Watertown, SD — A new video from the National Association of Tower Erectors highlights the importance of understanding and following the proper sequence of performing tower modifications.

Botanical ingredients have been key components in culinary traditions worldwide for centuries, not only for their unique flavors but also for their ability to enhance and balance the taste profiles of various dishes. Spices and herbs, in particular, are powerful tools for both flavor enhancement and masking off-flavors.

The USDA says 2022 will be a great year for agriculture, and climate-smart farming practices can help.

Children's Geographies; 12/01/2022
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The post Modifiers and Mechanisms of Loneliness Interventions was curated by information for practice.

Cybersecurity company, Egress, a KnowBe4 company, has launched its latest Phishing Threat Trends Report (October 2024), which examines the most recent phishing statistics and threat intelligence insights.

Plasmodium vivax is a major cause of malaria, which poses an increased health burden on approximately one third of the world's population due to climate change. Primaquine, the preferred treatment for P. vivax malaria, is contraindicated in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, a common genetic cause of hemolytic anemia, that affects ∼2.5% of the world's population and ∼8% of the population in areas of the world where P. vivax malaria is endemic. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) conducted a structure–function analysis of P. vivax N-myristoyltransferase (PvNMT) as part of efforts to develop alternative malaria drugs. PvNMT catalyzes the attachment of myristate to the N-terminal glycine of many proteins, and this critical post-translational modification is required for the survival of P. vivax. The first step is the formation of a PvNMT–myristoyl–CoA binary complex that can bind to peptides. Understanding how inhibitors prevent protein binding will facilitate the development of PvNMT as a viable drug target. NMTs are secreted in all life stages of malarial parasites, making them attractive targets, unlike current antimalarials that are only effective during the plasmodial erythrocytic stages. The 2.3 Å resolution crystal structure of the ternary complex of PvNMT with myristoyl-CoA and a novel inhibitor is reported. One asymmetric unit contains two monomers. The structure reveals notable differences between the PvNMT and human enzymes and similarities to other plasmodial NMTs that can be exploited to develop new antimalarials.

A second crystalline modification of the title compound, C12H19N3S [common name: cis-jasmone thio­semicarbazone] was crystallized from tetra­hydro­furane at room temperature. There is one crystallographic independent mol­ecule in the asymmetric unit, showing disorder in the cis-jasmone chain [site-occupancy ratio = 0.590 (14):0.410 (14)]. The thio­semicarbazone entity is approximately planar, with the maximum deviation from the mean plane through the N/N/C/S/N atoms being 0.0463 (14) Å [r.m.s.d. = 0.0324 Å], while for the five-membered ring of the jasmone fragment, the maximum deviation from the mean plane through the carbon atoms amounts to 0.0465 (15) Å [r.m.s.d. = 0.0338 Å]. The mol­ecule is not planar due to the dihedral angle between these two fragments, which is 8.93 (1)°, and due to the sp3-hybridized carbon atoms in the jasmone fragment chain. In the crystal, the mol­ecules are connected by N—H⋯S and C—H⋯S inter­actions, with graph-set motifs R22(8) and R21(7), building mono-periodic hydrogen-bonded ribbons along [010]. A Hirshfeld surface analysis indicates that the major contributions for the crystal cohesion are H⋯H (67.8%), H⋯S/S⋯H (15.0%), H⋯C/C⋯H (8.5%) and H⋯N/N⋯H (5.6%) [only non-disordered atoms and those with the highest s.o.f. were considered]. This work reports the second crystalline modification of the cis-jasmone thio­semicarbazone structure, the first one being published recently [Orsoni et al. (2020). Int. J. Mol. Sci. 21, 8681–8697] with the crystals obtained in ethanol at 273 K.

Proteins frequently undergo covalent modification at the post-translational level, which involves the covalent attachment of chemical groups onto amino acids. This can entail the singular or multiple addition of small groups, such as phosphorylation; long-chain modifications, such as glycosylation; small proteins, such as ubiquitination; as well as the interconversion of chemical groups, such as the formation of pyroglutamic acid. These post-translational modifications (PTMs) are essential for the normal functioning of cells, as they can alter the physicochemical properties of amino acids and therefore influence enzymatic activity, protein localization, protein–protein interactions and protein stability. Despite their inherent importance, accurately depicting PTMs in experimental studies of protein structures often poses a challenge. This review highlights the role of PTMs in protein structures, as well as the prevalence of PTMs in the Protein Data Bank, directing the reader to accurately built examples suitable for use as a modelling reference.

