A vibratory compactor having a first compacting element having a variable vibratory mechanism that sets a modifiable compaction effort, a second compacting element, a first sensor configured to measure a first surface compactability associated with the first compacting element, a second sensor configured to measure a second surface compactability associated with the second compacting element and a control system. The control system is configured to receive the first surface compactability, receive the second surface compactability, determine a target compaction effort for the first compacting element based on the first surface compactability and the second surface compactability, and modify the variable vibratory mechanism to set the compaction effort at the target compaction effort.

Certain example implementations of the disclosed technology include a light emitting device. The light emitting device may include an enclosure with four sides and a top edge surface associated with each of the four sides. The enclosure may be capable of mounting on a grid frame of a suspended ceiling such that a portion of the top edge surfaces contacts a portion of the grid frame. The light emitting device may further include a light modifying element characterized by a substrate with four or more edges, a back surface disposed on the top edge surface of each of the four sides of the enclosure, and a front surface. In certain example embodiments the substrate may further comprise two or more edge trusses. A periphery of the light-emitting front surface may be capable of contacting the grid frame after the light emitting device is mounted to the grid frame.

A driver performance mapping system for a vehicle system is disclosed. The system may include a GPS receiver generating GPS data indicative of a current location of the vehicle. In addition, the system may also have a radar device generating current gap data indicative of a current gap distance from the vehicle to a lead vehicle. Further, the system may include an electronic controller configured to generate learned gap data based on the current gap data and stored gap data, and then assign the learned gap data with the GPS data.

A computer-implemented fan control method includes measuring a temperature within a computer system and dynamically selecting a fan speed step in response to the temperature received, wherein the fan speed step is selected from a fan speed table defining a finite number of fan speed steps each having an associated fan speed. A fan is operated at the dynamically selected fan speed step, wherein the fan is positioned to drive air through the computer system where the temperature is being measured. The fan output variation is measured over a prescribed time interval and the fan speed table is automatically modified to change the fan speeds associated with each fan speed step, wherein the fan speeds are changed as a function of the measured fan output variation while continuing to drive the fan.

Compositions and methods for inhibiting and controlling the growth of microbes are disclosed. The composition comprises at least one chemically-modified peptide with antimicrobial activity and at least one carrier. The method comprises of administering an amount, effective for the prevention, inhibition and termination of microbial growth for industrial, pharmaceutical, household and personal care use.

A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.

Methods and compositions for targeted delivery of biotherapeutics are provided. The compositions comprise bile-sensitive St. thermophilus bacteria modified to release a biotherapeutic agent following bile exposure. Biotherapeutic agents released by the St. thermophilus bacteria disclosed herein include AQ and AQR rich peptides. Methods of the invention comprise administering to a subject a St. thermophilus bacterium modified to release a biotherapeutic agent following bile exposure. Administration of the St. thermophilus bacterium promotes a desired therapeutic response. The bacterium may be modified to express and release AQ or AQR rich peptides which subsequently inhibit cellular apoptosis or reduce mucosal damage. Thus, methods of the invention find use in treating or preventing a variety of gastrointestinal disorders including C. difficile infection and antibiotic-associated diarrhea.

A system and method for assessing a health and functionality of a locomotive friction modifying system wherein the locomotive has a friction modifying applicator associated with a wheel of the locomotive for applying a friction modifying agent to a rail on which the wheel is traversing. The system and method comprise a sensor detecting a predetermined operational condition of the locomotive. The system and method also comprise a controller associated with the sensor and responsive to input from the sensor determining a per unit creep of an axle of the locomotive. The controller also determines a tractive effort of the axle of the locomotive and determines a friction modifying applicator state for the applicator associated with the axle. The controller further compares the determined per unit creep of the axle, the tractive effort of the axle and the state of the friction modifying applicator associated with the axle to a predetermined value indicative of the health and functionality of the locomotive friction modifying system. The controller provides an indication of the health and functionality of the locomotive friction modifying system.

A system and method for controlling an application of a friction modifying agent to an area of contact between a railway wheel and a railway rail over which the wheel is traversing to selectively modify the coefficient of friction at the contact area. A sensor is used for detecting a parameter relating to the operation of the railway train. A controller is responsive to the sensor for selecting one or more of a plurality of friction modifying agents and controls the application of the agent to the rail as a function of the parameter. An applicator is responsive to the controller and applies the friction modifying agent to the area of contact between the railway wheel and rail. A second application of the agent may be predicated upon the effectiveness of a first application of the agent. The selection of the appropriate agent may include a consideration of a current location of the railway vehicle.

