Inside a hunk of a material called a semimetal, scientists have uncovered signatures of bizarre particles that sometimes move like they have no mass, but at other times move just like a very massive particle

A surprising reversal of our usual understanding of the second law of thermodynamics shows that it may be possible for heat to move in the “wrong” direction, flowing from a cold area to a warm one

Zinc nanoparticles, a common sunscreen ingredient, can make plants more resilient to climate change – in a surprising way

Visible particle is an important issue in the biopharmaceutical industry, and it may occur across all the stages in the life cycle of biologics. Upon the occurrence of visible particles, it is often necessary to conduct chemical identification and root cause analysis to safeguard the safety and efficacy of the biotherapeutic products. In this article, we present a number of typical particles and relevant root cause analysis in the categories of extrinsic, intrinsic, and inherent particles that are commonly encountered in the biopharma industry. In particular, the optical images of particles obtained both in situ and after isolation are provided, along with spectral and elemental information. The particle identification was carried out with multiple microscopic and microspectroscopic techniques, including stereo optical microscopy, Fourier-transform infrared microscopy, confocal Raman microscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. Both commercial and in-house spectral databases were used for comparison and identification. In addition to particle identification, we placed significant efforts on the root cause analysis of the addressed particles with the intention to provide a relatively whole picture of the particle-related issues and practical references to particle mitigation for our peers in the biopharmaceutical industry.

Inside a hunk of a material called a semimetal, scientists have uncovered signatures of bizarre particles that sometimes move like they have no mass, but at other times move just like a very massive particle

A surprising reversal of our usual understanding of the second law of thermodynamics shows that it may be possible for heat to move in the “wrong” direction, flowing from a cold area to a warm one

Zinc nanoparticles, a common sunscreen ingredient, can make plants more resilient to climate change – in a surprising way

A new enzyme that loads up fat-carrying particles in the liver before transporting it to different parts of the body has been discovered by the researchers.

A groundbreaking study has revealed a promising new approach to prostate cancer treatment. The nanoparticle-based therapy, guided by laser technology,

The media industry today may not have a very favorable view of AI — a technology that’s already been used to replace reporters with AI-written copy, while other AI companies have scooped up journalists’ work to feed their chatbots’ data demands, but without returning traffic to the publisher as search engines once did. However, one […]

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