blood

Majority of high blood-lead levels are work-related: report

By www.safetyandhealthmagazine.com
Published On :: Tue, 03 Dec 2013 00:00:00 -0500

Atlanta – Lead exposure remains an issue for workers, with elevated levels most common in manufacturing, construction, services and mining, according to a new report from the Centers for Disease Control and Prevention.

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Michigan lowers acceptable blood lead levels for workers

By www.safetyandhealthmagazine.com
Published On :: Wed, 16 Jan 2019 00:00:00 -0500

Lansing, MI — Michigan has become the first state to lower permissible blood lead levels – by as much as half – to protect workers, the Michigan Occupational Safety and Health Administration recently announced.

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Bloodborne and airborne pathogen exposure: Massachusetts DPH offers sample written control plans

By www.safetyandhealthmagazine.com
Published On :: Fri, 01 Nov 2024 00:00:00 -0400

Boston — Intended to give small health care employers an “easy-to-use format” for a written exposure control plan, the Massachusetts Department of Public Health has published sample written plans for a respiratory protection program and bloodborne pathogen exposure control.

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Tate & Lyle: Blood Glucose Control

By www.preparedfoods.com
Published On :: Thu, 14 Nov 2019 00:00:00 -0500

Diabetes affects more than 425 million people globally (Source: International Diabetes Federation) and today’s World Diabetes Day provides food and beverage businesses with an opportunity to consider what more they can do to support global efforts to tackle Type II diabetes.

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Sugarbreak: An All Natural Solution for Sugar Reduction and Healthy Blood Sugar Management

By www.preparedfoods.com
Published On :: Fri, 11 Sep 2020 08:00:00 -0400

Sugarbreak is empowering consumers to proactively achieve better health through a comprehensive, medical community-endorsed system that uses all natural, scientifically-proven ingredients to help manage blood sugar as part of a healthy diet and lifestyle.

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A1C Drinks to Control Blood Sugar

By www.preparedfoods.com
Published On :: Wed, 03 Jan 2024 05:00:00 -0500

Introducing A1C Drinks, a new brand of healthy beverages designed to help people manage blood sugar, weight, diabetes and pre-diabetes.

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V8, Grillo's Pickles Dill Pickle Bloody Mary Mix

By www.preparedfoods.com
Published On :: Mon, 11 Nov 2024 08:00:00 -0500

This bold new mix blends the iconic richness of V8 tomato juice, natural cucumber flavor and a medley of spices with the unmistakable tang of Grillo's signature brine, bringing a vibrant burst of flavor.

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V8, Grillo’s Pickles Partner on Bloody Mary Mix

By www.foodengineeringmag.com
Published On :: Fri, 25 Oct 2024 09:35:00 -0400

This mix blends the richness of V8 tomato juice, natural cucumber flavor and a medley of spices with the tang of Grillo's signature brine.

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Screaming With Meaning: The Definitive Blood Brothers Lyrics Q & A

By www.portlandmercury.com
Published On :: Fri, 08 Nov 2024 11:00:00 -0800

Ahead of the hardcore band's sold out show at Revolution Hall, Johnny Whitney and Jordan Blilie tell us what the group's intense, abstract song lyrics really mean. by Suzette Smith

Like any fan of Seattle hardcore band the Blood Brothers, I have found myself at a show, pressed up against a wall of people, shouting the wrong lyrics to their songs. For instance, on their hit "USA NAILS" there's a hook where you think you're singing a cheer-style "one, one, and two!" but the lyrics are actually: "These pigs locked me up to see what color I'd rot into!"

The energetic screamo group was active from 1997-2007, during which time they released five critically-acclaimed albums, completed several European tours, and even played a set on Jimmy Kimmel Live, overcoming the reservations of the show's freaked-out producers. Perhaps the best indicator of their success is the fact that their US reunion tour—which hits Portland on November 12—is completely sold out.

Ever ones to cut the bullshit, Blood Brothers don't have a new record; they're playing the fucking hits. Still, the tour is timed with Epitaph's anniversary reissue of one of their biggest albums Crimes (2004) on vinyl.

When we sat down to talk to Johnny Whitney, who fronts the band with fellow singer/screamer/guttural whisperer Jordan Blilie, he noted that plenty of lyrics websites list incorrect verses for Blood Brothers songs. "It's hilarious how wrong some of them are," Whitney said. "The lyrics on Spotify are not even close to what I'm actually saying. Just buy the fucking CD, and look it up. Come on, people."

We spoke with Whitney and Blilie separately, over sprawling phone calls that we have organized into this piece. For clarity, we're listing their responses together, as we seek to get into the nitty gritty of this group's danceable, screaming-nightmare material.

Blood Brothers in San Francisco, on the first night of their reunion tour. They were incredible. Photo by Suzette Smith Jordan Blilie (left) and Morgan Henderson (right) Suzette Smith

Foremost, Whitney and Blilie both began by gushing about the other three members of their band: frenetic drummer Mark Gajadhar, vigorous guitarist Cody Votolato, and ultra-versatile bassist Morgan Henderson, who is currently best known as a member of Fleet Foxes.

"I cannot fucking believe that I got to work with these guys," Whitney says. "I just took all those things for granted at the time. Everybody was, and still is, coming from totally different places [musically], but there was always something really special about all of us together that was there from the moment that we started."

PORTLAND MERCURY: Johnny, I've always gotten the impression that you're the major force behind the lyrics.

JOHNNY WHITNEY: I came up with the majority of the lyrics, but it certainly was collaborative between Jordan and I. I would freewrite as much as I could, to have material to draw from, and going back to those notebooks kept things as free and fresh and not contrived as possible. The drawback of that approach is the lyrics are very abstract and hard to parse direct meaning from, but that's also kind of the point. I found myself writing about the absence of answers, or the absence of concrete truths that you can hold onto.

A lot of times, my process would center around coming up with a cool idea: a song name or some common refrain that we would want to work into a song, like "Burn Piano Island, Burn." Something that has a hook or conveys an image or feeling. Then we would reverse engineer the lyrics from that.

JORDAN BLILIE: I would absolutely say that I felt like Johnny was the driver, and for good reason. He's really good. When you see someone who is in a flow state, you do your best to accentuate and collaborate, to help mold and shape and add your pieces. It was always stuff that I was really excited to dig into. It was just that rich and that vibrant. The challenge for me was what can I add to it, you know? It always pushed me to try and come up with the most creatively-inspired stuff that I could.

You two have such an engaging stage style. People would call it sassy, but that has always felt like a description from people who have never been to a play and can't recognize theater. Do either of you have a background in theater arts?

WHITNEY: I wanted to be a child actor—I actually auditioned for that movie Blank Check (1994). Actually, a year after Jordan and I met, we were both in a Jr. High production of Alice in Wonderland. He was the Mad Hatter, and I was the Mock Turtle.

BLILIE: Why would you say that? [Laughs]

Jordan Blilie (left) and Johnny Whitney (right) Suzette Smith Jordan Blilie screams on the tour's first night in San Francisco. Suzette Smith

"USA NAILS" was such a hit, and it involved a phone number everyone could scream. How did that come to be?

WHITNEY: The name and the "1-900-USA-NAILS" comes from the chain nail salon, but we reverse-engineered it into a song about somebody using their one phone call from the county jail to call a phone sex line. It's the idea of loneliness, disaffection, and parasocial relationships with things that exist solely for their own profit or gain.

And yet it's also danceable. There are these moments live where you have an audience of people shaking their asses and shouting "to see what color I'd rot into!" Did you start with that idea and work backwards, or just jam it into that moment of the song?

WHITNEY: At that time, the band would all sit together in a room and have a kind of song tribunal about how each part should go. Then, at some point, we'd have a semi -finished version and [Jordan and I] would just try to fit lyrics to the songs. Especially on Burn, Piano Island, Burn. Some of those songs needed an editor so bad, right? I wouldn't change a thing about it, but looking back, there are parts where it sounds like everybody's playing a different song at the same time, but it kind of works, right? And for the lyrics, sometimes we just had to make it work.

That wasn't the first time Jordan whispered his lyrics in a guttural tone, but it's one of the more emblematic, right? How did that start?

BLILIE: By necessity—I don't have much of a range, you know? I have this weird baritone. Very early on we were drawing from crust punk, where you just have two voices screaming. And we didn't put a whole lot of thought into even what the other person was doing. But then, as we continued to develop, the stuff became more complex, and there was more room for different sorts of shadings of what we could do vocally. So it was just finding out: What is it I can do other than scream at the top of my lungs?

WHITNEY: Jordan's part at the end just works right? He was very inspired by Jarvis Cocker.

BLILIE: Yeah, you can trace that right back to Pulp. If you listen to any Pulp song, there's gonna be some whispery storytelling, with the compression cranked up so you can kind of hear every lick of the lips.

<a href="https://thebloodbrothersofficial.bandcamp.com/album/burn-piano-island-burn">Burn, Piano Island, Burn by The Blood Brothers</a>

BLILIE: Some of my favorite moments of writing with Johnny are the ones that we would where we would crack each other up.

