En este episodio, La Luciérnaga se enciende para hablar de las
encuestas que perfilan a Rodolfo Hernández como el gran contrincante de Fico
para llegar a la segunda vuelta. Además, un estudió revelo que cada año los
colombianos pasan en promedio 100 horas en trancones. También, Cocoliso y
Corozo le trovan al día del Borracho. 



La Luciérnaga un
espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace
30 años a sus oyentes en el regreso a casa.

En este episodio, La Luciérnaga se enciende para estallar la burbuja en la que vie el Presidente Duque, quien reconoció que no ve TV ni oye radio. También, analizamos que se está haciendo con la plata de las regalías. Además, le explicamos porqué hay líos para la venta de iPhone y iPad en Colombia y otros países del mundoLa Luciérnaga un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

En este episodio, La Luciérnaga se enciende para revisar los traspiés del equipo ministerial de Gustavo Petro. También, le contamos sobre los trancones en las principales vías del país. Además, celebramos el día del nutricionista.La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

En este episodio, La Luciérnaga se enciende para hablar de la primera alocución de Gustavo Petro como presidente. Además, le contamos la situación de las vías de la capital. También, ¿cómo sería el entierro de la Reina Isabel II si fuera colombiana? La
Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio
que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

La Luciérnaga se enciende para hablar de los trancones que se hacen en navidad. Además, le contamos sobre los cambios en el pico y placa de la capital. También, ¿Usted ya compro los regalos?La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este jueves 31 de agosto. 

 Escuche el programa de este viernes 8 de diciembre. La Luciérnaga, un espacio un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

En 6AM Hoy por Hoy, el ministro de Las TIC, Mauricio Lizcano, presenta “Colombia Potencia Digital”, una estrategia con una inversión billonaria para llevar internet a zonas remotas y potenciar el desarrollo digital en todo el país.

Colombia logra conectividad de fibra óptica con Brasil en el Amazonas

En 6AM de Caracol Radio estuvo Félix Riaño, para hablar sobre cómo se conmemora en Colombia el Día Internacional del Podcast.

“The submission was carefully evaluated by the National Parks Commission, whose primary role is to advise on the long-term conservation and management of our parks system,” stated Minister of Public Works Lt/Col David Burch. A Government spokesperson said, “The Minister has officially approved the “Pink Sand Scrambling” motocross event at Coney Island, St. George’s, on […]

Tyrone forward Kyle Coney looks certain to be ruled out for the rest of this season after sustaining a groin injury.

A few years ago, I bought two orange traffic cones at a hardware store for twenty bucks. It was one of the best, most stress-relieving purchases I made. Parking space is scarce in big cities. In our car-centered culture, the rare days you absolutely need a large truck in a precise place can be a […]

These lime scones are something special. Made with fragrant Rangpur lime zest and juice, they’re tender and rustic with golden craggy edges and a zest-flecked icing shell on top.

Continue reading Rangpur Lime Scones on 101 Cookbooks

President Trump officially announced that he has selected Judge Amy Coney Barrett as his nominee to fill the vacancy of late Justice Ruth Bader Ginsburg to the Supreme Court, setting up a bitter Senate confirmation battle with just five weeks left until Election Day. “I stand before you today to fulfill one of my highest […]

The post Trump Officially Nominates Amy Coney Barrett To Fill Supreme Court Vacancy appeared first on Hispolitica.

Neelarnab Raha
Proc. Amer. Math. Soc. 152 (), 5067-5081.
Abstract, references and article information

Mutations in the GUCY2D gene coding for the dimeric human retinal membrane guanylyl cyclase (RetGC) isozyme RetGC1 cause various forms of blindness, ranging from rod dysfunction to rod and cone degeneration. We tested how the mutations causing recessive congenital stationary night blindness (CSNB), recessive Leber's congenital amaurosis (LCA1), and dominant cone–rod dystrophy-6 (CORD6) affected RetGC1 activity and regulation by RetGC-activating proteins (GCAPs) and retinal degeneration-3 protein (RD3). CSNB mutations R666W, R761W, and L911F, as well as LCA1 mutations R768W and G982VfsX39, disabled RetGC1 activation by human GCAP1, -2, and -3. The R666W and R761W substitutions compromised binding of GCAP1 with RetGC1 in HEK293 cells. In contrast, G982VfsX39 and L911F RetGC1 retained the ability to bind GCAP1 in cyto but failed to effectively bind RD3. R768W RetGC1 did not bind either GCAP1 or RD3. The co-expression of GUCY2D allelic combinations linked to CSNB did not restore RetGC1 activity in vitro. The CORD6 mutation R838S in the RetGC1 dimerization domain strongly dominated the Ca2+ sensitivity of cyclase regulation by GCAP1 in RetGC1 heterodimer produced by co-expression of WT and the R838S subunits. It required higher Ca2+ concentrations to decelerate GCAP-activated RetGC1 heterodimer—6-fold higher than WT and 2-fold higher than the Ser838-harboring homodimer. The heterodimer was also more resistant than homodimers to inhibition by RD3. The observed biochemical changes can explain the dominant CORD6 blindness and recessive LCA1 blindness, both of which affect rods and cones, but they cannot explain the selective loss of rod function in recessive CSNB.

