Each of the Great Feasts of the Church is followed by a commemoration of some holy one who figures in the events of the Feast. So, today we commemorate the Holy Archangel Gabriel, who brought the glad news of the conception of Christ to Mary, the Theotokos. The Prologue gives the following teaching:   "The herald of the incarnation of the Son of God, he is one of the seven great angels who stand before the throne of God. He revealed to Zacharias the birth of the Forerunner, and said of himself: 'I am Gabriel that stand in the presence of God' (Lk. 1:19). His name, Gabriel, signifies 'man of God'. Speaking about the Annunciation, the holy Fathers comment that an angel with such a name was sent to signify who He was, and of what nature He was, who would be born of the most pure Virgin. He would be the Man of God, the Man-God, the strong and mighty God. Others have found that it was this same Gabriel who announced the conception of the Virgin Mary to Joachim and Anna, and that it was he who taught Moses in the wilderness to write the Book of Genesis. The holy Fathers consider that Gabriel belongs to the foremost and highest order of the heavenly powers, the seraphim, since the seraphim stand closest to God. And so he is one of the seven seraphim closest to God. The names of these seven are: Michael, Gabriel, Raphael, Uriel, Selathiel, Jegudiel and Barachiel. Some would add Jeremiel to this number. Each has his own particular service, but all are equal in honour. Why did God not send Michael? For the reason that Michael's service is the suppression of the enemies of God's truth, while Gabriel's is the annunciation of the salvation of the human race."

Saint John of Damascus (December 4), the great defender of Orthodoxy against the iconoclasts, was falsely accused of plotting against the Caliph of Damascus through the intrigues of the iconoclast Emperor Leo the Isaurian (reigned 717-741). The Caliph ordered St John's hand to be cut off for his suspected treachery. The saint asked for the severed hand, and passed the night praying fervently for the aid before an icon of the most holy Theotokos. Waking in the morning, he found his hand miraculously restored, with only a scar around the wrist where it had been completely severed. In thanksgiving, St John had a silver hand mounted on the icon. When he became a monk in the monastery of St Sabbas in the Holy Land, he took the icon with him. It remained there until it was given to St Sabbas (Sava) of Serbia (January 14), who brought it to Serbia. Later it was miraculously taken to the Hilandar Monastery on the Holy Mountain (carried, according to legend, from Serbia to Mt Athos by an unguided donkey), where it may now be found.

Though each of the Twelve Apostles has his own Feast day, on this day they are commemorated together. Of the Twelve, only St John the Theologian died in peace; the rest met a martyr's end. Following are their individual feast days and the manner of their end. Roman citizens could not be crucified: crucifixion was considered a shameful death unworthy of a citizen. For this reason the Apostle Paul was 'privileged' to be beheaded.  Peter: June 29, January 16. Crucified upside down.  Andrew: November 30. Crucified.  James the Son of Zebedee: April 30. Beheaded.  John the Theologian: September 26, May 8. Died in peace in a wondrous way.  Philip: November 14. Crucified.  Bartholomew: June 11, August 25. Crucified, then flayed and beheaded.  Thomas: October 6. Pierced with five spears.  Matthew the Evangelist: November 16. Burned to death.  James the Son of Aphaeos: October 9. Crucified.  Thaddeus (or Jude the brother of James): June 19. Crucified.  Simon the Zealot: May 10. Crucified.  Matthias: August 9. Stoned, then beheaded with an axe when dead.  Paul: June 29. Beheaded.

The holy Scriptures, from beginning to end, are filled with mentions and descriptions of the Heavenly Host: not to believe in angels is not to believe in the Bible. In the heavens they behold the face of God, eternally hymning His glory. They are intimately involved with mankind as well: an angel is appointed guardian over every nation, and over every individual Christian. The Archangels Michael and Gabriel, whom we especially commemorate today along with all the other bodiless powers, have served as messengers to man. "Michael" means "Who is like God?";"Gabriel" means "God is mighty." Gabriel especially was appointed to announce the coming of Christ in the flesh.   There is no reckoning the number of the Heavenly Host, though we know that they are a great multitude. They are ranked in nine orders, called Thrones, Cherubim, Seraphim, Dominions, Powers, Authorities, Principalities, Archangels and Angels. "Angel" means "herald" or "messenger" and is properly applied only to those who serve as messengers from God to man; but the name is often applied to the entire host of bodiless powers.   Though bodiless, the angels are finite in knowledge, extension and power. The angel Lucifer, once the highest of them all, desired to be like God Himself, and was cast forever from the presence of God, along with countless others who followed him. These we now know as Satan and the demons. (Needless to say, they are not commemorated today).

