"Saint Irene, who was from Cappadocia, flourished in the ninth century. Because of her great beauty and virtue, she was brought to Constantinople as a prospective bride for the young Emperor Michael (8422-867); however, as St Joannicius the Great foretold, it was God's will that she assume the monastic habit instead. She shone forth in great ascetical labors, and suffered many attacks from the demons; while yet a novice, she attained to the practice of St Arsenius the Great, of praying the whole night long with arms stretched out towards Heaven (see May 8). God showed forth great signs and wonders in her, and she became the Abbess of the Convent of Chrysovalantou. She was granted the gift of clairvoyance and knew the thoughts of all that came to her. She appeared in a vision to the king and rebuked him for unjustly imprisoning a nobleman who had been falsely accused. Through a sailor from Patmos to whom he had appeared, St John the Theologian sent her fragrant and wondrous apples from Paradise. She reposed at the age of 103, still retaining the youthful beauty of her countenance. After her repose, marvellous healings beyond number have been wrought by her to the present day." (Great Horologion)

"Saint Irene, who was from Cappadocia, flourished in the ninth century. Because of her great beauty and virtue, she was brought to Constantinople as a prospective bride for the young Emperor Michael (8422-867); however, as St Joannicius the Great foretold, it was God's will that she assume the monastic habit instead. She shone forth in great ascetical labors, and suffered many attacks from the demons; while yet a novice, she attained to the practice of St Arsenius the Great, of praying the whole night long with arms stretched out towards Heaven (see May 8). God showed forth great signs and wonders in her, and she became the Abbess of the Convent of Chrysovalantou. She was granted the gift of clairvoyance and knew the thoughts of all that came to her. She appeared in a vision to the king and rebuked him for unjustly imprisoning a nobleman who had been falsely accused. Through a sailor from Patmos to whom he had appeared, St John the Theologian sent her fragrant and wondrous apples from Paradise. She reposed at the age of 103, still retaining the youthful beauty of her countenance. After her repose, marvellous healings beyond number have been wrought by her to the present day." (Great Horologion)

"Saint Irene, who was from Cappadocia, flourished in the ninth century. Because of her great beauty and virtue, she was brought to Constantinople as a prospective bride for the young Emperor Michael (8422-867); however, as St Joannicius the Great foretold, it was God's will that she assume the monastic habit instead. She shone forth in great ascetical labors, and suffered many attacks from the demons; while yet a novice, she attained to the practice of St Arsenius the Great, of praying the whole night long with arms stretched out towards Heaven (see May 8). God showed forth great signs and wonders in her, and she became the Abbess of the Convent of Chrysovalantou. She was granted the gift of clairvoyance and knew the thoughts of all that came to her. She appeared in a vision to the king and rebuked him for unjustly imprisoning a nobleman who had been falsely accused. Through a sailor from Patmos to whom he had appeared, St John the Theologian sent her fragrant and wondrous apples from Paradise. She reposed at the age of 103, still retaining the youthful beauty of her countenance. After her repose, marvellous healings beyond number have been wrought by her to the present day." (Great Horologion)

The Highland club had previously said the energy project could raise funds for community projects.

Residents raise concerns about the plans in an east Suffolk village.

Breast cancer is leading cause of mortality among women compared to other types of cancers. Hence, early breast cancer diagnosis is crucial to the success of treatment. Various pathological and imaging tests are available for the diagnosis of breast cancer. However, it may introduce errors during detection and interpretation, leading to false-negative and false-positive results due to lack of pre-processing of it. To overcome this issue, we proposed a effective image pre-processing technique-based on Otsu's thresholding and single-seeded region growing (SSRG) to remove artefacts and segment the pectoral muscle from breast mammograms. To validate the proposed method, a publicly available MIAS dataset was utilised. The experimental finding showed that proposed technique improved 18% breast cancer detection accuracy compared to existing methods. The proposed methodology works efficiently for artefact removal and pectoral segmentation at different shapes and nonlinear patterns.

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Having passed the mid-year point, it is always an interesting exercise to take stock of where we stand with respect to the approval of new medicines. Overall, when considering the volume of activity, things would seem to be looking up … Continue reading →

Robert F. Kennedy Jr. is pushing President-elect Donald Trump to crack down on fluoride levels in drinking water, saying the mineral can lead to unintended medical problems -- and setting up a clash with medical experts who defend it as a proven way to fighting cavities.

The ruling from the U.S. Court of Appeals for the District of Columbia upholds the lower permissible exposure limit in OSHA’s updated silica rule. Supporters of the rule call the court’s decision a “huge victory” for workers, while opponents say it disregards “legitimate concerns.”

Advanced collaborative robotics and AI boost productivity, ensure consistent quality and enhance ergonomics in the drywall finishing process.

