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Shared Health making preparations for patient notifications ahead of possible Canada Post work stoppage

Appointment letters and pre-appointment information for patients sent via mail are being temporarily paused, and patients will be contacted by phone or email prior to their appointments, Shared Health says as it prepares for a possible Canada Post strike.



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NextStar 'full speed ahead' with Windsor EV battery production amid Trump tariff uncertainty

Windsor, Ont.,'s massive electric vehicle battery plant expects to start producing cells by July — amid uncertainty surrounding possible automotive-related tariffs imposed by the U.S., as threatened by Donald Trump during his election campaign.



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Delhi Police Issues Traffic Advisory Ahead Of Pragati Maidan Trade Fair

Delhi Police on Wednesday issued a traffic advisory ahead of the two-week-long India International Trade Fair (IITF) being held in the national capital.




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Sri Lanka Heads For Snap Elections Today, Results Likely On Friday

Sri Lanka votes today in a second national election in as many months with a deeply divided opposition struggling to recover from a crushing defeat at presidential polls.




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Vivek Ramaswamy's High School Graduation Speech Goes Viral Ahead Of 'DOGE' Appointment With Elon Musk

The viral video features young Vivek Ramaswamy, then an 18-year-old student at St Xavier High School, reflecting on his journey through high school.




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Vivek Ramaswamy's Old Speech Goes Viral Ahead Of 'DOGE' Appointment

The viral video features young Vivek Ramaswamy, then an 18-year-old student at St Xavier High School, reflecting on his journey through high school.




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Sri Lanka Heads For Snap Elections Today, Results Likely On Friday

Sri Lanka votes today in a second national election in as many months with a deeply divided opposition struggling to recover from a crushing defeat at presidential polls.




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Delhi Police Issues Traffic Advisory Ahead Of Pragati Maidan Trade Fair

Delhi Police on Wednesday issued a traffic advisory ahead of the two-week-long India International Trade Fair (IITF) being held in the national capital.




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2025 Hyundai Ioniq 9 teased ahead of November 21 debut

Hyundai on Wednesday confirmed that the Ioniq 9 electric three-row SUV will debut on November 21 at the 2024 Los Angeles auto show. Hyundai used the same event in 2021 to preview the Ioniq 9 with the Seven concept. Hyundai in July said the Ioniq 9 will reach the U.S. as a 2025 model, though a firm date for the start of sales hasn't been announced...



  • Los Angeles Auto Show

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In Brussels, Blinken pledges support for Ukraine ahead of Trump transition

Brussels, Belgium    — U.S. Secretary of State Antony Blinken assured Ukraine and its NATO allies on Wednesday that Washington remains committed to putting Ukraine “in the strongest possible position” in the final months of President Joe Biden’s administration, before President-elect Donald Trump takes office in January. At the same time, Blinken expressed alarm about Russia possibly bolstering North Korea’s missile and nuclear capacities, as North Korean troops fight alongside Russian forces in Ukraine.   “President Biden has committed to making sure that every dollar we have at our disposal will be pushed out the door between now and January 20th,” Blinken told reporters at NATO headquarters in Brussels on Wednesday. “We’re making sure that Ukraine has the air defenses it needs, that has the artillery it needs, that it has the armored vehicles it needs,” he added. Blinken told VOA he expects U.S. allies' support for Ukraine to increase and emphasized that it’s critical for Washington’s partners to “continue to more than pick up their share of the burden.”    Speaking alongside NATO Secretary-General Mark Rutte, Blinken reiterated that Washington will “continue to shore up everything” to enable Ukraine to defend itself effectively against Russian aggression. Rutte and other European leaders voiced serious concerns over North Korea’s active support for Russia in its war on Ukraine. “These North Korean soldiers present an extra threat to Ukraine and will increase the potential for Putin to do harm,” Rutte told reporters. The U.S. State Department says that more than 10,000 North Korean troops have been deployed to eastern Russia, and most of them have moved to the far western Kursk oblast, part of which Ukraine controls. On Wednesday, Blinken described the military collaboration between Pyongyang and Moscow as “a two-way street.” “There is deep concern about what Russia is or may be doing to strengthen North Korea’s capacities — its missile capacity, its nuclear capacity,” as well as the battlefield experience North Korean forces are gaining, he told reporters. In Brussels, Blinken held talks with Ukrainian Foreign Minister Andrii Sybiha, European Union High Representative Josep Borrell and British Foreign Secretary, David Lammy, among others. The possibility of Ukraine using Western-supplied long-range missiles on Russian soil was among the topics discussed during Sybiha’s meeting with Blinken. “We need to speed up all critical decisions,” the Ukrainian foreign minister said before the meeting. “Ukraine has always cherished strong bipartisan support.  We maintain contact with both [Democratic and Republican] parties and work both with the [U.S.] president-elect and his team and also with the outgoing administration,” he added. In Washington, officials say Biden was expected to ask Trump during their talks at the White House on Wednesday not to walk away from Ukraine. Trump’s political allies have indicated that the incoming administration will prioritize achieving peace in Ukraine over enabling the country to reclaim Crimea and other territories occupied by Russia. Blinken has concluded talks with European counterparts in Brussels. He will next travel to Lima, Peru, for the Asia-Pacific Economic Cooperation, or APEC meetings, followed by stops in Manaus and Rio de Janeiro, Brazil, for a summit of the 20 largest economies, the G20. He will join Biden in Peru and Brazil. 