Can you give an example?

BLILIE: Every lyric of "Guitarmy." We really got a kick out of the idea of opening our major label debut with the words, "do you remember us?" Because of the audacity, the absurdity of it.

So you guys all started this band when you were in your teens.

BLILIE: Yeah, we started when we were like, 15-16.

Are there any lyrics that have not aged well, in your opinion?

BLILIE: I'm sure they're the ones that we're not playing. [Laughs.] This question reminds me of something one of my professors said. It was my first class at UCLA, Queer Lit from Walt Whitman to Stonewall. In class discussions my fellow classmates would critique writing from the 1800s for not satisfying certain criteria, and our professor would say: You cannot look at the text backwards. You have to look at it forwards. You can't apply current day criteria to something that was written when that criteria didn't even exist. You have to engage with it in the context of when it was written. I don't think anything we wrote is in a canon warranting that level of examination, but it's useful nonetheless. It's a way for me to remind myself that I was 20, and I had the tools of a 20-year-old. It helps me to not beat myself up too much about it.

WHITNEY: There's a story behind this. When we were doing the song "Camouflage, Camouflage" on Young Machetes, Jordan and I were going back and forth on the lyrics. He was like, "Yeah, I'm great with all this." But he put a line through one verse, where I say: "All the girls in Montreal are smashing skateboards in the street." And I was just like: Fuck you, dude. I'm gonna keep this in. But he was right, because it sounds stupid, and it's like, really horny and makes me want to light my skin on fire. So I'm changing it to something else, probably something different every night.

Johnny Whitney (left) holds a crowd member's hand for support. Suzette Smith The crowd supports Johnny Whitney while he sings. Suzette Smith

I wonder about imagery in Blood Brothers' songs that seems to be responding to beauty standards at the time. Like, in "Ambulance, Ambulance" you've got this blistering segue to the chorus: "What is love? / What is scam? / What is sun? / What is tan?"

WHITNEY: That's a double meaning. Because it's like tan—like suntan—but also tan is a blah color, right? It's like the color of a dentist's office wall. If you think of the idea of love being something that could feel on-fire, passionate, the color of a dentist's office wall is the opposite. Although, tanning does come into play in a lot of our lyrics. I've noticed as well.

Or on "Beautiful Horses" the lyrics are "gallop into your romance novels / dance atop heavy pectorals."

BLILIE: I think we were seeing an increasingly vapid culture, and we were trying to dig into that—dig into: What does it do to someone when they're bombarded by these sorts of images and messages? There was a lot of that in that writing; I can't say specifically with "Beautiful Horses," but I think "Trash Flavored Trash," would probably fit under that umbrella.

<a href="https://thebloodbrothersofficial.bandcamp.com/album/crimes-bonus-track-version">Crimes (Bonus Track Version) by The Blood Brothers</a>

In "Rats and Rats and Rats for Candy" there's an ongoing narrative of rats living inside a woman. It's like a play. There are characters. And the rats eventually chew out of her and try to find a new body to live in. I wondered if that was also about beauty standards or body dysmorphia?

WHITNEY: That song, it's about that, but it's also about manipulation, right? Not to get too personal, but I grew up with somebody who weaponized being sick—faked being sick—for their entire life in order to manipulate people and extract something they needed out of them. The character in that song is kind of a victim, but like a siren at the same time. They're trying to lure somebody in.

Is that person the rats, or are they Candy?

WHITNEY: The rats are in Candy. I mean, it's both.

What about "The Shame?" Your group resonates so much with "everything is gonna be just awful / when we're around" that you're putting it on t-shirts 20 years later. What does it mean?

WHITNEY: The whole premise of that song is having to sell yourself—how to commoditize yourself. It's about how you function in a capitalist society. You sink or swim by your ability to market yourself, make yourself desirable—whether it be in relationships, job market, blah blah blah. I've always been repulsed by that and was especially at the time we wrote it, which was in Venice Beach, while we were recording Burn, Piano Island, Burn. It was the longest time I'd ever been in LA, and that's the epicenter of being a self-salesman. That line encapsulates the feeling of being sold something. And you're in a position where, in order to survive, you have to be your own salesman.

Salesmen show up in other songs, like "The Salesman, Denver Max." That's another one that almost feels like a short story.

WHITNEY: I initially cribbed the idea for that song's lyrics from the Joyce Carol Oates short story, "Where Are You Going? Where Have You Been?" It follows a narrative of a very dangerous, predatory man in the process of stalking and kidnapping somebody. “Denver Max” was a huge, uncomfortable gamble for me, because I wrote the entire song on my acoustic guitar, recorded it to a 4-track, and then played it for the guys—totally expecting them to hate it. It was really daunting to try to contribute as a songwriter; Cody, Morgan, and Mark are such talented musicians. I think they may have hated it; I don't really remember how we ended up recording it. It was nobody's favorite thing, but we just tracked it, and it sounded great and worked.

Have you read anything by playwright Caryl Churchill?

WHITNEY: Never heard of her.

"Live at the Apocalypse Cabaret" has a lyric in it that reminds me of her play Far Away, which has a scene of milliners making hats for people to wear at a public execution, so I always felt a symmetry there, because of the lyrics "the cross-eyed map of the afterlife is knitting tiny neck ties."

WHITNEY: I'm going to be super honest, the songs that I'm the most familiar with the lyrics of, at this very moment, are songs that were going to be playing, because I've been rehearsing them. But I do remember, with that song, we were trying to be funny without being silly. Like, a cross-eyed map is a map that makes no sense, where you don't know where you're going. Knitting tiny neckties are noose ties. It's like dressing yourself up for death, right? It's trying to dress up something that's really heinous and horrible and incomprehensible, and also trying to navigate that, through a map that makes no sense.

At this moment you have cracked my understanding of a play you haven't even read. But I digress, I've read that "Celebrator" was a direct response to Toby Keith's "Courtesy of the Red, White and Blue."

BLILIE: That pumped up patriotism felt gross when taken in context with the images and much of the information that we were seeing come out of Iraq and Afghanistan.

Is that why there are so many mentions of amputated limbs on Crimes?

BLILIE: The bulk of Crimes was trying to engage with war so that's where you get a lot of that grizzly imagery.

Well, personally, it's so nice that you're touring right now. Blood Brothers are great for when you need to scream, but you can't. You can scream along to the Blood Brothers in your head, or out loud at a show.

BLILIE: I'm glad that we could be of service, in that regard. It's hard for me not to go into a really bleak mindset when I look at our current political landscape. I find myself equal parts enraged and terrified. And there are times when I have to just close all news down. I guess it is a good time to get up and scream.

The Blood Brothers play Revolution Hall, 1300 SE Stark, Tues Nov 12, 8 pm, SOLD OUT, all ages.

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Covid-19 can attack brain and target people with blood type A

By english.pravda.ru
Published On :: Tue, 28 Apr 2020 19:53:00 +0300

The new coronavirus SARS-CoV-2, which causes atypical pneumonia COVID-19, can also penetrate into the brain, disrupt the work of the nervous system and cause other severe complications. The disease may not be limited to respiratory infections only. As practical studies show, in a significant number of patients, the virus affects the nervous system. The mechanism of its impact on nerve cells has not been studied yet, but scientists believe that there is some connection: a temporary loss of taste or smell was recognized as specific symptoms of COVID-19 in the middle of March. To make matters worse, the virus may penetrate directly into the brain from the nasopharynx. In this case, the virus may trigger a series of complications, disrupting the normal functioning of almost any organ. The list of possible concomitant diseases is extensive:

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For blood quality and men's health: which vegetables need to be boiled

By english.pravda.ru
Published On :: Wed, 19 Apr 2023 21:17:00 +0300

Margarita Koroleva, a professor at the Federal Medical and Biological Agency of Russia, a doctor of medical sciences and a dietician, shared her recommendations regarding the way of cooking vegetables to get the best of them. Some vegetables should be boiled to extract as many nutrients as possible. For example, boiled carrots are better absorbed by the body than raw ones, which allows us to obtain more vitamin A from this vegetable. When tomatoes and red peppers are thermally processed, lycopene, a wonderful antioxidant that is highly beneficial for tissue and blood health, is activated and better absorbed by the body. The specialist also advised people with digestive problems should consume boiled turnip and radish, as their nutrients are better digested by the human body if those vegetables are boiled.

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Gay And Bisexual Men Are Now Allowed To Donate Blood In England, Scotland And Wales

By www.scpr.org
Published On :: Wed, 16 Jun 2021 02:20:11 -0700

Gay and bisexual men in England, Scotland, and Wales can now donate blood, plasma and platelets under certain circumstances without having to wait three months, the National Health Service announced this week.; Credit: Wilfredo Lee/AP

Jaclyn Diaz | NPR

Gay and bisexual men in England, Scotland, and Wales can now donate blood, plasma and platelets under certain circumstances, the National Health Service announced this week in a momentous shift in policy for most of the U.K.

