"New York Times-bestselling author and cultural critic Chuck Klosterman compiles and contextualizes the best of his articles and essays from the past decade. Chuck Klosterman has created an incomparable body of work in books, magazines, newspapers, and on the Web. His writing spans the realms of culture and sports, while also addressing interpersonal issues, social quandaries, and ethical boundaries. Klosterman has written nine previous books, helped found and establish Grantland, served as the New York Times MagazineEthicist, worked on film and television productions, and contributed profiles and essays to outlets such asGQ, Esquire,Billboard, The A.V. Club, andThe Guardian. Chuck Klosterman's tenth book (akaChuck Klosterman X) collects his most intriguing of those pieces, accompanied by fresh introductions and new footnotes throughout. Klosterman presents many of the articles in their original form, featuring previously unpublished passages and digressions. Subjects include Breaking Bad, Lou Reed, zombies, KISS, Jimmy Page, Stephen Malkmus, steroids, Mountain Dew, Chinese Democracy, The Beatles, Jonathan Franzen, Taylor Swift, Tim Tebow, Kobe Bryant, Usain Bolt, Eddie Van Halen, Charlie Brown, the Cleveland Browns, and many more cultural figures and pop phenomena. This is a tour of the past decade from one of the sharpest and most prolific observers of our unusual times"-- Provided by publisher.

Highly sensitive site-specific SUMOylation proteomics in Arabidopsis  Nature.com

EPA issued a final rule establishing a comprehensive program to cap and phase down the production and consumption of climate-damaging HFCs in the United States.

The new Chameleon bottle from Berry Agile Solutions features an outstanding construction that enables a base section with a special textured finish.

Hornetsecurity looks to entice MSPs looking to consolidate the number of tools they work with, offering a new suite to hep manage all of their Microsoft 365 subscribers.

(The Center Square) — Several North Carolina cities rank among those with the highest increases in homicide rates in the United States over the last two years, according to a recent analysis.

In his 1989 best-selling business and self-help book, The Seven Habits of Highly Effective People, Stephen Covey outlines a series of “true north” principles that help individuals attain their goals and adapt to change. More than 25 years later, do these tenets still ring true? And, what if we applied them to today’s search marketer? […]

If you’ve used Google’s Keyword Tool, you’ve probably seen the column called “Competitiveness,” with levels low, medium, and high. The low. medium, and high are based on the competitiveness of a keyword among paid search advertisers. The more advertisers are bidding on a keyword, the higher the competitiveness. By itself, paid search competitiveness tells you […]

Martin R. Larsen
Jul 1, 2005; 4:873-886
Technology

The dimeric ectonucleotidase CD73 catalyzes the hydrolysis of AMP at the cell surface to form adenosine, a potent suppressor of the immune response. Blocking CD73 activity in the tumor microenvironment can have a beneficial effect on tumor eradication and is a promising approach for cancer therapy. Biparatopic antibodies binding different regions of CD73 may be a means to antagonize its enzymatic activity. A panel of biparatopic antibodies representing the pairwise combination of 11 parental monoclonal antibodies against CD73 was generated by Fab-arm exchange. Nine variants vastly exceeded the potency of their parental antibodies with ≥90% inhibition of activity and subnanomolar EC50 values. Pairing the Fabs of parents with nonoverlapping epitopes was both sufficient and necessary whereas monovalent antibodies were poor inhibitors. Some parental antibodies yielded potent biparatopics with multiple partners, one of which (TB19) producing the most potent. The structure of the TB19 Fab with CD73 reveals that it blocks alignment of the N- and C-terminal CD73 domains necessary for catalysis. A separate structure of CD73 with a Fab (TB38) which complements TB19 in a particularly potent biparatopic shows its binding to a nonoverlapping site on the CD73 N-terminal domain. Structural modeling demonstrates a TB19/TB38 biparatopic antibody would be unable to bind the CD73 dimer in a bivalent manner, implicating crosslinking of separate CD73 dimers in its mechanism of action. This ability of a biparatopic antibody to both crosslink CD73 dimers and fix them in an inactive conformation thus represents a highly effective mechanism for the inhibition of CD73 activity.

You might be seconds away from regaining your focus with this scientifically backed method.

Two infectious disease experts weigh in on how a COVID-19 vaccine that’s 90 percent effective, as early results are showing, could change school health and safety protocols.

For the second year in a row, Grazer bested the massive male named Chunk to take the crown in the single elimination online popularity contest at Katmai National Park and Preserve

The overall crypto market grew by 1.42 percent in the last 24 hours. Bitcoin was joined by Dogecoin, Cardano, Ripple, and Tron on the profit-making side of the crypto charts on Monday, November 11.

Atlas Biomed's website is no longer active and the phone number listed is dead as well.

A few months ago, the rumour took root that GTA 6's release date would slip back from 2025 to 2026. An anonymous insider averred that studio heads were "worried" about the new open world game's progress - hence, perhaps, Rockstar's decision to mandate a full return to in-office work. Pshaw, say publishers Take-Two CEO. They announced a fall 2025 launch in March and have just doubled down on it in their latest financial briefing, with CEO Strauss Zelnick subsequently going on the tellybox to say that Take-Two are "highly confident in the timing", though he still has nothing to share about GTA 6 on PC.

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Customers of Atlas Biomed are angry and worried about what's happened to the highly sensitive data they shared.

South Korea's Agriculture Ministry announced the confirmation of the first highly pathogenic medlinkavian influenza/medlink case (!--ref1--) in

For most of us, life is completely hectic with the families, jobs and homes, taking most of our time and leaving us with no time to relax. That leaves the little time to enjoy the outdoors or look for peaceful natural surroundings for...

Harlow, England : Pearson, 2016.