Each of the Great Feasts of the Church is followed by a commemoration of some holy one who figures in the events of the Feast. So, today we commemorate the Holy Archangel Gabriel, who brought the glad news of the conception of Christ to Mary, the Theotokos. The Prologue gives the following teaching:   "The herald of the incarnation of the Son of God, he is one of the seven great angels who stand before the throne of God. He revealed to Zacharias the birth of the Forerunner, and said of himself: 'I am Gabriel that stand in the presence of God' (Lk. 1:19). His name, Gabriel, signifies 'man of God'. Speaking about the Annunciation, the holy Fathers comment that an angel with such a name was sent to signify who He was, and of what nature He was, who would be born of the most pure Virgin. He would be the Man of God, the Man-God, the strong and mighty God. Others have found that it was this same Gabriel who announced the conception of the Virgin Mary to Joachim and Anna, and that it was he who taught Moses in the wilderness to write the Book of Genesis. The holy Fathers consider that Gabriel belongs to the foremost and highest order of the heavenly powers, the seraphim, since the seraphim stand closest to God. And so he is one of the seven seraphim closest to God. The names of these seven are: Michael, Gabriel, Raphael, Uriel, Selathiel, Jegudiel and Barachiel. Some would add Jeremiel to this number. Each has his own particular service, but all are equal in honour. Why did God not send Michael? For the reason that Michael's service is the suppression of the enemies of God's truth, while Gabriel's is the annunciation of the salvation of the human race."

Though each of the Twelve Apostles has his own Feast day, on this day they are commemorated together. Of the Twelve, only St John the Theologian died in peace; the rest met a martyr's end. Following are their individual feast days and the manner of their end. Roman citizens could not be crucified: crucifixion was considered a shameful death unworthy of a citizen. For this reason the Apostle Paul was 'privileged' to be beheaded.  Peter: June 29, January 16. Crucified upside down.  Andrew: November 30. Crucified.  James the Son of Zebedee: April 30. Beheaded.  John the Theologian: September 26, May 8. Died in peace in a wondrous way.  Philip: November 14. Crucified.  Bartholomew: June 11, August 25. Crucified, then flayed and beheaded.  Thomas: October 6. Pierced with five spears.  Matthew the Evangelist: November 16. Burned to death.  James the Son of Aphaeos: October 9. Crucified.  Thaddeus (or Jude the brother of James): June 19. Crucified.  Simon the Zealot: May 10. Crucified.  Matthias: August 9. Stoned, then beheaded with an axe when dead.  Paul: June 29. Beheaded.

The holy Scriptures, from beginning to end, are filled with mentions and descriptions of the Heavenly Host: not to believe in angels is not to believe in the Bible. In the heavens they behold the face of God, eternally hymning His glory. They are intimately involved with mankind as well: an angel is appointed guardian over every nation, and over every individual Christian. The Archangels Michael and Gabriel, whom we especially commemorate today along with all the other bodiless powers, have served as messengers to man. "Michael" means "Who is like God?";"Gabriel" means "God is mighty." Gabriel especially was appointed to announce the coming of Christ in the flesh.   There is no reckoning the number of the Heavenly Host, though we know that they are a great multitude. They are ranked in nine orders, called Thrones, Cherubim, Seraphim, Dominions, Powers, Authorities, Principalities, Archangels and Angels. "Angel" means "herald" or "messenger" and is properly applied only to those who serve as messengers from God to man; but the name is often applied to the entire host of bodiless powers.   Though bodiless, the angels are finite in knowledge, extension and power. The angel Lucifer, once the highest of them all, desired to be like God Himself, and was cast forever from the presence of God, along with countless others who followed him. These we now know as Satan and the demons. (Needless to say, they are not commemorated today).