Beginning Monday, gay men in sexually active, monogamous relationships for at least three months can donate for the first time. The move reverses a policy that limited donor eligibility on perceived risks of contracting HIV/AIDs and other sexually transmitted infections.

The new rules come as the U.K. and other countries around the world report urgent, pandemic-induced blood supply issues.

Donor eligibility will now be based on each person's individual circumstances surrounding health, travel and sexual behaviors regardless of gender, according to the NHS. Potential donors will no longer be asked if they are a man who has had sex with another man, but they will be asked about recent sexual activity.

Anyone who has had the same sexual partner for the last three months can donate, the NHS said.

"Patient safety is at the heart of everything we do. This change is about switching around how we assess the risk of exposure to a sexual infection, so it is more tailored to the individual," said Ella Poppitt, Chief Nurse for blood donation at NHS Blood and Transplant, in a statement. "We screen all donations for evidence of significant infections, which goes hand-in-hand with donor selection to maintain the safety of blood sent to hospitals."

People who engage in anal sex with a new partner or multiple people or who have recently used PrEP or PEP (medication used to prevent HIV infection) will have to wait three months to donate - regardless of their gender.

Why did the U.K. make this change?

The NHS moved to alter its blood donation eligibility rules following a review by the FAIR (For the Assessment of Individualised Risk) steering group. The panel determined an individualized, gender-neutral approach to determining who can donate blood, platelets, and plasma is fairer and still maintains the safety of the U.K.'s blood supply.

The findings were accepted in full by the government last December.

Researchers will continue to monitor the impact of the donor selection changes for the next 12 months to determine if more changes are needed, NHS said.

What is the policy in the U.S.?

Despite efforts by advocates to change regulations in the U.S, the ability for gay and bisexual men to donate blood is still restricted.

A ban on gay and bisexual blood donors has been in effect since the early 1980s when fears about HIV/AIDS were widespread.

The Food and Drug Administration's current policy states a man who has sex with another man in the previous three months can't donate. Federal rules previously made such donors wait 12 months before giving blood, but due to low blood supplies during the pandemic the federal government changed the policy in April.

The Red Cross said they are participating in a pilot study funded by the FDA using behavior-based health history questionnaires, similar to those used in the U.K.

This content is from Southern California Public Radio. View the original story at SCPR.org.

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New Blood Cancer Treatment Shows Continued Response

By www.streetwisereports.com
Published On :: Thu, 07 Nov 2024 00:00:00 PST

Source: Dr. David Nierengarten 11/07/2024

The biotech behind this cell therapy has numerous near-term catalysts related to its pipeline, noted a Wedbush report.

TScan Therapeutics Inc. (TCRX:NASDAQ) Phase 1 ALLOHA study, evaluating its lead therapeutic candidates TSC-100 and TSC-101 in hematologic malignancies, showed patients continuing to have a positive response after one year, reported Wedbush analyst Dr. David Nierengarten in a Nov. 5 research note. TSC-100 and TSC-101 are T-cell receptor-engineered T-cell therapies (TCR-Ts).

"We see a catalyst-rich next few months ahead with data building in prominence on stock impact," Nierengarten wrote.

87% Return Potential

Wedbush has a US$10 per share target price on the Massachusetts-based biotech, trading at the time of the report at about US$5.36 per share, noted the analyst. The difference between these figures implies an 87% return potential for investors.

TScan Therapeutics remains rated Outperform.

Durability of Response Data

Nierengarten presented the clinical trial's latest results. As of the July 8, 2024 data cutoff date, in Phase 1 of ALLOHA, 16 patients with hematologic tumors had been administered TSC-100 or TSC-101, and 11 patients had been given a placebo. Median follow-ups had occurred at 5.8 months and 5.3 months, respectively.

At the time, none of the patients in the treatment arm had had a relapse. In the control arm, however, three, or 27% of, the 11 patients had, and the median time to relapse was 159 days. The analyst explained that this is typical for patients receiving a hematopoietic stem cell transplant after reduced-intensity conditioning.

One year out from treatment, five patients were evaluable, and all remained relapse free and minimal residual disease negative at the time. These data underscore the durability of response to this TCR-T treatment, Nierengarten commented. Its safety profile was shown to be favorable still, with no patients experiencing dose-limiting toxicities or adverse events associated with allogeneic hematopoietic cell transplantation.

"Enrollment continues in dose expansion cohorts, and results could support a registrational trial as early as 2025, pending regulatory feedback," Nierengarten wrote.

On the Horizon

TScan Therapeutics has several catalysts related to its clinical programs on the horizon, which Nierengarten listed.

On Nov. 8 and 9, the company will present preclinical data in the poster sessions at the annual Society for Immunotherapy of Cancer meeting. One poster will show in vitro combinatorial data for T-Plex, TScan's cellular therapy for treating solid tumors. It is comprised of two to three different TCR-Ts that target different tumor antigens on different human leukocyte antigen (HLA) types.

A second poster will detail the expansion of ImmunoBank, the biotech's diverse bank of therapeutic T-cell receptors (TCRs) that recognize diverse targets and are associated with multiple HLA types. The third will depict development of a target agnostic platform to evaluate how TCR-Ts affect primary human tissues.

On Dec. 9, TScan Therapeutics will present updated one-year data from ALLOHA, at the American Society for Hematology Annual Meeting in December.

By year-end, the biotech will announce initial data from administering singleplex therapy, cell therapy engineered using a single TCR, to patients with solid tumors. This treatment is being given to establish safety before administering multiplex therapy, cell therapy engineered from multiple TCRs.

In 2025, TScan Therapeutics will provide long-term duration of response data for multiplex therapy in solid tumors and will potentially commence a registrational trial for TSC-100 and TSC-101.

Important Disclosures:

This article does not constitute investment advice and is not a solicitation for any investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Each reader is encouraged to consult with his or her personal financial adviser and perform their own comprehensive investment research. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company.
This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

For additional disclosures, please click here.

Disclosures for Wedbush, TScan Therapeutics Inc., November 5, 2024

Analyst Certification We, David Nierengarten, Martin Fan and Dennis Pak, certify that the views expressed in this report accurately reflect our personal opinions and that we have not and will not, directly or indirectly, receive compensation or other payments in connection with our specific recommendations or views contained in this report.

Company Specific Disclosures This information is subject to change at any time. 1. WS makes a market in the securities of TScan Therapeutics, Inc.. 6. WS is acting as a financial advisor for TScan Therapeutics, Inc..

Wedbush disclosure price charts are updated within the first fifteen days of each new calendar quarter per FINRA regulations. Price charts for companies initiated upon in the current quarter, and rating and target price changes occurring in the current quarter, will not be displayed until the following quarter. Additional information on recommended securities is available on request. Disclosure information regarding historical ratings and price targets is available: Research Disclosures *WS changed its rating system from (Strong Buy/ Buy/ Hold/ Sell) to (Outperform/ Neutral/ Underperform) on July 14, 2009. Applicable disclosure information is also available upon request by contacting the Research Department at (212) 833-1375, by email to leslie.lippai@wedbush.com. You may also submit a written request to the following: Wedbush Securities, Attn: Research Department, 142 W 57th Street, New York, NY 10019.

OTHER DISCLOSURES The information herein is based on sources that we consider reliable, but its accuracy is not guaranteed. The information contained herein is not a representation by this corporation, nor is any recommendation made herein based on any privileged information. This information is not intended to be nor should it be relied upon as a complete record or analysis: neither is it an offer nor a solicitation of an offer to sell or buy any security mentioned herein. This firm, Wedbush Securities, its officers, employees, and members of their families, or any one or more of them, and its discretionary and advisory accounts, may have a position in any security discussed herein or in related securities and may make, from time to time, purchases or sales thereof in the open market or otherwise. The information and expressions of opinion contained herein are subject to change without further notice. The herein mentioned securities may be sold to or bought from customers on a principal basis by this firm. Additional information with respect to the information contained herein may be obtained upon request. Wedbush Securities does and seeks to do business with companies covered in its research reports. Thus, investors should be aware that the firm may have a conflict of interest that could affect the objectivity of this report. Investors should consider this report as only a single factor in making their investment decision. Please see pages 3–7 of this report for analyst certification and important disclosure information. Retail Investors The information provided is for general informational purposes only and should not be considered an individual recommendation or personalized investment advice. The companies/investments mentioned may not be suitable for everyone. Each investor needs to review their own respective situation(s) before making any investment decisions. All expressions of opinion are subject to change without notice due to shifting market(s), economic or political conditions. Investment involves risks including the risk of principal. Past performance is no guarantee of future results and the opinions presented cannot be viewed as an indicator of future performance.