Amy Coney Barrett succeeds the late Justice Ruth Bader Ginsburg in time to hear arguments in two cases being watched in the education community.

Silicone cookware is everywhere these days - from spatulas to baking moulds, it's become a kitchen staple.

Berlin ; Boston : De Gruyter, [2023]

Even if you have been brewing your coffee in the same way for ages, the VacOne Coffee Air Brewer could be the change your morning routine needs. A unique pump generates a 7-psi vacuum inside the glass carafe—draws the muddy water through the grounds, across a metal mesh filter, and into the carafe, where it dribbles in as coffee free of sediment bitter oils. Senior Editor Michael Calore shows us why you should consider adding this innovative brewer to your coffee arsenal.

1. Zijn hitlijst was lang, zijn invloed op latere iconen zoals The Beatles en Prince immens: flamboyant rock-'n-rollpionier Little Richard (87) is niet meer  Het Nieuwsblad
2. Rock-n'-rollpionier Little 'Tutti Frutti' Richard (87) overleden  Het Laatste Nieuws
3. Rock 'n' roll-pionier Little Richard is overleden, herontdek zijn grootste hits  VRT NWS
4. Little Richard drukte zware stempel op de rock-'n-roll  De Tijd
5. Muzieklegendes over Little Richard: “Als ik zijn muziek beluisterde, kon ik God horen”  Het Laatste Nieuws
6. Hele verhaal bekijken via Google Nieuws

In the title bis­chalcone, C17H12Br2O, the olefinic double bonds are almost coplanar with their attached 4-bromo­phenyl rings [torsion angles = −10.2 (4) and −6.2 (4)°], while the carbonyl double bond is in an s-trans conformation with with respect to one of the C=C bonds and an s-cis conformation with respect to the other [C=C—C=O = 160.7 (3) and −15.2 (4)°, respectively]. The dihedral angle between the 4-bromo­phenyl rings is 51.56 (2)°. In the crystal, mol­ecules are linked into a zigzag chain propagating along [001] by weak C—H⋯π inter­actions. The conformations of related bis­chalcones are surveyed and a Hirshfeld surface analysis is used to investigate and qu­antify the inter­molecular contacts.

The synthesis, spectroscopic data and crystal and mol­ecular structures of four 3-(3-phenyl­prop-1-ene-3-one-1-yl)thio­phene derivatives, namely 1-(4-hydroxy­phen­yl)-3-(thio­phen-3-yl)prop-1-en-3-one, C13H10O2S, (1), 1-(4-meth­oxy­phen­yl)-3-(thio­phen-3-yl)prop-1-en-3-one, C14H12O2S, (2), 1-(4-eth­oxy­phen­yl)-3-(thio­phen-3-yl)prop-1-en-3-one, C15H14O2S, (3), and 1-(4-­bromophen­yl)-3-(thio­phen-3-yl)prop-1-en-3-one, C13H9BrOS, (4), are described. The four chalcones have been synthesized by reaction of thio­phene-3-carbaldehyde with an aceto­phenone derivative in an absolute ethanol solution containing potassium hydroxide, and differ in the substituent at the para position of the phenyl ring: –OH for 1, –OCH3 for 2, –OCH2CH3 for 3 and –Br for 4. The thio­phene ring in 4 was found to be disordered over two orientations with occupancies 0.702 (4) and 0.298 (4). The configuration about the C=C bond is E. The thio­phene and phenyl rings are inclined by 4.73 (12) for 1, 12.36 (11) for 2, 17.44 (11) for 3 and 46.1 (6) and 48.6 (6)° for 4, indicating that the –OH derivative is almost planar and the –Br derivative deviates the most from planarity. However, the substituent has no real influence on the bond distances in the α,β-unsaturated carbonyl moiety. The mol­ecular packing of 1 features chain formation in the a-axis direction by O—H⋯O contacts. In the case of 2 and 3, the packing is characterized by dimer formation through C—H⋯O inter­actions. In addition, C—H⋯π(thio­phene) inter­actions in 2 and C—H⋯S(thio­phene) inter­actions in 3 contribute to the three-dimensional architecture. The presence of C—H⋯π(thio­phene) contacts in the crystal of 4 results in chain formation in the c-axis direction. The Hirshfeld surface analysis shows that for all four derivatives, the highest contribution to surface contacts arises from contacts in which H atoms are involved.