Each of the Great Feasts of the Church is followed by a commemoration of some holy one who figures in the events of the Feast. So, today we commemorate the Holy Archangel Gabriel, who brought the glad news of the conception of Christ to Mary, the Theotokos. The Prologue gives the following teaching:   "The herald of the incarnation of the Son of God, he is one of the seven great angels who stand before the throne of God. He revealed to Zacharias the birth of the Forerunner, and said of himself: 'I am Gabriel that stand in the presence of God' (Lk. 1:19). His name, Gabriel, signifies 'man of God'. Speaking about the Annunciation, the holy Fathers comment that an angel with such a name was sent to signify who He was, and of what nature He was, who would be born of the most pure Virgin. He would be the Man of God, the Man-God, the strong and mighty God. Others have found that it was this same Gabriel who announced the conception of the Virgin Mary to Joachim and Anna, and that it was he who taught Moses in the wilderness to write the Book of Genesis. The holy Fathers consider that Gabriel belongs to the foremost and highest order of the heavenly powers, the seraphim, since the seraphim stand closest to God. And so he is one of the seven seraphim closest to God. The names of these seven are: Michael, Gabriel, Raphael, Uriel, Selathiel, Jegudiel and Barachiel. Some would add Jeremiel to this number. Each has his own particular service, but all are equal in honour. Why did God not send Michael? For the reason that Michael's service is the suppression of the enemies of God's truth, while Gabriel's is the annunciation of the salvation of the human race."

Though each of the Twelve Apostles has his own Feast day, on this day they are commemorated together. Of the Twelve, only St John the Theologian died in peace; the rest met a martyr's end. Following are their individual feast days and the manner of their end. Roman citizens could not be crucified: crucifixion was considered a shameful death unworthy of a citizen. For this reason the Apostle Paul was 'privileged' to be beheaded.  Peter: June 29, January 16. Crucified upside down.  Andrew: November 30. Crucified.  James the Son of Zebedee: April 30. Beheaded.  John the Theologian: September 26, May 8. Died in peace in a wondrous way.  Philip: November 14. Crucified.  Bartholomew: June 11, August 25. Crucified, then flayed and beheaded.  Thomas: October 6. Pierced with five spears.  Matthew the Evangelist: November 16. Burned to death.  James the Son of Aphaeos: October 9. Crucified.  Thaddeus (or Jude the brother of James): June 19. Crucified.  Simon the Zealot: May 10. Crucified.  Matthias: August 9. Stoned, then beheaded with an axe when dead.  Paul: June 29. Beheaded.

The holy Scriptures, from beginning to end, are filled with mentions and descriptions of the Heavenly Host: not to believe in angels is not to believe in the Bible. In the heavens they behold the face of God, eternally hymning His glory. They are intimately involved with mankind as well: an angel is appointed guardian over every nation, and over every individual Christian. The Archangels Michael and Gabriel, whom we especially commemorate today along with all the other bodiless powers, have served as messengers to man. "Michael" means "Who is like God?";"Gabriel" means "God is mighty." Gabriel especially was appointed to announce the coming of Christ in the flesh.   There is no reckoning the number of the Heavenly Host, though we know that they are a great multitude. They are ranked in nine orders, called Thrones, Cherubim, Seraphim, Dominions, Powers, Authorities, Principalities, Archangels and Angels. "Angel" means "herald" or "messenger" and is properly applied only to those who serve as messengers from God to man; but the name is often applied to the entire host of bodiless powers.   Though bodiless, the angels are finite in knowledge, extension and power. The angel Lucifer, once the highest of them all, desired to be like God Himself, and was cast forever from the presence of God, along with countless others who followed him. These we now know as Satan and the demons. (Needless to say, they are not commemorated today).

On this Sunday, Fr. Andrew speaks about Expectation, Action, and Fulfillment, which lead to Salvation.

Fr. John discusses the importance of the Synaxis of the Theotokos, celebrated each year on December 26.

Fr. Philip LeMasters preaches on the example of the twelve holy apostles who sacrificed all for the sake of following Jesus.

Fr. John reflects on the Synaxis of the Holy Apostles, commemorated on the day following the Feast of Sts. Peter and Paul. "Their proclamation has gone out into all the world, and their words to the end of the universe."

During this difficult time, we consider wisdom concerning the role of angels, the humble strength of our Lord Jesus, the peace that cannot come through “sons of men,” and the marks of the Lord that are to be seen on us, as they were on the apostle Paul. (Hebrews 2:2-10; Joshua 5:13-15; Judges 6:2-24; Galatians 6:11-18)

Bobby Maddex interviews Christine Drechsler and Fr. John Rallis, both of whom are with an organization called Chicago Metropolis Family Synaxis.

The System and Organization Controls (SOC 2) Type 1 report highlights Axis Communication’s efforts to protect customer and partner data with robust cloud security measures.

With AXIS OS 11.8, MACsec is enabled by default. Data is encrypted at the Ethernet Layer 2 network level, safeguarding the integrity of data being transferred between Axis devices and MACsec-enabled Ethernet switches.

This robust, halogen-free thermal camera provides users with both reliable and consistent detection and verification at all hours of the day, regardless of weather or lighting conditions.