Triangle, VA — The United Mine Workers Association is suing the Mine Safety and Health Administration and its administrator, David Zatezalo, over the legality of the agency’s removal of a Sophia, WV, mine from Pattern of Violations status.

Working on jobsites painted before 1978 can pose risks associated with lead-based paints. Workers need to be aware of safe practices in removing this paint to avoid the health risks that come with lead exposure both during and after work has taken place.

Washington — The Bureau of Safety and Environmental Enforcement has issued a proposed rule that would codify existing agency practice concerning the review and approval of projects proposing to use “new or unusual technology.”

Washington — Catherine J.K. Sandoval was sworn in for a five-year term on the Chemical Safety Board on Feb. 2, returning a quorum to the short-staffed agency.

Washington – A new coalition composed of 10 leading construction industry organizations is calling on OSHA to revise and finalize certain certification requirements for crane operators “well ahead” of the 2017 deadline.

Washington — A State Plan covering Massachusetts’ state and local government employees is a step closer to reality after OSHA recently published a proposed rule outlining its initial approval.

Washington — A State Plan covering Massachusetts’ state and local government employees is now a reality after OSHA announced its initial approval.

Washington — OSHA has certified a revised State Plan for Maine that covers state and local government workers.

Washington — Manufacturers of certain N95 respirators will be able to submit a single application to NIOSH, rather than to both the Food and Drug Administration and NIOSH, before marketing their product to the health care industry, according to an FDA final order published in the May 17 Federal Register.

Washington — NIOSH has issued a pair of fact sheets on filtering facepiece respirators, detailing how to tell if an N95 is approved by the agency as well as procedures for fit testing and testing filtration efficiency.

A 28-year-old tree trimmer was part of a four-person crew removing a 127-foot fir tree from a residential property.

Shoveling and snowblowing can be potentially dangerous to your health if not performed properly

Rosemont, IL – The American Academy of Orthopedic Surgeons is advising people to be cautious when removing snow this winter.

Lansing, MI – The Michigan Occupational Safety and Health Administration is looking to protect workers from hazards linked to asbestos, lead and cadmium that may be encountered during blight removal projects, as part of a one-year state emphasis program launched in September.

When a facility has multiple areas where combustible dusts are present, are central vacuum cleaning systems the only option?

Ajinomoto’s zero-calorie sweetener, advantame, has been approved in Canada.  Due to its clean, sugar-like taste, functionality and cost effectiveness, advantame can be used to replace caloric sweeteners and other high-potency sweeteners in foods and beverages while maintaining or enhancing the flavor profile.

Washington — A new Bureau of Safety and Environmental Enforcement final rule codifies existing agency practice related to the review and approval of projects that will feature “new or unusual technology” – including equipment used in high-pressure or high-temperature environments.

Learn how this leader in resilient flooring emphasizes long-term planning, approaches the evolving role of digital printing, and discusses the importance of clear product storytelling. Plus, Wu highlights Novalis' commitment to domestic manufacturing.

Coval Technologies, an innovator in covalent bonding spray down coating systems, introduces the Coval SP-HV industrial sprayer.

President Biden called his predecessor — now, successor — a threat to democracy. Today he'll sit side by side with President-elect Trump as part of the ceremony around a smooth transfer of power.

This study introduces a novel iterative Bragg peak removal with automatic intensity correction (IBR-AIC) methodology for X-ray absorption spectroscopy (XAS), specifically addressing the challenge of Bragg peak interference in the analysis of crystalline materials. The approach integrates experimental adjustments and sophisticated post-processing, including an iterative algorithm for robust calculation of the scaling factor of the absorption coefficients and efficient elimination of the Bragg peaks, a common obstacle in accurately interpreting XAS data, particularly in crystalline samples. The method was thoroughly evaluated on dilute catalysts and thin films, with fluorescence mode and large-angle rotation. The results underscore the technique's effectiveness, adaptability and substantial potential in improving the precision of XAS data analysis. While demonstrating significant promise, the method does have limitations related to signal-to-noise ratio sensitivity and the necessity for meticulous angle selection during experimentation. Overall, IBR-AIC represents a significant advancement in XAS, offering a pragmatic solution to Bragg peak contamination challenges, thereby expanding the applications of XAS in understanding complex materials under diverse experimental conditions.

The title compound (systematic name: rac-2-hydroxy-3-methylbutanoic acid), C5H10O3, is the constitutional isomer of α-hy­droxy­butanoic acid. In the crystal, hydrogen bonds involving the alcoholic hydroxyl group give rise to centrosymmetric dimers that are extended to sheets perpendicular to the crystallographic c axis.