A friction management system for a traveling crane applies a liquid or solid friction modifier (FM) in precisely controlled quantities to the crane wheels or rail to improve performance and safety during movement of the crane. The friction modifier is applied by a nozzle mounted on a crane truck, which nozzle is opened and closed by a valve. The duration of the valve opening per second, which controls the friction modifier application rate, is approximately proportional to the average current draw, which is detected by current sensors connected to the truck motors.

In one example, a modified electrical device includes a body and at least one connector on the body to make power and control connections with an active cover plate. A system includes an active cover plate comprising low voltage circuitry and a first interface and a modified electrical device. The modified electrical device includes high voltage circuitry and a second interface to connect to the first interface to supply low voltage to the active cover plate. A method for controlling a flow of power through a modified electrical device is also provided.

A system and method for modifying a gas turbine engine in the field to drill a series of cooling holes in a turbine rotor disk made of a superalloy. A portable field repair system includes a stand configured to receive, support, and position a turbine rotor disk, a drill having a self-feeding spindle and configured to automatically drill a predetermined depth through a superalloy and to automatically stop upon completion, a drill guide configured to coordinate the drill with a plurality of radial axes associated with a precise hole pattern to be cut and a drill mount configured to mechanically couple the drill to the drill guide and to position the drill during the modification of the gas turbine engine turbine rotor disk.

Sequential write operations to a unit of compressed memory, known as a compression tile, are examined to see if the same compression tile is being written. If the same compression tile is being written, the sequential write operations are coalesced into a single write operation and the entire compression tile is overwritten with the new data. Coalescing multiple write operations into a single write operation improves performance, because it avoids the read-modify-write operations that would otherwise be needed.

A method to inexpensively and efficiently produce conductive materials on the surface of which a nano-level fine structure is formed includes surface modification including immersing a stable anode electrode and a workpiece as a cathode electrode, the workpiece including a conductive material with a work surface, in an electrolytic solution, then applying a voltage not less than a first voltage and less than a second voltage between the stable anode electrode and the workpiece as the cathode electrode immersed in the electrolytic solution, thereby modifying the work surface, the first voltage being a voltage corresponding to a current value that is ½ of the sum of a first maximum current value appearing first in a positive voltage region and a first minimum current value appearing first in the positive voltage region with respect to voltage-current characteristics of a surface modification treatment system, the second voltage exhibiting a complete-state plasma.

Processes for preparation of macroporous membranes having unusually high equilibrium protein binding capacities are described. Membranes include a self-supporting porous membrane substrate and a grafted polymeric film on the pore surfaces of the substrate. A polymeric film may be grafted to the porous membrane substrate using surface-initiated polymerization. The grafted polymer chains within the polymeric film can act as molecular ‘brushes’ or ‘tentacles’ in solution and can contain one or more capture chemistries for biomolecules. Membranes can be used in the separation and purification of biomolecules such as proteins, nucleic acids, virus or virus-like particles, endotoxins, and the like.

A patient wearable, continuously operating extracorporeal pump apparatus which accesses the patient's arterial venous pressure differential by applying external pressure to a subcutaneous graft that has been cannualized to modulate blood flow through an extracorporeal circuit and to drive the pump for delivering a medicament, such as an anticoagulant, to the site of an intravenous cannula to prevent clogging thereof and also to move a dialysate through a circuit, including a dialyzer and a dialysate rejuvenating cartridge, whereby kidney failure can be treated without recourse to prior art hemodialysis machines found in most treatment facilities. With slight modification, the present invention can be used to remove excess fluids from CHF patients, to remove toxins from the blood in those suffering from liver failure and to facilitate administration of insulin to diabetics and/or glucose to those having hypoglycemia.

The invention is a projectile, device and system having a roll control device which may be fixed or deployable, for providing torque counter to the spin of the projectile and providing drag on the projectile. The roll control device includes a guidance collar rotatably attached to the projectile located near a front end of the projectile wherein the guidance collar includes one or more guidance collar aero-surfaces shaped to provide torque counter to the spin on the projectile. The guidance collar aero-surfaces may be controlled by a brake and guidance electronics on the projectile. The invention also includes a body collar fixedly attached to the projectile aft of the guidance collar, wherein the body collar includes one or more body collar aero-surfaces and fixed or deployable drag devices. Another embodiment use only a guidance collar aero-surfaces to orient a fixed drag device relative to an Earth inertial reference frame to create asymmetrical drag on the projectile and thereby altering its trajectory.