AXIS Image Health Analytics notifies users of any issues with image quality and ensures that the cameras being used are capturing the right images at all times.

The cloud to camera service will be available on select cameras from Axis, allowing users to access advanced video analytics at the edge, such as object detection, to better identify potential risks and increase situational awareness.

Physical security systems need to be nimble to counter a changing threat landscape.

RAPID (RAtio method Pattern InDexing) is an ImageJ macro script developed for the quick determination of sample orientation and indexing of calibrated and uncalibrated zone axis aligned electron diffraction patterns from materials with a cubic crystal structure. In addition to SAED and NBED patterns, the program is also capable of handling zone axis TEM Kikuchi patterns and FFTs derived from HR(S)TEM images. The software enables users to rapidly determine whether materials are cubic, pseudo-cubic, or non-cubic, and to distinguish between P, I, and F Bravais lattices. It can also provide lattice parameters for material verification and aid in determining the camera constant of the instrument, thus making the program a convenient tool for on-site crystallographic analysis in the TEM laboratory.

This work presents observations of symmetry breakages in the intensity distributions of near-zone-axis convergent-beam electron diffraction (CBED) patterns that can only be explained by the symmetry of the specimen and not the symmetry of the unit cell describing the atomic structure of the material. The specimen is an aluminium–copper–tin alloy containing voids many tens of nanometres in size within continuous single crystals of the aluminium host matrix. Several CBED patterns where the incident beam enters and exits parallel void facets without the incident beam being perpendicular to these facets are examined. The symmetries in their intensity distributions are explained by the specimen morphology alone using a geometric argument based on the multislice theory. This work shows that it is possible to deduce nanoscale morphological information about the specimen in the direction of the electron beam – the elusive third dimension in transmission electron microscopy – from the inspection of CBED patterns.

Using the well known Rn ratio method, a protocol has been elaborated for determining the lattice direction for the 15 most common cubic zone axis spot patterns. The method makes use of the lengths of the three shortest reciprocal-lattice vectors in each pattern and the angles between them. No prior pattern calibration is required for the method to work, as the Rn ratio method is based entirely on geometric relationships. In the first step the pattern is assigned to one of three possible pattern types according to the angles that are measured between the three reciprocal-lattice vectors. The lattice direction [uvw] and possible Bravais type(s) and Laue indices of the corresponding reflections can then be determined by using lookup tables. In addition to determining the lattice direction, this simple geometric analysis allows one to distinguish between the P, I and F Bravais lattices for spot patterns aligned along [013], [112], [114] and [233]. Moreover, the F lattice can always be uniquely identified from the [011] and [123] patterns.

Praxis Impact Bond Fund (MIIAX) and (MIIIX) crosses both the 30-year mark and $1 billion in assets this year

New research shows the amount of carbon dioxide released into the atmosphere from private jets between 2019 and 2023.

Collaboration offers Praxis customers access to enhanced product tracing to meet compliance requirements such as the FDA-mandated DSCSA (Drug Supply Chain Security Act) regulation with a November 2024 enforcement deadline.

U4SSC - Urban Mobility - Dubai: Mobile solutions for ordering taxis and other transportation services, 'E-hailing'

Kinaxis a leader in supply chain management software, has announced that Infineum has selected Kinaxis to drive increased efficiency and reduce waste across its supply chain with improved navigation of supply and demand in today’s increasingly volatile business environment.

Panelistas consideran que la medida busca aliviar las finanzas de un sector golpeado, pero creen que puede tener un efecto sobre otros sectores que busquen el mismo beneficio.

La Luciérnaga se enciende para hablar del posible paro de taxistas. Además, le contamos cómo se prepara Bogotá para recibir el puente de reyes. Asimismo, el curioso cartel publicado por la policía de Santa Marta que se convirtió en un meme.

La Luciérnaga se enciende para hablar de cómo se desarrollaron las movilizaciones de taxistas a lo largo del país. Además, le contamos sobre lo qué pasa con una moción de censura contra la ministra de Minas. También, ¿El gabinete del presidente Petro está a punto de quedarse con vacantes?La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

Se detectó un plan criminal, terrorista de acuerdo con la información de inteligencia desde Venezuela por parte del Ejercito de Liberación Nacional para atentar contra la vida del Fiscal General de la Nación. Esto provocó en primer lugar, un rechazo generalizado en todos los estamentos del país así como una reunión de emergencia con el Gobierno Nacional para analizar la información de la Fiscalía. Así mismo, algunos bloqueos se mantuvieron en algunas ciudades del país como; Cúcuta, Medellín y Bucaramanga. Son al menos 1500 taxistas que salieron a las calles y carreteras, de esta manera se adelantaron 27 actividades en 13 municipios de 10 departamentos de Colombia. También, dos proyectos ley que se radicaron en el Congreso de La República, los cuales buscan beneficiar a los integrantes de las Fuerzas Militares como Policía Nacional, estos tuvieron algunos cambios positivos. 