Chalcones of type 4-XC6H4C(O)CH=CHC6H4(OCH2CCH)-4, where X = Cl, Br or MeO, have been converted to the corresponding 4,5-di­hydro­pyrazole-1-carbo­thio­amides using a cyclo­condensation reaction with thio­semicarbazide. The chalcones 1-(4-chloro­phen­yl)-3-[4-(prop-2-yn­yloxy)phen­yl]prop-2-en-1-one, C18H13ClO2, (I), and 1-(4-bromo­phen­yl)-3-[4-(prop-2-yn­yloxy)phen­yl]prop-2-en-1-one, C18H13BrO2, (II), are isomorphous, and their mol­ecules are linked into sheets by two independent C—H⋯π(arene) inter­actions, both involving the same aryl ring with one C—H donor approaching each face. In each of the products (RS)-3-(4-chloro­phen­yl)-5-[4-(prop-2-yn­yloxy)phen­yl]-4,5-di­hydro­pyrazole-1-carbo­thio­amide, C19H16ClN3OS, (IV), (RS)-3-(4-bromo­phen­yl)-5-[4-(prop-2-yn­yloxy)phen­yl]-4,5-di­hydro­pyrazole-1-carbo­thio­amide, C19H16BrN3OS, (V), and (RS)-3-(4-meth­oxy­phen­yl)-5-[4-(prop-2-yn­yloxy)phen­yl]-4,5-di­hydro­pyrazole-1-carbo­thio­amide, C20H19N3O2S, (VI), the reduced pyrazole ring adopts an envelope conformation with the C atom bearing the 4-prop-2-yn­yloxy)phenyl substituent, which occupies the axial site, displaced from the plane of the four ring atoms. Compounds (IV) and (V) are isomorphous and their mol­ecules are linked into chains of edge-fused rings by a combination of N—H⋯S and C—H⋯S hydrogen bonds. The mol­ecules of (VI) are linked into sheets by a combination of N—H⋯S, N—H⋯N and C—H⋯π(arene) hydrogen bonds. Comparisons are made with the structures of some related compounds.

A new conjugated carbazole chalcone compound, (E)-3-[4-(9,9a-di­hydro-8aH-carbazol-9-yl)phen­yl]-1-(4-nitro­phen­yl)prop-2-en-1-one (CPNC), C27H18N2O3, was synthesized using a Claisen–Schmidt condensation reaction. CPNC crystallizes in the monoclinic non-centrosymmetric space group Cc and adopts an s-cis conformation with respect to the ethyl­enic double bonds (C=O and C=C). The crystal packing features C—H⋯O and C—H⋯π inter­actions whose percentage contribution was qu­anti­fied by Hirshfeld surface analysis. Quantum chemistry calculations including geometrical optimization and mol­ecular electrostatic potential (MEP) were analysed by density functional theory (DFT) with a B3LYP/6–311 G++(d,p) basis set.

The title crystal structure is assembled from the superposition of two mol­ecular structures, (E)-1-(5-chloro­thio­phen-2-yl)-3-(3-methyl­thio­phen-2-yl)prop-2-en-1-one, C12H9ClOS2 (93%), and (Z)-1-(5-chloro­thio­phen-2-yl)-3-(3-methyl­thio­phen-2-yl)prop-1-en-1-ol, C12H11ClOS2 (7%), 0.93C12H9ClOS2·0.07C12H11ClOS2. Both were obtained from the reaction of 3-methyl­thio­phene-2-carbaldehyde and 1-(5-chloro­thio­phen-2-yl)ethanone. In the extended structure of the major chalcone component, mol­ecules are linked by a combination of C—H⋯O/S, Cl⋯Cl, Cl⋯π and π–π inter­actions, leading to a compact three-dimensional supra­molecular assembly.

In the past three years, Dirac half-metals (DHMs) have attracted considerable attention and become a high-profile topic in spintronics becuase of their excellent physical properties such as 100% spin polarization and massless Dirac fermions. Two-dimensional DHMs proposed recently have not yet been experimentally synthesized and thus remain theoretical. As a result, their characteristics cannot be experimentally confirmed. In addition, many theoretically predicted Dirac materials have only a single cone, resulting in a nonlinear electromagnetic response with insufficient intensity and inadequate transport carrier efficiency near the Fermi level. Therefore, after several attempts, we have focused on a novel class of DHMs with multiple Dirac crossings to address the above limitations. In particular, we direct our attention to three-dimensional bulk materials. In this study, the discovery via first principles of an experimentally synthesized DHM LaNiO3 with many Dirac cones and complete spin polarization near the Fermi level is reported. It is also shown that the crystal structures of these materials are strongly correlated with their physical properties. The results indicate that many rhombohedral materials with the general formula LnNiO3 (Ln = La, Ce, Nd, Pm, Gd, Tb, Dy, Ho, Er, Lu) in the space group R3c are potential DHMs with multiple Dirac cones.

Smithsonian scientists and colleagues, however, have recently found evidence that gymnosperm plants shared an intricate pollination relationship with scorpionfly insects 62 million years before flowering plants appear in fossil records.

The post Prehistoric pollination: Scorpionfly mouthparts fit tubular channels of gymnosperm cones appeared first on Smithsonian Insider.

Decorate your table with this inexpensive, natural arrangement that also happens to be compostable.

Today is Ben & Jerry’s annual free cone day, and you have permission to indulge in this socially responsible treat.

Find out where can you get a free cone of sustainable Chunky Monkey, Phish food or your flavor of choice on April 8.

SL6500 Silicone Lubricant for Slitting Media