The success of experimental phasing in macromolecular crystallography relies primarily on the accurate locations of heavy atoms bound to the target crystal. To improve the process of substructure determination, a modified phase-retrieval algorithm built on the framework of the relaxed alternating averaged reflection (RAAR) algorithm has been developed. Importantly, the proposed algorithm features a combination of the π-half phase perturbation for weak reflections and enforces the direct-method-based tangent formula for strong reflections in reciprocal space. The proposed algorithm is extensively demonstrated on a total of 100 single-wavelength anomalous diffraction (SAD) experimental datasets, comprising both protein and nucleic acid structures of different qualities. Compared with the standard RAAR algorithm, the modified phase-retrieval algorithm exhibits significantly improved effectiveness and accuracy in SAD substructure determination, highlighting the importance of additional constraints for algorithmic performance. Furthermore, the proposed algorithm can be performed without human intervention under most conditions owing to the self-adaptive property of the input parameters, thus making it convenient to be integrated into the structural determination pipeline. In conjunction with the IPCAS software suite, we demonstrated experimentally that automatic de novo structure determination is possible on the basis of our proposed algorithm.

The title compound, [Co(NCS)2(C6H7N)4] or Co(NCS)2(4-methyl­pyridine)4, was prepared by the reaction of Co(NCS)2 with 4-methyl­pyridine in water and is isotypic to one of the polymorphs of Ni(NCS)2(4-methyl­pyridine)4 [Kerr & Williams (1977). Acta Cryst. B33, 3589–3592 and Soldatov et al. (2004). Cryst. Growth Des. 4, 1185–1194]. Comparison of the experimental X-ray powder pattern with that calculated from the single-crystal data proves that a pure phase has been obtained. The asymmetric unit consists of one CoII cation, two crystallographically independent thio­cyanate anions and four independent 4-meth­yl­pyridine ligands, all located in general positions. The CoII cations are sixfold coordinated to two terminally N-bonded thio­cyanate anions and four 4-methyl­pyridine coligands within slightly distorted octa­hedra. Between the complexes, a number of weak C—H⋯N and C—H⋯S contacts are found. This structure represent a polymorphic modification of Co(NCS)2(4-methyl­pyridine)4 already reported in the CCD [Harris et al. (2003). NASA Technical Reports, 211890]. In contrast to this form, the crystal structure of the new polymorph shows a denser packing, indicating that it is thermodynamically stable at least at low temperatures. Thermogravimetric and differential thermoanalysis reveal that the title compound starts to decomposes at about 100°C and that the coligands are removed in separate steps without any sign of a polymorphic transition before decomposition.

Small-angle neutron scattering is a widely used technique to study large-scale structures in bulk samples. The largest accessible length scale in conventional Bragg scattering is determined by the combination of the longest available neutron wavelength and smallest resolvable scattering angle. A method is presented that circumvents this limitation and is able to extract larger length scales from the low-q power-law scattering using a modification of the well known Porod law connecting the scattered intensity of randomly distributed objects to their specific surface area. It is shown that in the special case of a highly aligned domain structure the specific surface area extracted from the modified Porod law can be used to determine specific length scales of the domain structure. The analysis method is applied to study the micrometre-sized domain structure found in the intermediate mixed state of the superconductor niobium. The analysis approach allows the range of accessible length scales to be extended from 1 µm to up to 40 µm using a conventional small-angle neutron scattering setup.

Germany-based fintech MODIFI has announced...

The emerging science of gene drives has the potential to address environmental and public health challenges, but gene-drive modified organisms are not ready to be released into the environment and require more research in laboratories and highly controlled field trials, says a new report from the National Academies of Sciences, Engineering, and Medicine.

ESET researchers detected multiple, widespread phishing campaigns targeting SMBs in Poland during May 2024, distributing various malware families

The ingredient aims to help producers amplify tomato flavor in response to shortages.

Penford Corp.'s PenPlus 2140 pre-gelatinized, modified potato starch is recommended for use in tortillas and baked goods.

CitruSweet, ThauSweet bring lingering sweetness without the need to mask afternotes.