La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este miércoles 25 de octubre. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en su regreso a casa. 

Escuche el programa de este martes 20 de noviembre. La Luciérnaga, un espacio un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este martes 23 de julio. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

Hassan Fares, candidato a la Alcaldía de Barranquilla, dio detalles sobre las acusaciones a la Policía.

En Caracol Radio estuvo Gustavo Bolívar, director del Departamento de Prosperidad Social

Julián Sánchez, alcalde de Soacha, habló en 6AM sobre que representa para Soacha convertirse en la primera ciudad que hará transición enrgética en 300 taxis 

Frederic Heihoff
Proc. Amer. Math. Soc. 152 (), 5229-5247.
Abstract, references and article information

Postoperative recurrence from microscopic residual disease must be prevented to cure intractable cancers, including pancreatic cancer. Key to this goal is the elimination of cancer stem cells (CSCs) endowed with tumor-initiating capacity and drug resistance. However, current therapeutic strategies capable of accomplishing this are insufficient. Using in vitro models of CSCs and in vivo models of tumor initiation in which CSCs give rise to xenograft tumors, we show that dexamethasone induces expression of MKP-1, a MAPK phosphatase, via glucocorticoid receptor activation, thereby inactivating JNK, which is required for self-renewal and tumor initiation by pancreatic CSCs as well as for their expression of survivin, an anti-apoptotic protein implicated in multidrug resistance. We also demonstrate that systemic administration of clinically relevant doses of dexamethasone together with gemcitabine prevents tumor formation by CSCs in a pancreatic cancer xenograft model. Our study thus provides preclinical evidence for the efficacy of dexamethasone as an adjuvant therapy to prevent postoperative recurrence in patients with pancreatic cancer.

Natalie Bruiners
Dec 1, 2020; 61:1617-1628
Research Articles

The rise of drug-resistant tuberculosis poses a major risk to public health. Statins, which inhibit both cholesterol biosynthesis and protein prenylation branches of the mevalonate pathway, increase anti-tubercular antibiotic efficacy in animal models. However, the underlying molecular mechanisms are unknown. In this study, we used an in vitro macrophage infection model to investigate simvastatin’s anti-tubercular activity by systematically inhibiting each branch of the mevalonate pathway and evaluating the effects of the branch-specific inhibitors on mycobacterial growth. The anti-tubercular activity of simvastatin used at clinically relevant doses specifically targeted the cholesterol biosynthetic branch rather than the prenylation branches of the mevalonate pathway. Using Western blot analysis and AMP/ATP measurements, we found that simvastatin treatment blocked activation of mechanistic target of rapamycin complex 1 (mTORC1), activated AMP-activated protein kinase (AMPK) through increased intracellular AMP:ATP ratios, and favored nuclear translocation of transcription factor EB (TFEB). These mechanisms all induce autophagy, which is anti-mycobacterial. The biological effects of simvastatin on the AMPK-mTORC1-TFEB-autophagy axis were reversed by adding exogenous cholesterol to the cells. Our data demonstrate that the anti-tubercular activity of simvastatin requires inhibiting cholesterol biosynthesis, reveal novel links between cholesterol homeostasis, the AMPK-mTORC1-TFEB axis, and Mycobacterium tuberculosis infection control, and uncover new anti-tubercular therapy targets.

Hi

In the environment I'm currently working, axes are shown for schematic, symbol, and layout views.For schematics and symbols, I'd prefer a dim gray, such that the axes are just visible but not dominant. For the layout, I'd prefer a brighter color. Is there a way to realize this? So far when I change the color of the 'axis' layer in the display resource editor, the axes in all three views get changed together:

Thanks very much for your input!

Changes in the distribution of groundwater around the planet between 1993 and 2010 were enough to make Earth's poles drift by 80 centimetres

I have a confession to make. After taking a handful of autonomous taxi rides, I have gone from a hater to a friend of robot cars in just a few weeks, says Annalee Newitz

The driverless vehicles still can't take L.A.'s notorious highways.