( Companies Mentioned: TCRX:NASDAQ, )

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New Report Calls for Lowering Blood Alcohol Concentration Levels for Driving, Increasing Federal and State Alcohol Taxes, Increasing Enforcement, Among Other Recommendations

By
Published On :: Wed, 17 Jan 2018 06:00:00 GMT

Despite progress in recent decades, more than 10,000 alcohol-impaired driving fatalities occur each year in the U.S. To address this persistent problem, stakeholders -- from transportation systems to alcohol retailers to law enforcement -- should work together to implement policies and systems to eliminate these preventable deaths, says a new report from the National Academies of Sciences, Engineering, and Medicine.

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Benefits of eating almonds: new study examines benefits on blood sugar and daily calorie intake

By www.snackandbakery.com
Published On :: Tue, 16 Nov 2021 17:01:00 -0500

Snack of almonds vs. a high-carbohydrate snack food resulted in a lower blood glucose response and fewer calories consumed over the course of the day.

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Blood donations critical in fight against cancer

By www.ishn.com
Published On :: Thu, 13 Feb 2020 10:00:00 -0500

The American Red Cross and the American Cancer Society have partnered to launch a Give Blood to Give Time campaign to raise awareness on how blood donations help patients fighting cancer. Chemotherapy and radiation, used to treat cancer, can damage the body's ability to generate healthy blood cells and cause potentially life-threatening conditions. Blood transfusions from generous donors help to provide patients with critical clotting factors, proteins and antibodies needed to help their bodies fight back.

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Health groups join forces to help Americans control blood pressure

By www.ishn.com
Published On :: Mon, 02 Mar 2020 10:00:00 -0500

In a move toward meeting goals for better cardiovascular health in the United States over the next decade, the American Heart Association (AHA) is joining the Centers for Disease Control and Prevention’s National Hypertension Control Roundtable (NHCR)® along with other founding members in a public, private and non-profit collaboration committed to increasing blood pressure control rates to 80% by 2025.

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Wynk Cran-Blood Orange

By www.bevindustry.com
Published On :: Wed, 06 Nov 2024 00:00:00 -0500

Wynk, an award-winning cannabis seltzer, announced the launch of its newest limited-edition flavor: Cran-Blood Orange.

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V8 Grillo’s Dill Pickle Bloody Mary Mix

By www.bevindustry.com
Published On :: Wed, 13 Nov 2024 00:00:00 -0500

Campbell’s V8 and Grillo's Pickles joined forces to create a fresh take on the classic Bloody Mary cocktail with the launch of V8 Grillo’s Dill Pickle Bloody Mary Mix.

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CSTM 2024: Reflections from Canadian Blood Services trainees, part 1

By www.blood.ca
Published On :: Mon, 22 Jul 2024 19:27:47 +0000

CSTM 2024: Reflections from Canadian Blood Services trainees, part 1

Tuesday, July 09, 2024 Trainees

The Canadian Society for Transfusion Medicine (CSTM) annual conference, held in partnership with Canadian Blood Services and Héma-Québec, took place on May 23-26, 2024, in Saskatoon with the theme of “Bridging transfusion communities.”

Coinciding with CSTM, Canadian Blood Services' annual Research Day also provided a chance for Canadian Blood Services’ extended research network to collaborate, share their research, and connect. We asked two Canadian Blood Services research trainees to reflect on their experiences and key learnings from these events. Read on for their perspectives!

This blog was prepared by Mahsa Yazdanbakhsh, a PhD candidate in Dr. Jason Acker’s lab in Edmonton, and Carina Paredes, a PhD candidate in Dr. Sandra Ramirez-Arcos' lab in Ottawa. Mahsa and Carina are recipients of Canadian Blood Services Graduate Fellowship Program as well as travel bursaries to support their attendance at these events.

Carina (left) and Mahsa (right) are pictured attending Canadian Blood Services’ Research Day event in Saskatoon, May 2024. Photo provided by Emily Wright.

1. You both contributed as planning committee members for Research Day 2024; why were you interested in contributing in this way?

Carina:

I volunteered for the Research Day organizing committee because I wanted to improve skills such as leadership and organizational abilities and because I believe that actively participating at Research Day is an opportunity for us [trainees] to engage in knowledge dissemination, networking and collaboration that will support our future careers!

The best part of participating in this event was being an active part of the organizing committee and connecting with trainees, scientists, and managers, which provided me with a great opportunity to network.

Mahsa:

I contributed to Research Day 2024 as a planning committee member and moderated a session of presentations. My role involved organizing speaker sessions and supporting team communication. Having attended previous Research Days, I was eager to help enhance the event and being on the planning committee gave me a deeper appreciation for the effort involved while collaborating with a dedicated team. I learned valuable skills in event planning, teamwork, and problem-solving. Additionally, it expanded my network and allowed me to connect with many professionals at Canadian Blood Services.

It's important for trainees to be involved because it offers leadership experience and fosters a greater connection to the academic community.

2. Did you also share your research during Research Day and/or CSTM and if so, in what ways?

Carina:

I was selected for a Poster presentation at CSTM and I was also able to briefly present it at Research Day. My poster was titled “Role of the efflux pump NorB in survival and increased quinolone resistance of Staphylococcus aureus grown in platelet concentrates.” Staphylococcus aureus is a round-shaped bacterium that is naturally found in the skin and mucosa of healthy humans. It is important to study because contamination of blood components with this bacterium is a major safety threat to transfusion patients. My work aims to unravel the role of a specific gene in antibiotic resistance and virulence of Staphylococcus aureus when grown in platelet components.

“Having this opportunity to present my work allowed me to receive feedback from peers and experts from different areas of the transfusion medicine. I find this aspect of presenting and sharing my work very important especially because the feedback received will direct me to improve my work and attain stronger research outcomes.”

Mahsa:

I presented my research during CSTM and Research Day through a poster and a rapid trainee presentation. My poster was titled, "Osmotic Variability in Red Blood Cells from Different Blood Donor Groups." A typical red blood cell’s lifespan is 120 days. This study compared how younger and older red blood cells from frequent and non-frequent blood donors respond to osmotic changes. Osmotic changes relate to the balance of fluid within a cell. Results showed significant differences in osmotic response among different donor groups, and these results may be useful for optimizing blood product quality and functionality.

“Sharing research at these events provides an opportunity to disseminate findings to a broader audience within the transfusion community, which is important because the research contributes to existing knowledge in the field and has the potential to influence future research directions and clinical practice.”

Overall, presenting at Canadian Blood Services’ Research Day and CSTM allows for collaboration, knowledge exchange, and advancements in the field of transfusion medicine, ultimately benefiting patients and health-care providers alike.

3. How many times have you attended Research Day and CSTM and what was your favourite moment or takeaway this year?

Carina:

I attended Research Day and CSTM in 2023 and 2024. I really enjoyed every day of this event, but the highlight of this year was to visit the Vaccine and Infectious Disease Organization (VIDO) facilities in Saskatoon and learn more about their very interesting work. I was very pleased to listen to the keynote speakers at CSTM and their opening remarks.

Mahsa:

This marked my third participation in CSTM and second in Research Day, and the highlight was the reunion with familiar faces after a year! Meeting my close friend, whom I hadn't anticipated seeing at CSTM, was particularly delightful and added an extra layer of joy to the event for me.

4. What would you say to other trainees about Research Day and/or CSTM?

Carina:

It’s a great opportunity for improvement and promotes learning, collaboration and innovation. It also allows us trainees to learn from each other's experiences, receive feedback from experts, and improve our individual performance.

“I would say to other trainees: Participate, be present and get involved! As a trainee, it is important to not only present our research, but also to engage in organizational activities that will build our skill set for our future career.”

Mahsa:

I would encourage other trainees to actively participate in both Research Day and CSTM. Attending Research Day provides a platform to present your work and receive constructive feedback, while CSTM offers a broader networking opportunity within the transfusion community. These events offer opportunities for trainees in Canadian Blood Services’ research and education network to share research findings, receive feedback, and network with peers and experts.

“By participating in these events, you not only contribute to the advancement of knowledge in transfusion medicine but also refine skills and establish connections that can be beneficial for your future endeavors.”

Canadian Blood Services – Driving world-class innovation 

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. 

CSTM 2024: Reflections from Canadian Blood Services trainees, part 2

Tuesday, July 16, 2024 Poojan Joshi

Coinciding with CSTM, Canadian Blood Services' annual Research Day also provided a chance for Canadian Blood Services’ extended research network to collaborate, share their research, and connect. Following these events, we asked Canadian Blood Services research trainees to reflect on their experiences and key learnings from the event.

This blog was prepared by Poojan Joshi, a research assistant working with Canadian Blood Services social scientists Drs. Jennie Haw and Kelly Holloway.

Dr. Jennie Haw (left), Dr. Kelly Holloway (centre) and Poojan Joshi (right) are pictured attending Research Day in Saskatoon. Photo by Emily Wright, Canadian Blood Services.

What was it like attending your first Canadian Blood Services Research Day and CSTM conference as a research assistant?

Attending CSTM 2024 for the first time (it was also my first conference ever!) as a social science research assistant was an incredible experience for many reasons. As I listened to the various presentations and engaged with experts in the field, I was struck by the vast array of knowledge and experience attendees brought to the field of transfusion medicine. I was also humbled by the multidisciplinary collaborations that go into building and maintaining an efficient blood system.