A system for diverting fluids from a wellhead in a subsea environment has a capping stack with a connector suitable for connection or interconnection to the wellhead, a flow base fixedly positioned in the subsea environment, and a conduit connected to the outlet of a diverter line of the capping stack and connected to the inlet of an interior passageway of the flow base. The conduit is suitable for passing fluids from the capping stack toward the flow base. The flow base is a modified horizontal Christmas tree. The interior passageway within the horizontal Christmas tree has a plug therein located a level below the level of the inlet to the flow base. The flow base can be attached to a wellhead or to an anchor pile in the subsea environment.

An exemplary embodiment provides a cardanol-modified silane coupling agent, which can improve strength and toughness by improving adhesion at an interface between a filler and a cellulose resin when being used as a surface-treatment agent, a resin additive, or the like; a cardanol-modified filler subjected to a surface treatment with the cardanol-modified silane coupling agent; and a cellulose resin composition having excellent toughness. More specifically, the exemplary embodiment provides a cardanol-modified silane coupling agent obtained by reacting cardanol or a derivative thereof with an epoxy silane coupling agent or an isocyanate silane coupling agent; a cardanol-modified filler obtained by subjecting a filler to a surface treatment with the cardanol-modified silane coupling agent; a cellulose resin composition comprising the cardanol-modified filler and a cellulose resin; and a cellulose resin composition comprising the cardanol-modified silane coupling agent, a filler and a cellulose resin.

A knit fabric having a modified knit structure, having a front layer of knit fabric and a back layer of knit fabric, wherein the front layer and back layer are joined together by rows of tuck stitches formed from a yarn having no more than 3% elongation and wherein the knit fabric is puncture resistant, and optionally cut and/or abrasion resistant, and a protective garment made therefrom.

The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies, comprising the same, and their uses.

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

Provided herein are compositions and methods for modifying a predetermined nucleic acid sequence. A programmable nucleoprotein molecular complex containing a polypeptide moiety and a specificity conferring nucleic acid (SCNA) which assembles in-vivo, in a target cell, and is capable of interacting with the predetermined target nucleic acid sequence is provided. The programmable nucleoprotein molecular complex is capable of specifically modifying and/or editing a target site within the target nucleic acid sequence and/or modifying the function of the target nucleic acid sequence.

A strap handle for a piece of luggage that has been modified to have the strap handle added thereon. The strap handle includes a strap, and apparatus for having the strap handle added onto the piece of luggage. The apparatus sits within the piece of luggage. The strap engages into the apparatus.

A double base propellant modifier uses a lead-tin component with a defined amount of lead and a copper component with a defined surface area to effect super-rate burning of double base propellants with defined plateau and mesa burning rate characteristics.

A double base propellant modifier uses a combination of a lead component, a tin component and a copper component in physical contact to effect super-rate burning of double base propellants with defined plateau and mesa burning rate characteristics.

A composition capable of producing either solid propellant grains, liquid or gel monopropellants, all of which are electrically ignitable and capable of sustained controllable combustion at ambient pressure. Additional compositions capable of sustained controllable combustion at elevated pressures are described. Applications for the compositions disclosed herein are provided, and include among other applications use in small micro thrusters, large core-burning solid propellant gains, shaped explosives charges for military application, and pumpable liquids and gel monopropellants or explosives for military, commercial mining or gas and oil recovery. In alternative embodiments the above compositions may also incorporate an energetic nitrate polymer, bum rate modifiers, and/or metal fuel(s). The HIPEP formulation makes it possible to ignite and sustain combustion at ambient and vacuum conditions (a) without continuous electrical power and (b) while providing faster bum rates.

Techniques and methods for utilizing ion implantation to modify dental archwires are provided. An example of a method of ion implanting a wire target includes providing the wire target in an ion implant system, implanting ions into the wire target such that a color of the wire target material after the implanting exhibits a changed appearance from the color of the wire target material before the implanting, and removing the wire target from the ion implant system. An example of a copper-aluminum-nickel (CuAlNi) wire includes an ion implanted atomic species wherein a color of an implanted CuAlNi wire is white, off-white and/or silver and further wherein the implanted CuAlNi wire exhibits mechanical properties of an unimplanted CuAlNi wire.