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HONOR Spearheads Dialogue on the Future of the Smartphone Industry, Echoes Transparent and Ethical Use of AI




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Support for Mia Le Roux ahead of the coronation night for Miss Universe 2024




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UN nuclear chief heads to Iran for crucial talks

Tehran, Iran — International Atomic Energy Agency chief Rafael Grossi is set to visit Tehran on Wednesday for crucial talks on Iran's nuclear program, warning just ahead of his trip that room for maneuver is narrowing. His visit comes only two days after the defense minister of Iran's nemesis Israel warned the Islamic republic was "more exposed than ever to strikes on its nuclear facilities". Israel has long accused Iran of seeking to acquire nuclear weapons, a claim Tehran denies. The two countries have traded missile strikes this year, as tensions soar over Israel's war with Iran's allies, Hamas in Gaza and Hezbollah in Lebanon. The strikes have brought to the surface their years-long shadow war and fueled fears of a wider Middle East conflict. "The margins for maneuver are beginning to shrink," Grossi said in an interview with AFP ahead of his visit, adding that "it is imperative to find ways to reach diplomatic solutions". While the IAEA is allowed to carry out inspections in Iran, Grossi stressed the need for "more visibility" into Iran's nuclear program, given its scale and ambition. "They have a lot of nuclear materials that could be used eventually to make a nuclear weapon, the IAEA chief told CNN on Tuesday, adding: "They do not have a nuclear weapon at this point."  Trump's warning Grossi's trip comes after Donald Trump -- who pulled out of a hard-won nuclear deal with Iran negotiated under Barack Obama -- was voted back into the White House. Trump said last week that he was not seeking to harm Iran and instead wanted its people to have "a very successful country", while insisting "they can't have a nuclear weapon". In 2015, major world powers including the United States reached an agreement with Iran on its nuclear program after 21 months of talks. The text provided for an easing of international sanctions on Iran in exchange for guarantees that it would not seek nuclear weapons. But Trump withdrew from the agreement in 2018 before re-imposing US sanctions on Iran. A year later, Iran started to gradually roll back its commitments to the nuclear deal, which only allowed Tehran to enrich uranium to 3.65 percent purity. The IAEA says Iran has considerably increased its reserves of enriched uranium to 60 percent, close to the 90 percent needed to develop an atomic bomb. It is against this backdrop that Grossi is schedule to visit Iran for the first time since May. In a statement, the IAEA said it would hold "high-level meetings with the Iranian government" and conduct "technical discussions on all aspects". Cameras unplugged Iranian President Masoud Pezeshkian, who came to office in July with hopes of improving ties with the West and having sanctions lifted, favors a revival of the nuclear deal. But all efforts to get the nuclear agreement off life support have so far failed. The IAEA chief has repeatedly called for more cooperation from Iran. In recent years, Tehran has decreased its interaction with the UN agency by deactivating surveillance devices needed to monitor the nuclear program and effectively barring its inspectors. The foundations of Iran's nuclear program date back to the late 1950s, when the United States signed a civil cooperation agreement with Iran's then Shah Mohammad Reza Pahlavi. In 1970, Iran ratified the Non-Proliferation Treaty, which requires signatory states to declare and place their nuclear materials under the IAEA control. But with Iran threatening to hit back at Israel for its latest missile strikes, some lawmakers in the Islamic republic have called on the government to revise its nuclear doctrine to pursue nuclear weapons. The parliamentarians called on supreme leader Ayatollah Ali Khamenei, who wields ultimate authority in Iran, to reconsider his long-standing religious edict or fatwa banning nuclear weapons. The Islamic republic has maintained its policy against acquiring nuclear weapons, insisting its nuclear activities were entirely peaceful.          