My background includes training in social psychology and qualitative research methods from the University of Guelph, where I developed interest in areas such as health, immigration and refugees, public and media discourse and policy. In December 2022, I had the opportunity to work on a social science research project with Dr. Kelly Holloway and Dr. Jennie Haw titled “Addressing Systemic Barriers to Donation for Donors of African and South Asian Ancestry.” This project aligned very well with my research interests and underscored the importance of applying a broader sociocultural perspective to donation practices and research. I soon realized that my diverse interests were more connected than I had originally thought as I began to understand donation as a complex social act embedded in a wide sociocultural and political context.

This understanding allowed me to view the presentations, posters, and plenary sessions of Research Day and CSTM 2024 through a social science lens. In doing so, I appreciated the impact that social science has on many aspects of the blood system, from donor to recipient, and the critical role it plays in addressing current and future complex challenges.

“Since joining Canadian Blood Services as a full-time research assistant in September 2023, I’ve gained a deeper understanding of the role of social science in transfusion medicine.

Under the excellent mentorship of Drs. Kelly Holloway and Jennie Haw, I have developed a profound appreciation for the intersection of these fields and the critical insights social science can bring to transfusion medicine.”

Thinking about Research Day specifically, what learnings or ideas have the presentations sparked for you?

Dr. Chantale Pambrun’s opening remarks highlighted the importance of the blood operator and how research plays a crucial role in improving transfusion medicine and health, as well as several challenges and opportunities ahead. One significant area where social science has played a key role is in donor policies and changes in deferral criteria. Dr. Mindy Goldman’s presentation noted that because donor policies impact blood safety, public perception, and product availability, a multidisciplinary approach is required to balance donor and recipient safety with the maintenance of an adequate supply.

Dr. Kelly Holloway’s presentation on the lived experiences of immunoglobulin recipients demonstrated the importance of incorporating patient stories to advance our understanding of health and inspire positive change. Immunoglobulin products (Ig) are manufactured from plasma and may be needed by patients with immunodeficiencies or autoimmune and alloimmune disorders.

What was the most memorable moment from the CSTM 2024 program this year and what reflections did you take away from it?

Dr. Jennie Haw’s presentation on the systemic barriers to blood donation experienced by donors of African and South Asian ancestry was memorable for me, as it illustrated the strengths and commitment of diverse communities in donating blood and plasma, highlighting the need to address the barriers they face. As I am actively involved in this project, it was powerful to see this perspective of social science shared with experts.

Another memorable session was the plenary on Indigenous health and well-being in Northern Saskatchewan. Presentations by Rena Sutherland, Janet Tootoosis, and Jack Janvier highlighted key considerations for transfusion medicine, such as trust, relationship-building, community engagement, and patient-centred care. They discussed the challenges of providing transfusions in remote areas and emphasized the importance of collaboration, expertise, resources, and clear communication.

The session also addressed the impact of colonialism, including residential schools, ongoing racism, and the exclusion of Indigenous holistic health views to provide guidance on effectively engaging Indigenous communities using a strengths-based approach. Social science research is crucial in these areas as it helps build and maintain trust through community engagement, ensuring inclusive and culturally safe care for donors and recipients.

“My time at CSTM 2024 was more than just an academic exercise; it was a recognition of the inseparability of social science from the field of transfusion medicine. The talks and discussions illustrated how societal factors are connected to health outcomes and donor policies.”

I am excited to carry this knowledge forward to the 2024 International Society of Blood Transfusion conference in June, where I hope to take my learning from a Canadian context and expand it by engaging with international experts in transfusion medicine. By fostering interdisciplinary collaborations and supporting innovative approaches, we can ensure that our blood systems not only operate efficiently but also resonate with the voices and needs of all communities.

Read more about social science and diversity in the blood system in these articles on blood.ca:

Canadian Blood Services – Driving world-class innovation

Driving excellence: The Centre for Blood Research and Canadian Blood Services renew collaboration to advance blood science education and training

Tuesday, July 30, 2024 Kaitlyn Chuong

This blog was originally prepared by CBR communications and programs coordinator Kaitlyn Chuong and former Canadian Blood Services knowledge broker Dr. Travis Sztainert, with edits provided by Abby Wolfe.

After more than 20 years, the Centre for Blood Research (CBR) and Canadian Blood Services are proud to share that they have renewed their collaboration agreement which supports education, training and knowledge mobilization for the next generation of trainees and researchers in blood science and transfusion at CBR.

The collaboration agreement which is administered by Innovation and Portfolio Management at Canadian Blood Services has recently been extended for three more years to 2027. This agreement formalizes the next iteration of this long-standing partnership and is the result of continued commitment from both organizations to improve blood research.

This partnership emerged in response to recommendations made following Canada’s public inquiry into the contaminated blood crisis of the 1980s and 1990s. Thus, to address a recognized gap in transfusion science knowledge, in 2002, a group of visionary blood researchers at the University of British Columbia (UBC) established Canada’s first interdisciplinary blood research centre — an entirely unique and valuable resource for established and emerging blood scientists. With its creation, the CBR brought together a wide range of multi-talented investigators to develop highly specialized labs to study blood and transfusion science. Since its inception, the CBR has grown to include more than 35 basic science, applied science, social science and clinical investigators in 12 departments, representing 6 faculties at UBC, with a focus on advancing knowledge of transfusion science and medicine in the lab and in the clinic.

"We are delighted to extend our partnership with the Centre for Blood Research through 2027. This renewal highlights our shared commitment to advancing education, training, and research in transfusion science. Together, we aim to drive innovation and improve transfusion practices, ensuring a safer and more effective future for the Canadian blood system."

Dr. Chantale Pambrun
Senior Medical Director, Innovation & Portfolio Management

“The long-term relationship of Canadian Blood Services and the CBR has been nothing less than fantastic! By combining resources and sharing knowledge, education and research outputs, this unique partnership has resulted in more rapid and meaningful advances that are recognized locally, nationally and internationally. The entire transfusion medicine community has benefitted and will continue to do so.”

Dr. Ed Conway
Director of the Centre for Blood Research

The partnership of Canadian Blood Services was integral to creating the Centre for Blood Research, providing essential start-up funding and continuing to support infrastructure for the centre and its training and education programs. Several Canadian Blood Services scientists are active members within the Centre for Blood Research including senior scientist Dr. Ed Pryzdial and adjunct scientists Dr. Ed Conway, Dr. Hongshen Ma and Dr. Jay Kizhakkedathu.

Learn more about some of the research these scientists and members of their labs undertake in our previous R.E.D. blogs and videos:

Pryzdial lab: Investigating envelope viruses (blood.ca)
Ma lab: A novel microfluidic device to aid in the search for red blood cell "super-storers"
Graduate trainees: Recipients of the Canadian Blood Services Graduate Fellowship Program

The CBR is grateful for Canadian Blood Services’ continuous support, without which its many educational, training and research programs would not be possible. This includes, for example, CBR’s Graduate Award Program and Summer Studentship Program, as well as the CBR's weekly seminar series and the annual Earl W. Davie and Norman Bethune symposia.

Canadian Blood Services – Driving world-class innovation 

Canadian Blood Services discovery research lab contributes to new knowledge on neutrophils

Plasma

Transfusion

Blood

Thursday, August 29, 2024 Abby Wolfe

Dr. Donald R. Branch’s work as a discovery scientist at Canadian Blood Services focuses on immunotherapy, seeking to further enhance understanding of the cellular and molecular mechanisms involved in autoimmune diseases. Based in Toronto, Dr. Branch’s laboratory develops models of rheumatoid arthritis, Alzheimer’s disease, immune thrombocytopenia (ITP) and multiple sclerosis in mice. These models are particularly useful in examining how cells affected by these conditions respond to current therapeutic agents like intravenous immunoglobulin – a blood product made from human plasma commonly known as IVIg – and investigating potential alternative therapeutics. 

Over the years, Dr. Branch’s lab research findings have included the discovery of a special reagent that makes identification of antibodies easier by “zapping" autoantibodies,  answers around unexpected side effects of IVIg therapy, and insights around recipients’ responses to bone marrow transplantation. It has also earned him numerous awards and accolades, including four from AABB, the Association for the Advancement of Blood & Biotherapies.

Dr. Don Branch, Canadian Blood Services senior scientist

New knowledge about neutrophils

Recently, contributions from Dr. Branch’s lab helped a U.K.-based team of researchers discover new information about how neutrophil function and activity is regulated. Neutrophils are a type of white blood cell that are part of the body’s normal immune response. A person’s neutrophil levels may be affected by infections as well as chronic or acute illnesses. Patients who have very low neutrophil counts and/or persistent infections may receive a boost to their neutrophil levels via granulocyte transfusion therapy. However, in some diseases, overactivation of neutrophils can also create an inflammatory environment and harm healthy tissue.

