Jenny E. Kanter
Dec 8, 2020; 0:jlr.ILR120001217v1-jlr.ILR120001217
Images in Lipid Research

French President Emmanuel Macron was joined in Paris on Monday by British Prime Minister Keir Starmer for Armistice Day commemorations after a meeting at which both leaders reaffirmed "unwavering" support for Ukraine.

Some researchers initially dismissed the remains of Palaeopascichnus lineari as teeny turds from a bygone era

SAS SGPLOT already provides the necessary graphical elements for complex visualization. 3D or high-dimensional data can be easily visualized after being projected appropriately. With SAS' strong support for animation features, SAS users can create complicated 3D or high dimension visualizations quickly.

The post A better 3D scatter plot macro appeared first on Graphically Speaking.

The two macros below introduce new syntax for adding definitions to more than one 'when' determinant value at the same time. The first macro overloads 'extend' keyword and the second is the equivalent for 'when' keyword.

A use example:

extend [HUGE, BIG] packet {
    // definitions that pertain to these subtypes
};

The above code would be expanded in the following (naive) way:

extend HUGE packet {
    // definitions that pertain to these subtypes
};
extend BIG packet {
    // definitions that pertain to these subtypes
};


The macros code:

define 'statement>
       "extend ['name>,...] 'name> ({;...})" as computed {
    for each in 'names> do {
        result = appendf("%sextend %s %s %s;",result,it,'name>,);
    };
    result = appendf("{%s}",result); // required only for versions 6.1.1 or earlier
};

define 'struct_member>
       "when ['name>,...] 'name> ({;...})" as computed {
    for each in 'names> do {
        result = appendf("%swhen %s %s %s;",result,it,'name>,);
    };
    result = appendf("{%s}",result); // required only for versions 6.1.1 or earlier
};

The following macros encapsulates a design pattern that enables constraining data item fields by 'do' actions of a high level sequence. This can be done without presupposing anything about the sequence tree generated under the do-ing sequence.

The tar file consists of 4 files:
- item_constraint_macro.e - the 'item_constraint' and 'sequence_export' macros definition
- item_constraint_example.e and sequence_export_example.e - use examples (one per each new construct)
- packet_seq.e - an auxiliary definition file for the examples

This topic was discussed in a Club-T presentation (Israel, Sophia-Antipolis, Munich). The presentation is also publicly avaiable.

Hi everybody,

The attached package is a tiny code example with a demo for an upcoming Team Specman blog post about writing macros.

Hilmar

Macron and Starmer lay wreath at Paris' Tomb of the Unknown Soldier on Armistice Day

Influenza A virus (IAV) is one of the leading causes of respiratory infections. The lack of efficient anti-influenza therapeutics requires a better understanding of how IAV interacts with host cells. Alveolar macrophages are tissue-specific macrophages that play a critical role in lung innate immunity and homeostasis, yet their role during influenza infection remains unclear. First, our review highlights an active IAV replication within alveolar macrophages, despite an abortive viral cycle. Such infection leads to persistent alveolar macrophage inflammation and diminished phagocytic function, alongside direct mitochondrial damage and indirect metabolic shifts in the alveolar micro-environment. We also discuss the "macrophage disappearance reaction", which is a drastic reduction of the alveolar macrophage population observed after influenza infection in mice but debated in humans, with unclear underlying mechanisms. Furthermore, we explore the dual nature of alveolar macrophage responses to IAV infection, questioning whether they are deleterious or protective for the host. While IAV may exploit immuno-evasion strategies and induce alveolar macrophage alteration or depletion, this could potentially reduce excessive inflammation and allow for the replacement of more effective cells. Despite these insights, the pathophysiological role of alveolar macrophages during IAV infection in humans remains understudied, urging further exploration to unravel their precise contributions to disease progression and resolution.

Although acute inflammation serves essential functions in maintaining tissue homeostasis, chronic inflammation is causally linked to many diseases. Macrophages are a major cell type that orchestrates inflammatory processes. During inflammation, macrophages undergo polarization and activation, thereby mobilizing pro-inflammatory and anti-inflammatory transcriptional programs that regulate ensuing macrophage functions. Fatty acid binding protein 5 (FABP5) is a lipid chaperone highly expressed in macrophages. FABP5 deletion is implicated in driving macrophages toward an anti-inflammatory phenotype, yet signaling pathways regulated by macrophage-FABP5 have not been systematically profiled. We leveraged proteomic and phosphoproteomic approaches to characterize pathways modulated by FABP5 in M1 and M2 polarized bone marrow-derived macrophages (BMDMs). Stable isotope labeling by amino acids-based analysis of M1 and M2 polarized wild-type and FABP5 knockout BMDMs revealed numerous differentially regulated proteins and phosphoproteins. FABP5 deletion impacted downstream pathways associated with inflammation, cytokine production, oxidative stress, and kinase activity. Toll-like receptor 2 (TLR2) emerged as a novel target of FABP5 and pharmacological FABP5 inhibition blunted TLR2-mediated activation of downstream pathways, ascribing a novel role for FABP5 in TLR2 signaling. This study represents a comprehensive characterization of the impact of FABP5 deletion on the proteomic and phosphoproteomic landscape of M1 and M2 polarized BMDMs. Loss of FABP5 altered pathways implicated in inflammatory responses, macrophage function, and TLR2 signaling. This work provides a foundation for future studies seeking to investigate the therapeutic potential of FABP5 inhibition in pathophysiological states resulting from dysregulated inflammatory signaling.

The leaders' discussions also focused on the Middle East and the problems caused by migration in Europe.

There were years when, despite El Niño, rainfall was close to normal and inflation remained benign; the officials

La Vergne : Anthem Press, 2024.

The crypto firm added that elevated interest rates, inflationary pressures, and tightening liquidity have created a more “cautious macroeconomic environment”

Mera Gao Power lights up 20,000 households across 1,500 Uttar Pradesh villages

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research

National Bureau of Economic Research