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A Pivotal Election - Somaliland's Fate Hangs in the Balance As Voters Head to the Polls

[Addis Standard] Addis Abeba -- As Somaliland reached a pivotal moment in its democratic journey, citizens are casting their votes today in an election anticipated not only for its outcome but for what it symbolizes. For a self-declared republic, albeit unrecognized internationally, Somaliland has managed to forge a unique and commendable path, consistently holding peaceful elections in a region often defined by turmoil. In today's election, Somalilanders showed their readiness to signal their desire for change, with Wadani, the




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‘England first’: Kane hits out at player withdrawals ahead of Nations League games

England skipper Harry Kane has hit out at several players who withdrew from the national team ahead of their Nations League crucial matches against Greece and Ireland, saying that country must always come before club football. England play Greece away on Thursday followed by Ireland three days later at Wembley but nine players, some of […]




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Sudan: WFP Urges Sudan to 'Keep Crossings Open' As Aid Convoy Heads to Famine-Stricken Darfur

[Dabanga] Adré / El Fasher -- The World Food Programme (WFP) has appealed to Sudan to keep the Adré border crossing open, as a convoy carrying crucial humanitarian aid heads toward the Zamzam camp for displaced people in North Darfur, where famine was confirmed earlier this year.




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Wildest Assassin's Creed kills from Pope to man stabbed in head with hidden blade



Assassin's Creed turns 17 years old today, so we're taking a blood-spattered walk down memory as we check out some of its most infamous fictional kills of real people




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Trump turns heads by nominating Gaetz for attorney general, Gabbard for top intelligence post

President-elect Donald Trump startled much of Washington Wednesday by selecting Rep. Matt Gaetz for attorney general, putting the Florida firebrand and MAGA loyalist in line to be the nation's chief law enforcement officer, a nomination that some Republicans doubt will survive.




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Pistons' Tim Hardaway Jr leaves game in wheelchair after slamming head on court in scary scene

Detroit Pistons veteran guard Tim Hardaway Jr. was wheelchaired out of the game against the Miami Heat after multiple hits to the head, including slamming it on the court.



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Angels GM puts $245M star on notice ahead of 2025 season

Los Angeles Angels general manager Perry Minasian put Anthony Rendon on notice, saying the third baseman needs to "earn the right to play every day."



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BYU cheerleading coach 'lost consciousness' after being struck in head with water bottle, Utah fan arrested

Police in Utah have arrested an 18-year-old fan on an assault charge after BYU cheerleading coach Jocelyn Allan was struck in the head with a water bottle after Saturday's win over Utah.



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Hrithik Roshan lends voice to ‘Karan Arjun’ trailer ahead of re-release

The trailer will be shown in theaters starting November 14, attached to upcoming releases such as ‘Kanguva’ and ‘The Sabarmati Report’, giving audiences a preview ahead of the re-release.




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Airbnb is inviting select guests to Rome’s Colosseum ahead of ‘Gladiator 2’ release

The experience provides a three-hour adventure where guests can explore the Colosseum after hours, beginning with a ceremonial welcome before delving into the ancient structure’s underground chambers




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Suspected bomber dead after trying to enter Brazil's top court ahead of G20

BRASILIA — A man killed himself with a bomb outside Brazil’s Supreme Court after trying to enter the building on Wednesday (Nov 13), officials said, stirring security concerns before the country hosts global leaders from the Group of 20 major economies. The blasts come five days before the G20 heads of state meet in Rio de Janeiro, followed by a state visit to the capital Brasilia by Chinese President Xi Jinping. The first of two explosions went off on Wednesday evening in a parking lot near the court building and a second blast came seconds later in front of the court, where the man’s body was found. Federal District Vice Governor Celina Leao said preliminary information suggested the man had killed himself with explosives after trying to enter the Supreme Court. She said he owned a nearby car in which another explosion blew open the trunk. Leao said she hoped it was the crime of a “lone wolf,” but she could not be sure. Police said they had not made a final identification of the dead man as they were confronting the risk of additional explosives on the body.




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Mexican city's security chief held over mayor's beheading

The mayor of Chilpancingo, Alejandro Arcos, was murdered just days after taking office last month.




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Providing better healthcare biggest priority: PM Modi ahead of Darbhanga AIIMS inauguration

Prime Minister Narendra Modi on Wednesday reaffirmed the Centre's commitment to providing better healthcare and improving the living conditions of the countrymen.