The research has been published in the high-impact scientific journal, Nature. This publication has filled a gap in knowledge about the mechanisms involved in maintaining balance between neutrophils’ infection-fighting power and inflammation-causing potential. As Dr. Branch describes: “This research by Dr. Brown and team shows that the myeloid inhibitory C-type lectin enzyme, which is known as MICL, controls neutrophil activity in rheumatoid arthritis. It is likely that MICL also regulates neutrophil activity in general. This suggests that if therapeutics can be designed to target MICL, they may be useful in controlling inflammation and infection. It is a fundamental finding that will change our understanding of the biology of neutrophils.” 

Discovery research, like the study to which Don and Ruqayyah contributed, is essential to improving patient care in the long run. New biomedical insights are essential to crafting new drugs and new therapeutic approaches in a rational way.

Dr. William (Bill) Sheffield, Canadian Blood Services senior scientist and associate director of research

Discovery research expertise leads to new collaboration

The special mouse model that Dr. Branch’s lab uses is known as K/BxN. In this model, two mouse populations are selectively bred to produce offspring whose genetic material carry an antibody that destroys bone cartilage. An arthritis-causing serum containing this destructive antibody can then be obtained from the mice for use as a reagent in research. This process is termed “serum-transfer arthritis” and has been used by many investigators in the study of treatments that may alleviate the condition.

Knowledge of Dr. Branch’s lab’s expertise in this area prompted a connection to the team of researchers at the Universities of Exeter and Aberdeen in the U.K. for this study. Says Dr. Branch, “In 2021, I supported a successful application to Canadian Blood Services’ Blood Efficiency Accelerator Program (BEAP) by Dr. Maria Fernandes, a researcher from  Héma-Québec who works with neutrophils. Through this collaboration, Dr. Fernandes was aware that I work on rheumatoid arthritis with K/BxN mice, and she also knew that Dr. Gordon Brown in the U.K. was looking to collaborate with a researcher in this area for some planned neutrophil research. My lab, which included postdoctoral fellow Dr. Ruqayyah Almizraq at the time, contributed to Dr. Brown’s research by providing the sera from our K/BxN mice. With this sera, Dr. Brown and his collaborators were able to induce rheumatoid arthritis and show that it could be resolved by removing the inhibition of a specific enzyme.” 

Science that is never boring

The Branch lab is currently using these same mouse models to investigate whether a recombinant protein called IgG1 Fc hexamer could be an effective replacement for IVIg in the treatment of autoimmune conditions like rheumatoid arthritis and ITP. While early results are promising, continued work is needed. In fact, back in 2018, Dr. Branch was asked in a previous R.E.D. blog post to describe what he found to be the most exciting part of science. Reflecting on the same question now, he reiterates that his response still rings true after 50 years in the field:  

The most exciting part of science is that when you do good science, you get more questions than you get answers, which means it is never boring. There is no end to imagination; new ideas, theories, experiments and discoveries occur often and provide a level of excitement to which many other professions cannot attest.

Dr. Donald (Don) Branch, Canadian Blood Services senior scientist

Canadian Blood Services – Driving world-class innovation 

And the winner of the first Canadian Blood Services Dana Devine Award is…

Transfusion

Tuesday, September 17, 2024 Aldis Brennan

Dr. Melika Loriamini!

This new award, in honour of Dr. Dana Devine, supports early career scientists in a field related to transfusion science and medicine, blood banking and blood biotherapies. It is awarded in collaboration with the Canadian Society for Transfusion Medicine’s at their annual conference.

“I truly appreciate the Committee for the recognition and I'm so proud that I'm the first person to win the Dana Devine Award,” Dr. Loriamini says. “When I walked into the conference, I felt like I was famous because everyone knew who I was. It was a great feeling that all the work, all the hard work, during these years that I did, it's now acknowledged, and everyone knows it.”

Dr. Loriamini began her career in medical laboratory science in Iran, obtaining a Bachelor of Science degree before immigrating to Canada. She completed a second Bachelor’s degree, this time in biomedical science from York University, and went on to enroll in the laboratory medicine and pathobiology PhD program at the University of Toronto. While completing her education, Dr. Loriamini worked as a Medical Laboratory Technologist at LifeLabs and the William Osler Hospital.

As part of her PhD, Dr. Loriamini worked with Canadian Blood Services Senior Scientist Dr. Donald Branch which she says allowed her to “acquire expertise in the fields of transfusion medicine and immunology and we were able to publish various articles.”

In fact, it was Dr. Branch who first sent her the application for the award and told her he thought she was a strong candidate.

“I want to say thanks to Dr. Branch, who was my supervisor. Actually, thank you is not enough,” Dr. Loriamini says. “He taught me how to think as a scientist and how to become a scientist. I truly appreciate him. He always trusted me.”

Dr. Loriamini’s research focused on developing a new drug to help people who have autoimmune cytopenias — a cluster of conditions which causes your immune system to attack your own healthy blood cells. She was able to identify a potential drug which is expected to undergo clinical trials in the future.

In addition to receiving the Canadian Blood Services Dana Devine Award, Dr. Loriamini has also been recognized with the Canadian Blood Services Graduate Fellowship Program award in 2019 and 2021, the AABB Outstanding Abstract Award for Trainees as a Fellow/Post-Doctoral Student in 2022, the SGS travel award from the University of Toronto in 2022, the Best Poster for Translation/Basic research award from Hematology Academic Day in 2023, and the Best Poster for Infectious Diseases, Inflammation, and Immunology award from the 2023-Laboratory Medicine & Pathobiology Research Conference.

Dr. Loriamini is now a Clinical Practice Leader at Humber River Health in Toronto which allows her to bring her research to a clinical setting. Congratulations Dr. Melika Loriamini!

Canadian Blood Services – Driving world-class innovation

Lay Science Writing Competition 2024: Evaluating umbilical cord blood transfusion efficacy and safety in neonates

Thursday, October 17, 2024 Mahsa Yazdanbakhsh

Our partnership with the Centre for Blood Research (CBR) at the University of British Columbia is helping to train the next generation of researchers in transfusion science. This blog post highlights just some of the achievements in education, training or knowledge mobilization accomplished by CBR trainees.

Canadian Blood Services 2024 Lay Science Writing Competition offered in partnership with the Centre for Blood Research (CBR) provides research trainees an opportunity to exercise and enhance their science communication skills by sharing their research with lay audiences. The competition was open to research trainees in the broad Canadian Blood Services research network – including trainees that are directly funded by Canadian Blood Services, in laboratories that receive funding from Canadian Blood Services, and at the Centre for Blood Research in Vancouver. In this blog, graduate student Mahsa Yazdanbakhsh, author of the third prize-winning entry, provides some behind-the-scenes insights into the preparation of her submission. The full entry text is also shared below.

Mahsa Yazdanbakhsh is a PhD candidate training in the laboratory of Canadian Blood Services senior scientist, Dr. Jason Acker at the University of Alberta.

Why did you choose to participate in the competition this year?

I chose to participate in the competition because it gave me a chance to highlight important research in neonatal blood transfusion, specifically focusing on umbilical cord blood (UCB) transfusions for extremely premature newborns. I saw this as an opportunity to show how UCB could improve survival and outcomes for these vulnerable babies. Since I’m involved in this research, I felt it was important to share my insights and the potential benefits this work could bring to neonatal medicine.

The theme this year was “Connecting science with society”; what did this theme mean to you?

The theme was particularly meaningful to me because it emphasizes the importance of making scientific discoveries accessible and relevant to the broader public. For me, it’s about bridging the gap between complex research and real-world applications that can improve lives. In our work on umbilical cord blood transfusions for premature infants, the potential benefits go beyond the laboratory—they directly impact vulnerable newborns. This theme reminded me that research is not just about advancing knowledge within the scientific community, but also about ensuring that society understands and benefits from these advancements. By participating in this competition, I aimed to contribute to this connection, demonstrating how science can address critical healthcare challenges and ultimately improve outcomes for neonates.

Did the writing process help you learn or discover something new about your research?

Yes, the writing process helped me gain a new perspective on our research. It required me to step back and think about how to explain complex scientific concepts in a way that is clear and relatable to a wider audience. This helped me see my work from a different angle, focusing not just on the technical aspects, but also on the broader impact it could have on neonatal care. Writing about my research also reinforced the importance of effective science communication, reminding me that research isn't just about what happens in the lab, but how it can be applied to make a real difference in society.

What tips would you share with others who are writing about research for lay audiences?

When writing about research for lay audiences, I recommend simplifying complex ideas without losing the essence of the work. Break down the concepts into clear and simple language, but ensure key details remain intact. I suggest focusing on why the research matters by connecting it to real-world applications or benefits, helping readers understand its relevance. Avoid jargon whenever possible, and if you need to use technical terms, explain them in an accessible way. I also recommend using relatable examples to make complex concepts easier to grasp. Present the research in an engaging way, perhaps by telling a story or highlighting its human impact.

Read the prize-winning entry in its entirety below...