An object of the invention is to provide cellulose fibers which can give a cellulose composite that renders high transparency, a reduction in linear expansion coefficient, and a high modulus of elasticity possible. The invention relates to: a process for producing modified cellulose fibers which includes a modification reaction step of reacting cellulose with an aromatic compound in an organic acid to thereby modify the cellulose with an aromatic-ring-containing substituent; cellulose fibers modified with aromatic-ring-containing substituent; a dispersion of the cellulose fibers; and a cellulose fiber composite obtained from the same.

The invention provides a burner module for use in combusting an air/fluid fuel flow wherein the burner module comprises a burner face comprising catalytic material for combusting the air/fluid fuel flow and a perforated screen having a plurality of micro-perforations wherein the perforated screen is positioned upline to the burner face to increase combustion; an integrated gas burner for connection to a pressurised fluid fuel flow wherein the integrated gas burner comprises a burner module and a gas train wherein the burner module comprises a burner face comprising catalytic material for combusting the air/fluid fuel flow and a perforated screen having a plurality of micro-perforations wherein the perforated screen is positioned upline to the burner face to increase combustion; and the gas train comprises: (a) an ejector for entraining air with the fluid fuel flow; and(b) a diffusor for converting the air/fluid fuel flow kinetic energy into pressure and for performing flow expansion; and an appliance comprising the integrated burner.

Certain example embodiments relate to a sliding window assembly (e.g., of the type found in utility cabs or other vehicles), and methods of making the same. A slidable window panel includes at least one top pin and at least one bottom pin attached thereto. A single fixed window panel includes a hole being defined therein for receiving the slidable panel. Elongated upper and lower rails connected to the fixed panel include upper and lower rail channels defined therein for slidingly receiving the at least one top and bottom pin attached to the slidable panel. Forward and rear end details are provided to each of the upper and lower rails proximate to the hole for slidingly receiving, in respective channels formed therein, the at least one top and bottom pins. The slidable panel is laterally movable when being opened via the respective rail channels provided to the upper and lower rails. The channels in the forward and rear end details are formed so that the slidable panel is movable slightly outwardly towards the hole when the slidable window is being closed and slightly inwardly away from the hole when the slidable window is being opened.

Embodiments of the present disclosure include systems and methods for controlling modification of a data file that is accessed by multiple components of an application platform. The method for controlling modification of a data file includes: preparing a link constraint data that includes information of a data file and a component of an application platform, the component being associated with the data file; preparing an alert data that includes information of the data file and a person having a permission to modify the data file; responsive to an attempt of a user to modify the data file, retrieving the information of the component from the link constraint data and the information of the person from the alert data; and sending a notice of the attempt to at least one of the person and the user.

The present disclosure provides systems for mitigating brake vibration. In various embodiments, a brake force distribution arrangement may comprise: a member in operable communication with an actuator having at least two contact surfaces such that as one of the at least two contact surfaces moves in a direction of actuation of the actuator the other moves in a direction opposite to the direction of actuation of the actuator.

A chemically-modified mixed fuel includes methane gas from at least two methane-production sources and can be utilized in any process that incorporates a Kellogg Primary Reformer. A method for producing the chemically-modified mixed fuel described herein includes providing a first methane-containing gas from a first methane-production source, providing a second methane-containing gas from a second methane-production source and blending the first methane-containing gas with the second methane-containing gas at a suitable pressure to form a chemically-modified mixed fuel. In some cases, at least one additional methane-containing gas can be provided from at least one additional methane-production source and blended with the chemically-modified fuel.

Electrolytic liquid generating device (1) includes laminated body (41) in which conductive film (46) is laminated to be interposed between mutually adjacent electrodes (44, 45), and electrolytic part (40) which electrolyzes liquid. Furthermore, electrolytic liquid generating device (1) includes a passage having inflow port (71) in which liquid to be provided to electrolytic part (40) flows and outflow port (72) from which electrolytic liquid generated in electrolytic part (40) flows out. The passage is formed such that liquid flowing direction (X) crosses laminated direction (Z) of laminated body (41).