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Trump appoints "The Great Elon Musk", Ramaswamy to head Dept of Government Efficiency

US President-elect Donald Trump appointedElon Musk and Vivek Ramaswamy to lead the new Department of Government Efficiency (DoGE).




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John Ratcliffe is Trump's pick to head CIA

US President-elect Donald Trump has named John Ratcliffe, a former congressman and Director of National Intelligence, as his Director of the Central Intelligence Agency, contrary to feverish speculation that the job was going to Kash Patel, an Indian-American.




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Trump names South Dakota governor to head Homeland Security with immigration mandate

US President-elect Donald Trump has nominated South Dakota Governor Kristi Noem as his secretary of the Department of Homeland Security, which controls immigration-related agencies.





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Providing better healthcare biggest priority: PM Modi ahead of Darbhanga AIIMS inauguration




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Vistara's last flight from Odisha takes off for Delhi ahead of merger with Air India




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Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Nagamohan Das to head panel to suggest internal reservation among SC communities




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Meet man who used to earn just Rs 65, now heads Rs 23416 crore company, he is...

R. G. Chandramogan, chairman of Hatsun Agro Product, hails from Chennai and was a college dropout who began by selling ice cream from pushcarts.




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Transgender student bathroom bill clears Ohio legislature, heads to governor

The Ohio Senate on Wednesday approved a ban on transgender students using bathrooms that fit their gender identities and sent the measure to Republican Gov. Mike DeWine.






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Statement by Head of the OSCE Mission to Bosnia and Herzegovina on conviction of Radovan Karadzic

Ambassador Jonathan Moore, Head of the OSCE Mission to Bosnia and Herzegovina, issued the following statement after the conviction of Radovan Karadzic ...




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Austrian Post Q1-3: Double-digit revenue growth – despite the economic headwind

Austrian Post has published its Q1-3 results revealing revenue of the Group rose by 13.6%.




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Evri CEO on second hand shopping: we see a long runway of growth ahead

More than half of the UK adult population have bought a second-hand item online in the last year – and it’s not just the youngest clicking away, as older consumers are also driving the second-hand shopping mega-trend, according to Evri’s inaugural UK Ecommerce Pulse report.




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Cyclists Head To Guyana For Championships

Bermuda are sending a team of five cyclists to compete at the Caribbean Road Cycling Championships in Guyana this weekend. Conor White and Kaden Hopkins will compete in the Elite Men’s time-trial and road races. Tyler Smith, who represented Bermuda in triathlon at the Olympic Games in Paris in July, will compete in the Elite […]




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Bowling: Butt & Vallis, Pin Heads & Secret Win

Commercial bowling league action at the Warwick Lanes saw Butt & Vallis defeat Spare Parts 3 – 1, the league leaders Pin Heads defeat Too Legit To Split 3 – 1, while the Secret Weapons defeated Sweet Life 3 – 1, and the match between the Strike Force and the Bailey’s Bay Strikers ended 2 […]




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Bowling: Sweet, Who Gives & Pin Heads Win

The Commercial bowling league season continued at Warwick Lanes, which saw several victories and a hard-fought draw, shaking up the standings. Men’s High Scratch Game Jache Adams 218 Quinton Perinchief 187 Marcus Johnson 152 Women’s High Scratch Game Charnae Richardson 182 Corinne Durrant 168 Charmane Cann / Ashley Belgrave 167 Men’s High Handicap Game Jache […]




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iPhone SE 4 Camera Production to Begin Soon Ahead of Anticipated Debut in March 2025: Report - Gadgets 360

  1. iPhone SE 4 Camera Production to Begin Soon Ahead of Anticipated Debut in March 2025: Report  Gadgets 360
  2. iPhone SE 4 likely to be the cheapest iPhone offering Apple Intelligence  India Today
  3. iPhone SE 4 expected to launch in March 2025, supply chain data suggests  Business Standard
  4. iPhone SE 4: All the Rumours  Gadgets 360
  5. iPhone SE 4 may spell trouble for iPhone 16 and premium Android phones, here’s why  Hindustan Times





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The New Headlight Doesn't Quite Fit

What should you do when you hit a deer and it breaks your headlight? Take a headlight out of your John Deere, of course!




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Candyology 101 - Episode 37 - Lemonheads

How about something tangy? In this episode from last month, Maria and I talk about the never-duplicated LemonHeads and their companion candies.




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Head of F1 owner to leave role at key time for sport

President and chief executive officer of Formula 1 owner Liberty Media, Greg Maffei, is to step down from his role at the end of the year.




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The masked headliners freshening up Download festival

Mysterious metal group Sleep Token are one of three headliners announced for Download festival.