Evaluating umbilical cord blood transfusion efficacy and safety in neonates

Imagine a small infant who was born prematurely and is having a hard time surviving in the outside world. These extraordinarily early newborns, referred to as ELGANs (Extremely Low Gestational Age Newborns), are born before 28 weeks of pregnancy and must fight a losing battle against anemia, a disorder in which there are insufficient healthy red blood cells in their blood to carry oxygen throughout their bodies. A common strategy used by physicians to win this conflict is blood transfusions. These transfusions now depend on adult donors' blood. This method, while life-saving, has limitations. Adult blood cells might not always meet these delicate babies' unique needs, which could occasionally result in complications and less positive results. But what if there was a more efficient method?

Umbilical cord blood (UCB) has been proposed as a treatment for anemia in infants in the past. Fetal hemoglobin (HbF), a particular type of hemoglobin that is beneficial at carrying oxygen and protecting cells from harm, is rich in UCB. The fragility of fetal red blood cells and low volumes presented practical challenges that led to a decline in the use of UCB, despite its promising results. However, scientists are now looking again at this overlooked hero. They think that the secret to safer and more efficient treatments for premature babies may lie with UCB. According to recent research, UCB may be able to supply the necessary transfusions, and ongoing clinical trials are examining its advantages over adult blood.

How to store UCB is a big obstacle when using it. UCB has a shorter life span than adult blood, which can be kept in storage for longer periods of time. Scientists are actively working on new methods to freeze and store UCB so it can be readily available when needed. This process is known as cryopreservation. Our research team has developed a meticulous method to freeze and thaw UCB. This technique, involving the addition and removal of a substance called glycerol, aids in protecting the blood cells during the freezing process. Having demonstrated the effectiveness of this method with adult blood, we are now adapting it for UCB.

Our research is guided by three primary objectives: optimizing the freezing process, minimizing immune reactions, and assessing survival rates. By refining our freezing and thawing methods, our aim is to ensure that UCB cells remain healthy and functional. Furthermore, we seek to compare how the immune system responds to UCB and adult blood to ascertain the safety and efficacy of UCB transfusions. Lastly, we will evaluate the survival of UCB cells after cryopreservation and thawing, comparing them to adult blood cells. Success in these endeavors could offer a more potent treatment for anemia in premature babies, leading to improved health outcomes and fewer complications, thereby revolutionizing neonatal care and providing these vulnerable recipients with a stronger start in life.

In conclusion, our research in Dr. Jason Acker's lab on UCB aims to address the critical needs of premature infants by optimizing cryopreservation techniques, understanding immune responses, and comparing the efficacy of UCB to adult blood. The potential benefits of utilizing UCB are immense, and if successful, this work could transform the landscape of neonatal transfusions, offering these vulnerable babies a better chance at a healthy start in life.

About the author:

Mahsa's research is supported by the Canadian Blood Services Graduate Fellowship Program award. In her work, Mahsa focuses on optimizing blood manufacturing methods and investigating how to improve the efficacy of blood transfusion.

Canadian Blood Services – Driving world-class innovation 

Canadian Blood Services research engineer applies network modelling techniques and mentorship skills to benefit Canada’s Lifeline

Tuesday, October 22, 2024 Dr. Emily Freeman

Dr. John Blake is a research engineer at Canadian Blood Services and a Professor in the Department of Industrial Engineering at Dalhousie University. Based in Halifax, Nova Scotia, Dr. Blake and his trainees use engineering principles and various computer-based optimization techniques to inform large scale decisions at Canadian Blood Services.

Applying network modelling to biologics

To some, it may be surprising to learn that there is such opportunity to integrate engineering into the health-care focused setting of Canadian Blood Services. However, as Dr. Blake explains, the same engineering principles that apply to the development and quality assurance of other products also apply to biologics such as blood, stem cells and organs. One of these classic engineering approaches currently applied to improving operations at Canadian Blood Services is network modelling.

Network modelling is a computer-based method that creates a virtual representation of objects and their relation to each other. The resulting models are particularly useful for maintaining adaptability in the collection of blood donations, as well as the distribution and inventory management strategies that allow Canadian Blood Services to remain a safe and reliable provider of life-saving products.

Dr. Blake making friends while walking the Camino de Santiago in Spain

Contributing to efficiency and sustainability in Canada’s Lifeline

For Dr. Blake’s team, modelling is not about the data acquired but rather how they can turn existing data into real life change. Part of this approach is ensuring that Canadian Blood Services is asking the right questions when it comes to allocating resources. For example, Dr. Blake has worked on models to assess how changing stem cell donor recruitment will affect the number of matches for Canadian patients. By modelling things such as recruitment approaches, Dr. Blake’s work assists Canadian Blood Services to consistently identify ways to improve Canada’s Lifeline.

Recently, Dr. Blake has also been applying this method to optimize the number and location of mobile and permanent donor facilities across the nation. This redesign of the donation facility network will address the growing demand for donations by bringing Canadian Blood Services’ facilities closer to the donors.

“I have waited my entire career for a problem of this type – it is truly a once in a lifetime opportunity.”

Dr. John Blake, Canadian Blood Services Research Engineer

Securing the future of Canada’s Lifeline

To sustain a safe and effective blood system in Canada for years to come, network modelling and optimization is a never-ending process. This is one of the reasons that Dr. Blake is committed to securing the future of transfusion and transplantation systems by training and mentoring the next generation of engineers. In fact, seeing his former students join Canadian Blood Services and dedicate their talents to improving the future of Canada’s Lifeline is one of Dr. Blake’s proudest achievements.

One of Dr. Blake’s former students, Matt Nelson, is now an industrial engineer at Canadian Blood Services.

“In my role, I use systematic thinking to build and run complex models; collect and analyze the required data; produce useful results; and explain these results to non-technical leaders on a regular basis,” Matt says. Recently, Matt contributed to the launch and expansion of pathogen-reduced platelets, a new product that was implemented across Canadian Blood Services production sites starting in 2022. The implementation of pathogen-reduced platelets has provided an additional layer of safety for recipients by reducing the risk of potential transfusion-transmitted pathogens without compromising the quality of the component. Matt credited Dr. Blake in helping him develop the necessary skills he now dedicates to safeguarding Canada’s Lifeline:

“Dr. Blake was the professor who introduced me to the uses of simulation to understand complex non-linear systems. This type of system is very common in situations that have a lot of variability – like the blood system – and simulation allows for exploration of the response of the system to changes.”

Matt Nelson, Canadian Blood Services Industrial Engineer

Over the years, Dr. Blake’s ongoing modelling work and mentorship activities have also led to many recognitions and awards, but he is most proud of being recognized as Professor of the Year by Dalhousie Undergraduate students, and with awards for his contributions to the Canadian Operational Research Society. He has even the earned the distinction of being Dalhousie’s first engineer to be awarded grant funding from the tri-council agency, Social Sciences and Humanities Research Council (SSHRC).

“I am proud to work on projects that have a measurable impact on people’s health and well-being,” Dr. Blake says. “I am forever grateful to Dr. Dana Devine for first giving me the opportunity to serve Canadians in this role at Canadian Blood Services.”

Canadian Blood Services – Driving world-class innovation

Perseverance and collaboration: How a new clinical trial aims to determine whether sex matters when matching blood products to patients

Transfusion

Blood

Thursday, October 31, 2024 Abby Wolfe

As the Principal Investigator for the SexMatters trial described in this blog, Dr. Mickey Zeller is an Associate Professor in the Department of Medicine at McMaster University. She is also a Medical Officer at Canadian Blood Services.

Around 2018, Dr. Mickey Zeller's grandmother asked her a question that she couldn’t fully answer at the time. It’s a question that Dr. Zeller continues to keep top-of-mind in her roles as an Associate Professor at McMaster University and a Medical Officer at Canadian Blood Services. Having sustained a pelvic fracture at the age of 94, she asked her granddaughter, “If I need a blood transfusion, could it come from a man... and if it does, would that be safe?”. As Dr. Zeller describes, “I looked at her and, in that moment, I said, ‘Grandma, no one knows! But it’s on my list to find out!’.”

In fact, questions about whether selecting products based on the sex of donor and recipient could improve outcomes following blood transfusions have been around for years. However, there is not yet been enough evidence to definitively answer whether this strategy would help optimize hospital and blood operator practices.

After much perseverance, collaboration with researchers across Canadian Blood Services’ extended research network, and a successful bid for CIHR funding, a research team led by Dr. Zeller is embarking on a new research journey they hope will finally provide the evidence to answer questions about whether sex matters in red blood cell transfusion.

What will the study focus on and why is it needed?

When a patient requires a transfusion of red blood cells (RBCs), the matching of product to patient is based on compatibility testing that looks at whether the blood is group A, B, AB or O, whether it is Rh positive or negative, and what other antibodies are present. Canadian Blood Services’ Rare Blood Program also helps ensure patients with specific combinations of antigens – proteins that appear on the surface of red blood cells – can be matched with appropriate blood components. Laboratory studies on donor factors such as age and sex have looked at their impact on characteristics of RBCs in terms of hematocrit, cell volume, hemoglobin content, and deformability – that is, the flexibility or “squeeze-ability” of the cells. However, currently available evidence has not demonstrated a need for red blood cells for transfusion to be matched based on the sex of either donor or recipient.