MbenzGram has recently published an article to discuss the top performance parts for vehicles.

The Oregon Court of Appeals ruled that an insurer was obligated to modify its notice of acceptance upon receipt of a report that clearly identified a meniscus tear caused by…

The Commonwealth Court of Pennsylvania upheld the modification of an injured worker’s benefits from wage loss to a specific loss based on the partial amputation of a toe. Case: Perkins v.

The Commonwealth Court of Pennsylvania upheld the modification of a worker’s status from totally to partially disabled. Case: Hines v. Aria Health (WCAB), No. 708 C.D. 2023, 08/22/2024, unpublished. Facts and procedural…

Pennsylvania’s Supreme Court will be weighing in on the proper allocation of the burden of proving the existence of available positions for an injured worker, and the suitability of those…

The Kansas Court of Appeals upheld a decision of the Workers’ Compensation Appeals Board denying a government employee’s request for a modification of her award. Case: Jackson v. Johnson County, No.

Toronto, ON – Augmented reality startup ModiFace will make a major announcement Tuesday, aimed to accelerate development of augmented reality (AR) and artificial intelligence (AI) talent at Canada’s top-ranked engineering school. The company, founded by Professor Parham Aarabi of The Edward S. Rogers Sr. Department of Electrical & Computer Engineering, uses AR and AI to […]

Modine's offer to schools of Needlepoint Bipolar Ionization Technology was prompted by recent Canadian wildfires, which have created smoke that has blanketed significant portions of the U.S.

When installing or repairing a refrigeration system, technicians should look for opportunities to slightly modify the system (without changing its design) to make it more serviceable.

The unit includes a standard neoprene, vibration-isolated blower and motor for quiet operation.

Ideal for cost-conscious applications that require 100 percent outside air, the new unit from Modine provides first-rate efficiency with a 100 percent thermal efficiency (92 percent sensible), and extends airflow capability to as low as 800CFM to cover far more applications than previously offered.

The two donated Airedale ClassMate packaged units were installed in the football team's fieldhouse at Parry McCluer High School in Buena Vista, Virginia.

Customer comfort is the top sales driver in the HVAC industry, or at least it should be.

 Redesigned packaging features a "New & Improved" badge, setting the stage for a new chapter of growth for the brand.

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Modification to SSE reason identifier codes to support voice band data and text relay

Location: Electronic Resource- 

In this episode, Thomas Domville demonstrates how to enable the Fast long-press speed option on iOS 17. This new feature allows for quicker access to context menus and other Haptic Touch actions, enhancing your workflow and making your iPhone feel more responsive.

Here’s how you can activate the Fast Long-Press Speed Option:

1. Launch the Settings app.
2. Navigate to Accessibility.
3. Select Touch.
4. Choose Haptic Touch.

5. Under Touch Duration, opt for Fast.

   You can gauge the new response time by long-pressing on the flower image displayed on the same screen. This simple adjustment can significantly boost your iPhone’s responsiveness.

Panelistas consideran que inacción de la Policía puede enviar graves mensajes a la ciudadanía; consideran que se necesita claridad.

Francisco Ospina, presidente de la Agencia Nacional de Infraestructura, habló sobre cuál es la inversión y cómo será la remodelación del Aeropuerto Internacional El Dorado 

1. PM Modi’s Rs 12,100 crore infrastructure push to transform Bihar’s railways and roadways – Here’s all you need to know  The Financial Express
2. PM Modi to visit Bihar on Wednesday, inaugurate projects worth Rs 12,100 Cr  Deccan Herald
3. PM Modi lays foundation stone for AIIMS Darbhanga, says NDA Govt committed to welfare of people  The Hindu
4. PM Modi Bihar Visit Live: Nitish Kumar removed 'jungle raj' in Bihar, says PM Modi in Darbhanga  Moneycontrol
5. Politics News Today Live Updates on November 13, 2024: ‘BJP trying to create controversy’: Karnataka Deputy CM Shivakumar on ‘Kaalia’ remark against Kumaraswamy  Mint

Illustrator, writer, and filmmaker Mordicai Gerstein died earlier this month. He leaves behind an amazing body of work which is sure to be read and appreciated; several have already been anointed as modern classics.

Yue Chen
May 1, 2007; 6:812-819
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Ivan Matic
Jan 1, 2008; 7:132-144
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