Metal-based complexes with their unique chemical properties, including multiple oxidation states, radio-nuclear capabilities and various coordination geometries yield value as potential pharmaceuticals. Understanding the interactions between metals and biological systems will prove key for site-specific coordination of new metal-based lead compounds. This study merges the concepts of target coordination with fragment-based drug methodologies, supported by varying the anomalous scattering of rhenium along with infrared spectroscopy, and has identified rhenium metal sites bound covalently with two amino acid types within the model protein. A time-based series of lysozyme-rhenium-imidazole (HEWL-Re-Imi) crystals was analysed systematically over a span of 38 weeks. The main rhenium covalent coordination is observed at His15, Asp101 and Asp119. Weak (i.e. noncovalent) interactions are observed at other aspartic, asparagine, proline, tyrosine and tryptophan side chains. Detailed bond distance comparisons, including precision estimates, are reported, utilizing the diffraction precision index supplemented with small-molecule data from the Cambridge Structural Database. Key findings include changes in the protein structure induced at the rhenium metal binding site, not observed in similar metal-free structures. The binding sites are typically found along the solvent-channel-accessible protein surface. The three primary covalent metal binding sites are consistent throughout the time series, whereas binding to neighbouring amino acid residues changes through the time series. Co-crystallization was used, consistently yielding crystals four days after setup. After crystal formation, soaking of the compound into the crystal over 38 weeks is continued and explains these structural adjustments. It is the covalent bond stability at the three sites, their proximity to the solvent channel and the movement of residues to accommodate the metal that are important, and may prove useful for future radiopharmaceutical development including target modification.

A new pyridine-fused seleno­diazo­lium salt, 3-(phenyl­selan­yl)[1,2,4]selena­diazolo[4,5-a]pyridin-4-ylium chloride di­chloro­methane 0.352-solvate, C12H9N2Se2+·Cl−·0.352CH2Cl2, was obtained from the reaction between 2-pyridyl­selenenyl chloride and phenyl­seleno­cyanate. Single-crystal structural analysis revealed the presence of C—H⋯N, C—H⋯Cl−, C—H⋯Se hydrogen bonds as well as chalcogen–chalcogen (Se⋯Se) and chalcogen–halogen (Se⋯Cl−) inter­actions. Non-covalent inter­actions were explored by DFT calculations followed by topological analysis of the electron density distribution (QTAIM analysis). The structure consists of pairs of seleno­diazo­lium moieties arranged in a head-to-tail fashion surrounding disordered di­chloro­methane mol­ecules. The assemblies are connected by C—H⋯Cl− and C—H⋯N hydrogen bonds, forming layers, which stack along the c-axis direction connected by bifurcated Se⋯Cl−⋯H—C inter­actions.

We recently launched a new website intended to highlight the science underlying questions that our research shows Americans have about current issues.

The U.S. should undertake a new research program to better understand the potential risks and benefits of ocean-based interventions to remove or sequester carbon dioxide from the atmosphere and learn how these methods could be used to mitigate the impacts of climate change.

Experts discuss the future of ocean-based approaches to carbon dioxide removal — including the ethics of investigating proposed strategies, how research can respond to public concerns, and what we need to know to make informed climate decisions.

The oils meet World Health Organization standards on industrial-produced trans-fatty acids.

Georgia-based HRS Heat Exchangers has been awarded the American 3-A Sanitary Standards approval for two of its key heat exchanger models for food and beverage use.

MGP Ingredients, Inc. is pleased to announce the formal approval of its citizen petition requesting dietary fiber status under the new nutrition facts labeling regulations for its flagship brands of Fibersym RW and FiberRite RW.

PureCircle will offer three ingredients from bioconversion—Reb D, Reb M, and Reb AM—to food and beverage manufacturers across the European Union.

The customer says there is water at the base of the toilet after flushing, which means you get to replace the wax seal. 

Root intrusion in sewer systems causes blockages, slow drainage, unpleasant odors, and overflow. Preventative root control is essential to maintain the sewer system's hydraulic capacity. This issue deserves our full attention.

When snow and “ice missiles” blowing off semi-trailers and trucks are added to the equation, the risk factor increases exponentially.

The regulatory approval marks a milestone in Sweegen opening new markets in countries where brands seek new generation stevia ingredients, the company says.

Ingredient companies announced new hires as well as case studies detailing consumer trends influencing new product development.

- Gyeonggi-do exchanged opinions under the topic of station F, an incubator of fledgling businesses on the 29th - Starting with Station F, Gyeonggi-do plans to interact with Junggwang village, the Chinese version of Silicon Valley

According to a briefing by Cheong Wa Dae spokesperson Park Kyung-mee, President Moon said after hearing the news on the same day, "I highly anticipate for the first Korean vaccine to be produced and commercialized.