The principal research question being posed by this study is: In adults admitted to the ICU who require RBC transfusions, do donor-recipient sex-matched RBC transfusions result in improved 30-day mortality compared with sex-mismatched RBC transfusions? Answering this question has a large potential for impact because of the substantial number of blood transfusions that occur throughout Canada every year.

“If there was a risk identified [from the sex of the donor and recipient], even moving the needle a little bit to improve the matching of blood product to recipient could add another layer of safety to current practices,” Dr. Zeller explains.

What had to happen to make this study possible?

While it seems like a basic question to remain unanswered, Dr. Zeller acknowledges the investments of energy, expertise, and funding to get the study to this point.

“Sometimes these basic questions remain for a long time because it is challenging to get the funding and infrastructure in place to be able to answer them in a scientifically rigorous way; even if they’re basic-level questions, it’s only by investing that you are able to gather the evidence to answer the question.” Dr. Zeller says.

That’s part of the reason why Canadian Blood Services’ investments in networks like CTTG are important. The Canadian Transfusion Trials Group (CTTG) is funded by Canadian Blood Services with the aim of supporting and accelerating clinical trials that can inform best practices in transfusion medicine in Canada. CTTG reviewed and endorsed this SexMatters study and provided support through its development, making it the second RCT since CTTG’s inception to earn CIHR funding following participation in their review process.

"I had the opportunity to present to CTTG twice and receive feedback that improved this study design and my application to CIHR for its funding. Having it reviewed by people like Dr. Donald Arnold, Dr. Jeannie Callum, Dr. Nadine Shehata – people with world-recognized expertise in this area – really led to the success of this application,” Dr. Zeller says. “We were able to have really rich discussions on tough questions about study design and impact, including details like how we would account for patients that are pre-transfused entering the study.”

Dr. Mickey Zeller, Principal Investigator for the SexMatters clinical trial, and Dr. Donald Arnold, Co-Director of the CTTG network, discuss aspects of the newly funded clinical trial.

Says Dr. Zeller, “Each time the application went through reviews, I could present to these colleagues to essentially say, 'Here are the criticisms it has received and here’s how I’ve handled them.' And they would provide me advice and encouragement to resubmit. It is really valuable having people across the country who are cheering for you, and who are hand-in-hand with you to celebrate your success!”

“It’s an absolute privilege to do high quality research because you have to be surrounded by an incredible group of humans. Academic curiosity and commitment by those that have mentored me have enabled me to do this work. It’s out of a generosity of spirit that people have shared their expertise with me for this work, and it takes a lot of time and effort.”

Dr. Mickey Zeller, Principal Investigator for the SexMatters trial

What other research has informed this study?

Before this study received CIHR support, the research team undertook an exploratory analysis, a systematic review and meta-analysis, and a pilot trial which took place in 2022 across five Ontario-based hospitals to establish feasibility of the randomized controlled trial. Findings of retrospective observational studies indicated potential association between sex-mismatched transfusions and mortality, but some aspects remained unclear due to low certainty of evidence, inconsistencies or contradictory subgroup analyses in the available literature.

Much previous research involving Canadian Blood Services researchers has also supported the need for this randomized controlled trial. This includes:

research undertaken in the lab of Canadian Blood Services Senior Scientist, Dr. Jason Acker, which has investigated impacts of various factors (including age and sex) on red blood cell storage and other factors of quality;
the iTADs clinical trial (short for “An innovative Trial Assessing Donor Sex on Recipient Mortality") undertaken by Canadian Blood Services Adjunct Scientist Dr. Dean Fergusson and colleagues that signalled there may be increased risks with blood from younger, female donors;
as well as research by Canadian Blood Services Adjunct Scientists Nancy Heddle and Dr. Donald Arnold at McMaster University’s Michael G. DeGroote Centre for Transfusion Research (formerly known as the McMaster Centre for Transfusion Research) which was supported through Canadian Blood Services’ Transfusion Medicine Research Program Support Award.

Read the Research Unit summarizing some of MCTR’s research on blood.ca (2019): Sex-mismatched red blood cell transfusions and mortality | Canadian Blood Services

Earlier publications involving these and other researchers have also investigated the impact that blood donor age and sex have on outcomes for transfusion recipients, summarized evidence related to sex-matched versus mismatched transfusions and mortality, and the biological mechanisms implicated in adverse outcomes of sex-mismatched transfusions. There is still room for more investigation to build on this previously completed research, and that aligns with Canadian Blood Services' emphasis on the importance of research that spans the continuum from bench-to-bedside to continuously improve our processes, products and services. As Dr. Zeller describes: “There are biological studies and retrospective data, but we only have one existing RCT. There’s a real importance to pursue a prospective, RCT so we can look forward as opposed to looking back.”

“As every blood donor is unique, the challenge we have is to understand which donor-specific factors can be better matched to improve patient outcomes. Differences in the biology of blood cells from male and female blood donors are well defined, but what we do not understand is if these differences affect health outcomes in transfused patients. This is very important question that the SexMatters clinical trial is proposing to address.”

Dr. Jason Acker, Co-Investigator in the SexMatters trial

How will the study work and why the focus on transfusions in the ICU?

Focusing on transfusions in the ICU is a significant distinguishing feature of this study. The iTADS trial was completed as a multicentre, double-blind trial, but it looked at mortality rates across the whole hospital. This new trial will look at transfusions received by patients in the intensive care unit (ICU) specifically.

“In the hospital, we know that mortality rate is much higher in a transfused ICU patient compared to a patient in another part of the hospital,” Dr. Zeller says. “We’ve chosen to focus this study on the sickest population of patients – those in the ICU – with the idea that any impact will be seen most prominently in this group. The analysis will include consideration to dosage so we can adjust for the specific number of units transfused to each patient.”

The study is also designed so that participants will not know whether a blood transfusion is matched or mismatched based on the sex of donor or recipient – a method used to prevent potential bias in the trial.

“At the hospital, you always get a list with each shipment of blood product that says what units you have received from the blood operator”, Dr. Zeller explains. “As part of this study’s protocol, participating hospitals will see an additional colour-coding noted on this inventory, and this is what will be used when it comes time for us to do our analysis.”

Who could benefit from this knowledge and what are the next steps?

Dr. Zeller is glad to have Canadian Blood Services involved in this research, acknowledging that changing policy related to matching of blood products would be a significant change for hospitals and blood suppliers, requiring strong evidence from RCTs like this one.

“This study will help to inform health-care professionals who prescribe and administer blood products, along with patients, donors, and the blood operator, too. One of the important questions if it does turn out to have a significant difference is ‘Then what?’ We already divide our inventory by group (ABO) and by Rh status (+/-). Would the need to be matching by sex further impact inventory? We don’t know yet, but that’s why it’s important to have the blood supplier involved,” Dr. Zeller says.

The study will require a total sample size of approximately 11,000 patients across an expected nine hospital sites in Ontario.

“We’ve designed this study to be very efficient; it’s got components of what would be considered a pragmatic study design,” Dr. Zeller says. “In terms of the products, Canadian Blood Services does not have to provide anything different than they already do for this study (other than the colour-coded markers) and we will use electronic capture to pull data, so we don’t need to collect study information at bedside. These were processes leveraged from the earlier iTADS study as the iTADS research team was very supportive of us learning from what they did.”

“Whether transfusions should be matched for donor sex is a question that has been percolating in people’s minds for many years. Dr. Zeller has had the courage and perseverance to tackle this important question, which could have important policy implications. I’m excited for Dr. Zeller to embark on this journey and advance knowledge on best transfusion practices.”

Dr. Donald Arnold, Co-Director of CTTG and Co-Investigator in the SexMatters trial

Canadian Blood Services – Driving world-class innovation 

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CSTM 2024: Reflections from Canadian Blood Services trainees, part 1

CSTM 2024: Reflections from Canadian Blood Services trainees, part 1

1. You both contributed as planning committee members for Research Day 2024; why were you interested in contributing in this way?

2. Did you also share your research during Research Day and/or CSTM and if so, in what ways?

3. How many times have you attended Research Day and CSTM and what was your favourite moment or takeaway this year?

4. What would you say to other trainees about Research Day and/or CSTM?

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What was the most memorable moment from the CSTM 2024 program this year and what reflections did you take away from it?

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Lay Science Writing Competition 2024: Evaluating umbilical cord blood transfusion efficacy and safety in neonates

Why did you choose to participate in the competition this year?

The theme this year was “Connecting science with society”; what did this theme mean to you?

Did the writing process help you learn or discover something new about your research?

What tips would you share with others who are writing about research for lay audiences?

Read the prize-winning entry in its entirety below...

About the author:

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