelling of the school in government-held western Aleppo.

He says a “disciplined solider” like him cannot keep quiet when injustice is being meted out to the party

P.K. Srinivasan took his ideals across the world, from Indian village classrooms to American lecture halls and African colleges, embodying a lifelong rebellion against a system that suppressed creativity

Pentagon press secretary said the Iranian-backed Houthis launched at least eight drones, five anti-ship ballistic missiles and three anti-ship cruise missiles at the USS Stockdale and the USS Spruance

'I am not the kind of person who will stand up and complain. I have no complaints against anyone. If I've been away from the entertainment industry, it's because I am not into selling myself.'

Libyan rebels have heavily attacked an airport in the capital Tripoli, killing six civilians and inflicting damage in and around the facility. Several civilians were also injured in the attack on Mitiga International Airport on Saturday, the country’s internationally-recognized government said. The Libyan Interior Ministry said at least 80 rockets were fired in the attack,...

SRINAGAR: Indian authorities did not hand over the bodies of the slain Kashmiri fighters to their families under a new government policy designed to thwart large-scale funerals that have become a rallying point for anti-India protests, foreign media reported.Instead, they are being buried in...

AHMEDABAD, India: Indian security forces clashed with angry residents who flouted a pandemic lockdown in the city of Ahmedabad on Friday as the country saw a surge in coronavirus deaths and cases that is predicted to worsen. While authorities have insisted that the crisis is under control in the...

The three British sporting stars have put their years of mixed success behind them to combine for a special video with a Star Wars theme, coinciding with the release of the new blockbuster film.

Archives, Room Use Only - E608.K47 1890

Archives, Room Use Only - E470.2.W55 1888