A renal failure blood therapy system includes a renal failure blood therapy machine, concentration levels for each of a plurality of solutes removed from a patient's blood at each of the multiple times, a display device configured to display for selection at least one removed blood solute from the plurality of removed blood solutes, and a device programmed to (i) estimate at least one renal failure blood therapy patient parameter using the determined concentration levels for the at least one selected removed blood solute, (ii) determine a plurality of acceptable renal failure blood therapy treatments that meet a predetermined removed blood solute clearance for the at least one selected removed blood solute using the at least one renal failure blood therapy patient parameter, and (iii) enable selection of at least one of the plurality of acceptable renal failure blood therapy treatments for operation at the renal failure blood therapy machine.

Scientists at Yale and other universities came to some surprising findings when they studied a group of genetically modified mosquitoes released in Brazil.

Flintpope has announced the release of Mikroprism Flintpope Mod, a modification to the Mikro Prism synthesizer ensemble for Native Instruments Reaktor 6. When I first started messing about with Reaktor 6 I wrote a set of 24 presets for Mikroprism (still freely available on the NI Reaktor Users Library) as I was attracted to its […]

The post Flintpope releases modified Mikro Prism ensemble for NI Reaktor 6 appeared first on rekkerd.org.

The 49-year-old, who has been lodged at Wandsworth Prison in south-west London since his arrest last year, appeared before a UK court via videolink.

The decision would empower the central government and states/union territories to regulate prices, production, sale, distribution, transport, movement, storage, information of alcohols used in manufacturing hand sanitizers, used as preventive measure to avoid infection from COVID-19, Ministry of Consumer Affairs said in a statement.

The last few players at this small town's croquet club are forced to close the door after 91 years but the sport isn't finished just yet.

South Australia'sdecisiontoaxe its banongeneticallymodified cropscouldopen the doors for the cotton industry many locals have traditionally opposed.

Brendan Russell's body modification work includes tongue splitting and scarification, but court documents allege he used a branding iron to burn a woman's genitals, who later complained to police.

A man is charged over the death of a woman after he allegedly implanted a plastic snowflake under her skin at a NSW Central Coast tattoo shop.

Caroline Harte is mostly confined to her bed after a fall at work. While her insurer completes modifications to her home she sleeps next to a portable toilet and shower.

(California Court of Appeal) - Held that Apple Inc. was not liable for a five-year-old girl's death and injuries to her family members that occurred when a driver using the FaceTime application on his iPhone crashed into her parents' car on a Texas highway. Affirmed dismissal of the complaint, concluding that Apple did not owe a duty of care and that the iPhone's design was not a proximate cause.

BACKGROUND Preclinical experiments have shown that donor blood cells, modified in vitro by an alkylating agent (modified immune cells [MICs]), induced long-term specific immunosuppression against the allogeneic donor.METHODS In this phase I trial, patients received either 1.5 × 106 MICs per kg BW on day –2 (n = 3, group A), or 1.5 × 108 MICs per kg BW on day –2 (n = 3, group B) or day –7 (n = 4, group C) before living donor kidney transplantation in addition to post-transplantation immunosuppression. The primary outcome measure was the frequency of adverse events (AEs) until day 30 (study phase) with follow-up out to day 360.RESULTS MIC infusions were extremely well tolerated. During the study phase, 10 treated patients experienced a total of 69 AEs that were unlikely to be related or not related to MIC infusion. No donor-specific human leukocyte antigen Abs or rejection episodes were noted, even though the patients received up to 1.3 × 1010 donor mononuclear cells before transplantation. Group C patients with low immunosuppression during follow-up showed no in vitro reactivity against stimulatory donor blood cells on day 360, whereas reactivity against third-party cells was still preserved. Frequencies of CD19+CD24hiCD38hi transitional B lymphocytes (Bregs) increased from a median of 6% before MIC infusion to 20% on day 180, which was 19- and 68-fold higher, respectively, than in 2 independent cohorts of transplanted controls. The majority of Bregs produced the immunosuppressive cytokine IL-10. MIC-treated patients showed the Immune Tolerance Network operational tolerance signature.CONCLUSION MIC administration was safe and could be a future tool for the targeted induction of tolerogenic Bregs.TRIAL REGISTRATION EudraCT number: 2014-002086-30; ClinicalTrials.gov identifier: NCT02560220FUNDING Federal Ministry for Economic Affairs and Technology, Berlin, Germany, and TolerogenixX GmbH, Heidelberg, Germany.